1,564 research outputs found
Mechanism of thermal decomposition of poly(ether ether ketone) (PEEK) from a review of decomposition studies
A review of the literature on the flammability and decomposition of poly(oxy-1,4-phenyleneoxy-1,4-phenylenecarbonyl-1,4-phenylene) (PEEK) is presented. This paper provides an overview of the flammability of PEEK and its decomposition mechanisms. Based on this literature, mechanisms have been suggested which attempt to explain the products formed at each stage of PEEK decomposition and indicate the intermediates which should be formed at each of these stages
Dental practice during a world cruise: treatment needs and demands of crew
Aims: To describe dental treatment needs and demands of crew on a cruise ship
during a world cruise.
Methods: The routine dental documentation of a two months period at sea on a
cruise ship carrying 999 crew was analysed. Age, gender, diagnosis, treatment
performed, percentage of emergency and routine procedures, number of appointments,
duration of appointment and time since last visit to the dentist were recorded. Oral
health-related quality of life (OHRQoL) was measured using the 14-item Oral Health
Impact Profile.
Results: Subjects were n = 56 crew with a mean age of 37 (± 12.0) years. Out of
114 patient contacts n = 29 (25 %) were for emergency treatment. Caries and its
sequelae accounted for 85 % of time spent treating emergencies and 50 % of routine
treatment time. The two most frequent treatment options during emergency
appointments were extractions and endodontics. In routine cases fillings and periodontal
treatment were dominating. Per 1000 persons per month crew required 14.5 emergency
plus 42.5 routine appointments. 80 % of crew had seen a dentist within 12 months
before their shipboard dental appointment. Oral health-related quality of life was most
impaired in case of emergency patients with a particular emphasis on the diagnosis of
pulpal disease.
Conclusion: High numbers of dental emergencies largely due to caries indicated
that International Labour Organisation (ILO) recommendations requiring seafarers to be
dentally fit were not adhered to. It is suggested that some doctors performing pre-sea
medical examinations may not adequately diagnose caries. A pre-sea examination by a
dental professional has the potential to reduce the number of emergency port referrals to
dentists. Treatment costs and attitude to preventive dental care were identified as
barriers impeding the access of low-wage crew to the ship’s dental clinic. Cosmetic
dentistry and prophylaxis attracted those crew with an interest in prevention and the
ability to pay the fees. In large cruise ships there is a substantial demand for both
emergency and routine dental care among crew
DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with Ulcerative Colitis (UC)
Introduction: Epigenetic marking such as DNA methylation influence gene transcription and chromosomal stability and may also be affected by environmental exposures. Few studies exist on alteration in DNA methylation profiles (genomic and gene specific methylation) in patients with Ulcerative Colitis (UC) and none assessing its relationship with lifestyle exposures.
Aims & Methods: To assess genomic methylation and promoter methylation of the ESR-1 (oestrogen receptor - 1) and N-33 (tumour suppressor candidate-3) genes in the macroscopically normal mucosa of UC patients as well as to investigate effects of anthropometric and lifestyle exposures on DNA methylation. Sixty eight subjects were recruited (24 UC and 44 age and sex matched controls). Colorectal mucosal biopsies were obtained and DNA was extracted. Genomic DNA methylation was quantified using the tritium-labelled cytosine extension assay (3[H] dCTP) whilst gene specific methylation was quantified using the COBRA method.
Results: The methylation level of both ESR-1 and N-33 genes were significantly higher in UC subjects compared with controls (7.9% vs 5.9%; p = 0.015 and 66% vs 9.3%; p < 0.001 respectively). There was no detectable difference in global DNA methylation between patients with UC and age and sex matched controls. No associations between indices of DNA methylation and anthropometric measures or smoking patterns were detected.
