33 research outputs found
The COSINE-100 liquid scintillator veto system
This paper describes the liquid scintillator veto system for the COSINE-100 dark matter experiment and its performance. The COSINE-100 detector consists of eight NaI(Tl) crystals immersed in 2200 L of linear alkylbenzene-based liquid scintillator. The liquid scintillator tags between 65 and 75% of the internal 40K background in the 2–6 keV energy region. We also describe the background model for the liquid scintillator, which is primarily used to assess its energy calibration and threshold
Measurement of the cosmic muon annual and diurnal flux variation with the COSINE-100 detector
We report measurements of annual and diurnal modulations of the cosmic-ray muon rate in the Yangyang underground laboratory (Y2L) using 952 days of COSINE-100 data acquired between September 2016 and July 2019. A correlation of the muon rate with the atmospheric temperature is observed and its amplitude on the muon rate is determined. The effective atmospheric temperature and muon rate variations are positively correlated with a measured effective temperature coefficient of αT = 0.80 ± 0.11. This result is consistent with a model of meson production in the atmosphere. We also searched for a diurnal modulation in the underground muon rate by comparing one-hour intervals. No significant diurnal modulation of the muon rate was observed
Comparison between DAMA/LIBRA and COSINE-100 in the light of quenching factors
There is a long standing debate about whether or not the annual modulation signal reported by the DAMA/LIBRA collaboration is induced by Weakly Interacting Massive Particles (WIMP) in the galaxy's dark matter halo scattering from nuclides in their NaI(Tl) crystal target/detector. This is because regions of WIMP-mass vs. WIMP-nucleon cross-section parameter space that can accommodate the DAMA/LIBRA-phase1 modulation signal in the context of the standard WIMP dark matter galactic halo and isospin-conserving (canonical), spin-independent (SI) WIMP-nucleon interactions have been excluded by many of other dark matter search experiments including COSINE-100, which uses the same NaI(Tl) target/detector material. Moreover, the recently released DAMA/LIBRA-phase2 results are inconsistent with an interpretation as WIMP-nuclide scattering via the canonical SI interaction and prefer, instead, isospin-violating or spin-dependent interactions. Dark matter interpretations of the DAMA/LIBRA signal are sensitive to the NaI(Tl) scintillation efficiency for nuclear recoils, which is characterized by so-called quenching factors (QF), and the QF values used in previous studies differ significantly from recently reported measurements, which may have led to incorrect interpretations of the DAMA/LIBRA signal. In this article, the compatibility of the DAMA/LIBRA and COSINE-100 results, in light of the new QF measurements is examined for different possible types of WIMP-nucleon interactions. The resulting allowed parameter space regions associated with the DAMA/LIBRA signal are explicitly compared with 90% confidence level upper limits from the initial 59.5 day COSINE-100 exposure. With the newly measured QF values, the allowed 3σ regions from the DAMA/LIBRA data are still generally excluded by the COSINE-100 data
Study of cosmogenic radionuclides in the COSINE-100 NaI(Tl) detectors
COSINE-100 is a direct detection dark matter search experiment that uses a 106 kg array of eight NaI(Tl) crystals that are kept underground at the Yangyang Underground Laboratory to avoid cosmogenic activation of radioisotopes by cosmic rays. Even though the cosmogenic activity is declining with time, there are still significant background rates from the remnant nuclides. In this paper, we report measurements of cosmogenic isotope contaminations with less than one year half-lives that are based on extrapolations of the time dependent activities of their characteristic energy peaks to activity rates at the time the crystals were deployed underground. For longer-lived 109Cd (T1/2=1.6 y) and 22Na (T1/2=2.6 y), we investigate time correlations and coincidence events due to several emissions. The inferred sea-level production rates are compared with calculations based on the ACTIVIA and MENDL-2 model calculations and experimental data. The results from different approaches are in reasonable agreement with each other. For 3H, which has a long, 12.3 year half-life, we evaluated the activity levels and the exposure times that are in reasonable agreement with the time period estimated for each crystal’s exposure
Search for boosted dark matter in COSINE-100
