A Gestão Escolar no Portugal Democrático: Uma Perspectiva da Administração Pública

Com base na decisão política de proceder à modernização da Administração Pública, as estratégias e práticas tradicionais do funcionamento das organizações estatais dão lugar a novas formas de actuação. Como resposta às consequências da globalização, as teorias da Nova Gestão Pública tendem a alterar o modelo de gestão estatal de modo a reduzir a dívida pública e aumentar a satisfação do cidadão. No terreno educativo, a aplicação destas políticas, presente nos diversos normativos legais, caracteriza-se por implementar uma gestão centrada na escola, visando o alargamento do conceito de autonomia mediante a adopção de medidas de descentralização e desconcentração de serviços. Com base na interpretação de legislação publicada e recolha literária, este projecto pretende focar como as reformas decretadas moldam a gestão dos estabelecimentos públicos portugueses de ensino não superior

Pathophysiological mechanisms of renal fibrosis: a review of animal models and therapeutic strategies

Chronic kidney disease (CKD) is a long-term condition in which the kidneys do not work correctly. It has a high prevalence and represents a serious hazard to human health and estimated to affects hundreds of millions of people. Diabetes and hypertension are the two principal causes of CKD. The progression of CKD is characterized by the loss of renal cells and their replacement by extracellular matrix (ECM), independently of the associated disease. Thus, one of the consequences of CKD is glomerulosclerosis and tubulointerstitial fibrosis caused by an imbalance between excessive synthesis and reduced breakdown of the ECM. There are many molecules and cells that are associated with progression of renal fibrosis e.g. angiotensin II (Ang II). Therefore, in order to understand the biopathology of renal fibrosis and for the evaluation of new treatments, the use of animal models is crucial such as: surgical, chemical and physical models, spontaneous models, genetic models and in vitro models. However, there are currently no effective treatments for preventing the progression of renal fibrosis. Therefore it is essential to improve our knowledge of the cellular and molecular mechanisms of the progress of renal fibrosis in order to achieve a reversion/elimination of renal fibrosis.This work was supported in part by a project grant from the Fundação para a Ciência e Tecnologia, Ministério da Educação, Portugal (grant no. SFRH/PROTEC/67576/2010).info:eu-repo/semantics/publishedVersio

Unlocking the in vitroanti- inflammatory and antidiabetic potential of Polygonum maritimum

Context: Several Polygonum species (Polygonaceae) are used in traditional medicine in Asia, Europe and Africa to treat inflammation and diabetes. Objective: Evaluate the in vitro antioxidant, anti-inflammatory and antidiabetic potential of methanol and dichloromethane extracts of leaves and roots of the halophyte Polygonum maritimum L. Material and methods: Antioxidant activity was determined (up to 1mg/mL) as radical-scavenging activity (RSA) of 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2'azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), copper (CCA) and iron (ICA) chelating activities and iron reducing power (FRAP). NO production was measured in lipopolysaccharide (LPS)-stimulated macrophages for 24 h at concentrations up to 100 mu g/mL and antidiabetic potential was assessed by alpha-amylase and alpha-glucosidase inhibition (up to 10 g/mL) assays. The phytochemical composition of the extracts was determined by gas chromatography-mass spectrometry (GC-MS). Results: The methanol leaf extract had the highest activity against DPPH center dot (IC50 = 26 mu g/mL) and ABTS1(+)center dot (IC50 = 140 mu g FRAP (IC50 = 48 mu g/mL) and CCA (IC50 = 770 mu g/mL). Only the dichloromethane leaf extract (LDCM) showed anti-inflammatory activity (IC50 = 48 mu g/mL). The methanol root (IC50 = 19 mu g/mL) and leaf (IC50 = 29 mu g/mL) extracts strongly inhibited baker's yeast alpha-glucosidase, but LDCM had higher rat's alpha-glucosidase inhibition (IC50 = 2527 mu g/mL) than acarbose (IC50 = 4638 mu g/mL). GC-MS analysis identified beta-sitosterol, stigmasterol, 1-octacosanol and linolenic acid as possible molecules responsible for the observed bioactivities. Conclusions: Our findings suggest P. maritimum as a source of high-value health promoting commodities for alleviating symptoms associated with oxidative and inflammatory diseases, including diabetes.XtremeBio project - Foundation for Science and Technology (FCT) [PTDC/MAR-EST/4346/2012]; Portuguese National Budget; FCT [CCMAR/Multi/04326/ 2013, IF/00049/2012, SFRH/BPD/86071/2012, UID/Multi/00612/2013

Creation of a vehicular delay-tolerant network prototype

Vehicular Delay-Tolerant Network (VDTN) is a new disruptive network architecture where vehicles act as the communication infrastructure. VDTN follows a layered architecture based on control and data planes separation, and positioning the bundle layer under the network layer. VDTN furnishes low-cost asynchronous communications coping with intermittent and sparse connectivity, variable delays and even no end-to-end connection. This paper presents a VDTN prototype (testbed) proposal, which implements and validates the VDTN layered architecture considering the proposed out-of-band signaling. The main goals of the prototype are emulation, demonstration, performance evaluation, and diagnose of protocol stacks and services, proving the applicability of VDTNs over a wide range of environments.Part of this work has been supported by the Instituto de Telecomunicações, Next Generation Networks and Applications Group (NetGNA), Covilhã Delegation, Portugal in the framework of the VDTN@Lab Project, and by the Euro-NF Network of Excellence from the Seventh Framework Programme of EU

Inclusivity and corporate social responsibility in marketing

Inclusivity and corporate social responsibility (CSR) in a community where ethnic diversity and conflict are very low compared to other countries still need to be researched more. This study aims to analyze university students’ awareness of inclusivity and CSR in marketing teaching using a pretest-posttest control group design. Both experimental (n = 138) and control (n = 140) groups are homogeneous regarding nationality, ethnicity, and age. The experimental group was subject to specific training on inclusive products, marketing communication, and CSR, which allowed testing of their perceptions and the training’s effectiveness. The first trial showed that the change in the experimental group was 8%, against 2.5% in the control group. The second trial demonstrated that the change in the experimental group was 30.4%, noting inclusive reasons, and, in the control group, only 6.4%. The third trial found a positive evolution in the experimental group, with more than 8.3% of students choosing the CSR company, and a negative evolution in the control group of –5.6%. These differences were not statistically significant within both groups but significant when comparing the two groups. The results of this study highlight that this homogeneous population does not think about those issues when analyzing businesses, products, or marketing communication. However, when people are submitted to specific training, they become aware and change their perceptions accordingly to what was expected. Thus, one concludes that education for inclusivity and CSR should be part of students’ training, independently of the homogeneity of the social and human environment. AcknowledgmentThe authors would like to thank their students at Universidade Portucalense for accepting that their school tests were used to design and publish this paper

Qualidade físico-química e microbiológica da água de piscinas do distrito de Bragança

A piscina é utilizada para fins recreativos, formativos, terapêuticos ou desportivos e de forma a impedir que a sua água seja um veiculo de infeções é importante a sua desinfeção. Por conseguinte, os utilizadores de piscinas e os vários grupos profissionais que aí desempenham atividades podem estar sujeitos a diversos perigos, nomeadamente biológicos e químicos. A contaminação biológica relaciona-se com o desenvolvimento de diferentes microrganismos onde se pode distinguir os de origem fecal e origem não-fecal. Quanto aos perigos químicos, estes estão relacionados principalmente com a exposição a substâncias químicas tóxicas presentes na água