Conclusions: For the first time, we have shown increased methylation in the promoter regions of the putative tumour suppressor gene N-33 in macroscopically normal mucosa of patients with UC. In addition, we have confirmed that methylation of ESR-1 promoter is higher in UC patients compared with age and sex matched controls. These findings suggests that, inactivation through methylation of the putative tumour suppressor genes N-33 and ESR-1, may not be associated with colorectal carcinogenesis in UC
Dental practice during a world cruise: Characterization of oral health at sea
Aims: To describe oral health of passengers and crew attending the dental service
aboard during a two months world cruise.
Methods: In a retrospective, descriptive epidemiologic study design the routine
documentation of all dental treatment provided at sea was analysed after the voyage. Subjects were n = 57 passengers (3.5 % of 1619) with a mean age of 71 (± 9.8) years
and n =56 crew (5.6 % of 999) with a mean age of 37 (± 12.0) years. Age, gender,
nationality, number of natural teeth and implants were extracted. The prosthetic status
was described by recording the number of teeth replaced by fixed prosthesis and
number of teeth replaced by removable prosthesis. Oral health-related quality of life
(OHRQoL) was measured using the 14-item Oral Health Impact Profile (OHIP-14) and
characterised by the OHIP sum score.
Results: Women attended for treatment more often than men. Passengers had a
mean number of 20 natural teeth plus substantial fixed and removable prosthodontics.
Crew had a mean of 26 teeth. British crew and Australian passengers attended the dental
service above average. Crew tended to have a higher average OHIP-14 sum score than
passengers indicating an increased rate of perceived problems. Emergency patients from
both crew and passengers have a higher sum score than patients attending for routine
treatment.
Conclusion: In passengers the average number of teeth appears to be higher than
that of an age matched population of industrialized countries. However, the passengers’
socioeconomic status was higher which has an effect on this finding. Socioeconomic
factors also serve to explain the high standard of prosthetic care in passengers. Crew in
general present with less sophisticated prosthetic devices. This is in line with their
different socioeconomic status and origin from developing countries. The level of dental
fees aboard in comparison to treatment costs in home countries may explain some of the
differences in attendance. Passengers have enjoyed high standards of prosthetic care in
the past and will expect a similarly high standard from ship based facilities. The ease of
access to quality dental care may explain the relatively low level of perceived problems
as characterised by oral health-related quality of life scores. The dental officer aboard
has to be prepared to care for very varied diagnostic and treatment needs
Association between perceived chewing ability and oral health-related quality of life in partially dentate patients
<p>Abstract</p> <p>Background</p> <p>One of the most immediate and important functional consequences of many oral disorders is a reduction in chewing ability. The ability to chew is not only an important dimension of oral health, but is increasingly recognized as being associated with general health status. Whether perceived chewing ability and oral health-related quality of life (OHRQoL) are correlated to a similar degree in patient populations has been less investigated. The aim of this study was to examine whether perceived chewing ability was related to OHRQoL in partially dentate patients.</p> <p>Methods</p> <p>Consecutive partially dentate patients (N = 489) without signs or symptoms of acute oral disease at Tokyo Medical and Dental University's Prosthodontic Clinic participated in the study (mean age 63.0 Ā± 11.5, 71.2% female). A 20-item chewing function questionnaire (score range 0 to 20) was used to assess perceived chewing ability, with higher scores indicating better chewing ability. The 14-item Oral Health Impact Profile-Japanese version (OHIP-J14, score range 0 to 56) was used to measure OHRQoL, with higher scores indicating poorer OHRQoL. A Pearson correlation coefficient was calculated to assess the correlation between the two questionnaire summary scores. A linear regression analysis was used to describe how perceived chewing ability scores were related to OHRQoL scores.</p> <p>Results</p> <p>The mean chewing function score was 12.1 Ā± 4.8 units. The mean OHIP-J14 summary score was 13.0 Ā± 9.1 units. Perceived chewing ability and OHRQoL were significantly correlated (Pearson correlation coefficient: -0.46, 95% confidence interval [CI]: -0.52 to -0.38), indicating that higher chewing ability was correlated with lower OHIP-J14 summary scores (p < 0.001), which indicate better OHRQoL. A 1.0-unit increase in chewing function scores was related to a decrease of 0.87 OHIP-J14 units (95% CI: -1.0 to -0.72, p < 0.001). The correlation between perceived chewing ability and OHRQoL was not substantially influenced by age and number of teeth, but by gender, years of schooling, treatment demand and denture status.</p> <p>Conclusion</p> <p>Patients' perception of their chewing ability was substantially related to their OHRQoL.</p
Parsnips in ELT: stepping out of the comfort zone (Vol. 2)
The PARSNIP is, as many of you will know, a reference to all those topics that are commonly left out of the standard ELT coursebook: Politics, Alcohol, Religion, Sex, Narcotics, -Isms, Pork.
