981 research outputs found

    Choice of Law: A Well-Watered Plateau

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    De flesta stora företag anvÀnder idag ett affÀrssystem, för att exempelvis integrera olikafunktioner i verksamheten och automatisera affÀrsprocesser, vilket har bidragit till attmÄnga leverantörer har ökat försÀljningsfokus mot mindre företag. SmÄ företag inserocksÄ behovet av affÀrssystem (Iskanius et al., 2009) och statistik visar Àven attanvÀndandet ökar i mindre företag (SCB, 2013). SmÄ företag kan inte ses som mindreversioner av stora företag (Malhotra och Temponi, 2010; Welsh och White, 1981), dÄdessa skiljer sig i exempelvis striktare resursbegrÀnsningar, vilket innebÀr attaffÀrssystemsprojekt ocksÄ skiljer sig frÄn de i stora företag. Av denna anledning Àr detviktigt för leverantörer att förstÄ vad som pÄverkar smÄ företag underinförskaffningsprocessen av ett affÀrssystem. Denna rapport syftar till att, för smÄsvenska företag, identifiera faktorer som Àr avgörande för valet att införskaffa ettaffÀrssystem och undersöka hur dessa pÄverkar viktiga faktorer senare i processen.UtifrÄn en litteraturstudie och en inledande empirisk datainsamling stÀlldes en teori uppi form av hypoteser om hur avgörande faktorer i införskaffandeprocessens initieringsfaspÄverkar viktiga faktorer under anskaffnings- och implementeringsfasen. Genom enfallstudiemetod, dÀr sex företag som införskaffat ett affÀrssystem under de senaste Ärenundersöktes, analyserades och testades den framtagna teorin.Studiens resultat belyser vikten av inblandade personers befintliga kunskap, en faktorsom pÄverkar bland annat möjligheten att ta fram en genomtÀnkt kravspecifikation ochprojektets struktur. Vidare identifierades stora skillnader i instÀllningen till att förÀndraoch effektivisera verksamheten och en syn pÄ resursbegrÀnsningar som leder till attexempelvis otillrÀcklig tid avvaras för projektet. Trots att affÀrssystem i smÄ företag oftaanvÀnds endast för ekonomi och ibland Àven logistik tyder undersökningen ocksÄ pÄ attinförskaffandet kan medföra ett stort vÀrde genom ett effektivare arbetssÀtt.Most large companies today use an ERP system, for example to integrate differentfunctional areas of the organization and automate business processes. This has mademany suppliers increase their sales focus on smaller companies. These companiesrealize the need for ERP systems (Iskanius et al., 2009) and statistics also show that theusage is increasing in smaller companies (SCB, 2013). However, small enterprisescannot be seen as smaller versions of large companies (Malhotra and Temponi, 2010;Welsh and White, 1981) as these differ, for example in more stringent resourceconstraints, which means that ERP projects also differ from those of large companies.For this reason, it is important for suppliers and consultants to understand what affectssmall companies during the process of acquiring an ERP system. This report aims to, insmall Swedish companies, identify factors that affect the decision to acquire an ERPsystem and examine how these affect important factors later in the process.Based on a literature review and an initial empirical data collection, a theory wascreated in the form of hypotheses about how the determinants of the aquiring processinitialization phase affects important factors during the acquisition and implementationphases. Through a case study method, in which six companies that has acquired an ERPsystem in recent years were studied, the developed theory was analyzed and tested.Our results highlight the importance of the existing knowledge of involved persons, afactor that influences, for example, the ability to develop a good requirementsspecification and the project structure. Furthermore, we identified significantdifferences in the openness to changing and improving the work flow of the companyand a view of resource constraints that often leads to insufficient time being spared forthe project. Although ERP system in small enterprises often are used only for financialmanagement and sometimes logistics the study shows that the acquisition can add largevalue to the organization through more efficient work processes

    Porcine intestinal glycosphingolipids recognized by F6-fimbriated enterotoxigenic Escherichia coli

