Convective Mixing: The Formation Channel of Li-rich Giants

Increasing observed data indicate that part of giants has abnormally high lithium (Li) inside their surface, and their proportion is around 1%. Instead of pursuing the feasible mechanisms for extra Li enrichment, we focus on how to inhibit Li depletion from the main sequence (MS) phase of giants. With this in mind, we find that convective mixing is capable of achieving this goal and forming Li-rich giants, which is mainly attributed to the convection model with the convective boundary defined by the Ledoux criterion. Another factor in the formation of Li-rich giants in our convection models is related to the Li abundances of their progenitors. If the Li abundances of the progenitors exceed the meteoritic value (3.3 dex), then the majority of giants will be rich in Li. This is the general pattern of stellar Li abundance evolution without factoring in extra Li depletion. We propose that other Li depletion processes should also be adopted in the future, as they may be the key to the 1% puzzle.Comment: Main text: 12 pages, 10 figures; Appendix: 5 pages, 5 figures; Accepted for publication in MNRA

Research on Automatic Identification of Rumors in Stock Forum Based on Machine Learning

When rumors prevail in securities market, it is very difficult for investors to identify valid information. In the meantime, investors have much more ways to access information with the evolution of internet. But there is an overwhelming quantity of information on the Internet, the coexistence of facts and rumors, namely, “widely circulated” and “specious”, yet “unconfirmed officially” vague information, makes it more difficult for investors who with limited rationality to distinguish facts from rumors. Existing studies are mainly devoted in the method of event study, namely screening rumors from “official channels” that clarified, which is neither timely efficient in terms of accessing to rumors nor providing the basis for decision-making. Traditional news has evolved into various forms of social media, including forums, blogs, micro-blogs etc., and users can not only gain quick access to more valuable and timely information, but also amplify information that embed the news effectively by participating in commenting on various social media. Dynamic information creation, sharing and coordination among Web users are exerting increasingly prominent impact on the securities market in now days. Thus, it is very necessary to study the effects of social media as online forums on the securities market. In this paper, the method of machine learning is adopted for the first time to identifying the Internet rumors automatically, and successfully in crawling massive forum data by smart computer technology. Unlike the case study and statistical sampling of rumors, this paper conduct automatic identification of Internet rumors by utilize the smart technology, thus paving the way for more in-depth analysis about the effects of Internet media on the securities market in future

Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies

Background: To assess synthetically the association between polymorphisms in the vitamin D receptor (VDR) gene (FokI, BsmI, ApaI, and TaqI) and diabetic retinopathy (DR).Methods: Pubmed, Embase, ISI Web of Science, Google-scholar and CBMDisc, CNKI and Chongqing VIP databases were searched. A meta-analysis was performed.Results: Six studies with 636 cases and 1,035 controls were included in this meta-analysis. The outcomes showed that the FokI polymorphism (F allele) of VDR gene had no statistical protective relationship with DR in overall studies. Interestingly, stratification analysis showed that the FokI polymorphism (Fallele) was significantly associated with decreased DR risk in the Chinese population, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. However, the TaqI, BsmI and ApaI polymorphisms of VDR gene had no significant association with the risk of DR.Conclusion: This meta-analysis of case-control studies revealed that the VDR-FokI polymorphism (F allele) decreased the risk of DR in Chinese people, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. Further rigorous and prospective studies with large sample size are needed to confirm our findings.Keywords: Diabetic retinopathy; polymorphism; Vitamin D receptor

Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.

The fusion of inner mitochondrial membranes requires dynamin-like GTPases, Mgm1 in yeast and OPA1 in mammals, but how they mediate membrane fusion is poorly understood. Here, we determined the crystal structure of Saccharomyces cerevisiae short Mgm1 (s-Mgm1) in complex with GDP. It revealed an N-terminal GTPase (G) domain followed by two helix bundles (HB1 and HB2) and a unique C-terminal lipid-interacting stalk (LIS). Dimers can form through antiparallel HB interactions. Head-to-tail trimers are built by intermolecular interactions between the G domain and HB2-LIS. Biochemical and in vivo analyses support the idea that the assembly interfaces observed here are native and critical for Mgm1 function. We also found that s-Mgm1 interacts with negatively charged lipids via both the G domain and LIS. Based on these observations, we propose that membrane targeting via the G domain and LIS facilitates the in cis assembly of Mgm1, potentially generating a highly curved membrane tip to allow inner membrane fusion

