Prospectus, April 14, 2010

FEDERAL WORK STUDY PROGRAM FUNDS EXHAUSTED FOR SPRING SEMESTER; Is Parkland prepared to assist the disabled in case of an emergency?; Surge in campus hate crimes challenges notion of a post-racial America; Chuck Shepherd’s News of the Weird; Fantastic, fun and not too far away: The top five summer music festivals you need to see; Parkland Event: Typeface documentary premier; Earth Week celebrations: What to know about upcoming events; How Washington is spending your taxes in 2010; Wrong man convicted even though ‘everybody did their best’; Prospectus Pick: Meeting People is Easy; Give a Hand: Help a Student in Need; Do birds help curb global warming?; Faculty, staff and students involved in sports; The health care bill and youhttps://spark.parkland.edu/prospectus_2010/1011/thumbnail.jp

Prospectus, March 3, 2010

SPRING IS NEAR, BUT NOT TO FEAR: IDEAS FOR WHEN THE WEATHER TURNS WARM; Father of the Bride to elate audiences starting this week; Chuck Shepherd’s News of the Weird; Chuck Shepherd’s News of the Weird; Parkland Art Gallery Presents: Cup-a-palooza; Woman becomes victim of identity theft; Woman becomes victim of identity theft; Insurrectos! Yesterday s Taliban; Ask MNN: Whats the difference between cellulose sponges and those other kitchen sponges?; Not just for jocks: students turn to alternative exercise for fun fitness; Prospectus Pick: Halo Legends; Where is your Cobra Enthusiasm?; Celebrating women all year longhttps://spark.parkland.edu/prospectus_2010/1006/thumbnail.jp

Prospectus, March 10, 2010

THE C-U ROLLERS TAKE CHAMPAIGN BY STORM; Recession pushes parents to enroll at community colleges along with kids; Chuck Shepherd’s News of the Weird; The superheroes of music; Online community covers unrest in Iran, post by post; Prospectus Pick: Pizza; Oh, Canada: Opinions on the closing ceremonies of the winter Olympics; The Earth has its own set of rules; Rest assured: Sleep is vital to your health; Student Government; What’s the future for ESPN 3D television?https://spark.parkland.edu/prospectus_2010/1007/thumbnail.jp

Prospectus, March 31, 2010

FEDERAL PELL GRANT PROGRAM SERVES AS THEME FOR SENATOR DURBIN\u27S VISIT TO PARKLAND; Pros and cons of apartment amenities; Chuck Shepherd\u27s News of the Weird; Manowar kills, other bands just play; A guide to apartment searching; The trouble with easy listening; If dinner is still twitching, don\u27t eat it; Prospectus Pick: T.V.; 6 things that tell you it\u27s time to see a doctor; Lynn O\u27Brien performs CD release concert at planetariumhttps://spark.parkland.edu/prospectus_2010/1009/thumbnail.jp

Prospectus, March 31, 2010 - April Fool\u27s Edition

BIG NEW THINGS TO HAPPEN AT PARKLAND; Parkland announces new classes, future aquarium; Parkland hires all-star processor to teach new course; Metered spaces now a sure bet for Parkland; Chuck Shepherd\u27s News of the Weird; music downloads; In keeping April showers and May flowers green; The benefits of being illiterate; Prospectus Pick: Laser Cats; New sports on the way for Parkland; Students and faculty gear up for unofficial ; 2010 Staff Excellence Awards; April Fool\u27s Pranks!https://spark.parkland.edu/prospectus_2010/1010/thumbnail.jp

Prospectus, April 28, 2010

THREE-YEAR BACHELOR\u27S DEGREE GAINS POPULARITY; Exhibit seeks to show more human side of Civil War; Chuck Shepherd’s News of the Weird; Embracing the new age; 10 worst comic book movies; The need for Americans to enter public life has never been greater; Re: Are we truly receiving an education?; FDA moves to reduce salt in American diet; The Survival Guide for Finals!; Prospectus Pick: Phantogram’s Eyelid Movies; Is American Sign Language a ‘foreign’ language?; More myths busted about electric cars; Cobra’s season breakdown; Battle of the Bandshttps://spark.parkland.edu/prospectus_2010/1013/thumbnail.jp

Prospectus, May 5, 2010

THE HISTORY OF PARKLAND UNFOLDED; Up close and personal with Parkland\u27s Student Government; The benefits of finals week; Chuck Shepherd\u27s News of the Weird; Jobs in the music industry; The top 5 places to study for finals; Welcome to heartbreak: cheating; Video games are protected speech; Letter to the Editor; Workouts 101: How to Find a Plan That Works for You- and Then Stick With It; Prospectus Pick: Pride and Prejudice and Zombies; Dawn of the Dreadfuls; More restaurants are trying to do the green thing; Lesson in patience: Aid cuts slow down fast track into teaching profession; Baroness to impress: A word with the up and coming metal band, Baroness; Parkland\u27s Motor Sports Car Showhttps://spark.parkland.edu/prospectus_2010/1014/thumbnail.jp