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    One important virulence factor of enterotoxigenic Escherichia coli is their ability to adhere via fimbrial adhesins to specific receptors located on the intestinal mucosa. Here, the potential glycosphingolipid receptors of enterotoxigenic F6-fimbriated E. coli were examined by binding of purified F6 fimbriae, and F6-expressing bacteria, to glycosphingolipids on thin-layer chromatograms. When intestinal mucosal non-acid glycosphingolipids from single pigs were assayed for F6 binding capacity, a selective interaction with two glycosphingolipids was observed. The binding-active glycosphingolipids were isolated and characterized as lactotriaosylceramide (GlcNAc beta 3Gal beta 4Glc beta 1Cer) and lactotetraosylceramide (Gal beta 3GlcNAc beta 3Gal beta 4Glc beta 1Cer). Further binding assays using a panel of reference glycosphingolipids showed a specific interaction between the F6 fimbriae and a number of neolacto core chain (Gal beta 4GlcNAc) glycosphingolipids. In addition, an occasional binding of the F6 fimbriae to sulfatide, galactosylceramide, lactosylceramide with phytosphingosine and/or hydroxy fatty acids, isoglobotriaosylceramide, gangliotriaosylceramide, and gangliotetraosylceramide was obtained. From the results we conclude that lactotriaosylceramide and lactotetraosylceramide are major porcine intestinal receptors for F6-fimbriated E. coli

    The Future Climate Moisture Susceptibility of Wall Assemblies: Analysis Based on Monte Carlo Simulation Using a Simplified Deterministic Hygrothermal Simulation Model

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    A newly developed generic algorithm to assess moisture susceptibility of simplified wall assemblies has been developed within the CIB-W080 WG 2. This group is focusing on guidelines for design for durability of building envelopes. The algorithm is implemented in a publicly available Matlab code. A simplified wall assembly consisting of up to four material elements is considered. Optional vapor retarder and thermal resistances are located between the elements. In this paper modelling of a ventilated cladding is implemented. Using the simplified numerical model, a probability‐based risk analysis using the Monte Carlo method is demonstrated. The risk assessment of the wall assembly considers the interior and exterior climatic load. The moisture transport mechanism accounted for in the analysis is diffusion. The rain load is assumed to be transferred directly to a chosen outer susceptible material element in the construction. An insulated wooden wall structure is analyzed and the probability distribution of the time of wetness is presented for cases using sequence of 31 consecutive climatic years, randomly varying indoor moisture excess, indoor temperature and driving rain leakages

    Low-Complexity MISO Models of T1DM Glucose Metabolism

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    The New Zealand Thrush: An Extinct Oriole

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    The New Zealand Thrush, or Piopio, is an extinct passerine that was endemic to New Zealand. It has often been placed in its own family (Turnagridae), unresolved relative to other passerines, but affinities with thrushes, Australaian magpies, manucodes, whistlers, birds-of-paradise and bowerbirds has been suggested based on morphological data. An affinity with the bowerbirds was also indicated in an early molecular study, but low statistical support make this association uncertain. In this study we use sequence data from three nuclear introns to examine the phylogenetic relationships of the piopios. All three genes independently indicate an oriole (Oriolidae) affinity of the piopios, and the monophyly of the typical orioles (Oriolus), figbirds (Sphecotheres), and the piopios is strongly supported in the Bayesian analysis of the concatenated data set (posterior probability = 1.0). The exact placement of the piopios within Oriolidae is, however, more uncertain but in the combined analysis and in two of the gene trees the piopios are placed basal to the typical orioles while the third gene suggest a sister relationship with the figbirds. This is the first time an oriole affinity has been proposed for the piopios. Divergence time estimates for the orioles suggest that the clade originated ca 20 million years ago, and based on these estimates it is evident that the piopios must have arrived on New Zealand by dispersal across the Tasman Sea and not as a result of vicariance when New Zealand separated from Gondwana in the late Cretaceous