We search for energetic electron recoil signals induced by boosted dark matter (BDM) from the galactic center using the COSINE-100 array of NaI(Tl) crystal detectors at the Yangyang Underground Laboratory. The signal would be an excess of events with energies above 4 MeV over the well-understood background. Because no excess of events are observed in a 97.7 kg·yr exposure, we set limits on BDM interactions under a variety of hypotheses. Notably, we explored the dark photon parameter space, leading to competitive limits compared to direct dark photon search experiments, particularly for dark photon masses below 4 MeV and considering the invisible decay mode. Furthermore, by comparing our results with a previous BDM search conducted by the Super-Kamionkande experiment, we found that the COSINE-100 detector has advantages in searching for low-mass dark matter. This analysis demonstrates the potential of the COSINE-100 detector to search for MeV electron recoil signals produced by the dark sector particle interactions
An induced annual modulation signature in COSINE-100 data by DAMA/LIBRA’s analysis method
The DAMA/LIBRA collaboration has reported the observation of an annual modulation in the event rate that has been attributed to dark matter interactions over the last two decades. However, even though tremendous efforts to detect similar dark matter interactions were pursued, no definitive evidence has been observed to corroborate the DAMA/LIBRA signal. Many studies assuming various dark matter models have attempted to reconcile DAMA/LIBRA’s modulation signals and null results from other experiments, however no clear conclusion can be drawn. Apart from the dark matter hypothesis, several studies have examined the possibility that the modulation is induced by variations in detector’s environment or their specific analysis methods. In particular, a recent study presents a possible cause of the annual modulation from an analysis method adopted by the DAMA/LIBRA experiment in which the observed annual modulation could be reproduced by a slowly varying time-dependent background. Here, we study the COSINE-100 data using an analysis method similar to the one adopted by the DAMA/LIBRA experiment and observe a significant annual modulation, however the modulation phase is almost opposite to that of the DAMA/LIBRA data. Assuming the same background composition for COSINE-100 and DAMA/LIBRA, simulated experiments for the DAMA/LIBRA without dark matter signals also provide significant annual modulation with an amplitude similar to DAMA/LIBRA with opposite phase. Even though this observation does not directly explain the DAMA/LIBRA results directly, this interesting phenomenon motivates more profound studies of the time-dependent DAMA/LIBRA background data
Search for bosonic super-weakly interacting massive particles at COSINE-100
We present results of a search for bosonic super-weakly interacting massive particles (BSW) as keV scale dark matter candidates that is based on an exposure of 97.7 kg·year from the COSINE experiment. In this search, we employ, for the first time, Compton-like as well as absorption processes for pseudoscalar and vector BSWs. No evidence for BSWs is found in the mass range from 10 keV/c2 to 1 MeV/c2, and we present the exclusion limits on the dimensionless coupling constants to electrons gae for pseudoscalar and κ for vector BSWs at 90% confidence level. Our results show that these limits are improved by including the Compton-like process in masses of BSW, above O(100 keV/c2)
Background modeling for dark matter search with 1.7 years of COSINE-100 data
We present a background model for dark matter searches using an array of NaI(Tl) crystals in the COSINE-100 experiment that is located in the Yangyang underground laboratory. The model includes background contributions from both internal and external sources, including cosmogenic radionuclides and surface 210Pb contamination. To build the model in the low energy region, with a threshold of 1 keV, we used a depth profile of 210Pb contamination in the surface of the NaI(Tl) crystals determined in a comparison between measured and simulated spectra. We also considered the effect of the energy scale errors propagated from the statistical uncertainties and the nonlinear detector response at low energies. The 1.7 years COSINE-100 data taken between October 21, 2016 and July 18, 2018 were used for this analysis. Our Monte Carlo simulation provides a non-Gaussian peak around 50 keV originating from beta decays of bulk 210Pb in a good agreement with the measured background. This model estimates that the activities of bulk 210Pb and 3H are dominating the background rate that amounts to an average level of 2.85±0.15 counts/day/keV/kg in the energy region of (1-6) keV, using COSINE-100 data with a total exposure of 97.7 kg⋅years
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
Introduction:
The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations with patient-related outcome measures.
