Computer simulation of radiation damage in gallium arsenide

A version of the binary-collision simulation code MARLOWE was used to study the spatial characteristics of radiation damage in proton and electron irradiated gallium arsenide. Comparisons made with the experimental results proved to be encouraging

JLFT 006 John C. Randolph 10-17-1996

Acc #: 328; JLFT 006 In this recording, John C. Randolph is interviewed by John Beebee and Sheila Flanagan to discuss John LeFlore and the Civil Rights Movement in Mobile, Alabama. The interview begins with Mr. Randolph discussing his early life and meeting John LeFlore through the NAACP. He talks about the integration of Murphy High School and the Birdie Mae Davis case in Mobile. Mr. Randolph remarks on the way Mr. LeFlore treated people in general, and how he carried himself as a person. The interview concludes with Mr. Randolph discussing Mr. LeFlore’s work with the Non-Partisan Voters League and his election to the Alabama House of Representatives

Working Together: Rural Nebraskans’ Views of Regional Collaboration

Some people support regional collaboration because they believe it better enables communities to increase the region’s economic vitality and quality of life. However, others worry that such collaboration threatens individual communities’ identities and limits citizens’ access to services. How do rural Nebraskans view regional collaboration? Do they support combining certain services with neighboring communities or counties more than others? Are they already purchasing their goods and services outside their local community? This report details 3,087 responses to the 2003 Nebraska Rural Poll, the eighth annual effort to understand rural Nebraskans’ perceptions. Respondents were asked a series of questions about regional collaboration. Comparisons were made among different respondent subgroups, i.e., comparisons by age, occupation, region, etc. Based on these analyses, some key findings emerged: • Most rural Nebraskans have a positive view of regional collaboration. At least three-quarters either strongly agreed or agreed that “communities in a region working together to generate new businesses are better able to create quality jobs for their residents” (82%) and “retail businesses in a region can provide a better variety of goods and services by working together collaboratively” (75%). Sixty percent agreed that combining community or county services will improve access to services. Fifty-nine percent disagreed that combining services would lead to lower quality services and 47 percent disagreed that combining services would lead to increased prices for the consumer. • Persons with higher education levels, younger respondents, persons with higher incomes and females are the groups most likely to have a positive view of regional collaboration. • At least one-half of rural Nebraskans are willing to raise revenue to keep fire protection and emergency medical services at their current level. When asked how they would cover the costs of various services if faced with a shortage of money, 53 percent were willing to raise revenue to support fire protection services and 50 percent would raise revenue to maintain emergency medical services. Forty-eight percent were willing to raise revenue for their schools (K - 12). • Over one-half of rural Nebraskans would combine or share the following services with other nearby communities or counties if faced with a shortage of money: county road maintenance, veterans services, health clinic, telecommunications services, economic development activities, licenses and permits, street maintenance, property assessment and county weed control. • Younger persons are more likely than older persons to support raising revenue to keep their school services at their current level. Seventy-six percent of the persons age 19 to 29 supported raising revenue to keep their school services at their current level. Only 35 percent of the persons age 65 and older supported raising revenue. The older respondents were more likely than the younger respondents to support combining the school with other nearby communities or reducing its level of service. Forty-five percent of the persons age 65 and older supported combining their school with others and 14 percent said they would reduce its level of service. In comparison, only 21 percent of the persons age 19 to 29 supported combining their school with other communities and only two percent supported reducing its level of service. • Persons living in or near the largest communities are more likely than the persons living in or near the smallest communities to support raising revenue to keep their school services the same. Fifty-two percent of the persons living in or near the communities with populations of 10,000 or more supported raising revenue to keep their school’s services at their current level. Only 39 percent of the persons living in or near communities with less than 500 people supported this option. The persons living in or near the smallest communities were slightly more likely to support combining their school with other communities and were also more likely to not currently have a school in their community. • Differences in the level of support for various alternatives to cover the costs of law enforcement are detected by community size. Persons living in or near the smallest communities were more likely than the persons living in or near the larger communities to say they don’t have law enforcement. Persons living in or near communities with populations ranging from 500 to 999 were the group most likely to support combining law enforcement services with another community or county. Persons living in or near the largest communities were more likely than the persons living in or near the smaller communities to advocate raising revenue to keep their law enforcement services at their current level. • Farmers and ranchers are more likely than persons with different occupations to say they would raise revenue to maintain their county roads. Thirty-two percent of the farmers and ranchers would raise revenue to keep their county road maintenance services at their current level. Only 15 percent of the persons with sales and administrative support occupations agreed. • On average, at least one-half of the following items are purchased by rural Nebraskans in their local community: banking/financial services (75.7%), groceries (73%), automobile/machinery repairs (72%), insurance (67%), farm and ranch inputs (66.9%), doctor/clinic services (63.6%) and hospital services (57.3%). • For each item, rural Nebraskans living in or near the larger communities purchased more locally than did those living in or near the smaller communities. As an example, persons living in or near the communities with populations of 10,000 or more purchased an average of 96.1% of their groceries in their local community. Persons living in or near communities with less than 500 people purchased an average of 38.2% of their groceries in their local community. For most items, respondents living in the smallest communities purchased at least one-half in another community within 50 miles. • For most items, Panhandle residents purchased more in their local community than did residents living in other parts of the state. As an example, Panhandle residents purchased an average of 53.5% of their recreation/entertainment in their local community, compared to an average of 38.7% for Southeast residents. But, South Central residents were more likely than other regional groups to have purchased hospital services, banking/financial services and insurance locally

