Virtual Grid - New Paradigm of System Resources Dynamic Organization

This paper describes the model and software tools for virtualization of the Grid execution environment. The basic assumption of this study is that Virtual Grid (VG) is constructed dynamically according to application requirements with virtualized computational and communication resources. A VG instance is dynamically created for each application and its initial configuration can be further modified during runtime to satisfy the requested level of resource usage and to maintain the quality of service indexes at agreed-upon values. A VG model that takes into account this approach has been proposed and analyzed in the context of Grid-related technology

Flexible Organization of Repositories for Provisioning Cloud Infrastructures

The paper proposes an architecture of a system automating the provisioning process of cloud computing infrastructures. Its structure and components are specified, based on an analysis of three types of requirements: infrastructure providers, service providers and end users. These considerations have led us to formulate a new infrastructural model, offered to end users as a collection of Virtual Machines (VM) connected by a dedicated Virtual Private Network (VPN) with QoS guarantees. The role of repositories in cloud provisioning systems is specified along with the relevant data acquisition processes. The applicability of the proposed system is illustrated by practical usage scenarios

Comparison and assessment of thyroid morphology and function in inhabitants of Lower Silesia before and after administration of a single dose of iodine-containing contrast agent during cardiac intervention procedure

Wstęp: Wiadomym jest, że mieszkańcy terenów ubogich w jod rozwijają szereg niemych klinicznie patologii tarczycy. Celem badania była ocena morfologii i funkcji tarczycy w populacji dorosłych mieszkańców Dolnego Śląska oraz ocena wpływu na gruczoł tarczowy jednorazowo podanej dawki jodu w postaci kontrastu w trakcie kardiologicznych procedur interwencyjnych. Materiały i metody: Do pierwszej części badania, której celem była ocena morfologii i funkcji tarczycy u zdrowych mieszkańców Dolnego Śląska zakwalifikowano 120 osób (78 mężczyzn i 42 kobiety). Z tej grupy wyłoniono 60 osób (38 mężczyzn i 22 kobiety) które, z racji wskazań do inwazyjnych zabiegów kardiologicznych (koronarografii/PTCA), obciążono dużą dawką jodu oraz przeprowadzano u nich ocenę tyreologiczną po 1, 3 i 6 miesiącach od interwencji. Wyniki: 1) Patologiczne zmiany w morfologii tarczycy stwierdzono u 49,1%, zaburzenia dotyczące stężeń hormonów tarczycy i przeciwciał przeciwtarczycowych stwierdzono u 17,6%, które przekładały się na zaburzenia funkcji tarczycy u 9,3% zdrowych tyreologicznie mieszkańców Dolnego Śląska. 2) Największe zmiany: obniżenie stężenia TSH i wzrost stężenia fT3 były widoczne 4 tygodnie po obciążeniu jodem, prowadząc do rozpoznania nadczynności tarczycy u 15% pacjentów. Wnioski: 1) Z uwagi na dużą ilość klinicznie niemych zaburzeń morfologii i funkcji tarczycy ważna jest jej dokładna ocena przed obciążeniem chorego jodem. 2) Jest poparte dowodami i polecane monitorowanie stężenia TSH i fT3 przed i 4 tygodnie po obciążeniu chorego jodem. 3) Zaburzenia morfologii i funkcji tarczycy po podaniu pacjentowi jodu mają charakter przemijający, wymagają monitorowania, ale nie leczenia.Introduction: Inhabitants living in areas with endemic dietary iodine intake deficiency develop nodular goitre. The aim of our study was to evaluate thyroid morphology and function among adults residing in Lower Silesia and to assess the effect on the thyroid gland of an iodine-based contrasting agent administered during a cardiac intervention procedure. Materials and methods: The first part of the study (evaluation of thyroid gland) was carried out on 120 subjects (78 men and 42 women). From among this group, invasive cardiac procedures were performed on 60 subjects (38 men and 22 women) during the second part of the study. Endocrine tests were repeated one, three, and six months after the invasive procedure. Results: 1) Within the studied group, pathological changes in thyroid morphology were found in 49.1%, and thyroid function disturbances in 9.3%, of all subjects. 2) A decrease in TSH concentration with a corresponding increase in fT3 concentration was seen at the second visit (four weeks after iodine administration) leading to the diagnosis of hyperthyroidism in 15% of subjects. Conclusions: 1) Considering the multitude of silent thyroid pathologies, particular care is required before administering an iodine-based medium. 2) It is reasonable and advisable to monitor TSH and fT3 levels before and at four weeks after administration of an iodine-containing contrast agent. 3) Thyroid morphology and function disturbances after iodine administration do not necessitate treatment, as they are of transient character and only require monitoring

