469 research outputs found
Multi-Signal Reconstruction Using Masked Autoencoder From EEG During Polysomnography
Polysomnography (PSG) is an indispensable diagnostic tool in sleep medicine,
essential for identifying various sleep disorders. By capturing physiological
signals, including EEG, EOG, EMG, and cardiorespiratory metrics, PSG presents a
patient's sleep architecture. However, its dependency on complex equipment and
expertise confines its use to specialized clinical settings. Addressing these
limitations, our study aims to perform PSG by developing a system that requires
only a single EEG measurement. We propose a novel system capable of
reconstructing multi-signal PSG from a single-channel EEG based on a masked
autoencoder. The masked autoencoder was trained and evaluated using the
Sleep-EDF-20 dataset, with mean squared error as the metric for assessing the
similarity between original and reconstructed signals. The model demonstrated
proficiency in reconstructing multi-signal data. Our results present promise
for the development of more accessible and long-term sleep monitoring systems.
This suggests the expansion of PSG's applicability, enabling its use beyond the
confines of clinics.Comment: Proc. 12th IEEE International Winter Conference on Brain-Computer
Interfac
Impact of Nap on Performance in Different Working Memory Tasks Using EEG
Electroencephalography (EEG) has been widely used to study the relationship
between naps and working memory, yet the effects of naps on distinct working
memory tasks remain unclear. Here, participants performed word-pair and
visuospatial working memory tasks pre- and post-nap sessions. We found marked
differences in accuracy and reaction time between tasks performed pre- and
post-nap. In order to identify the impact of naps on performance in each
working memory task, we employed clustering to classify participants as high-
or low-performers. Analysis of sleep architecture revealed significant
variations in sleep onset latency and rapid eye movement (REM) proportion. In
addition, the two groups exhibited prominent differences, especially in the
delta power of the Non-REM 3 stage linked to memory. Our results emphasize the
interplay between nap-related neural activity and working memory, underlining
specific EEG markers associated with cognitive performance.Comment: Submitted to 2024 12th IEEE International Winter Conference on
Brain-Computer Interfac
Relationship Between Mood, Sleepiness, and EEG Functional Connectivity by 40 Hz Monaural Beats
The monaural beat is known that it can modulate brain and personal states.
However, which changes in brain waves are related to changes in state is still
unclear. Therefore, we aimed to investigate the effects of monaural beats and
find the relationship between them. Ten participants took part in five separate
random sessions, which included a baseline session and four sessions with
monaural beats stimulation: one audible session and three inaudible sessions.
Electroencephalogram (EEG) were recorded and participants completed pre- and
post-stimulation questionnaires assessing mood and sleepiness. As a result,
audible session led to increased arousal and positive mood compared to other
conditions. From the neurophysiological analysis, statistical differences in
frontal-central, central-central, and central-parietal connectivity were
observed only in the audible session. Furthermore, a significant correlation
was identified between sleepiness and EEG power in the temporal and occipital
regions. These results suggested a more detailed correlation for stimulation to
change its personal state. These findings have implications for applications in
areas such as cognitive enhancement, mood regulation, and sleep management
Neurophysiological Response Based on Auditory Sense for Brain Modulation Using Monaural Beat
Brain modulation is a modification process of brain activity through external
stimulations. However, which condition can induce the activation is still
unclear. Therefore, we aimed to identify brain activation conditions using 40
Hz monaural beat (MB). Under this stimulation, auditory sense status which is
determined by frequency and power range is the condition to consider. Hence, we
designed five sessions to compare; no stimulation, audible (AB), inaudible in
frequency, inaudible in power, and inaudible in frequency and power. Ten
healthy participants underwent each stimulation session for ten minutes with
electroencephalogram (EEG) recording. For analysis, we calculated the power
spectral density (PSD) of EEG for each session and compared them in frequency,
time, and five brain regions. As a result, we observed the prominent power peak
at 40 Hz in only AB. The induced EEG amplitude increase started at one minute
and increased until the end of the session. These results of AB had significant
differences in frontal, central, temporal, parietal, and occipital regions
compared to other stimulations. From the statistical analysis, the PSD of the
right temporal region was significantly higher than the left. We figure out the
role that the auditory sense is important to lead brain activation. These
findings help to understand the neurophysiological principle and effects of
auditory stimulation.Comment: Accepted to EMBC 202
Efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia: study protocol for a randomized controlled trial (SALSA trial)
