1,520 research outputs found
New applications of Equinox code for real-time plasma equilibrium and profile reconstruction for tokamaks
Recent development of real-time equilibrium code Equinox [1] using a
fixed-point algorithm [2] allow major plasma magnetic parameters to be
identified in real-time, using rigorous analytical method. The code relies on
the boundary flux code providing flux values on the first wall of vacuum
vessel. By means of least-square minimization of differences between magnetic
field obtained from previous solution and the next measurements the code
identifies the source term of the non-linear Grad-Shafranov equation [3]. The
strict use of analytical equations together with a flexible algorithm offers an
opportunity to include new measurements into stable magnetic equilibrium code
and compare the results directly between several tokamaks while maintaining the
same physical model (i.e. no iron model is necessary inside the equilibrium
code). The successful implementation of this equilibrium code for JET and Tore
Supra have been already published [1], in this paper, we show the preliminary
results of predictive runs of the Equinox code using the ITER geometry.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des. 82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D-T mixtures since 1997 and the first ever D-T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D-T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D-T preparation. This intense preparation includes the review of the physics basis for the D-T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D-T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfven eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D-T campaign provides an incomparable source of information and a basis for the future D-T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.Peer reviewe
Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins
Glycosaminoglycan (GAG)–protein interactions mediate critical physiological and pathological processes, such as neuronal plasticity, development, and viral invasion. However, mapping GAG–protein interaction networks is challenging as these interactions often require specific GAG sulfation patterns and involve transmembrane receptors or extracellular matrix-associated proteins. Here, we report the first GAG polysaccharide-based photoaffinity probes for the system-wide identification of GAG-binding proteins in living cells. A general platform for the modular, efficient assembly of various chondroitin sulfate (CS)-based photoaffinity probes was developed. Systematic evaluations led to benzophenone-containing probes that efficiently and selectively captured known CS-E-binding proteins in vitro and in cells. Importantly, the probes also enabled the identification of >50 new proteins from living neurons that interact with the neuroplasticity-relevant CS-E sulfation motif. Several candidates were independently validated and included membrane receptors important for axon guidance, innate immunity, synapse development, and synaptic plasticity. Overall, our studies provide a powerful approach for mapping GAG–protein interaction networks, revealing new potential functions for these polysaccharides and linking them to diseases such as Alzheimer’s and autism
Overview of the JET preparation for deuterium-tritium operation with the ITER like-wall
For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des.82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T, leading up to 2020 and the first experiments with 50%/50% D–T mixtures since 1997 and the first ever D–T plasmas with the ITER mix of plasma-facing component materials. For this purpose, a concerted physics and technology programme was launched with a view to prepare the D–T campaign (DTE2). This paper addresses the key elements developed by the JET programme directly contributing to the D–T preparation. This intense preparation includes the review of the physics basis for the D–T operational scenarios, including the fusion power predictions through first principle and integrated modelling, and the impact of isotopes in the operation and physics of D–T plasmas (thermal and particle transport, high confinement mode (H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving several aspects of plasma operation for DTE2, such as real time control schemes, heat load control, disruption avoidance and a mitigation system (including the installation of a new shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the three-ions scheme), new diagnostics (neutron camera and spectrometer, active Alfvèn eigenmode antennas, neutral gauges, radiation hard imaging systems...) and the calibration of the JET neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation of JET for the 2020 D–T campaign provides an incomparable source of information and a basis for the future D–T operation of ITER, and it is also foreseen that a large number of key physics issues will be addressed in support of burning plasmas.This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under grant agreement No. 633053Postprint (published version
Photoaffinity Probes for the Identification of Sequence-Specific Glycosaminoglycan-Binding Proteins
Glycosaminoglycan (GAG)–protein interactions mediate critical physiological and pathological processes, such as neuronal plasticity, development, and viral invasion. However, mapping GAG–protein interaction networks is challenging as these interactions often require specific GAG sulfation patterns and involve transmembrane receptors or extracellular matrix-associated proteins. Here, we report the first GAG polysaccharide-based photoaffinity probes for the system-wide identification of GAG-binding proteins in living cells. A general platform for the modular, efficient assembly of various chondroitin sulfate (CS)-based photoaffinity probes was developed. Systematic evaluations led to benzophenone-containing probes that efficiently and selectively captured known CS-E-binding proteins in vitro and in cells. Importantly, the probes also enabled the identification of >50 new proteins from living neurons that interact with the neuroplasticity-relevant CS-E sulfation motif. Several candidates were independently validated and included membrane receptors important for axon guidance, innate immunity, synapse development, and synaptic plasticity. Overall, our studies provide a powerful approach for mapping GAG–protein interaction networks, revealing new potential functions for these polysaccharides and linking them to diseases such as Alzheimer’s and autism
Dielectric constant of glasses: first observation of a two-dimensional behavior
The 1kHz real part of the dielectric constant of a structural glass
was measured at low temperature down to 14 mK. Reducing the sample
thickness to 10 nm suppresses the usual minimum of for measuring
fields MV/m. This contradicts the Two Level System (TLS) model but is
well accounted for by including TLS-TLS interactions where excitations
delocalize between TLS's through a -induced mechanism recently designed: for
small 's this interaction is reduced, which explains the two-dimensional
behavior of . Hence, interactions play a key role in standard thick
samples.Comment: latex finesse3.tex, 5 files, 4 figures, 4 pages [SPEC-S02/050],
submitted to Phys. Rev. Let
Overview of the JET preparation for deuterium–tritium operation with the ITER like-wall
For the past several years, the JET scientific programme (Pamela et al 2007 Fusion Eng. Des.
82 590) has been engaged in a multi-campaign effort, including experiments in D, H and T,
leading up to 2020 and the first experiments with 50%/50% D–T mixtures since 1997 and the
first ever D–T plasmas with the ITER mix of plasma-facing component materials. For this
purpose, a concerted physics and technology programme was launched with a view to prepare
the D–T campaign (DTE2). This paper addresses the key elements developed by the JET
programme directly contributing to the D–T preparation. This intense preparation includes
the review of the physics basis for the D–T operational scenarios, including the fusion power
predictions through first principle and integrated modelling, and the impact of isotopes in the
operation and physics of D–T plasmas (thermal and particle transport, high confinement mode
(H-mode) access, Be and W erosion, fuel recovery, etc). This effort also requires improving
several aspects of plasma operation for DTE2, such as real time control schemes, heat load
control, disruption avoidance and a mitigation system (including the installation of a new
shattered pellet injector), novel ion cyclotron resonance heating schemes (such as the threeions scheme), new diagnostics (neutron camera and spectrometer, active Alfvèn eigenmode
antennas, neutral gauges, radiation hard imaging systems…) and the calibration of the JET
neutron diagnostics at 14 MeV for accurate fusion power measurement. The active preparation
of JET for the 2020 D–T campaign provides an incomparable source of information and a
basis for the future D–T operation of ITER, and it is also foreseen that a large number of key
physics issues will be addressed in support of burning plasmas.EURATOM 63305
Partager et collaborer : la clé d’une démarche marketing réussie ?
Toutes deux traductrices indépendantes, l’une spécialisée dans la traduction médicale et le développement international (Cécile) et l’autre dans la traduction juridique et rédactionnelle (Nelia), nous avons été confrontées à une baisse d’activité de plusieurs semaines début 2014. Si cette période a été source de doutes, elle a aussi fourni l’occasion à chacune de faire le bilan de sa clientèle et d’analyser précisément son chiffre d’affaires. Au détour d’un échange de courriels, nous nous som..
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