INVESTIGATION OF THE URANIUM CONTENT IN SOME SOIL SAMPLES FROM BARKIN LADI LGA, PLATEAU STATE – NIGERIA

In this work the Uranium (238U) content in soil samples collected in BarkinLadi LGA from some villages was been determined. The measurement of the soil Uranium activity concentration were made using a multi –channel pulse height analyzer (Canberra series 10 plus) coupled to a 76.2mm x 76.2mm NaI (TI) scintillation detector. The mean uranium content in the analyzed samples was found to be (39.61 ±2.93) Bq/kg which is slightly higher than the world mean value of 35Bq/kg. The results were in good agreement with others for soils from region which is considered as normal or slightly high in radioactivity level. Keywords: Uranium,Soil samples, Barkinladi,Gamma ray spectrometry and Nigeri

NMR-Based Metabolic Profiles of Intact Zebrafish Embryos Exposed to Aflatoxin B1 Recapitulates Hepatotoxicity and Supports Possible Neurotoxicity

Aflatoxin B1 (AFB1) is a widespread contaminant of grains and other agricultural crops and is globally associated with both acute toxicity and carcinogenicity. In the present study, we utilized nuclear magnetic resonance (NMR), and specifically high-resolution magic angle spin (HRMAS) NMR, coupled to the zebrafish (Danio rerio) embryo toxicological model, to characterize metabolic profiles associated with exposure to AFB1. Exposure to AFB1 was associated with dose-dependent acute toxicity (i.e., lethality) and developmental deformities at micromolar (≤ 2 µM) concentrations. Toxicity of AFB1 was stage-dependent and specifically consistent, in this regard, with a role of the liver and phase I enzyme (i.e., cytochrome P450) bioactivation. Metabolic profiles of intact zebrafish embryos exposed to AFB1 were, furthermore, largely consistent with hepatotoxicity previously reported in mammalian systems including metabolites associated with cytotoxicity (i.e., loss of cellular membrane integrity), glutathione-based detoxification, and multiple pathways associated with the liver including amino acid, lipid, and carbohydrate (i.e., energy) metabolism. Taken together, these metabolic alterations enabled the proposal of an integrated model of the hepatotoxicity of AFB1 in the zebrafish embryo system. Interestingly, changes in amino acid neurotransmitters (i.e., Gly, Glu, and GABA), as a key modulator of neural development, supports a role in recently-reported neurobehavioral and neurodevelopmental effects of AFB1 in the zebrafish embryo model. The present study reinforces not only toxicological pathways of AFB1 (i.e., hepatotoxicity, neurotoxicity), but also multiple metabolites as potential biomarkers of exposure and toxicity. More generally, this underscores the capacity of NMR-based approaches, when coupled to animal models, as a powerful toxicometabolomics tool

Thermal emission from large area chemical vapor deposited graphene devices

Copyright © 2013 AIP PublishingThe spatial variation of thermal emission from large area graphene grown by chemical vapor deposition, transferred onto SiO2/Si substrates and fabricated into field effect transistor structures, has been investigated using infra-red microscopy. A peak in thermal emission occurs, the position of which can be altered by reversal of the current direction. The experimental results are compared with a one dimensional finite element model, which accounts for Joule heating and electrostatic effects, and it is found that the thermal emission is governed by the charge distribution in the graphene and maximum Joule heating occurs at the point of minimum charge density.This research was supported by the Engineering and Physical Sciences Research Council, and the European Union under the FET-open grant GOSFELEngineering and Physical Sciences Research Council (EPSRC)European Unio

On Conformal Infinity and Compactifications of the Minkowski Space

Using the standard Cayley transform and elementary tools it is reiterated that the conformal compactification of the Minkowski space involves not only the "cone at infinity" but also the 2-sphere that is at the base of this cone. We represent this 2-sphere by two additionally marked points on the Penrose diagram for the compactified Minkowski space. Lacks and omissions in the existing literature are described, Penrose diagrams are derived for both, simple compactification and its double covering space, which is discussed in some detail using both the U(2) approach and the exterior and Clifford algebra methods. Using the Hodge * operator twistors (i.e. vectors of the pseudo-Hermitian space H_{2,2}) are realized as spinors (i.e., vectors of a faithful irreducible representation of the even Clifford algebra) for the conformal group SO(4,2)/Z_2. Killing vector fields corresponding to the left action of U(2) on itself are explicitly calculated. Isotropic cones and corresponding projective quadrics in H_{p,q} are also discussed. Applications to flat conformal structures, including the normal Cartan connection and conformal development has been discussed in some detail.Comment: 38 pages, 8 figures, late

Quantum entanglement and information processing via excitons in optically-driven quantum dots

