The Controversy over Maltby’s Hong Kong Dispatch

The recent release of the full text of Major-General CM. Maltby’s Official Dispatch as the General Officer Commanding at Hong Kong (Public Record Office WO 106/240113) prompted British and Canadian newspapers to run sensational stories quoting Maltby’s criticisms of the discipline and battlefield performance of the Canadian battalions. Maltby’s statements, which were censored when the Dispatch was initially released, require a detailed examination and will be discussed in a future issue of CMH. In addition, the Spring 1994 issue will carry an article by Paul Dickson on “Crerar and the Decision to Garrison Hong Kong.” For the present we are publishing an exchange of correspondence, dated January 1948, between Lieutenant-Colonel G.W.L. Nicholson, then Deputy Director of the Army Historical Section, and Brigadier John H. Price who was second-in-command of the Royal Rifles of Canada in Hong Kong. Brigadier Price was asked to comment, not on the censored Dispatch, but on extracts from a draft report prepared by the Historical Section of the British Cabinet Office. This report contained the substance of the most serious charges Maltby made about the conduct of the Royal Rifles. For the information of the reader, other officers mentioned in the exchange include Brigadier C. Wallis, Indian Army, commander of the East Brigade (to which the Royal Rifles belonged), Lieutenant-Colonel W.J. Home, commander of the Royal Rifles, Lieutenant-Colonel J.L.R. Sutcliffe, Commanding Officer, Winnipeg Grenadiers, Brigadier J.K. Lawson, Commanding Officer, “C” Force (as the Canadian contingent was known) and Colonel P. Hennessy, Lawson’s second-in-command

Turning Points in the Development of Blended Families

A modified retrospective interview technique (RIT) was employed with members of 53 blended families to determine the types of turning points they reported experiencing and the developmental trajectories of their respective blended family’s first 4 years. Findings revealed 15 primary types of turning points, of which “Changes in Household Configuration,” “Conflict,” “Holidays/Special Events,” “Quality Time,” and “Family Crisis” were the most frequent. A cluster analysis revealed five basic trajectories of development for the first 48 months of family development: Accelerated, Prolonged, Stagnating, Declining, and High-Amplitude Turbulent. The trajectories differed in the overall positive-to-negative valence ratio, the frequency of conflict related events, the average amplitude of change in feeling like a family, and the current reported level of feeling like a family

Fluoride release and uptake in enhanced bioactivity glass ionomer cement (“glass carbomer™”) compared with conventional and resin-modified glass ionomer cements

Objectives: To study the fluoride uptake and release properties of glass carbomer dental cements and compare them with those of conventional and resin-modified glass ionomers. Materials and Methods: Three materials were used, as follows: glass carbomer (Glass Fill), conventional glass ionomer (Chemfil Rock) and resin-modified glass ionomer (Fuji II LC). For all materials, specimens (sets of six) were matured at room temperature for time intervals of 10 minutes, 1 hour and 6 weeks, then exposed to either deionized water or sodium fluoride solution (1000 ppm in fluoride) for 24 hours. Following this, all specimens were placed in deionized water for additional 24 hours and fluoride release was measured. Results: Storage in water led to increase in mass in all cases due to water uptake, with uptake varying with maturing time and material type. Storage in aqueous NaF led to variable results. Glass carbomer showed mass losses at all maturing times, whereas the conventional glass ionomer gained mass for some maturing times, and the resin-modified glass ionomer gained mass for all maturing times. All materials released fluoride into deionized water, with glass carbomer showing the highest release. For both types of glass ionomer, uptake of fluoride led to enhanced fluoride release into deionized water. In contrast, uptake by glass carbomer did not lead to increased fluoride release, although it was substantially higher than the uptake by both types of glass ionomer. Conclusions: Glass carbomer resembles glass ionomer cements in its fluoride uptake behavior but differs when considering that its fluoride uptake does not lead to increased fluoride release

The preparation and characterisation of monomeric and linked metal carbonyl clusters containing the closo-Si2Co4 pseudo-octahedral core

PhSiH3 reacts with [Co₄(CO)₁₂] at 50 °C in hydrocarbon solvents to give [(µ₄-SiPh)₂Co₄(CO)₁₁], 2c, shown by an X-ray crystal structure determination to have a pseudo-octahedral Si₂Co₄ core. Substituted aryl-silanes behaved similarly. Mixtures of PhSiH₃, H₃SiC₆H₄SiH₃ and [Co₄(CO)₁₂] in a ca. 2 1 2 ratio gave the dimeric cluster [{Co₄(µ₄-SiPh)(CO)₁₁Si}₂C₆H₄], 3a, which has the two Si₂Co₄ cores linked by a C₆H₄ group to give a rigid molecule which an X-ray structure analysis shows to be over 23 Å long. Related dimers linked by –(CH₂)₈– groups were isolated from mixtures of PhSiH₃, α ,ω-(H₃Si)₂(CH₂)₈ and [Co₄(CO)₁₂]. Electrochemical studies show the two cluster units in 3a do not interact electronically