Abstract Background Hyponatremia is the most common electrolyte imbalance encountered in clinical practice, associated with increased mortality and length of hospital stay. However, no high-quality evidence regarding whether hypertonic saline is best administered as a continuous infusion or a bolus injection has been found to date. Therefore, in the current study, we will evaluate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe symptomatic hyponatremia. Methods/design This is a prospective, investigator-initiated, multicenter, open-label, randomized controlled study with two experimental therapy groups. A total of 178 patients with severe symptomatic hyponatremia will be enrolled and randomly assigned to receive either rapid intermittent bolus or slow continuous infusion management with hypertonic saline. The primary outcome is the incidence of overcorrection at any given period over 2 days. The secondary outcomes will include the efficacy and safety of two other approaches to the treatment of hyponatremia with 3% hypertonic saline. Discussion This is the first clinical trial to investigate the efficacy and safety of rapid intermittent correction compared with slow continuous correction with hypertonic saline in patients with moderately severe or severe hyponatremia. Trial registration ClinicalTrials.gov, identifier number: NCT02887469 . Registered on 1 August 2016
IL-10 Mediates Rosiglitazone-Induced Kidney Protection in Cisplatin Nephrotoxicity
Cisplatin, a major anti-neoplastic drug, is known to be nephrotoxic and inflammation-inducing. A peroxisome proliferator-activated receptor gamma agonist, regulating lipid metabolism, has known to have anti-inflammatory effect, but the protection mechanisms in various kidney injuries are not fully understood. The purpose of this study was to examine the reno-protective effect of rosiglitazone on cisplatin nephrotoxicity in mice focusing on inflammation and apoptosis. Male BALB/c mice were pretreated with rosiglitazone (10 mg/kg) or vehicle through daily intraperitoneal injection for 3 days and then were given a single injection of cisplatin (20 mg/kg). Cisplatin induced a significant rise in blood urea nitrogen and creatinine levels, and tubular cell damage with marked tissue inflammation. Tissue cytokines and chemokines measured by a cytometric bead array showed increased TNF-α, IL-6, MCP-1, and IFN-γ levels, while IL-10, an anti-inflammatory cytokine, was significantly decreased by cisplatin treatment. However, rosiglitazone pretreatment substantially reversed the depressed IL-10 level with simultaneous suppression of proinflammatory cytokines and chemokines. This tissue cytokine and chemokine milieu was associated with marked attenuation of kidney injury elicited by cisplatin. These findings suggest that the rosiglitazone-mediated renoprotective effect in cisplatin nephrotoxicity of mice is partially mediated by upregulation of anti-inflammatory IL-10 production
Hemophagocytic Syndrome in a Patient with Acute Tubulointerstitial Nephritis Secondary to Hepatitis A Virus Infection
Hepatitis A virus (HAV) infection is generally a self-limited disease, but the infection in adults can be serious, to be often complicated by acute kidney injury (AKI) and rarely by virus-associated hemophagocytic syndrome (VAHS). Our patient, a 48-yr-old man, was diagnosed with HAV infection complicated by dialysis-dependent AKI. His kidney biopsy showed acute tubulointerstitial nephritis with massive infiltration of activated macrophages and T cells, and he progressively demonstrated features of VAHS. With hemodialysis and steroid treatment, he was successfully recovered
Beneficial Effects of a Curcumin Derivative and Transforming Growth Factor-β Receptor I Inhibitor Combination on Nonalcoholic Steatohepatitis
Background Curcumin 2005-8 (Cur5-8), a derivative of curcumin, improves fatty liver disease via AMP-activated protein kinase activation and autophagy regulation. EW-7197 (vactosertib) is a small molecule inhibitor of transforming growth factor β (TGF-β) receptor I and may scavenge reactive oxygen species and ameliorate fibrosis through the SMAD2/3 canonical pathway. This study aimed to determine whether co-administering these two drugs having different mechanisms is beneficial. Methods Hepatocellular fibrosis was induced in mouse hepatocytes (alpha mouse liver 12 [AML12]) and human hepatic stellate cells (LX-2) using TGF-β (2 ng/mL). The cells were then treated with Cur5-8 (1 μM), EW-7197 (0.5 μM), or both. In animal experiments were also conducted during which, methionine-choline deficient diet, Cur5-8 (100 mg/kg), and EW-7197 (20 mg/kg) were administered orally to 8-week-old C57BL/6J mice for 6 weeks. Results TGF-β-induced cell morphological changes were improved by EW-7197, and lipid accumulation was restored on the administration of EW-7197 in combination with Cur5-8. In a nonalcoholic steatohepatitis (NASH)-induced mouse model, 6 weeks of EW-7197 and Cur5-8 co-administration alleviated liver fibrosis and improved the nonalcoholic fatty liver disease (NAFLD) activity score. Conclusion Co-administering Cur5-8 and EW-7197 to NASH-induced mice and fibrotic hepatocytes reduced liver fibrosis and steatohepatitis while maintaining the advantages of both drugs. This is the first study to show the effect of the drug combination against NASH and NAFLD. Similar effects in other animal models will confirm its potential as a new therapeutic agent
The effect of milrinone on the intraoperative hemodynamics during off-pump coronary bypass surgery in patients with an elevated echocardiographic index of the ventricular filling pressure
Apolipoprotein E gene polymorphism is not a strong risk factor for diabetic nephropathy and retinopathy in Type I diabetes: case-control study
BACKGROUND: The gene encoding apolipoprotein E (APOE) has been proposed as a candidate gene for vascular complications in Type I diabetes. This study aimed to investigate the influence of three-allelic variations in the APOE gene for the development of diabetic retinopathy and nephropathy. RESULTS: Neither APOE alleles frequencies or APOE genotypes frequencies differed between Type I diabetic groups either with or without nephropathy. Similar results were found for patients with and without diabetic retinopathy. CONCLUSIONS: APOE gene polymorphism does not determine genetic susceptibility for the development of diabetic retinopathy in Type I diabetes patients. Association between APOE gene polymorphism and diabetic nephropathy may be weak or moderate, but not strong
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