Evaluation of Satellite-Based Rainfall Estimates in the Lower Mekong River Basin (Southeast Asia)

Satellite-based precipitation is an essential tool for regional water resource applications that requires frequent observations of meteorological forcing, particularly in areas that have sparse rain gauge networks. To fully realize the utility of remotely sensed precipitation products in watershed modeling and decision-making, a thorough evaluation of the accuracy of satellite-based rainfall and regional gauge network estimates is needed. In this study, Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) 3B42 v.7 and Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS) daily rainfall estimates were compared with daily rain gauge observations from 2000 to 2014 in the Lower Mekong River Basin (LMRB) in Southeast Asia. Monthly, seasonal, and annual comparisons were performed, which included the calculations of correlation coefficient, coefficient of determination, bias, root mean square error (RMSE), and mean absolute error (MAE). Our validation test showed TMPA to correctly detect precipitation or no-precipitation 64.9% of all days and CHIRPS 66.8% of all days, compared to daily in-situ rainfall measurements. The accuracy of the satellite-based products varied greatly between the wet and dry seasons. Both TMPA and CHIRPS showed higher correlation with in-situ data during the wet season (JuneSeptember) as compared to the dry season (NovemberJanuary). Additionally, both performed better on a monthly than an annual time-scale when compared to in-situ data. The satellite-based products showed wet biases during months that received higher cumulative precipitation. Based on a spatial correlation analysis, the average r-value of CHIRPS was much higher than TMPA across the basin. CHIRPS correlated better than TMPA at lower elevations and for monthly rainfall accumulation less than 500 mm. While both satellite-based products performed well, as compared to rain gauge measurements, the present research shows that CHIRPS might be better at representing precipitation over the LMRB than TMPA

The Evolutionary and Biogeographic Origin and Diversification of the Tropical Monocot Order Zingiberales

Zingiberales are a primarily tropical lineage of monocots. The current pantropical distribution of the order suggests an historical Gondwanan distribution, however the evolutionary history of the group has never been analyzed in a temporal context to test if the order is old enough to attribute its current distribution to vicariance mediated by the break-up of the supercontinent. Based on a phylogeny derived from morphological and molecular characters, we develop a hypothesis for the spatial and temporal evolution of Zingiberales using Dispersal-Vicariance Analysis (DIVA) combined with a local molecular clock technique that enables the simultaneous analysis of multiple gene loci with multiple calibration points. We employ a pairwise relative rates test to assign four rate classes to 24 ingroup and 12 outgroup taxa using evidence from three gene regions (rbcL, atpB, 18S). Five nodes of in group and outgroup taxa were calibrated using fossils and previous monocot-wide age estimates. The results are compared with non-parametric rate smoothing and penalized likelihood estimates of temporal diversification. The divergence of Zingiberales from the remaining commelinid monocots is found to have occurred around 124 million years ago, with major family-level lineages becoming established in the late Cretaceous (80-110 mya) and crown lineages within each family beginning to diversify during the early to mid-Tertiary (29-64 mya). Ancestral Gondwanan vicariance combined with a potential Laurasian distribution and multiple secondary dispersal events within families during the Tertiary can explain the main biogeographic events leading to the current pantropical distribution of this tropical order

A Community and University Collaborative: Responding to the Opioid Crisis

One of the 12 Grand Challenges of Social Work, as identified by the American Academy of Social Work and Social Welfare (2018), is Ensuring Healthy Development for all Youth. This article explores the importance of community-wide prevention efforts in meeting this challenge by utilizing grassroots coalition action in concert with engaged universities. Through perspectives of the Communities that Care Model and an Engaged University Model, this case study examines one community’s response to reduce the prevalence of youth substance abuse behaviors. Recommendations include effective coalition building strategies

SDSSJ14584479+3720215: A Benchmark JHK Blazar Light Curve from the 2MASS Calibration Scans