Balanced Justice: Mr. Justice Powell and the Constitution

In his first five years on the United States Supreme Court, Justice Lewis F. Powell, Jr. has become and will most likely continue to be a leading force in shaping the direction of the Court. In many areas, Justice Powell\u27s desire for judicial flexibility as well as judicial restraint has made him a leader in turning the Burger Court away from the bright-line tests enunciated by the Warren Court. However, where the Warren Court had been flexible, Justice Powell has usually preserved this flexibility and expanded it if possible. The tool consistently utilized to achieve this flexibility has been a balancing formula that has sought to accommodate all the competing interests

An Evaluation of The Effectiveness of Adaptive Histogram Equalization for Contrast Enhancement

Adaptive Histogram Equalization (AHE), a method of contrast enhancement which is sensitive to local spatial information in an image, has been proposed as a solution to the problem of the inability of ordinary display devices to depict the full dynamic intensity range in some medical images. This method is automatic, reproducible, and simultaneously displays most of the information contained in the grey-scale contrast of the image. However, it has not been known whether the use of AHE causes the loss of diagnostic information relative to the commonly-used method intensity windowing. In the current work, AHE and intensity windowing are compared using psychophysical observer studies. In studies performed at North Carolina Memorial Hospital, experienced radiologists were shown clinical CT images of the chest. Into some of the images, appropriate artificial lesion were introduced; the physicians were then shown the images processed with both AHE and intensity windowing. They were asked to assess the probability that as given image contained the artificial lesion, and their accurate was measured. The results of these experiments shown that for this particular diagnostic task, there was no significant difference in the ability of the two methods to depict luminance contrast; thus, further evaluation of AHE using controlled clinical trials is indicated

Evaluation of the Emergency Response Dose Assessment System(ERDAS)

The emergency response dose assessment system (ERDAS) is a protype software and hardware system configured to produce routine mesoscale meteorological forecasts and enhanced dispersion estimates on an operational basis for the Kennedy Space Center (KSC)/Cape Canaveral Air Station (CCAS) region. ERDAS provides emergency response guidance to operations at KSC/CCAS in the case of an accidental hazardous material release or an aborted vehicle launch. This report describes the evaluation of ERDAS including: evaluation of sea breeze predictions, comparison of launch plume location and concentration predictions, case study of a toxic release, evaluation of model sensitivity to varying input parameters, evaluation of the user interface, assessment of ERDA's operational capabilities, and a comparison of ERDAS models to the ocean breeze dry gultch diffusion model

The Development of Speech Research Tools on MIT\u27s Lisp Machine-based Workstations

In recent years, a number of useful speech- and language-related research tools have been under development at MIT. These tools are aids for efficiently analyzing the acoustic characteristics of speech and the phonological properties of a language. They are playing a valuable role in our own research, as well as in research conducted elsewhere. This paper describes several of the systems being developed for use on our Lisp Machine workstations