    Retrofitting of a listed brick and wood building using vacuum insulation panels on the exterior of the facade: Measurements and simulations

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    Many old listed buildings have an unsatisfactory thermal performance compared to the standards of today. The listing often limits the position and necessary thickness of an added insulation layer in the building envelope. Vacuum insulation panels (VIP) present unprecedented possibilities to reduce the required thickness of the insulation layer. The aim of this study is to explore the performance of VIP in the retrofitting of listed buildings. The goal is to improve the thermal transmittance and moisture performance of the wall and the thermal comfort for the occupants. Hygrothermal sensors were installed in the wall of a listed building insulated with VIP on the exterior. Sensors were also installed in a neighboring (non-retrofitted) wall as reference. Through a comparative analysis of the measured data it was concluded that the hygrothermal performance of the retrofitted wall was substantially better than of the reference wall. The measurement results were also compared to hygrothermal simulations to quantify the improvements in the thermal transmittance and moisture performance. A deviation was found between the measured and simulated relative humidity in the wall which was explained by vertical air leakage paths in the wall

    Brukarinflytandets villkor och professionella hjÀlpare

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    The aim was to gain insight into how specialist-teams intervening in psychiatric illness among individuals with disabilites handled and viewed service-user participation and how the view of the service-user effected service-user influence. Also other factors like authority and organizational context and limitations were recognized and accounted for. Data were collected by use of semi-structured interviews of the specialist-team and professional caregivers at the grouphomes where the interventions had taken places. By using primarily Ernesto Laclau and Chantelle MouffeÂŽs discourse analysis as method for highlighting discourses, and organization theory and Berger and LuckmannÂŽs sociology of knowledge approach interpretative I found several discourses and factors impacting the service-users participation and possible means of user influence practice in various degrees. The dilemmas of service-user influence on professional interventions were not to be solved by my research but the study clearly shows how both discourses and organizational frame impacts and also show the necessity of service-user influence

    Zimpl: Utveckling och utvÀrdering av anvÀndbarhet för textinmatning till smartphones

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    The aim of the Master's Thesis was to go in depth of Zimpls introductionary tutorial but also the writing itself on the keyboard. The weight of the study was on improving the current state of both introduction and the writing from an interaction design perspective. The project was divided into three major parts where each part was divided into even smaller parts. The first part concentrated on getting a grasp of how the user percieved the system. This was done by creating tests and having people test it in order to generate data which then could be analyzed. The second part was to create Lo-Fi prototypes which tried to solve problems that were identied during the0 first part. In total, three prototype stages were made, each focusing on dierent problems. The third and final part consisted of creating Hi-Fi prototypes as android implementations covering areas which were given positive response during the second phase. The implementations were then tested on real people to evaluate if an enhancement of the system was made

    The dimer contact area of sorghum NADP-malate dehydrogenase: role of aspartate 101 in dimer stability and catalytic activity

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    AbstractDuring thioredoxin-mediated activation of chloroplastic NADP-malate dehydrogenase, a homodimeric enzyme, the interaction between subunits is known to be loosened but maintained. A modeling of the 3D structure of the protein identified Asp-101 as being potentially involved in the association between subunits through an electrostatic interaction. Indeed, upon site-directed substitution of Asp-101 by an asparagine, the mutated enzyme behaved mainly as a monomer. The mutation strongly affected the catalytical efficiency of the enzyme. The now available 3D structure of the enzyme shows that Asp-101 is protruding at the dimer interface, interacting with Arg-268 of the neighbouring subunit

    Tool Life and Wear Modelling in Metal Cutting, Part 2 ─ Based on Combining the Archard and the Colding Equations

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    In this article an analytical and empirical model for describing tool life and tool wear in metal cutting is presented. The model is based on combining the Colding tool life equation and an extended version of the Archard wear function. It is shown that through the combining of these two models a substantial saving of resources can be achieved in terms of the workpiece material required, as well as the manpower and machine time needed for determining the model constants and the optimum cutting data to be employed
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