We show how optically-driven coupled quantum dots can be used to prepare maximally entangled Bell and Greenberger-Horne-Zeilinger states. Manipulation of the strength and duration of the selective light-pulses needed for producing these highly entangled states provides us with crucial elements for the processing of solid-state based quantum information. Theoretical predictions suggest that several hundred single quantum bit rotations and Controlled-Not gates could be performed before decoherence of the excitonic states takes place.Comment: 3 separate PostScript Figures + 7 pages. Typos corrected. Minor changes added. This updated version is to appear in PR

On tight immersions of maximal codimension

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46589/1/222_2005_Article_BF01404629.pd

Cerebral Perfusion and Gray Matter Changes Associated With Chemotherapy-Induced Peripheral Neuropathy

PURPOSE: To investigate the longitudinal relationship between chemotherapy-induced peripheral neuropathy (CIPN) symptoms (sx) and brain perfusion changes in patients with breast cancer. Interaction of CIPN-sx perfusion effects with known chemotherapy-associated gray matter density decrease was also assessed to elucidate the relationship between CIPN and previously reported cancer treatment-related brain structural changes. METHODS: Patients with breast cancer treated with (n = 24) or without (n = 23) chemotherapy underwent clinical examination and brain magnetic resonance imaging at the following three time points: before treatment (baseline), 1 month after treatment completion, and 1 year after the 1-month assessment. CIPN-sx were evaluated with the self-reported Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity four-item sensory-specific scale. Perfusion and gray matter density were assessed using voxel-based pulsed arterial spin labeling and morphometric analyses and tested for association with CIPN-sx in the patients who received chemotherapy. RESULTS: Patients who received chemotherapy reported significantly increased CIPN-sx from baseline to 1 month, with partial recovery by 1 year (P < .001). CIPN-sx increase from baseline to 1 month was significantly greater for patients who received chemotherapy compared with those who did not (P = .001). At 1 month, neuroimaging showed that for the group that received chemotherapy, CIPN-sx were positively associated with cerebral perfusion in the right superior frontal gyrus and cingulate gyrus, regions associated with pain processing (P < .001). Longitudinal magnetic resonance imaging analysis in the group receiving chemotherapy indicated that CIPN-sx and associated perfusion changes from baseline to 1 month were also positively correlated with gray matter density change (P < .005). CONCLUSION: Peripheral neuropathy symptoms after systemic chemotherapy for breast cancer are associated with changes in cerebral perfusion and gray matter. The specific mechanisms warrant further investigation given the potential diagnostic and therapeutic implications

The Ties that Double Bind Us: Career, Emotion and Narrative Coping in Difficult Working Relationships

This article examines through an autoethnographic account how career aspirations and constraints may lead individuals to endure emotionally aversive situations. It presents evidence that individuals in such situations engage in emotion‐focused coping through narrative, illustrated by the author’s autoethnographic narrative of a difficult working relationship which developed into a double bind situation. The paper suggests that narrative coping in response to a double bind can actually serve to reify and prolong such situations. The paper concludes that autoethnographic research does not lend itself to simple organisational solutions. Possible avenues for further research are outlined and discussed

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt1

Seroprevalence and Risk Factors for Human Herpesvirus 8 Infection, Rural Egypt, Salivary and nosocomial transmission are possible

Performance of BRCA1/2 mutation prediction models in male breast cancer patients

To establish whether existing mutation prediction models can identify which male breast cancer (MBC) patients should be offered BRCA1 and BRCA2 diagnostic DNA screening, we compared the performance of BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm), BRCAPRO (BRCA probability) and the Myriad prevalence table ("Myriad"). These models were evaluated using the family data of 307 Dutch MBC probands tested for BRCA1/2, 58 (19%) of whom were carriers. We compared the numbers of observed vs predicted carriers and assessed the Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) for each model. BOADICEA predicted the total number of BRCA1/2 mutation carriers quite accurately (observed/predicted ratio: 0.94). When a cut-off of 10% and 20% prior probability was used, BRCAPRO showed a non-significant better performance (observed/predicted ratio BOADICEA: 0.81, 95% confidence interval [CI]: [0.60-1.09] and 0.79, 95% CI: [0.57-1.09], vs. BRCAPRO: 1.02, 95% CI: [0.75-1.38] and 0.94, 95% CI: [0.68-1.31], respectively). Myriad underestimated the number of carriers in up to 69% of the cases. BRCAPRO showed a non-significant, higher AUC than BOADICEA (0.798 vs 0.776). Myriad showed a significantly lower AUC (0.671). BRCAPRO and BOADICEA can efficiently identify MBC patients as BRCA1/2 mutation carriers. Besides their general applicability, these tools will be of particular value in countries with limited healthcare resources