And it is easy to understand why these things are not included - in simple terms coursebooks are written for the largest possible market and therefore can only ever concentrate on the safest common denominator in terms of topics. You might be able to get away with a discussion on the differences between democratic governments and dictatorships in Portugal, but the chances are
you might find it more difficult in Belarus. So if you want to sell a coursebook in both Portugal and Belarus, you have to make sure that the topics are not going to prove overly contentious or possibly lead to the arrest and deportation of the teacher and closing of the school.
The result though, is what Mario Rinvolucri described as āāthe soft, fudgey, sub-journalistic, womanās magaziney world of EFLese course materialsā - endless worthy discussions about the environment, the role of technology in life and how to have a healthy lifestyle.
The Parsnips in ELT project is an attempt to provide resources and support for teachers who do want to engage their classes in more meaningful topics and discussions. Or at the very least to do something different! It is however, up to you and your own personal and professional judgment whether you choose to use these lesson plans in your context and with your classes, or even if you choose to read them at all! Inevitably, there will be some lessons that you will feel are inappropriate to use and some that you feel will really get the class engaged in the topic and the discussion
Frequency of four-dimensional oral health problems across dental fields - A comparative survey of Slovenian and international dentists
Objectives: To compare the frequency of patients' oral health problems and prevention needs among Slovenian and international dentists with the aim to validate the four oral health-related quality of life (OHRQoL) dimensions across six clinical dental fields in all World Health Organization (WHO) regions. Methods: An anonymous electronic survey in the English language was designed using Qualtrics software. A probability sampling for Slovenia and a convenience sampling strategy for dentist recruitment was applied for 31 countries. Dentists engaged in six dental fields were asked to categorize their patients' oral health problems and prevention needs into the four OHRQoL dimensions (Oral Function, Orofacial Pain, Orofacial Appearance, and Psychosocial Impact). Proportions of patients' problems and prevention needs were calculated together with the significance of Slovenian and international dentists' differences based on dental fields and WHO regions. Results: Dentists (n=1,580) from 32 countries completed the survey. There were 223 Slovenian dentists (females: 68%) with a mean age (SD) of 41 (10.6) years and 1,358 international dentists (females: 51%) with a mean age (SD) of 38 (10.4). Pain-related problems and prevention needs were the most prevalent among all six dental fields reported by dentists; Slovenian (37%) and 31 countries (45%). According to Cohen, differences between Slovenia, the broader European Region, and 31 countries were considered non-significant (<0.1). Conclusion: According to the dentists' responses, the frequency of patients' oral health problems and prevention needs are proportionate between Slovenia and 31 countries, regionally and globally. The four OHRQoL dimensions can be considered universal across all dental fields
A depositional model for spherulitic carbonates associated with alkaline, volcanic lakes
The South Atlantic Aptian āPre-saltā reservoirs are formed by a combination of spherulitic carbonates and Mg-rich clays accumulated in volcanic alkaline lake settings with exotic chemistries. So far, outcrop analogues characterised by metre-thick successions deposited in lacustrine scenarios are elusive so disentangling the genesis of spherulitic carbonates represents a major scientific challenge with business impact. In particular the controls on spatial distribution and the environment of spherulitic facies formation remain poorly constrained, little studied, and hotly debated. To shed light on this conundrum, a spherulitic carbonate-rich, alkaline volcanic lacustrine succession has been analysed at outcrop scale: the Carboniferous East Kirkton Limestone (Scotland). Despite clays being very