Methods:
In a prospective, UK-wide, multicentre MRI follow-up study (C-MORE), adults (aged ≥18 years) discharged from hospital following COVID-19 who were included in Tier 2 of the Post-hospitalisation COVID-19 study (PHOSP-COVID) and contemporary controls with no evidence of previous COVID-19 (SARS-CoV-2 nucleocapsid antibody negative) underwent multiorgan MRI (lungs, heart, brain, liver, and kidneys) with quantitative and qualitative assessment of images and clinical adjudication when relevant. Individuals with end-stage renal failure or contraindications to MRI were excluded. Participants also underwent detailed recording of symptoms, and physiological and biochemical tests. The primary outcome was the excess burden of multiorgan abnormalities (two or more organs) relative to controls, with further adjustments for potential confounders. The C-MORE study is ongoing and is registered with ClinicalTrials.gov, NCT04510025.
Findings:
Of 2710 participants in Tier 2 of PHOSP-COVID, 531 were recruited across 13 UK-wide C-MORE sites. After exclusions, 259 C-MORE patients (mean age 57 years [SD 12]; 158 [61%] male and 101 [39%] female) who were discharged from hospital with PCR-confirmed or clinically diagnosed COVID-19 between March 1, 2020, and Nov 1, 2021, and 52 non-COVID-19 controls from the community (mean age 49 years [SD 14]; 30 [58%] male and 22 [42%] female) were included in the analysis. Patients were assessed at a median of 5·0 months (IQR 4·2–6·3) after hospital discharge. Compared with non-COVID-19 controls, patients were older, living with more obesity, and had more comorbidities. Multiorgan abnormalities on MRI were more frequent in patients than in controls (157 [61%] of 259 vs 14 [27%] of 52; p<0·0001) and independently associated with COVID-19 status (odds ratio [OR] 2·9 [95% CI 1·5–5·8]; padjusted=0·0023) after adjusting for relevant confounders. Compared with controls, patients were more likely to have MRI evidence of lung abnormalities (p=0·0001; parenchymal abnormalities), brain abnormalities (p<0·0001; more white matter hyperintensities and regional brain volume reduction), and kidney abnormalities (p=0·014; lower medullary T1 and loss of corticomedullary differentiation), whereas cardiac and liver MRI abnormalities were similar between patients and controls. Patients with multiorgan abnormalities were older (difference in mean age 7 years [95% CI 4–10]; mean age of 59·8 years [SD 11·7] with multiorgan abnormalities vs mean age of 52·8 years [11·9] without multiorgan abnormalities; p<0·0001), more likely to have three or more comorbidities (OR 2·47 [1·32–4·82]; padjusted=0·0059), and more likely to have a more severe acute infection (acute CRP >5mg/L, OR 3·55 [1·23–11·88]; padjusted=0·025) than those without multiorgan abnormalities. Presence of lung MRI abnormalities was associated with a two-fold higher risk of chest tightness, and multiorgan MRI abnormalities were associated with severe and very severe persistent physical and mental health impairment (PHOSP-COVID symptom clusters) after hospitalisation.
Interpretation:
After hospitalisation for COVID-19, people are at risk of multiorgan abnormalities in the medium term. Our findings emphasise the need for proactive multidisciplinary care pathways, with the potential for imaging to guide surveillance frequency and therapeutic stratification
Global Retinoblastoma Presentation and Analysis by National Income Level
Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4) were female. Most patients (n = 3685 84.7%) were from low-and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 62.8%), followed by strabismus (n = 429 10.2%) and proptosis (n = 309 7.4%). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 95% CI, 12.94-24.80, and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 95% CI, 4.30-7.68). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs. © 2020 American Medical Association. All rights reserved