922 research outputs found

    Running Economy while Running in Extreme Cushioning and Normal Cushioning Running Shoes

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    The purpose of the study was to determine if running economy was influenced by wearing maximal cushioning shoes vs. control (neutral cushioning) shoes. (Please see Abstract in text

    ECONOMICALLY OPTIMAL WILDFIRE INTERVENTION REGIMES

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    Wildfires in the United States result in total damages and costs that are likely to exceed billions of dollars annually. Land managers and policy makers propose higher rates of prescribed burning and other kinds of vegetation management to reduce amounts of wildfire and the risks of catastrophic losses. A wildfire public welfare maximization function, using a wildfire production function estimated using a time series model of a panel of Florida counties, is employed to simulate the publicly optimal level of prescribed burning in an example county in Florida (Volusia). Evaluation of the production function reveals that prescribed fire is not associated with reduced catastrophic wildfire risks in Volusia County Florida, indicating a short-run elasticity of -0.16 and a long-run elasticity of wildfire with respect to prescribed fire of -0.07. Stochastic dominance is used to evaluate the optimal amount of prescribed fire most likely to maximize a measure of public welfare. Results of that analysis reveal that the optimal amount of annual prescribed fire is about 3 percent (9,000 acres/year) of the total forest area, which is very close to the actual average amount of prescribed burning (12,700 acres/year) between 1994-99.Resource /Energy Economics and Policy,

    Flamingo Vol. III N 2

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    Anonymous. Cover. Picture. 0. Anonymous. Untitled. Picture. 4. Price, John M. Dada--Esthetic Nihilism. Prose. 5. G.C. Tolerance. Poem. 6. G.W.B. The Castaway. Poem. 6. G.W.B. Cinquains. Poem. 7. Holt, K. HORATI CARMINA, Liber I, ix. Prose. 7. W.A.V. Untitled. Poem. 7. A.E.R. Moods. Poem. 7. G.W.B. Some Say The Moon. Poem. 7. A.E.R. On Quoting The Night Has A Thousand Eyes . Poem. 7. Anonymous. Chapel Cherubs. Prose. 8. E.B. Untitled. Picture. 8. E.B. Untitled. Picture. 8. Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. FLIP— MIGHT I ASK YOU FOR THIS DANCE? FLAP— PLEASE DO, I\u27VE BEEN DYING TO REFUSE YOU ALL EVENING. . Picture. 9. Anonymous. HUSBAND (SAVAGELY)— MARIA, WHERE\u27S MY CLOTHES? MARIA— GOOD HEAVENS, DEAR, I WONDER IF I USED THEM IN THE SALAD. Picture. 9. Anonymous. Our Log Table. Prose. 9. Anonymous. Approved Vocabulary For Fans. Prose. 9. Anonymous. Untitled. Prose. 9.; Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. Untitled. Prose. 9. Anonymous. Only Too True! Prose. 10. F.T. GEORGE TOLD ME ALL THE SECRETS OF HIS PAST LAST NIGHT. REALLY! WHAT DID YOU THINK OF THEM? OH, I THOUGHT THEY WERE HORRIBLY DISAPPOINTING. Picture. 10. Anonymous. Untitled. Prose. 10. Anonymous. Untitled. Prose. 10. Anonymous. Untitled. Prose. 10. Howard, Lillis. The Engaged Homo. Poem. 10. Anonymous. Before and After. Poem. 11. Anonymous. Untitled. Poem. 11. Ubersax. AS OTHERS MIGHT SEE US—CLEVELAND HALL TO A CUBIST. Picture. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. Anonymous. SECOND FROM THE RIGHT— WHAT\u27S THAT DESERTED OLD BUILDING OVER THERE? DITTO LEFT— MUST BE WHERE THEY USED TO MAKE HAIRPINS. Picture. 11. Anonymous. Untitled. Prose. 11. Anonymous. Untitled. Prose. 11. E.T.B. Broadway Bizarre. Prose. 12. E.B. Untitled. Picture. 13. E.B. The First One. Picture. 13. Anonymous. It\u27s done. Prose. 14. W.G.M. Mother. Prose. 15. Anonymous. Our Daily Mud. Prose. 15. G.C. Optimism. Poem. 15. Bridge. Denison Comics. Picture. 16. Anonymous. Our Asinetic Appreciation Corner. Prose. 18. Anonymous. STILL LIFE OF A NEAR-BEER AT THE TURNING POINT. Picture. 18. Rine, Russell. Stewed and Hashed. Poem. 18. Anonymous. Untitled. Poem. 18. Anonymous. Untitled. Poem. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Mercer, Hod. OUR OWN IDEA OF SOMETHING AESTHETIC. Picture. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Anonymous. Such Is Life. Poem. 19. Anonymous. Untitled. Prose. 19. Anonymous. Untitled. Prose. 19. Grayce. THE FLIGHT IS ON—THE FESTIVAL IS HERE. Picture. 20. W.G.K. Eutopia Regained. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Oh You Nine Weeks. Poem. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. Untitled. Prose. 20. Anonymous. THAT MAUSOLEUM HAS BEEN CONDEMNED BY THE BUILDING INSPECTOR. WHAT\u27S WRONG WITH IT? IT HASN\u27T ANY FIRE ESCAPES. Picture. 20. Jester. Untitled. Prose. 24. Anonymous. Untitled. Prose. 24. Panther. Untitled. Prose. 24. Octopus. Untitled. Prose. 24. Mugwump. Untitled. Prose. 24. Reel, Virginia. Untitled. Prose. 24. Garber, Jock. Kows and Why Not. Prose. 25. Texas Scalper. Untitled. Prose. 25. Lord Jeff. Untitled. Prose. 28. Lampoon. Cut Rates. Prose. 28. Malteaser. Untitled. Prose. 28. Sun Dodger. Untitled. Prose. 28. Beanpot. Untitled. Prose. 28. Malteaser. Untitled. Prose. 28. Gargoyle. Putting It Fairly. Prose. 29. Malteaser. Untitled. Prose. 29. Gargoyle. Untitled. Prose. 29. Sun Dial. Untitled. Prose. 29. Gargoyle. Untitled. Prose. 30. Malteaser. Untitled. Prose. 30. Panther. Untitled. Prose. 30. Sun Dial. The Stuffed Kind. Prose. 30. Student Life. Untitled. Prose. 30. Malteaser. Heard in EC. Class. Prose. 30. Nashville Tennessean. Untitled. Prose. 30. Lemon Punch. Untitled. Prose. 31. Sun Dial. Untitled. Prose. 31. Gargoyle. Two is a Crowd. Prose. 31. Phoenix. Untitled. Prose. 31