Active galactic nuclei (AGNs) are well-known to exhibit flux variability across a wide range of wavelength regimes, but the precise origin of the variability at different wavelengths remains unclear. To investigate the relatively unexplored near-IR variability of the most luminous AGNs, we conduct a search for variability using well sampled JHKs-band light curves from the 2MASS survey calibration fields. Our sample includes 27 known quasars with an average of 924 epochs of observation over three years, as well as one spectroscopically confirmed blazar (SDSSJ14584479+3720215) with 1972 epochs of data. This is the best-sampled NIR photometric blazar light curve to date, and it exhibits correlated, stochastic variability that we characterize with continuous auto-regressive moving average (CARMA) models. None of the other 26 known quasars had detectable variability in the 2MASS bands above the photometric uncertainty. A blind search of the 2MASS calibration field light curves for AGN candidates based on fitting CARMA(1,0) models (damped-random walk) uncovered only 7 candidates. All 7 were young stellar objects within the {\rho} Ophiuchus star forming region, five with previous X-ray detections. A significant {\gamma}-ray detection (5{\sigma}) for the known blazar using 4.5 years of Fermi photon data is also found. We suggest that strong NIR variability of blazars, such as seen for SDSSJ14584479+3720215, can be used as an efficient method of identifying previously-unidentified {\gamma}-ray blazars, with low contamination from other AGN.Comment: 6 pages, 3 figures, ApJ Accepte

B cells are capable of independently eliciting rapid reactivation of encephalitogenic CD4 T cells in a murine model of multiple sclerosis

<div><p>Recent success with B cell depletion therapies has revitalized efforts to understand the pathogenic role of B cells in Multiple Sclerosis (MS). Using the adoptive transfer system of experimental autoimmune encephalomyelitis (EAE), a murine model of MS, we have previously shown that mice in which B cells are the only MHCII-expressing antigen presenting cell (APC) are susceptible to EAE. However, a reproducible delay in the day of onset of disease driven by exclusive B cell antigen presentation suggests that B cells require optimal conditions to function as APCs in EAE. In this study, we utilize an <i>in vivo</i> genetic system to conditionally and temporally regulate expression of MHCII to test the hypothesis that B cell APCs mediate attenuated and delayed neuroinflammatory T cell responses during EAE. Remarkably, induction of MHCII on B cells following the transfer of encephalitogenic CD4 T cells induced a rapid and robust form of EAE, while no change in the time to disease onset occurred for recipient mice in which MHCII is induced on a normal complement of APC subsets. Changes in CD4 T cell activation over time did not account for more rapid onset of EAE symptoms in this new B cell-mediated EAE model. Our system represents a novel model to study how the timing of pathogenic cognate interactions between lymphocytes facilitates the development of autoimmune attacks within the CNS.</p></div

Entertainment 721

The goal of this project was to design a luxury, aesthetically pleasing entertainment system with a TV lift mechanism that could be remote controlled. The design would also include a cooling cabinet for gaming systems, a remote locking system, and additional storage. Using a morphological chart and weighted decision matrix for each subsystem key features were determined to be included in the design. Several performance benchmarks were determined to accomplish the team’s design. Almost every benchmark was successful in the build of the first prototype. Several heat calculations and FEA analyses were performed on the system to ensure the success of the system. The design was overall determined to be a success, and some ideas for future improvements were proposed by the team

Toward the synthesis of an acetal-free Tn antigen anti-cancer vaccine candidate

Cancer vaccines are a promising approach to cancer treatment by activating the immune system towards cancer cells. The challenge, however, comes with the identification of biomarkers correlated with cancer. Unfortunately, many oncotargets are simply upregulated in cancer; these are inappropriate vaccine targets as they are also present on healthy cells and therefore would ultimately initiate a very dangerous systemic immune response. In contrast, Tumor-Associated Carbohydrate Antigens (TACAs) are not found in healthy adult tissue but are found on over 90% of biopsied carcinomas. When incorporated into glycopeptides or other immunogenic scaffolds, these carbohydrate antigens have formed the basis of the development of anti-tumor immunotherapies through the induction of a specific immune response against cancer cells. However, despite promising preliminary data, none of these candidates have reached the clinic. Our hypothesis is that the carbohydrates on the vaccines may not survive antigen processing, and so more stable versions of these materials are required to create viable vaccines. Our approach is to incorporate TACAs lacking the labile glycosidic bond: acetal-free carbohydrates (AFCs). This project aims to remove the unstable acetal functional group to yield a more robust carbohydrate structure that can then be incorporated into a vaccine candidate. In this presentation, two synthetic pathways will be described: conversion of a carbohydrate to a carbasugar through a rearrangement, and de novo synthesis from noncarbohydrate materials