The research about interpersonal stress in workplaces of nurses：Effects of an organizational climate and a narcissistic personality

広島大学(Hiroshima University)博士(学術)Doctor of Philosophydoctora

Synchronized multiple regression of diagnostic radiation-induced rather than spontaneous: disseminated primary intracranial germinoma in a woman: a case report

<p>Abstract</p> <p>Introduction</p> <p>Examples of the spontaneous regression of primary intracranial germinomas can be found in the literature. We present the case of a patient with disseminated lesions of primary intracranial germinoma which synchronously shrunk following diagnostic irradiation. We will discuss whether this regression was spontaneous or radiation-induced.</p> <p>Case presentation</p> <p>A 43-year-old Japanese woman presented to our hospital complaining of memory problems over a period of one year and blurred vision over a period of three months. Following magnetic resonance imaging, she was found to have a massive lesion in the third ventricle and small lesions in the pineal region, fourth ventricle, and in the anterior horn of the left lateral ventricle. Prior to an open biopsy to confirm the pathology of the lesions, she underwent a single cranial computed tomography scan and a single cranial digital subtraction angiography for a transcranial biopsy. Fourteen days after the first magnetic resonance image - 12 and eight days after the computed tomography scan and digital subtraction angiography, respectively - a pre-operative magnetic resonance image was taken, which showed a notable synchronous shrinkage of the third ventricle tumor, as well as shrinkage of the lesions in the pineal region and in the fourth ventricle. She did not undergo steroid administration until after a biopsy that confirmed the pathological diagnosis of pure germinoma. She then underwent whole craniospinal irradiation and went into a complete remission.</p> <p>Conclusions</p> <p>In our case report, we state that diagnostic radiation can induce the regression of germinomas; this is the most reasonable explanation for the synchronous multiple regression observed in this case of germinoma. Clinicians should keep this non-spontaneous regression in mind and monitor germinoma lesions with minimal exposure to diagnostic radiation before diagnostic confirmation, and also before radiation treatment with or without chemotherapy begins.</p

