PSR J1926-0652: A Pulsar with Interesting Emission Properties Discovered at FAST

We describe PSR J1926-0652, a pulsar recently discovered with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). Using sensitive single-pulse detections from FAST and long-term timing observations from the Parkes 64-m radio telescope, we probed phenomena on both long and short time scales. The FAST observations covered a wide frequency range from 270 to 800 MHz, enabling individual pulses to be studied in detail. The pulsar exhibits at least four profile components, short-term nulling lasting from 4 to 450 pulses, complex subpulse drifting behaviours and intermittency on scales of tens of minutes. While the average band spacing P3 is relatively constant across different bursts and components, significant variations in the separation of adjacent bands are seen, especially near the beginning and end of a burst. Band shapes and slopes are quite variable, especially for the trailing components and for the shorter bursts. We show that for each burst the last detectable pulse prior to emission ceasing has different properties compared to other pulses. These complexities pose challenges for the classic carousel-type models.Comment: 13pages with 12 figure

Spatio-temporal analysis of urban air pollutants throughout China during 2014–2019

Air pollution control has become the top priority of China's "green development" concept since 2013. The Chinese government has enacted a range of policies and statutes to control contaminant emissions and improve air quality. On the basis of the national air quality ground observation database, the spatial and temporal distribution of air quality index value (AQI), fine particulate matter (PM2.5), coarse particles (PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), carbon monoxide (CO), and ozone (O3) were explored in 336 cities throughout China from 2014 to 2019. AQI and most pollutants (except O3) decreased in concentrations from 2014 to 2019. In 2019, all cities except Henan reached the level 2 of the ambient air quality index, and six cities had a lower ambient air quality index and reached the level 1. Spatially, higher pollutant concentrations were concentrated in large city clusters, whereas the areas with high O3 concentration were found across the country. Furthermore, central heating was shown to have a negative impact on air quality. The observed AQI value, PM2.5, PM10, SO2, NO2, and CO concentrations were highest in north and northwest China and Henan province in central China. The correlations among pollutants suggest that the main sources of pollutants are fossil fuel combustion, industrial production, and motor vehicle emissions. The influence of meteorological factors on air quality, long-distance transportation, and the transformations of pollutants should be explored in future research.Supplementary informationThe online version contains supplementary material available at 10.1007/s11869-021-01043-5

Protein Profiling of Bladder Urothelial Cell Carcinoma

<div><p>This study aimed to detect protein changes that can assist to understand the underlying biology of bladder cancer. The data showed forty five proteins were found to be differentially expressed comparing tumors vs non-tumor tissues, of which EGFR and cdc2p34 were correlated with muscle invasion and histological grade. Ten proteins (ß-catenin, HSP70, autotaxin, Notch4, PSTPIP1, DPYD, ODC, cyclinB1, calretinin and EPO) were able to classify muscle invasive BCa (MIBC) into 2 distinct groups, with group 2 associated with poorer survival. Finally, 3 proteins (P2X7, cdc25B and TFIIH p89) were independent factors for favorable overall survival.</p></div

The volcano plot depicts the fold and p-value differences in expression levels of 136 proteins between the tumor and non-tumor tissues.

<p>The horizontal blue line indicates p = 0.05 with points above the line having p < 0.05.</p

The Kaplan–Meier and log-rank survival analysis showed that the group with low level expression of P2X7 and high level expression cdc25B and TFIIH p89 was associated with a poorer prognosis (p = 0.032, p = 0.019, and p = 0.005, respectively) and risk score could stratify patients more accurately (p = 0.001).

<p>The Kaplan–Meier and log-rank survival analysis showed that the group with low level expression of P2X7 and high level expression cdc25B and TFIIH p89 was associated with a poorer prognosis (p = 0.032, p = 0.019, and p = 0.005, respectively) and risk score could stratify patients more accurately (p = 0.001).</p

Differentially expressed proteins in different T stages.

<p>a) The hexagonal array displays the changing patterns of the proteins expression from Ta to T4. Each hexagon represents a protein, the color of a hexagon reflects its level of expression in current T stage with respect to corresponding non-tumor tissue. b) The significantly expressed proteins between tumor and non-tumor tissues in different T stages were listed in their own circle which represents a specific stage. The proteins listed in the overlap area were shared by 2 adjacent stages. Proteins in red are upregulated and proteins in green are downregulated.</p

Hierarchical clustering analysis of 11 differentially expressed proteins in 31 tumors (T) and 43 non-tumor (N) samples.

<p>The color scale showed the level of expression. Red indicates overexpression, green indicates underexpression, black indicates no change, and gray no expression. The number in each column represents the sample number. Each row represents a protein.</p

Results of uni-variate Cox Proportional HR analyses.

<p>Results of uni-variate Cox Proportional HR analyses.</p

Correlations of protein expression with clinicopathological characteristics.

<p>Correlations of protein expression with clinicopathological characteristics.</p