scarce and limited to layers of amorphous Mg-Si minerals, a diverse array of spherulitic calcitic components were formed, including coated grains, crusts, and build-ups. This setting enables the mechanisms of spherulitic calcite development and the patterns of sediment accumulation to be explored in a geobiological and hydrochemical scenario similar to the āPre-Saltā subsurface occurrences but divorced from clay influence. The integration of logs, borehole data, outcrop photomosaics and petrographic observations collectively allowed the reconstruction of a depositional model for the East Kirkton lacustrine succession. In this model, calcite spherule nucleation took place at the sediment-water interface in the littoral zone, driven by the co-occurrence of 1) high alkalinity, 2) Ca-Mg rich hydrochemistry, and 3) microbial-derived colloidal exopolymeric substances. These environmental conditions permitted the coeval development of spherulitic cementstone build-ups and spherulitic grainstone-packstone within the wave-agitated zone, and the accumulation of floatstones and laminites of spherulitic grains in deeper lake regions by means of downslope reworking. This model is consistent with the previously documented microbial bloom occurrences and highlights the need to better understand the complex āmicrobe-solutionā interactions before any reliable facies model is envisaged
Evaluation of a magnetic resonance-compatible dentoalveolar tactile stimulus device
<p>Abstract</p> <p>Background</p> <p>Few methods exist to study central nervous system processes following dentoalveolar tactile stimulation using functional magnetic resonance imaging (fMRI), likely due to inherent technical difficulties. Our primary goal was to develop and perform feasibility testing of a novel device capable of delivering valid and reliable dentoalveolar stimuli at dental chair-side and during MRI. Details of a device designed to deliver dentoalveolar dynamic pressure stimuli are described. Device testing took place in three settings: a) laboratory testing to assess range of stimulus force intensities, b) dental chair-side to assess reliability, validity and discriminant ability in force-pain relationship; and c) MRI to evaluate magnetic compatibility and ability to evoke brain activation in painfree subjects similar to those described in the literature.</p> <p>Results</p> <p>A novel device capable of delivering valid and reliable dentoalveolar somatosensory stimulation was developed (ICC = 0.89, 0.78-1 [95% CI]). Psychophysical data analysis showed high discriminant ability in differentiating painfree controls from cases with chronic dentoalveolar pain related to deafferenting dental procedures (sensitivity = 100%, specificity = 86.7%, area under ROC curve = 0.99). FMRI results of dentoalveolar dynamic pressure pain in painfree subjects revealed activation of brain areas typically associated with acute pain processing including thalamus, primary/secondary somatosensory, insular and prefrontal cortex.</p> <p>Conclusions</p> <p>A novel psychophysical method to deliver dynamic dentoalveolar pressure stimulation was developed and validated, allowing non-invasive MRI-based exploration of central nervous system function in response to intraoral somatosensation.</p> <p>Background</p> <p>The organization of the trigeminal system is unique as it provides somatosensory innervation to the face, masticatory and oral structures, the majority of the intracranial contents <abbrgrp><abbr bid="B1">1</abbr></abbrgrp> and to specialized structures (tongue, nasal mucosa, auricle, tympanic membrane, cornea and part of the conjunctiva) <abbrgrp><abbr bid="B2">2</abbr></abbrgrp>. Somatic sensory information transmitted by the trigeminal nerve is crucial for normal orofacial function; however, the mechanisms of many chronic pain conditions affecting areas innervated by this sensory system are not well understood <abbrgrp><abbr bid="B3">3</abbr><abbr bid="B4">4</abbr><abbr bid="B5">5</abbr></abbrgrp>. The clinical presentation of chronic intraoral pain in the area of a tooth or in a site formally occupied by a tooth with no clinical or radiological signs of pathology, referred to as atypical odontalgia (AO) <abbrgrp><abbr bid="B6">6</abbr><abbr bid="B7">7</abbr></abbrgrp>, is one such chronic pain condition of particular interest to dentists that is difficult to diagnose and manage. Recent research suggests both peripheral and central nervous system mechanisms being involved in AO pathophysiology <abbrgrp><abbr bid="B8">8</abbr><abbr bid="B9">9</abbr><abbr bid="B10">10</abbr></abbrgrp>, but the majority of mechanism-based research of patients with AO has focused on the "peripheral aspect" <abbrgrp><abbr bid="B7">7</abbr></abbrgrp>.