55 research outputs found
The Nucleosynthetic Imprint of 15-40 Solar Mass Primordial Supernovae on Metal-Poor Stars
The inclusion of rotationally-induced mixing in stellar evolution can alter
the structure and composition of presupernova stars. We survey the effects of
progenitor rotation on nucleosynthetic yields in Population III and II
supernovae using the new adaptive mesh refinement (AMR) code CASTRO. We examine
spherical explosions in 15, 25 and 40 solar mass stars at Z = 0 and 10^-4 solar
metallicity with three explosion energies and two rotation rates. Rotation in
the Z = 0 models resulted in primary nitrogen production and a stronger
hydrogen burning shell which led all models to die as red supergiants. On the
other hand, the Z=10^-4 solar metallicity models that included rotation ended
their lives as compact blue stars. Because of their extended structure, the
hydrodynamics favors more mixing and less fallback in the metal free stars than
the Z = 10^-4 models. As expected, higher energy explosions produce more
enrichment and less fallback than do lower energy explosions, and less massive
stars produce more enrichment and leave behind smaller remnants than do more
massive stars. We compare our nucleosynthetic yields to the chemical abundances
in the three most iron-poor stars yet found and reproduce the abundance pattern
of one, HE 0557-4840, with a zero metallicity 15 solar mass, 2.4 x 10^51 erg
supernova. A Salpeter IMF averaged integration of our yields for Z=0 models
with explosion energies of 2.4x10^51 ergs or less is in good agreement with the
abundances observed in larger samples of extremely metal-poor stars, provided
15 solar mass stars are included. Since the abundance patterns of extremely
metal-poor stars likely arise from a representative sample of progenitors, our
yields suggest that low-mass supernovae contributed the bulk of the metals to
the early universe.Comment: 16 pages, 11 figures; submitted to Ap
A single low-energy, iron-poor supernova as the source of metals in the star SMSS J 031300.36-670839.3
The element abundance ratios of four low-mass stars with extremely low
metallicities indicate that the gas out of which the stars formed was enriched
in each case by at most a few, and potentially only one low-energy, supernova.
Such supernovae yield large quantities of light elements such as carbon but
very little iron. The dominance of low-energy supernovae is surprising, because
it has been expected that the first stars were extremely massive, and that they
disintegrated in pair-instability explosions that would rapidly enrich galaxies
in iron. What has remained unclear is the yield of iron from the first
supernovae, because hitherto no star is unambiguously interpreted as
encapsulating the yield of a single supernova. Here we report the optical
spectrum of SMSS J031300.36- 670839.3, which shows no evidence of iron (with an
upper limit of 10^-7.1 times solar abundance). Based on a comparison of its
abundance pattern with those of models, we conclude that the star was seeded
with material from a single supernova with an original mass of ~60 Mo (and that
the supernova left behind a black hole). Taken together with the previously
mentioned low-metallicity stars, we conclude that low-energy supernovae were
common in the early Universe, and that such supernovae yield light element
enrichment with insignificant iron. Reduced stellar feedback both chemically
and mechanically from low-energy supernovae would have enabled first-generation
stars to form over an extended period. We speculate that such stars may perhaps
have had an important role in the epoch of cosmic reionization and the chemical
evolution of early galaxies.Comment: 28 pages, 6 figures, Natur
Epigenetic Dysregulation in Mesenchymal Stem Cell Aging and Spontaneous Differentiation
BACKGROUND: Mesenchymal stem cells (MSCs) hold great promise for the treatment of difficult diseases. As MSCs represent a rare cell population, ex vivo expansion of MSCs is indispensable to obtain sufficient amounts of cells for therapies and tissue engineering. However, spontaneous differentiation and aging of MSCs occur during expansion and the molecular mechanisms involved have been poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: Human MSCs in early and late passages were examined for their expression of genes involved in osteogenesis to determine their spontaneous differentiation towards osteoblasts in vitro, and of genes involved in self-renewal and proliferation for multipotent differentiation potential. In parallel, promoter DNA methylation and hostone H3 acetylation levels were determined. We found that MSCs underwent aging and spontaneous osteogenic differentiation upon regular culture expansion, with progressive downregulation of TERT and upregulation of osteogenic genes such as Runx2 and ALP. Meanwhile, the expression of genes associated with stem cell self-renewal such as Oct4 and Sox2 declined markedly. Notably, the altered expression of these genes were closely associated with epigenetic dysregulation of histone H3 acetylation in K9 and K14, but not with methylation of CpG islands in the promoter regions of most of these genes. bFGF promoted MSC proliferation and suppressed its spontaneous osteogenic differentiation, with corresponding changes in histone H3 acetylation in TERT, Oct4, Sox2, Runx2 and ALP genes. CONCLUSIONS/SIGNIFICANCE: Our results indicate that histone H3 acetylation, which can be modulated by extrinsic signals, plays a key role in regulating MSC aging and differentiation
Dust in Supernovae and Supernova Remnants I : Formation Scenarios
Supernovae are considered as prime sources of dust in space. Observations of local supernovae over the past couple of decades have detected the presence of dust in supernova ejecta. The reddening of the high redshift quasars also indicate the presence of large masses of dust in early galaxies. Considering the top heavy IMF in the early galaxies, supernovae are assumed to be the major contributor to these large amounts of dust. However, the composition and morphology of dust grains formed in a supernova ejecta is yet to be understood with clarity. Moreover, the dust masses inferred from observations in mid-infrared and submillimeter wavelength regimes differ by two orders of magnitude or more. Therefore, the mechanism responsible for the synthesis of molecules and dust in such environments plays a crucial role in studying the evolution of cosmic dust in galaxies. This review summarises our current knowledge of dust formation in supernova ejecta and tries to quantify the role of supernovae as dust producers in a galaxy.Peer reviewe
Infektionsschutz.Neu.Gestalten (I.N.Ge) - ein Verbundprojekt zur Vernetzung von Ă–GD und Wissenschaft
Participatory study development on workplace-related mental health in the nationwide research, training and evidence network for public health (OGD-FORTE)
Mack J, Schmidt K, Duwendag S, et al. Partizipative Studienentwicklung zur arbeitsplatzbezogenen psychischen Gesundheit im bundesweiten Forschungs-, Trainings- und Evidenznetzwerk fĂĽr die Ă–ffentliche Gesundheit (Ă–GD-FORTE). Das Gesundheitswesen. 2023;85(S 01):S15
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