Biodegradable Polydepsipeptides

This paper reviews the synthesis, characterization, biodegradation and usage of bioresorbable polymers based on polydepsipeptides. The ring-opening polymerization of morpholine-2,5-dione derivatives using organic Sn and enzyme lipase is discussed. The dependence of the macroscopic properties of the block copolymers on their structure is also presented. Bioresorbable polymers based on polydepsipeptides could be used as biomaterials in drug controlled release, tissue engineering scaffolding and shape-memory materials

Antibody‐independent targeted quantification of TMPRSS2‐ERG fusion protein products in prostate cancer

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135707/1/mol22014871169-sup-mmc1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/135707/2/mol22014871169.pd

Novel Co3O4 Nanoparticles/Nitrogen-Doped Carbon Composites with Extraordinary Catalytic Activity for Oxygen Evolution Reaction (OER)

Abstract Herein, Co3O4 nanoparticles/nitrogen-doped carbon (Co3O4/NPC) composites with different structures were prepared via a facile method. Structure control was achieved by the rational morphology design of ZIF-67 precursors, which were then pyrolyzed in air to obtain Co3O4/NPC composites. When applied as catalysts for the oxygen evolution reaction (OER), the M-Co3O4/NPC composites derived from the flower-like ZIF-67 showed superior catalytic activities than those derived from the rhombic dodecahedron and hollow spherical ZIF-67. The former M-Co3O4/NPC composite displayed a small over-potential of 0.3 V, low onset potential of 1.41 V, small Tafel slope of 83 mV dec−1, and a desirable stability. (94.7% OER activity was retained after 10 h.) The excellent performance of the flower-like M-Co3O4/NPC composite in the OER was attributed to its favorable structure

Sex-specific associations of cardiovascular risk factors and coronary plaque composition for hemodynamically significant coronary artery stenosis: a coronary computed tomography angiography study

Abstract Background It has been reported that there are sex differences in plaque composition and hemodynamically significant stenosis. This study aimed to explore the impact of sex on cardiovascular risk factors for specific plaque compositions and hemodynamically significant stenosis. Methods Data regarding demographics and cardiovascular risk factors were collected. Hemodynamically significant stenosis was identified by a computed tomography-derived fractional flow reserve of ≤ 0.8. Associations among cardiovascular risk factors, plaque composition, and hemodynamically significant stenosis were assessed using a multivariate binary logistic regression analysis across sexes. The discriminating capacity of diverse plaque components for hemodynamically significant stenosis was assessed by area under the receiver-operating characteristics curve with 95% confidence intervals. Results A total of 1164 patients (489 men and 675 women) were included. For men, hyperlipidemia and cigarette smoking were risk factors for each plaque component (all P < 0.05), and diabetes mellitus also predicted fibrotic components (P < 0.05). For women, risk factors for each plaque component were hypertension and diabetes mellitus (all P < 0.01). Nonetheless, hyperlipidemia (P < 0.05) was a specific risk factor for non-calcified components. Calcified components combined with fibrotic components showed superior discrimination of hemodynamically significant stenosis in men and calcified components alone in women (all P < 0.01). Hypertension (P < 0.01) was a risk factor for hemodynamically significant stenosis in women. In contrast, diabetes, hyperlipidemia, and cigarette smoking were risk factors for hemodynamically significant stenosis in men (all P < 0.05). Conclusions In men, hemodynamically significant stenosis was predicted by a combination of calcified and fibrotic components with multiple risk factors. In women, hemodynamically significant stenosis was predicted by calcified components caused by a single risk factor. It might be a key point to improve prognosis by more precise risk management between men and women, which needs to be proved by further prospective trials

Kinetic Hydrate Inhibition of Natural Gels in Complex Sediment Environments

Natural gels are emerging as a hotspot of global research for their greenness, environmental-friendliness, and good hydrate inhibition performance. However, previous studies mostly performed experiments for simple pure water systems and the inhibition mechanism in the sediment environment remains unclear. Given this, the inhibition performance of xanthan gum and pectin on hydrate nucleation and growth in sediment environments was evaluated via hydrate formation inhibition tests, and the inhibition internal mechanisms were revealed via a comprehensive analysis integrating various methods. Furthermore, the influences of natural gels on sediment dispersion stability and low-temperature fluid rheology were investigated. Research showed that the sediments of gas hydrate reservoirs in the South China Sea are mainly composed of micro-nano quartz and clay minerals. Xanthan gum and pectin can effectively inhibit the hydrate formation via the joint effects of the binding, disturbing, and interlayer mass transfer suppression processes. Sediments promote hydrate nucleation and yet inhibit hydrate growth. The interaction of sediments with active groups of natural gels weakens the abilities of gels to inhibit hydrate nucleation and reduce hydrate formation. Nonetheless, sediments help gels to slow down hydrate formation. Our comprehensive analysis pointed out that pectin with a concentration of 0.5 wt% can effectively inhibit the hydrate nucleation and growth while improving the dispersion stability and low-temperature rheology of sediment-containing fluids

Analysis and Discussion of Baoji “Shigu • Tian Xi Tai”, “Shigu • Sun City” Ground Source Heat Pump Energy Station System

Baoji “Shigu • Tian Xi Tai”, “Shigu • Sun City” ground source heat pump energy station system is an important energy supply project in Shigu. In this paper, we systematically introduce the design of green building and ground-source heat pump system, points of construction process, pre-cooling station technology, EMC economic model in detail. In addition, the ground source heat pump system of the project was tested in the field to analyze and evaluate the running performance of the system. We hope our research can provide some reference and help to the practitioners

MOESM1 of Oligohistidine and targeting peptide functionalized TAT-NLS for enhancing cellular uptake and promoting angiogenesis in vivo

Additional file 1: Figure S1. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn micelles characterized by DLS. Figure S2. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn/pZNF580 complexes (w/w = 1) characterized by DLS. Figure S3. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn/pZNF580 complexes (w/w = 2) characterized by DLS. Figure S4. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn/pZNF580 complexes (w/w = 3) characterized by DLS. Figure S5. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn/pZNF580 complexes (w/w = 4) characterized by DLS. Figure S6. Hydrodynamic diameter distribution of REDV-TAT-NLS-Hn/pZNF580 complexes (w/w = 5) characterized by DLS