Silicon Photonics Rectangular Universal Interferometer

[EN] Universal multiport photonic interferometers that can implement any arbitrary unitary transformation between input and output optical modes are essential to support advanced optical functions. Integrated versions of these components can be implemented by means of either a fixed triangular or a fixed rectangular arrangement of the same components. We propose the implementation of a fixed rectangular universal interferometer using a reconfigurable hexagonal waveguide mesh circuit. A suitable adaptation synthesis algorithm tailored to this mesh configuration is provided and the experimental demonstration of a rectangular multiport interferometer by means of a fabricated silicon photonics chip is reported. The 7¿hexagonal cell chip can implement 2 × 2, 3 × 3 and 4 × 4 arbitrary unitary transformations. The proposed hexagonal waveguide mesh operates in a similar way as a Field Programmable Gate Array (FPGA) in electronics. We believe that this work represents an important step¿forward towards fully programmable and integrable multiport interferometers.The authors acknowledge financial support by the ERC ADG-2016 741415 UMWP-Chip, the Generalitat Valenciana PROMETEO 2013/012 research excellency award, I. G. acknowledges the funding through the Spanish MINECO Ramon y Cajal program. D.P. acknowledges financial support from the UPV through the FPI predoctoral funding scheme. D.J.T. acknowledges funding from the Royal Society for his University Research Fellowship. The chips were fabricated in the frame of the CORNERSTONE project funded by the EPSRC in the UK (EP/L021129/1)Pérez-López, D.; Gasulla Mestre, I.; Fraile, FJ.; Crudgington, L.; Thomson, D.; Khokhar, AZ.; Li, K.... (2017). Silicon Photonics Rectangular Universal Interferometer. Laser & Photonics Review. 11(6):1-13. https://doi.org/10.1002/lpor.201700219113116Reck, M., Zeilinger, A., Bernstein, H. J., & Bertani, P. (1994). Experimental realization of any discrete unitary operator. Physical Review Letters, 73(1), 58-61. doi:10.1103/physrevlett.73.58Miller, D. A. B. (2013). Self-configuring universal linear optical component [Invited]. Photonics Research, 1(1), 1. doi:10.1364/prj.1.000001Carolan, J., Harrold, C., Sparrow, C., Martin-Lopez, E., Russell, N. J., Silverstone, J. W., … Laing, A. (2015). Universal linear optics. Science, 349(6249), 711-716. doi:10.1126/science.aab3642Silverstone, J. W., Bonneau, D., O’Brien, J. L., & Thompson, M. G. (2016). Silicon Quantum Photonics. IEEE Journal of Selected Topics in Quantum Electronics, 22(6), 390-402. doi:10.1109/jstqe.2016.2573218Metcalf, B. J., Thomas-Peter, N., Spring, J. B., Kundys, D., Broome, M. A., Humphreys, P. C., … Walmsley, I. A. (2013). Multiphoton quantum interference in a multiport integrated photonic device. Nature Communications, 4(1). doi:10.1038/ncomms2349Capmany, J., Gasulla, I., & Pérez, D. (2015). The programmable processor. Nature Photonics, 10(1), 6-8. doi:10.1038/nphoton.2015.254Miller, D. A. B. (2013). Self-aligning universal beam coupler. Optics Express, 21(5), 6360. doi:10.1364/oe.21.006360Chen, L., Hall, E., Theogarajan, L., & Bowers, J. (2011). Photonic Switching for Data Center Applications. IEEE Photonics Journal, 3(5), 834-844. doi:10.1109/jphot.2011.2166994Stabile, R., Albores-Mejia, A., Rohit, A., & Williams, K. A. (2016). Integrated optical switch matrices for packet data networks. Microsystems & Nanoengineering, 2(1). doi:10.1038/micronano.2015.42Miller, D. A. B. (2015). Perfect optics with imperfect components. Optica, 2(8), 747. doi:10.1364/optica.2.000747Clements, W. R., Humphreys, P. C., Metcalf, B. J., Kolthammer, W. S., & Walsmley, I. A. (2016). Optimal design for universal multiport interferometers. Optica, 3(12), 1460. doi:10.1364/optica.3.001460Grillanda, S., Carminati, M., Morichetti, F., Ciccarella, P., Annoni, A., Ferrari, G., … Melloni, A. (2014). Non-invasive monitoring and control in silicon photonics using CMOS integrated electronics. Optica, 1(3), 129. doi:10.1364/optica.1.000129Ribeiro, A., Ruocco, A., Vanacker, L., & Bogaerts, W. (2016). Demonstration of a 4 × 4-port universal linear circuit. Optica, 3(12), 1348. doi:10.1364/optica.3.001348Birth of the programmable optical chip. (2015). Nature Photonics, 10(1), 1-1. doi:10.1038/nphoton.2015.265Zhuang, L., Roeloffzen, C. G. H., Hoekman, M., Boller, K.-J., & Lowery, A. J. (2015). Programmable photonic signal processor chip for radiofrequency applications. Optica, 2(10), 854. doi:10.1364/optica.2.000854Pérez, D., Gasulla, I., Capmany, J., & Soref, R. A. (2016). Reconfigurable lattice mesh designs for programmable photonic processors. Optics Express, 24(11), 12093. doi:10.1364/oe.24.012093Miller, D. A. B. (2012). All linear optical devices are mode converters. Optics Express, 20(21), 23985. doi:10.1364/oe.20.023985Pérez, D., Gasulla, I., Crudgington, L., Thomson, D. J., Khokhar, A. Z., Li, K., … Capmany, J. (2017). Multipurpose silicon photonics signal processor core. Nature Communications, 8(1). doi:10.1038/s41467-017-00714-1Peruzzo, A., Laing, A., Politi, A., Rudolph, T., & O’Brien, J. L. (2011). Multimode quantum interference of photons in multiport integrated devices. Nature Communications, 2(1). doi:10.1038/ncomms1228Spagnolo, N., Vitelli, C., Bentivegna, M., Brod, D. J., Crespi, A., Flamini, F., … Sciarrino, F. (2014). Experimental validation of photonic boson sampling. Nature Photonics, 8(8), 615-620. doi:10.1038/nphoton.2014.135Bonneau, D., Engin, E., Ohira, K., Suzuki, N., Yoshida, H., Iizuka, N., … Thompson, M. G. (2012). Quantum interference and manipulation of entanglement in silicon wire waveguide quantum circuits. New Journal of Physics, 14(4), 045003. doi:10.1088/1367-2630/14/4/045003Madsen, C. K., & Zhao, J. H. (1999). Optical Filter Design and Analysis. Wiley Series in Microwave and Optical Engineering. doi:10.1002/0471213756Jinguji, K., & Kawachi, M. (1995). Synthesis of coherent two-port lattice-form optical delay-line circuit. Journal of Lightwave Technology, 13(1), 73-82. doi:10.1109/50.350643Jinguji, K. (1996). Synthesis of coherent two-port optical delay-line circuit with ring waveguides. Journal of Lightwave Technology, 14(8), 1882-1898. doi:10.1109/50.532026Madsen, C. K. (2000). General IIR optical filter design for WDM applications using all-pass filters. Journal of Lightwave Technology, 18(6), 860-868. doi:10.1109/50.848399Yariv, A., Xu, Y., Lee, R. K., & Scherer, A. (1999). Coupled-resonator optical waveguide:?a proposal and analysis. Optics Letters, 24(11), 711. doi:10.1364/ol.24.000711Heebner, J. E., Chak, P., Pereira, S., Sipe, J. E., & Boyd, R. W. (2004). Distributed and localized feedback in microresonator sequences for linear and nonlinear optics. Journal of the Optical Society of America B, 21(10), 1818. doi:10.1364/josab.21.001818Yvind, K., & Hvam, J. M. (2010). High-efficiency, large-bandwidth silicon-on-insulator grating coupler based on a fully-etched photonic crystal structure. Applied Physics Letters, 96(5), 051126. doi:10.1063/1.330479