    How much do delayed health care seeking, delayed care provision and diversion from primary care contribute to the transmission of STIs

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    Objectives: To explore the changing pattern of condom use from 1990 to 2000; to identify sociodemographic and behavioural factors associated with condom use; and reasons for condom use in 2000. Methods: Large probability sample surveys administered among those resident in Britain aged 16–44 (n = 13 765 in 1990, n = 11 161 in 2000). Face to face interviews with self completion components collected sociodemographic, behavioural, and attitudinal data. Results: Condom use in the past year among sexually active 16–24 year old men increased from 61.0% in 1990 to 82.1% in 2000 (p<0.0001), and from 42.0% to 63.2% (p<0.0001) among women of the same age, with smaller increases among older age groups. Among individuals reporting at least two partners in the previous 4 week period, approximately two thirds reported inconsistent or no condom use (63.1% (95% CI 55.9% to 69.8%) of the men and 68.5% (95% CI 57.6% to 77.7%) of the women). Conclusions: Rates of condom use increased substantially between 1990 and 2000, particularly among young people. However, inconsistent condom use by individuals with high rates of partner acquisition may contribute significantly to the recent resurgence in STIs. This group is an important target for intensive and specific sexual health interventions

    Long noncoding RNAs are generated from the mitochondrial genome and regulated by nuclear-encoded proteins

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    Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their expression by Northern blotting and strand-specific qRT-PCR. We show that the abundance of these lncRNAs is comparable to their complementary mRNAs and that nuclear-encoded mitochondrial proteins involved in RNA processing regulate their expression. We also identify the 5′ and 3′ transcript ends of the three lncRNAs and show that mitochondrial RNase P protein 1 (MRPP1) is important for the processing of these transcripts. Finally, we show that mitochondrial lncRNAs form intermolecular duplexes and that their abundance is cell- and tissue-specific, suggesting a functional role in the regulation of mitochondrial gene expression. Published by Cold Spring Harbor Laboratory Press

    Examining the potential public health benefit of offering STI testing to men in amateur football clubs: evidence from cross-sectional surveys