Association of circulating sex hormones with inflammation and disease severity in patients with COVID-19

Importance: Male sex is a risk factor for developing severe COVID-19 illness. It is not known whether sex hormones contribute to this predisposition. Objective: To investigate the association of concentrations of serum testosterone, estradiol, and insulinlike growth factor 1 (IGF-1, concentrations of which are regulated by sex hormone signaling) with COVID-19 severity. Design, Setting, and Participants: This prospective cohort study was conducted using serum samples collected from consecutive patients who presented from March through May 2020 to the Barnes Jewish Hospital in St Louis, Missouri, with COVID-19 (diagnosed using nasopharyngeal swabs). Exposures: Testosterone, estradiol, and IGF-1 concentrations were measured at the time of presentation (ie, day 0) and at days 3, 7, 14, and 28 after admission (if the patient remained hospitalized). Main Outcomes and Measures: Baseline hormone concentrations were compared among patients who had severe COVID-19 vs those with milder COVID-19 illness. RNA sequencing was performed on circulating mononuclear cells to understand the mechanistic association of altered circulating hormone concentrations with cellular signaling pathways. Results: Among 152 patients (90 [59.2%] men; 62 [40.8%] women; mean [SD] age, 63 [16] years), 143 patients (94.1%) were hospitalized. Among 66 men with severe COVID-19, median [interquartile range] testosterone concentrations were lower at day 0 (53 [18 to 114] ng/dL vs 151 [95 to 217] ng/dL; P = .01) and day 3 (19 [6 to 68] ng/dL vs 111 [49 to 274] ng/dL; P = .006) compared with 24 men with milder disease. Testosterone concentrations were inversely associated with concentrations of interleukin 6 (β = -0.43; 95% CI, -0.52 to -0.17; P \u3c .001), C-reactive protein (β = -0.38; 95% CI, -0.78 to -0.16; P = .004), interleukin 1 receptor antagonist (β = -0.29; 95% CI, -0.64 to -0.06; P = .02), hepatocyte growth factor (β = -0.46; 95% CI, -0.69 to -0.25; P \u3c .001), and interferon γ-inducible protein 10 (β = -0.32; 95% CI, -0.62 to -0.10; P = .007). Estradiol and IGF-1 concentrations were not associated with COVID-19 severity in men. Testosterone, estradiol, and IGF-1 concentrations were similar in women with and without severe COVID-19. Gene set enrichment analysis revealed upregulated hormone signaling pathways in CD14+CD16- (ie, classical) monocytes and CD14-CD16+ (ie, nonclassical) monocytes in male patients with COVID-19 who needed intensive care unit treatment vs those who did not. Conclusions and Relevance: In this single-center cohort study of patients with COVID-19, lower testosterone concentrations during hospitalization were associated with increased disease severity and inflammation in men. Hormone signaling pathways in monocytes did not parallel serum hormone concentrations, and further investigation is required to understand their pathophysiologic association with COVID-19

Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants

During transport and storage, vaccines may be exposed to temperatures outside of the range recommended for storage, potentially causing efficacy losses. To better understand and prevent such losses, Dominant Negative Inhibitor (DNI), a recombinant protein antigen for a candidate vaccine against anthrax, was formulated as a liquid and as a glassy lyophilized powder with the adjuvants aluminum hydroxide and glycopyranoside lipid A (GLA). Freeze-thawing of the liquid vaccine caused the adjuvants to aggregate and decreased its immunogenicity in mice. Immunogenicity of liquid vaccines also decreased when stored at 40 °C for 8 weeks, as measured by decreases in neutralizing antibody titers in vaccinated mice. Concomitant with efficacy losses at elevated temperatures, changes in DNI structure were detected by fluorescence spectroscopy and increased deamidation was observed by capillary isoelectric focusing (cIEF) after only 1 week of storage of the liquid formulation at 40 °C. In contrast, upon lyophilization, no additional deamidation after 4 weeks at 40 °C and no detectable changes in DNI structure or reduction in immunogenicity after 16 weeks at 40 °C was observed. Vaccines containing aluminum hydroxide and GLA elicited higher immune responses than vaccines adjuvanted with only aluminum hydroxide, with more mice responding to a single dose