Chlamydia trachomatis genotypes in a cross-sectional study of urogenital samples from remote Northern and Central Australia

his is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/Abstract OBJECTIVES: The objective was to determine the frequency of trachoma genotypes of Chlamydia trachomatis-positive urogenital tract (UGT) specimens from remote areas of the Australian Northern Territory (NT). SETTING: The setting was analysis of remnants of C. trachomatis positive primarily UGT specimens obtained in the course of clinical practice. The specimens were obtained from two pathology service providers. PARTICIPANTS: From 3356 C. trachomatis specimens collected during May 2012-April 2013, 439 were selected for genotyping, with a focus on specimens from postpubescent patients, in remote Aboriginal communities where ocular trachoma is potentially present. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome measure was the proportion of successfully genotyped UGT specimens that were trachoma genotypes. The secondary outcome measures were the distribution of genotypes, and the frequencies of different classes of specimens able to be genotyped. RESULTS: Zero of 217 successfully genotyped UGT specimens yielded trachoma genotypes (95% CI for frequency=0-0.017). For UGT specimens, the genotypes were E (41%), F (22%), D (21%) and K (7%), with J, H and G and mixed genotypes each at 1-4%. Four of the five genotyped eye swabs yielded trachoma genotype Ba, and the other genotype J. Two hundred twenty-two specimens (50.6%) were successfully genotyped. Urine specimens were less likely to be typable than vaginal swabs (p<0.0001). CONCLUSIONS: Unlike in some other studies, in the remote NT, trachoma genotypes of C. trachomatis were not found circulating in UGT specimens from 2012 to 2013. Therefore, C. trachomatis genotypes in UGT specimens from young children can be informative as to whether the organism has been acquired through sexual contact. We suggest inclusion of C. trachomatis genotyping in guidelines examining the source of sexually transmitted infections in young children in areas where trachoma genotypes may continue to circulate, and continued surveillance of UGT C. trachomatis genotypes

Radio continuum observations of Class I protostellar disks in Taurus: constraining the greybody tail at centimetre wavelengths

We present deep 1.8 cm (16 GHz) radio continuum imaging of seven young stellar objects in the Taurus molecular cloud. These objects have previously been extensively studied in the sub-mm to NIR range and their SEDs modelled to provide reliable physical and geometrical parametres.We use this new data to constrain the properties of the long-wavelength tail of the greybody spectrum, which is expected to be dominated by emission from large dust grains in the protostellar disk. We find spectra consistent with the opacity indices expected for such a population, with an average opacity index of beta = 0.26+/-0.22 indicating grain growth within the disks. We use spectra fitted jointly to radio and sub-mm data to separate the contributions from thermal dust and radio emission at 1.8 cm and derive disk masses directly from the cm-wave dust contribution. We find that disk masses derived from these flux densities under assumptions consistent with the literature are systematically higher than those calculated from sub-mm data, and meet the criteria for giant planet formation in a number of cases.Comment: submitted MNRA

Novel epoxy-tiglianes stimulate skin keratinocyte wound healing responses and re-epithelialization via protein kinase C activation

Epoxy-tiglianes are a novel class of diterpene esters. The prototype epoxy-tigliane, EBC-46 (tigilanol tiglate), possesses potent anti-cancer properties and is currently in clinical development as a local treatment for human and veterinary cutaneous tumors. EBC-46 rapidly destroys treated tumors and consistently promotes wound re-epithelialization at sites of tumor destruction. However, the mechanisms underlying these keratinocyte wound healing responses are not completely understood. Here, we investigated the effects of EBC-46 and an analogue (EBC-211) at 1.51 nM-151 µM concentrations, on wound healing responses in immortalized human skin keratinocytes (HaCaTs). Both EBC-46 and EBC-211 (1.51 nM-15.1 µM) accelerated G0/G1-S and S-G2/M cell cycle transitions and HaCaT proliferation. EBC-46 (1.51-151 nM) and EBC-211 (1.51 nM-15.1 µM) further induced significant HaCaT migration and scratch wound repopulation. Stimulated migration/wound repopulation responses were even induced by EBC-46 (1.51 nM) and EBC-211 (1.51-151 nM) with proliferation inhibitor, mitomycin C (1 μM), suggesting that epoxy-tiglianes can promote migration and wound repopulation independently of proliferation. Expression profiling analyses showed that epoxytiglianes modulated keratin, DNA synthesis/replication, cell cycle/proliferation, motility/migration, differentiation, matrix metalloproteinase (MMP) and cytokine/chemokine gene expression, to facilitate enhanced responses. Although epoxy-tiglianes down-regulated established cytokine and chemokine agonists of keratinocyte proliferation and migration, enhanced HaCaT responses were demonstrated to be mediated via protein kinase C (PKC) phosphorylation and significantly abrogated by pan-PKC inhibitor, bisindolylmaleimide-1 (BIM-1, 1 μM). By identifying how epoxy-tiglianes stimulate keratinocyte healing responses and re-epithelialization in treated skin, our findings support the further development of this class of small molecules as potential therapeutics for other clinical situations associated with impaired re-epithelialization, such as non-healing skin wounds