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    Background: In Britain, young people continue to bear the burden of sexually transmitted infections (STIs) so efforts are required, especially among men, to encourage STI testing. The SPORTSMART study trialled an intervention that sought to achieve this by offering chlamydia and gonorrhoea test-kits to men attending amateur football clubs between October and December 2012. With football the highest participation team sport among men in England, this paper examines the potential public health benefit of offering STI testing to men in this setting by assessing their sociodemographic characteristics, sexual behaviours, and healthcare behaviour and comparing them to men in the general population. Methods: Data were collected from 192 (male) members of 6 football clubs in London, United Kingdom, aged 18–44 years via a 20-item pen-and-paper self-completion questionnaire administered 2 weeks after the intervention. These were compared to data collected from 409 men of a similar age who were resident in London when interviewed during 2010–2012 for the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3), a national probability survey that used computer-assisted-personal-interviewing with computer-assisted-self-interview. Age standardisation and multivariable regression were used to account for sociodemographic differences between the surveys. Results: Relative to men in the general population, SPORTSMART men were younger (32.8 % vs. 21.7 % aged under 25 y), and more likely to report (all past year) at least 2 sexual partners (adjusted odds ratio, AOR: 3.25, 95 % CI: 2.15–4.92), concurrent partners (AOR: 2.05, 95 % CI: 1.39–3.02), and non-use of condoms (AOR: 2.17, 95 % CI: 1.39–3.41). No difference was observed in STI/HIV risk perception (AOR for reporting “not at all at risk” of STIs: 1.25, 95 % CI: 0.76–2.04; of HIV: AOR: 1.54, 95 % CI: 0.93–2.55), nor in reporting STI testing in the past year (AOR: 0.83, 95 % CI: 0.44–1.54), which was reported by only one in six men. Conclusions: Relative to young men in the general population, football club members who completed the SPORTSMART survey reported greater sexual risk behaviour but similar STI/HIV risk perception and STI testing history. Offering STI testing in amateur football clubs may therefore widen access to STI testing and health promotion messages for men at higher STI risk, which, given the minority currently testing and the popularity of football in England, should yield both individual and public health benefit

    Myosin-Vb functions as a dynamic tether for peripheral endocytic compartments during transferrin trafficking

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    <p>Abstract</p> <p>Background</p> <p>Myosin-Vb has been shown to be involved in the recycling of diverse proteins in multiple cell types. Studies on transferrin trafficking in HeLa cells using a dominant-negative myosin-Vb tail fragment suggested that myosin-Vb was required for recycling from perinuclear compartments to the plasma membrane. However, chemical-genetic, dominant-negative experiments, in which myosin-Vb was specifically induced to bind to actin, suggested that the initial hypothesis was incorrect both in its site and mode of myosin-Vb action. Instead, the chemical-genetic data suggested that myosin-Vb functions in the actin-rich periphery as a dynamic tether on peripheral endosomes, retarding transferrin transport to perinuclear compartments.</p> <p>Results</p> <p>In this study, we employed both approaches, with the addition of overexpression of full-length wild-type myosin-Vb and switching the order of myosin-Vb inhibition and transferrin loading, to distinguish between these hypotheses. Overexpression of full-length myosin-Vb produced large peripheral endosomes. Chemical-genetic inhibition of myosin-Vb after loading with transferrin did not prevent movement of transferrin from perinuclear compartments; however, virtually all myosin-Vb-decorated particles, including those moving on microtubules, were halted by the inhibition. Overexpression of the myosin-Vb tail caused a less-peripheral distribution of early endosome antigen-1 (EEA1).</p> <p>Conclusion</p> <p>All results favored the peripheral dynamic tethering hypothesis.</p

    Exploring the costs and outcomes of sexually transmitted infection (STI) screening interventions targeting men in football club settings: preliminary cost-consequence analysis of the SPORTSMART pilot randomised controlled trial

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    Background: The objective of this study was to compare the costs and outcomes of two sexually transmitted infection (STI) screening interventions targeted at men in football club settings in England, including screening promoted by team captains. Methods: A comparison of costs and outcomes was undertaken alongside a pilot cluster randomised control trial involving three trial arms: (1) captain-led and poster STI screening promotion; (2) sexual health advisor-led and poster STI screening promotion and (3) poster-only STI screening promotion (control/comparator). For all study arms, resource use and cost data were collected prospectively. Results: There was considerable variation in uptake rates between clubs, but results were broadly comparable across study arms with 50% of men accepting the screening offer in the captain-led arm, 67% in the sexual health advisor-led arm and 61% in the poster-only control arm. The overall costs associated with the intervention arms were similar. The average cost per player tested was comparable, with the average cost per player tested for the captain-led promotion estimated to be £88.99 compared with £88.33 for the sexual health advisor-led promotion and £81.87 for the poster-only (control) arm. Conclusions: Costs and outcomes were similar across intervention arms. The target sample size was not achieved, and we found a greater than anticipated variability between clubs in the acceptability of screening, which limited our ability to estimate acceptability for intervention arms. Further evidence is needed about the public health benefits associated with screening interventions in non-clinical settings so that their cost-effectiveness can be fully evaluated
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