Performance of the Components of the XJ34-WE-32 Turbojet Engine over a Range of Engine and Flight Conditions

Performance of the compressor, combustor, and turbine operating as integral parts of the XJ34-WE-32 turbojet engine was determined in the Lewis altitude wind tunnel over a range of altitudes from 5000 to 55,000 feet and flight Mach numbers from 0.28 to 1.05. Data were obtained for each of four exhaust-nozzle areas and are presented in graphical and tabular form

Reduction in Asthma Morbidity in Children as a Result of Home Remediation Aimed at Moisture Sources

OBJECTIVE: Home dampness and the presence of mold and allergens have been associated with asthma morbidity. We examined changes in asthma morbidity in children as a result of home remediation aimed at moisture sources. DESIGN: In this prospective, randomized controlled trial, symptomatic, asthmatic children (n = 62), 2–17 years of age, living in a home with indoor mold, received an asthma intervention including an action plan, education, and individualized problem solving. The remediation group also received household repairs, including reduction of water infiltration, removal of water-damaged building materials, and heating/ventilation/air-conditioning alterations. The control group received only home cleaning information. We measured children’s total and allergen-specific serum immuno-globulin E, peripheral blood eosinophil counts, and urinary cotinine. Environmental dust samples were analyzed for dust mite, cockroach, rodent urinary protein, endotoxin, and fungi. The follow-up period was 1 year. RESULTS: Children in both groups showed improvement in asthma symptomatic days during the preremediation portion of the study. The remediation group had a significant decrease in symptom days (p = 0.003, as randomized; p = 0.004, intent to treat) after remodeling, whereas these parameters in the control group did not significantly change. In the postremediation period, the remediation group had a lower rate of exacerbations compared with control asthmatics (as treated: 1 of 29 vs. 11 of 33, respectively, p = 0. 003; intent to treat: 28.1% and 10.0%, respectively, p = 0.11). CONCLUSION: Construction remediation aimed at the root cause of moisture sources and combined with a medical/behavioral intervention significantly reduces symptom days and health care use for asthmatic children who live in homes with a documented mold problem

The Grizzly, December 6, 2001

UC Students: Dancin\u27 The Night Away • Celebrating the Holidays Around the World • Pomenti Wins World History Association / Phi Alpha Theta Essay Competition • US Economy Faces Economic Recession • Campus Residence Halls Compete in a Holiday Decorating Contest • Opinions: Wismer\u27s Fantastic Harvest Moon Festival; Lancaster not Just for the Amish • Final Exam Schedule • Christmas Price Comparison: Lights, Cards and Wrapping Paper • How to Make Your Own Christmas Gifts • \u27Twas the Night Before Finals • Fun Activities in Philly • UC Swim Teams Maintain Winning Streak Over Arcadia and Goucher • Women\u27s Hoops Knock Off the Devils • Bears Finally Find First Victory • UC Track & Field Indoor Once More at Dickinson Holiday Meet • Wrestlers Finish 6th at Petrofes Invitationalhttps://digitalcommons.ursinus.edu/grizzlynews/1503/thumbnail.jp

The Grizzly, November 1, 2001

Students Join Together to Take Back the Night • World-Renowned Composer, Arranger and Educator will Unite the Ursinus Campus in Song this Weekend • Ursinus Students Celebrate the Haunting Holiday with Local Children • Understanding Biological Terrorism • UC Groups Clean up the Environment • Professor Valerie Martinez Named a Commonwealth Speaker • Opinions: Community Service for all Campus Organizations?; Your Patriotic Duty: Voting Guarantees Your Freedom; Inspirational Take Back the Night • Faustus a Devilishly Good Play • Cost of the Midnight Munchies • RHA Sponsors Spades Tournament • Farewell Game Leaves Bears Women\u27s Soccer Kicked by Mules •XC Digs in at Centennial Conference Meet • Dale Named Centennial Conference Player of the Week • Duncan Becomes All-time Leader in Rush • Volleyball Downed by G-M • Bears Brush Away Colgate • Muhlenberg Strikes Yet Again • Bears Football Kicked by Muhlenberg\u27s Mules, 23-20https://digitalcommons.ursinus.edu/grizzlynews/1499/thumbnail.jp

