Duty Versus Proximate Cause in the Law of Negligence - A Comparative Study

Duty Versus Proximate Cause in the Law of Negligence - A Comparative Stud

Great Expectations: Plans and Predictions for New Horizons Encounter with Kuiper Belt Object 2014 MU69 ('Ultima Thule')

The New Horizons encounter with the cold classical Kuiper Belt object (KBO) 2014 MU69 (informally named 'Ultima Thule,' hereafter Ultima) on 1 January 2019 will be the first time a spacecraft has ever closely observed one of the free-orbiting small denizens of the Kuiper Belt. Related to but not thought to have formed in the same region of the Solar System as the comets that been explored so far, it will also be the largest, most distant, and most primitive body yet visited by spacecraft. In this letter we begin with a brief overview of cold classical KBOs, of which Ultima is a prime example. We give a short preview of our encounter plans. We note what is currently known about Ultima from earth-based observations. We then review our expectations and capabilities to evaluate Ultima's composition, surface geology, structure, near space environment, small moons, rings, and the search for activity

Grey and white matter correlates of recent and remote autobiographical memory retrieval:Insights from the dementias

The capacity to remember self-referential past events relies on the integrity of a distributed neural network. Controversy exists, however, regarding the involvement of specific brain structures for the retrieval of recently experienced versus more distant events. Here, we explored how characteristic patterns of atrophy in neurodegenerative disorders differentially disrupt remote versus recent autobiographical memory. Eleven behavioural-variant frontotemporal dementia, 10 semantic dementia, 15 Alzheimer's disease patients and 14 healthy older Controls completed the Autobiographical Interview. All patient groups displayed significant remote memory impairments relative to Controls. Similarly, recent period retrieval was significantly compromised in behavioural-variant frontotemporal dementia and Alzheimer's disease, yet semantic dementia patients scored in line with Controls. Voxel-based morphometry and diffusion tensor imaging analyses, for all participants combined, were conducted to investigate grey and white matter correlates of remote and recent autobiographical memory retrieval. Neural correlates common to both recent and remote time periods were identified, including the hippocampus, medial prefrontal, and frontopolar cortices, and the forceps minor and left hippocampal portion of the cingulum bundle. Regions exclusively implicated in each time period were also identified. The integrity of the anterior temporal cortices was related to the retrieval of remote memories, whereas the posterior cingulate cortex emerged as a structure significantly associated with recent autobiographical memory retrieval. This study represents the first investigation of the grey and white matter correlates of remote and recent autobiographical memory retrieval in neurodegenerative disorders. Our findings demonstrate the importance of core brain structures, including the medial prefrontal cortex and hippocampus, irrespective of time period, and point towards the contribution of discrete regions in mediating successful retrieval of distant versus recently experienced events

Teaching Complex, In-Depth Programs

Changing demographics of rural Extension audiences create challenges to program delivery, and multiple delivery methods may be needed to effectively improve skills and knowledge of clients. We examined the effectiveness of different delivery methods and changes in client skills, knowledge and abilities as a result of a complex, in-depth program, the Virginia Cow/Calf Management Course. Almost 500 producers took the 5-month course. Changes were measured from pre- and post-course surveys. Skills easily employed by the producers were readily adopted. Experiential learning opportunities and written materials had the greatest impact on producers, while Web-based information and discussion groups were marginally effective

Teaching Complex, In-Depth Programs

Changing demographics of rural Extension audiences create challenges to program delivery, and multiple delivery methods may be needed to effectively improve skills and knowledge of clients. We examined the effectiveness of different delivery methods and changes in client skills, knowledge and abilities as a result of a complex, in-depth program, the Virginia Cow/Calf Management Course. Almost 500 producers took the 5-month course. Changes were measured from pre- and post-course surveys. Skills easily employed by the producers were readily adopted. Experiential learning opportunities and written materials had the greatest impact on producers, while Web-based information and discussion groups were marginally effective

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Baseline natural killer and T cell populations correlation with virologic outcome after regimen simplification to atazanavir/ritonavir alone (ACTG 5201)

Objectives: Simplified maintenance therapy with ritonavir-boosted atazanavir (ATV/r) provides an alternative treatment option for HIV-1 infection that spares nucleoside analogs (NRTI) for future use and decreased toxicity. We hypothesized that the level of immune activation (IA) and recovery of lymphocyte populations could influence virologic outcomes after regimen simplification. Methods: Thirty-four participants with virologic suppression ≥48 weeks on antiretroviral therapy (2 NRTI plus protease inhibitor) were switched to ATV/r alone in the context of the ACTG 5201 clinical trial. Flow cytometric analyses were performed on PBMC isolated from 25 patients with available samples, of which 24 had lymphocyte recovery sufficient for this study. Assessments included enumeration of T-cells (CD4/CD8), natural killer (NK) (CD3+CD56 +CD16+) cells and cell-associated markers (HLA-DR, CD's 38/69/94/95/158/279). Results: Eight of the 24 patients had at least one plasma HIV-1 RNA level (VL) <50 copies/mL during the study. NK cell levels below the group median of 7.1% at study entry were associated with development of VL <50 copies/mL following simplification by regression and survival analyses (p = 0.043 and 0.023), with an odds ratio of 10.3 (95% CI: 1.92-55.3). Simplification was associated with transient increases in naïve and CD25+ CD4+ T-cells, and had no impact on IA levels. Conclusions: Lower NK cell levels prior to regimen simplification were predictive of virologic rebound after discontinuation of nucleoside analogs. Regimen simplification did not have a sustained impact on markers of IA or T lymphocyte populations in 48 weeks of clinical monitoring. Trial Registration: ClinicalTrials.gov NCT00084019

Dark sectors 2016 Workshop: community report

This report, based on the Dark Sectors workshop at SLAC in April 2016, summarizes the scientific importance of searches for dark sector dark matter and forces at masses beneath the weak-scale, the status of this broad international field, the important milestones motivating future exploration, and promising experimental opportunities to reach these milestones over the next 5-10 years