A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma : a study protocol

Objective Pheochromocytoma and paraganglioma (PPGLs) are rare neuroendocrine tumors derived from the adrenal medulla or extra-adrenal paraganglioma from extra-adrenal chromaffin tissue. Although malignant PPGLs has miserable prognosis, the treatment strategy remains to be established. An internal radiation therapy using [131I]meta-iodobenzylguanidine (131I-mIBG) called MIBG therapy has been attempted as one of the systemic treatment of malignant PPGLs. The aim of this study is therefore to evaluate the safety and the efficacy of MIBG therapy for refractory PPGLs. Methods Patients with refractory PPGLs will be enrolled in this study. The total number of patients for registration is 20. The patients receive a fixed dose of 7,400 MBq of 131I-mIBG. Adverse events are surveyed during 20 weeks after 131I-mIBG injection and all severe adverse events will be documented and reported in detail in accordance with the Common Terminology Criteria for Adverse Events (CTCAE). Examination and imaging diagnosis are performed in 12 weeks after 131I-mIBG injection for the evaluation of therapeutic effect in accordance with the Response Evaluation in Solid Tumours (RECIST). Conclusion The current study is the first multi-institutional prospective study of MIBG therapy and thereby will play a significant role in improving the patients’ prognosis of refractory PPGLs

Correlation between High Resolution Dynamic MR Features and Prognostic Factors in Breast Cancer

OBJECTIVE: To correlate high resolution dynamic MR features with prognostic factors in breast cancer. MATERIALS AND METHODS: One hundred and ninety-four women with invasive ductal carcinomas underwent dynamic MR imaging using T1-weighted three-dimensional fast low-angle shot (3D-FLASH) sequence within two weeks prior to surgery. Morphological and kinetic MR features were determined based on the breast imaging and reporting data system (BI-RADS) MR imaging lexicon. Histological specimens were analyzed for tumor size, axillary lymph node status, histological grade, expression of estrogen receptor (ER), expression of progesterone receptor (PR), and expression of p53, c-erbB-2, and Ki-67. Correlations between the MR features and prognostic factors were determined using the Pearson chi(2) test, linear-by-linear association, and logistic regression analysis. RESULTS: By multivariate analysis, a spiculated margin was a significant, independent predictor of a lower histological grade (p < 0.001), and lower expression of Ki-67 (p = 0.007). Rim enhancement was significant, independent predictor of a higher histological grade (p < 0.001), negative expression of ER (p = 0.001), negative expression of PR (p < 0.001) and a larger tumor size (p = 0.006). A washout curve may predict a higher level of Ki-67 (p = 0.05). Most of the parameters of the initial enhancement phase cannot predict the status of the prognostic factors. Only the enhancement ratio may predict a larger tumor size (p = 0.05). CONCLUSION: Of the BI-RADS-MR features, a spiculated margin may predict favorable prognosis, whereas rim enhancement or washout may predict unfavorable prognosis of breast cancer