The Grizzly, October 18, 2001

Sisters of Omega Chi Sponsor Blood Drive • Taking a Hike with the Environmental Studies Classes • World Cultures Club Encourages Campus-Wide Cultural Awareness • Gil Cook and Heather Potts Named 2001 Homecoming King and Queen • Understanding the Social Norms at Ursinus College • Ursinus Bookstore Holding Coat and Blanket Drive • Ursinus Alumna Martha Kriebel Reflects on the Unexpected Turns in Life\u27s Path • The Economic Effects of Terrorism • Struggling to Survive: The Way of Life for Women in Afghanistan • From Mexico to Collegeville: International Exchange Student Enrique Cobarrubias • Sophomore Week: Helping Students Reach Academic Goals • Second Annual Take Back the Night Rally & March Planned for Next Week • Opinions: Lady Wismer Attacks Students Saying Next Time, I\u27m Gonna Nail You! ; A Student\u27s Battle with Smoking; New Gym is Great, not Awkward; Message of Tolerance and Peace; One Resident Complains: Loss of Interest in Special Interest Houses • Dr. David Releases his own CD • New Road Brewhouse Ready to Rock! • Scary Way to Have a Fun Fall Day • Chinese Food: The Staple of Every College Student\u27s Diet • Can\u27t Decide What to do after Graduation? This Online Program Will Help • Class of 2003 has a new President • Ruby\u27s Restaurant: A Tasty Time Capsule • Give the Wismer Staff a Break: They\u27re Working for You • Who is Grizzly the Bear? • Ursinus Field Hockey Takes Victory over Holy Cross • Bears Wake from Hibernation; Crush Gettysburg 31-7 • Men\u27s Soccer Meets Gettysburg • Volleyball Wins Against Bryn Mawr and U. of the Sciences • XC Cleans up at Lehigh University • Barth Becomes Record-holder for Points • Field Hockey Changing NCAA Division • Women\u27s Soccer Rocks the Househttps://digitalcommons.ursinus.edu/grizzlynews/1497/thumbnail.jp

Discovery of a small molecule agonist of phosphatidylinositol 3-kinase p110α that reactivates latent HIV-1

Combination antiretroviral therapy (cART) can effectively suppress HIV-1 replication, but the latent viral reservoir in resting memory CD4+ T cells is impervious to cART and represents a major barrier to curing HIV-1 infection. Reactivation of latent HIV-1 represents a possible strategy for elimination of this reservoir. In this study we describe the discovery of 1,2,9,10-tetramethoxy-7H-dibenzo[de,g]quinolin-7-one (57704) which reactivates latent HIV-1 in several cell-line models of latency (J89GFP, U1 and ACH-2). 57704 also increased HIV-1 expression in 3 of 4 CD8+-depleted blood mononuclear cell preparations isolated from HIV-1-infected individuals on suppressive cART. In contrast, vorinostat increased HIV-1 expression in only 1 of the 4 donors tested. Importantly, 57704 does not induce global T cell activation. Mechanistic studies revealed that 57704 reactivates latent HIV-1 via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. 57704 was found to be an agonist of PI3K with specificity to the p110a isoform, but not the p110β, δ or γ isoforms. Taken together, our work suggests that 57704 could serve as a scaffold for the development of more potent activators of latent HIV-1. Furthermore, it highlights the involvement of the PI3K/Akt pathway in the maintenance of HIV-1 latency. © 2014 Doyon et al

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

Background and purpose: Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year. Methods: We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020). Results: There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P<0.0001) and 2020 (41.4%; 95% CI, 37.0 to 46.0; P<0.0001). A COVID-19 diagnosis was present in 7.6% (132/1,738) of CVT hospitalizations. CVT was present in 0.04% (103/292,080) of COVID-19 hospitalizations. During the first pandemic year, CVT mortality was higher in patients who were COVID positive compared to COVID negative patients (8/53 [15.0%] vs. 41/910 [4.5%], P=0.004). There was an increase in CVT mortality during the first 5 months of pandemic years 2020 and 2021 compared to the first 5 months of the pre-pandemic year 2019 (2019 vs. 2020: 2.26% vs. 4.74%, P=0.05; 2019 vs. 2021: 2.26% vs. 4.99%, P=0.03). In the first 5 months of 2021, there were 26 cases of vaccine-induced immune thrombotic thrombocytopenia (VITT), resulting in six deaths. Conclusions: During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT

From METS to malaria: RRx-001, a multi-faceted anticancer agent with activity in cerebral malaria

BACKGROUND: The survival of malaria parasites, under substantial haem-induced oxidative stress in the red blood cells (RBCs) is dependent on the pentose phosphate pathway (PPP). The PPP is the only source of NADPH in the RBC, essential for the production of reduced glutathione (GSH) and for protection from oxidative stress. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, therefore, increases the vulnerability of erythrocytes to oxidative stress. In Plasmodium, G6PD is combined with the second enzyme of the PPP to create a unique bifunctional enzyme, named glucose-6-phosphate dehydrogenase–6-phosphogluconolactonase (G6PD-6PGL). RRx-001 is a novel, systemically non-toxic, epigenetic anticancer agent currently in Phase 2 clinical development for multiple tumour types, with activity mediated through increased nitric oxide (NO) production and PPP inhibition. The inhibition of G6PD and NO overproduction induced by RRx-001 suggested its application in cerebral malaria (CM). METHODS: Plasmodium berghei ANKA (PbA) infection in C57BL/6 mice is an experimental model of cerebral malaria (ECM) with several similar pathological features to human CM. This study uses intravital microscopy methods with a closed cranial window model to quantify cerebral haemodynamic changes and leukocyte adhesion to endothelial cells in ECM. RESULTS: RRx-001 had both single agent anti-parasitic activity and significantly increased the efficacy of artemether. In addition, RRx-001 preserved cerebral perfusion and reduced inflammation alone or combined with artemether. RRx-001’s effects were associated with inhibition of PPP (G6PD and G6PD-6PGL) and by improvements in microcirculatory flow, which may be related to the NO donating properties of RRx-001. CONCLUSION: The results indicate that RRx-001 could be used to potentiate the anti-malarial action of artemisinin, particularly on resistant strains, and to prevent infection