Exkursionspunkt 1: Liegender Grenzbereich der Ostharz-Decke im Ludetal

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Was sagen uns die hydrothermalen Mineralgänge des Harzes und des Thüringer Waldes zur geologischen Entwicklung des Gebietes?

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Spätpleistozäne bis frühholozäne Tektonik in einem Karsttrichter im Bereich der Störungszone des Harznordrandes nahe Benzingerode (Sachsen-Anhalt)

In einem Karsttrichter etwa 1 km SSE von Benzingerode wurde eine Störung im Bereich der Nordrand-Störungszone des Harzes angetroffen (Flächenlage 15/75), die einen wahrscheinlich spätweichselkaltzeitlichen solifluidalen Schuttstrom schneidet und kumulativ um mindestens 1 m dextral-schrägabschiebend nach ENE verwirft. Die durchtrennten Sedimente zeigen an, dass es sich um spätpleistozäne bis frühholozäne Aktivitäten in der Nordrandstörungszone des Harzes handelt. Es können auf dieser Störung zwei Aktivierungen ausgehalten werden, die mit dem heute in weiten Teilen Mitteleuropas ansetzenden Stressfeld (SHmax aus SE bis SSE) kompatibel sind.In a sinkhole, located about one kilometer SSE of the village of Benzingerode, a fault (fault plan 15/75) was discovered in the area of the “Harznordrand” fault. This fault cuts a solifluidal debris flow of the last glacial period that probably is of late Weichselian age. The fault of at least 1 meter throw is a normal fault with a dextral component to the ENE. These fault activities point to late Pleistocene to early Holocene activities in the range of the “Harznordrand” fault. Two activities can be observed on this fault, which are compatible with the stress field (SHmax from SE to SSE) pushing wide parts of present Middle Europe (SHmax from SE to SSE

Study of Controlled Atmosphere Flexible Microtube Plasma Soft Ionization Mass Spectrometry for Detection of Volatile Organic Compounds as Potential Biomarkers in Saliva for Cancer

A new soft ionization device for mass spectrometry is presented using the flexible microtube plasma under controlled atmospheric conditions. The controlled atmosphere flexible microtube plasma consists of the plasma source itself connected to a gas chromatograph and a mass spectrometer using a borosilicate glass cross piece. Controlled atmosphere, for example, nitrogen and/or an oxygen mixture, is introduced to the system to create a clean ionization environment. Reproducibility issues are discussed, and solutions are presented manipulating the gas flow in the cross piece. A proof of concept is shown using a ketone mixture introduced to the mass spectrometer to optimize atmospheric conditions. Furthermore, application of the presented device for the sensitive and nonfragmenting ionization of volatile organic biomarkers relevant for cancer is carried out. Sample treatment for human saliva is described, and relevant candidate biomarkers are measured in the saliva matrix, showing a very good ionization efficiency and neglectable matrix effects with limits of detection below 80 ppt

A microfluidic array with cellular valving for single cell co-culture

We present a highly parallel microfluidic approach for contacting single cell pairs. The approach combines a differential fluidic resistance trapping method with a novel cellular valving principle for homotypic and heterotypic single cell co-culturing. Differential fluidic resistance was used for sequential single cell arraying, with the adhesion and flattening of viable cells within the microstructured environment acting to produce valves in the open state. Reversal of the flow was used for the sequential single cell arraying of the second cell type. Plasma stencilling, along the linear path of least resistance, was required to confine the cells within the trap regions. Prime flow conditions with minimal shear stress were identified for highly efficient cell arraying (similar to 99%) and long term cell culture. Larger trap dimensions enabled the highest levels of cell pairing (similar to 70%). The single cell co-cultures were in close proximity for the formation of connexon structures and the study of contact modes of communication. The research further highlights the possibility of using the natural behaviour of cells as the working principle behind responsive microfluidic element

Characterization of a Nitrogen-based Dielectric Barrier Discharge Ionization Source for Mass Spectrometry Reveals Factors Important for Soft Ionization

ISSN:1520-6882ISSN:0003-270

Microplasma writing for surface-directed millifluidics

Hydrophilic patterns were directly written on a hydrophobic glass substrate with a microplasma jet and used for surface-directed capillary flow operations