Multipurpose silicon photonics signal processor core

[EN] Integrated photonics changes the scaling laws of information and communication systems offering architectural choices that combine photonics with electronics to optimize performance, power, footprint, and cost. Application-specific photonic integrated circuits, where particular circuits/chips are designed to optimally perform particular functionalities, require a considerable number of design and fabrication iterations leading to long development times. A different approach inspired by electronic Field Programmable Gate Arrays is the programmable photonic processor, where a common hardware implemented by a two-dimensional photonic waveguide mesh realizes different functionalities through programming. Here, we report the demonstration of such reconfigurable waveguide mesh in silicon. We demonstrate over 20 different functionalities with a simple seven hexagonal cell structure, which can be applied to different fields including communications, chemical and biomedical sensing, signal processing, multiprocessor networks, and quantum information systems. Our work is an important step toward this paradigm.J.C. acknowledges funding from the ERC Advanced Grant ERC-ADG-2016-741415 UMWP-Chip, I.G. acknowledges the funding through the Spanish MINECO Ramon y Cajal program. D.P. acknowledges financial support from the UPV through the FPI predoctoral funding scheme. D.J.T. acknowledges funding from the Royal Society for his University Research Fellowship.Pérez-López, D.; Gasulla Mestre, I.; Crudgington, L.; Thomson, DJ.; Khokhar, AZ.; Li, K.; Cao, W.... (2017). Multipurpose silicon photonics signal processor core. Nature Communications. 8(1925):1-9. https://doi.org/10.1038/s41467-017-00714-1S1981925Doerr, C. R. & Okamoto, K. Advances in silica planar lightwave circuits. J. 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Reflective arrayed waveguide gratings based on Sagnac loop reflectors with custom spectral response

© 2014 Optical Society of America. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modifications of the content of this paper are prohibitedIn this paper, a model for the analysis and design of a reflective Arrayed Waveguide Grating is presented. The device consists of one half of a regular AWG where each arm waveguide in the array is terminated with a phase shifter and a Sagnac loop reflector. By individually adjusting the phase shifter and Sagnac reflectivity in each arm, additional functionality to that previously reported in the literature is attained, since this enables tailoring the spectral response of the AWG. The design and experimental demonstration of Gaussian pass-band shape devices in Silicon-on-Insulator technology are reported. Methods to obtain flattened and arbitrary spectral responses are described and supported by simulation results. (C) 2014 Optical Society of AmericaThe authors acknowledge financial support by the Spanish MINECO projects TEC2010-21337, TEC2013-42332-P; FEDER UPVOV 10-3E-492 and UPVOV 08-3E-008. B. Gargallo acknowledges financial support through FPI grant BES-2011-046100. The authors thank J.S. Fandino for helpful discussions.Gargallo Jaquotot, BA.; Muñoz Muñoz, P.; Baños López, R.; Giesecke, AL.; Bolten, J.; Wahlbrink, T.; Kleinjans, H. (2014). Reflective arrayed waveguide gratings based on Sagnac loop reflectors with custom spectral response. Optics Express. 22(12):14348-14362. https://doi.org/10.1364/OE.22.014348S14348143622212Brackett, C. A. (1990). Dense wavelength division multiplexing networks: principles and applications. IEEE Journal on Selected Areas in Communications, 8(6), 948-964. doi:10.1109/49.57798Kirchain, R., & Kimerling, L. (2007). A roadmap for nanophotonics. 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