Insight into the Interaction of Metal Ions with TroA from Streptococcus suis

The scavenging ability of sufficient divalent metal ions is pivotal for pathogenic bacteria to survive in the host. ATP-binding cassette (ABC)-type metal transporters provide a considerable amount of different transition metals for bacterial growth. TroA is a substrate binding protein for uptake of multiple metal ions. However, the function and structure of the TroA homologue from the epidemic Streptococcus suis isolates (SsTroA) have not been characterized.Here we determined the crystal structure of SsTroA from a highly pathogenic streptococcal toxic shock syndrome (STSS)-causing Streptococcus suis in complex with zinc. Inductively coupled plasma mass spectrometry (ICP-MS) analysis revealed that apo-SsTroA binds Zn(2+) and Mn(2+). Both metals bind to SsTroA with nanomolar affinity and stabilize the protein against thermal unfolding. Zn(2+) and Mn(2+) induce distinct conformational changes in SsTroA compared with the apo form as confirmed by both circular dichroism (CD) and nuclear magnetic resonance (NMR) spectra. NMR data also revealed that Zn(2+)/Mn(2+) bind to SsTroA in either the same site or an adjacent region. Finally, we found that the folding of the metal-bound protein is more compact than the corresponding apoprotein.Our findings reveal a mechanism for uptake of metal ions in S. suis and this mechanism provides a reasonable explanation as to how SsTroA operates in metal transport

Ring-Like Solitons in Plasmonic Fiber Waveguide Composed of Metal-Dielectric Multilayers

We design a plasmonic fiber waveguide (PFW) composed of coaxial cylindrical metal-dielectric multilayers in nanoscale, and constitute the corresponding dynamical equations describing the modes of propagation in the PFW with the Kerr nonlinearity in the dielectric layers. The physics is connected to the discrete matrix nonlinear Schr\"{o}dinger equations, from which the highly confined ring-like solitons in scale of subwavelength are found both for the visible light and the near-infrared light in the self-defocusing condition. Moreover, the confinement could be further improved when increasing the intensity of the input light due to the cylindrical symmetry of the PFW, which means both the width and the radius of the ring are reduced.Comment: 4 figures, submitte

Comparative numerical study on focusing wave interaction with FPSO-like structure

Evaluating the interactions between offshore structures and extreme waves plays an essential role for securing the survivability of the structures. For this purpose, various numerical tools—for example, the fully nonlinear potential theory (FNPT), the Navier–Stokes (NS) models, and hybrid approaches combining different numerical models—have been developed and employed. However, there is still great uncertainty over the required level of model fidelity when being applied to a wide range of wave-structure interaction problems. This paper aims to shed some light on this issue with a specific focus on the overall error sourced from wave generation/absorbing techniques and resolving the viscous and turbulent effects, by comparing the performances of three different models, including the quasi-arbitrary Lagrangian Eulerian finite element method (QALE-FEM) based on the FNPT, an in-house two-phase NS model with large-eddy simulation and a hybrid model coupling the QALE-FEM with the OpenFOAM/InterDymFoam, in the cases with a fixed FPSO-like structure under extreme focusing waves. The relative errors of numerical models are defined against the experimental data, which are released after the numerical works have been completed (i.e., a blind test), in terms of the pressure and wave elevations. This paper provides a practical reference for not only choosing an appropriate model in practices but also on developing/optimizing numerical tools for more reliable and robust predications

Prostaglandin E(2 )receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein

BACKGROUND: The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute significantly to neurodegeneration in PD. It has been demonstrated that aggregated α-synuclein potently activates microglia and causes neurotoxicity. However, the mechanisms by which aggregated α-synuclein activates microglia are not understood fully. METHODS: We investigated the role of prostaglandin E(2 )receptor subtype 2 (EP2) in α-synuclein aggregation-induced microglial activation using ex vivo, in vivo and in vitro experimental systems. RESULTS: Results demonstrated that ablation of EP2(EP2(-/-)) significantly enhanced microglia-mediated ex vivo clearance of α-synuclein aggregates (from mesocortex of Lewy body disease patients) while significantly attenuating neurotoxicity and extent of α-synuclein aggregation in mice treated with a parkinsonian toxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Furthermore, we report that reduced neurotoxicity by EP2(-/- )microglia could be attributed to suppressed translocation of a critical cytoplasmic subunit (p47-phox) of NADPH oxidase (PHOX) to the membranous compartment after exposure to aggregated α-synuclein. CONCLUSION: Thus, it appears that microglial EP2 plays a critical role in α-synuclein-mediated neurotoxicity

Association of FokI, TaqI, BsmI and ApaI polymorphisms with diabetic retinopathy: a pooled analysis of case-control studies

Background: To assess synthetically the association between polymorphisms in the vitamin D receptor (VDR) gene (FokI, BsmI, ApaI, and TaqI) and diabetic retinopathy (DR). Methods: Pubmed, Embase, ISI Web of Science, Google-scholar and CBMDisc, CNKI and Chongqing VIP databases were searched. A meta-analysis was performed. Results: Six studies with 636 cases and 1,035 controls were included in this meta-analysis. The outcomes showed that the FokI polymorphism (F allele) of VDR gene had no statistical protective relationship with DR in overall studies. Interestingly, stratification analysis showed that the FokI polymorphism (Fallele) was significantly associated with decreased DR risk in the Chinese population, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. However, the TaqI, BsmI and ApaI polymorphisms of VDR gene had no significant association with the risk of DR. Conclusion: This meta-analysis of case-control studies revealed that the VDR-FokI polymorphism (F allele) decreased the risk of DR in Chinese people, among included studies without publication bias, during a comparison analysis between normal subjects and DR patients, and among articles published after 2010. Further rigorous and prospective studies with large sample size are needed to confirm our findings