A Novel Monoallelic Nonsense Mutation in the NFKB2 Gene Does Not Cause a Clinical Manifestation

NF-κB signaling, acting through NFKB1 dependent canonical and NFKB2 dependent non-canonical pathways plays a critical role in inflammatory and immune responses. Recent studies have associated mutations in these two genes with a common variable immunodeficiency (CVID). While evaluating a female patient seeking a diagnosis explaining her recurrent infections, we found a novel heterozygous c.1831C > T (p.Arg611∗) nonsense mutation in the NFKB2 gene which introduces a Stop codon in the ankyrin repeat domain of p100. Whole exome sequencing (WES) analysis, followed by Sanger sequencing, identified this previously unknown mutation in two other family members. Penetrance of the c.1831C > T variant was assessed by flow-cytometry and protein expression in peripheral blood mononuclear cells (PBMC); whereas, activation of the NF-κB2 signaling pathway was examined through immunoblotting and real-time PCR. Heterozygous c.1831C > T variant led to the expansion of lymphocyte B subpopulations with concomitant reduction of plasmablasts, low IgG levels, and accumulation of p52 in PBMC. On the other hand, tested subjects had normal levels of IgM, IgA, IgE and no impairment in lymphocytes proliferation. Although evaluated patients did not fulfill all clinical features of CVID, their health should be monitored in the future for possible late manifestation of the disease. In conclusion, we showed that NFKB2 haplodeficiency caused by c.1831C > T nonsense mutation is asymptomatic, possibly due to the compensatory mechanisms and allele redundancy

Procedure of customs warehousing

Celem pracy jest przybliżenie procedury składowania celnego jako jednej z ważniejszych procedur celnych. W szczególności analizie zostały poddane jego rodzaje, proces tworzenia oraz funkcjonowanie w świetle przepisów prawa Unii Europejskiej oraz uzupełniającego je polskiego prawa celnego. W tym celu wykorzystano przepisy zawarte w Unijnym Kodeksie Celnym oraz Przejściowym Rozporządzeniu Delegowanym. Efektem pracy jest poznanie stosunkowo nowej procedury funkcjonowania składów celnych, która po wejściu w życie 1 maja 2016 roku Unijnego Kodeksu Celnego różni się nieco od tej, która istniała za czasów obowiązywania Wspólnotowego Kodeksu Celnego.The purpose of the work is to describe customs warehousing industry as one of the major customs procedures. The analysis included the type of warehousing, it`s proces of creation and operations In the light of European Union law and complementary Polish customs law. For this purpose the study used the provisions of the EU Customs Code and the Transitional Regulation on Delegated Use. The result of this work is the knowledge of a relatively new customs warehousing procedure, which after the entry into force on 1 May 2016, of the EU Customs Code differs slightly from that which existed during the time of the Community Customs Code

Running a business outside the public utility sphere

Celem pracy jest przeanalizowanie uprawnień samorządu terytorialnego odnośnie prowadzenia działalności gospodarczej poza sferą użyteczności publicznej. W szczególności badaniu zostały poddane pojęcia użyteczności publicznej, interesu publicznego, zadania publicznego, zasadność prowadzenia działalności gospodarczej, przedstawione zostały argumenty przeciwników i zwolenników owej procedury oraz podjęto próbę uzasadnienia ratio legis takiej dopuszczalności.The purpose of the work is to describe permissions of local government about running a business outside the public utility sphere. The analysis included the term of public utility, public interest, public task, the legitimacy of running a business, the position of supporters and opponents of this procedure and there was tried to justify ratio legis of this permissibility

CHARACTERISTICS OF RAW WASTEWATER FROM THE FRUIT AND VEGETABLE INDUSTRY

The aim of the study was to characterize the raw wastewaters with fruit and vegetable industry (vegetable fruit juices and frozen food) in Podlaskie. Based on the survey, it was found that raw wastewater in the fruit and vegetable industry contain large amounts of organic compound expressed in BOD (900 mg O2 / dm3 to 2200 mg O2 / dm3) and COD (1320 mg O2 / dm3 to 2316 mg O2 / dm3) and low in nitrogen and phosphorus. The highest values of organic compounds are of the August and September and the lowest in March and May