Complex Genetic Interactions in a Quantitative Trait Locus

Whether in natural populations or between two unrelated members of a species, most phenotypic variation is quantitative. To analyze such quantitative traits, one must first map the underlying quantitative trait loci. Next, and far more difficult, one must identify the quantitative trait genes (QTGs), characterize QTG interactions, and identify the phenotypically relevant polymorphisms to determine how QTGs contribute to phenotype. In this work, we analyzed three Saccharomyces cerevisiae high-temperature growth (Htg) QTGs (MKT1, END3, and RHO2). We observed a high level of genetic interactions among QTGs and strain background. Interestingly, while the MKT1 and END3 coding polymorphisms contribute to phenotype, it is the RHO2 3′UTR polymorphisms that are phenotypically relevant. Reciprocal hemizygosity analysis of the Htg QTGs in hybrids between S288c and ten unrelated S. cerevisiae strains reveals that the contributions of the Htg QTGs are not conserved in nine other hybrids, which has implications for QTG identification by marker-trait association. Our findings demonstrate the variety and complexity of QTG contributions to phenotype, the impact of genetic background, and the value of quantitative genetic studies in S. cerevisiae

The beginning of time? Evidence for catastrophic drought in Baringo in the early nineteenth century

New developments in the collection of palaeo-data over the past two decades have transformed our understanding of climate and environmental history in eastern Africa. This article utilises instrumental and proxy evidence of historical lake-level fluctuations from Baringo and Bogoria, along with other Rift Valley lakes, to document the timing and magnitude of hydroclimate variability at decadal to century time scales since 1750. These data allow us to construct a record of past climate variation not only for the Baringo basin proper, but also across a sizable portion of central and northern Kenya. This record is then set alongside historical evidence, from oral histories gathered amongst the peoples of northern Kenya and the Rift Valley and from contemporary observations recorded by travellers through the region, to offer a reinterpretation of human activity and its relationship to environmental history in the nineteenth century. The results reveal strong evidence of a catastrophic drought in the early nineteenth century, the effects of which radically alters our historical understanding of the character of settlement, mobility and identity within the Baringo–Bogoria basin

BRACELET: Hierarchical Edge-Cloud Microservice Infrastructure for Scientific Instruments’ Lifetime Connectivity

Recent advances in cyber-infrastructure have enabled digital data sharing and ubiquitous network connectivity between scientific instruments and cloud-based storage infrastructure for uploading, storing, curating, and correlating of large amounts of materials and semiconductor fabrication data and metadata. However, there is still a significant number of scientific instruments running on old operating systems that are taken offline and cannot connect to the cloud infrastructure, due to security and performance concerns. In this paper, we propose BRACELET - an edge-cloud infrastructure that augments the existing cloud-based infrastructure with edge devices and helps to tackle the unique performance and security challenges that scientific instruments face when they are connected to the cloud through public network. With BRACELET, we put a networked edge device, called cloudlet, in between the scientific instruments and the cloud as the middle tier of a three-tier hierarchy. The cloudlet will shape and protect the data traffic from scientific instruments to the cloud, and will play a foundational role in keeping the instruments connected throughout its lifetime, and continuously providing the otherwise missing performance and security features for the instrument as its operating system ages.NSF Award Number 1659293NSF Award Number 1443013Ope

Flavin Mononucleotide as a Biomarker of Organ Quality-A Pilot Study.

BACKGROUND: Flavin mononucleotide (FMN), released from damaged mitochondrial complex I during hypothermic liver perfusion, has been shown to be predictive of 90-day graft loss. Normothermic machine perfusion (NMP) and normothermic regional perfusion (NRP) are used for organ reconditioning and quality assessment before transplantation. This pilot study aimed to investigate the changes of FMN levels during normothermic reperfusion of kidneys, livers, and lungs and examine whether FMN could serve as a biomarker to predict posttransplant allograft quality. METHODS: FMN concentrations, in perfusates collected during NMP of kidneys, abdominal NRP, and ex vivo lung perfusion, were measured using fluorescence spectrometry and correlated to the available perfusion parameters and clinical outcomes. RESULTS: Among 7 transplanted kidneys out of the 11 kidneys that underwent NMP, FMN levels at 60 minutes of NMP were significantly higher in the allografts that developed delayed graft function and primary nonfunction (P = 0.02). Fifteen livers from 23 circulatory death donors that underwent NRP were deemed suitable for transplantation. Their FMN levels at 30 minutes of NRP were significantly lower than those not procured for transplantation (P = 0.004). In contrast, little FMN was released during the 8 lung perfusions. CONCLUSIONS: This proof of concept study suggested that FMN in the perfusates of kidney NMP has the potential to predict posttransplant renal function, whereas FMN at 30 minutes of NRP predicts whether a liver would be accepted for transplantation. More work is required to validate the role of FMN as a putative biomarker to facilitate safe and reliable decision-making before embarking on transplantation.NIHR BTR