</p> <p>Functional magnetic resonance imaging (fMRI) is an established research technique to study the central aspects of pain <abbrgrp><abbr bid="B11">11</abbr></abbrgrp>. Of existing neuroimaging techniques, fMRI provides good spatial resolution of cortical and subcortical structures critical in the processing of nociception, acceptable temporal resolution, does not involve ionizing radiation, and can be performed using most MRI systems that already exist in research centers and the community. For these reasons, we sought to develop a protocol that allows us to use this tool to investigate the central mechanisms involved in the processes of intraoral pain arising from the dentoalveolar region. Using this device, our long-term objective is to improve our understanding of the underlying mechanisms of persistent dentoalveolar pain.</p> <p>In the past few years several studies used fMRI to investigate the human trigeminal system <abbrgrp><abbr bid="B12">12</abbr><abbr bid="B13">13</abbr></abbrgrp>, with a limited subset focusing on intraoral stimulation - specifically on the dentoalveolar processes, such as lip, tongue and teeth stimulation <abbrgrp><abbr bid="B14">14</abbr></abbrgrp> or only teeth <abbrgrp><abbr bid="B15">15</abbr><abbr bid="B16">16</abbr><abbr bid="B17">17</abbr></abbrgrp>. Some reasons for scarce literature on this topic may be the technical challenges involved in delivering facial/intraoral stimulation inside a MR scanner <abbrgrp><abbr bid="B17">17</abbr><abbr bid="B18">18</abbr></abbrgrp>: possibility of magnetic interference, detriment of image quality, subject discomfort and reduced working space between the subject's head and the radiofrequency coil. As a consequence a MR-compatible device would need to not only overcome these challenges but also be capable of delivering a controlled and reproducible stimuli <abbrgrp><abbr bid="B19">19</abbr></abbrgrp>, as reliability/reproducibility is a necessary feature of sensory testing <abbrgrp><abbr bid="B20">20</abbr></abbrgrp>.</p> <p>Existing MR-compatible methods of dentoalveolar stimulation are limited and do not adequately deliver stimuli across a range of non-painful to painful intensities and/or cannot be adjusted to reach posterior aspects of the dentoalveolar region. Therefore our goal was to develop and test the feasibility of a device able to: 1) provide reliable and valid dentoalveolar stimuli, 2) deliver such stimulation within the restricted space of an MR head coil, 3) be compatible for use within an MR environment, and 4) produce brain activation in painfree controls consistent to those observed by others using fMRI.</p
Excavation on the Moon: Regolith Collection for Oxygen Production and Outpost Site Preparation
The development of a robust regolith moving system for lunar and planetary processing and construction is critical to the NASA mission to the Moon and Mars. Oxygen production may require up to 200 metric tons of regolith collection per year; outpost site development may require several times this amount. This paper describes progress in the small vehicle implement development and small excavation system development. Cratos was developed as a platform for the ISRU project to evaluate the performance characteristics of a low center of gravity, small (0.75m x 0.75m x 0.3m), low-power, tracked vehicle performing excavation, load, haul, and dump operations required for lunar ISRU. It was tested on loose sand in a facility capable of producing level and inclined surfaces, and demonstrated the capability to pick up, carry, and dump sand, allowing it to accomplish the delivery of material to a site. Cratos has demonstrated the capability to pick up and deliver simulant to a bury an inflatable habitat, to supply an oxygen production plant, and to build a ramp
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