Diseño y caracterización de sistemas farmacéuticos elaborados por impresión en 3D (II)

El concepto de fractales, uno de los grandes desarrollos en la comunidad científica durante el siglo pasado, ha sido destinado a explicar la presencia de objetos o fenómenos que, debido a su irregularidad, no habían podido ser estudiados previamente. A nivel farmacéutico, gracias al avance de la informática y la tecnología de impresión en 3D, se han podido diseñar nuevos sistemas farmacéuticos cuya estructura interna posee cierta complejidad. Además, han demostrado tener importantes ventajas frente a las formas farmacéuticas previamente existentes. Concretamente, han propiciado la obtención de medicamentos que se adapten a las características de los pacientes dando lugar a una mayor adherencia al tratamiento. Por tanto, el propósito del presente trabajo ha sido elaborar comprimidos mediante una impresora 3D (imprimidos) para caracterizar la estructura interna de los mismos. Por ello, se partió de gránulos del polímero Tecoflex TM EG-72D para formar filamentos destinados a conformar la estructura base o scaffold de los imprimidos. Paralelamente, se utilizó Hidroxipropilmetilcelulosa (HPMC) como excipiente y teofilina como principio activo modelo para preparar gel hidroalcohólico al 1% de HPMC. Seguidamente, se inició la impresión de lotes de imprimidos 3D con diferentes volúmenes de gel. Por último, la porosidad de los imprimidos fue medida, empleando para ello un porosímetro de mercurio. Los datos obtenidos se sometieron a un tratamiento matemático con el objetivo de determinar la dimensión fractal en volumen de cada uno de ellos además de evaluar el efecto del gel sobre la porosidad. Como resultado, se concluyó que la dimensión fractal no era dependiente del volumen de gel adicionado pues adquiría valores similares en cada imprimido. Además, se vio que la porosidad teórica inicial y final presentaban valores diferentes lo cual no era debido a la presencia de volúmenes variables de gel, si no al método de cálculo de ambos parámetros.Universidad de Sevilla. Grado en Farmaci

Gender-based differences in the high-risk sexual behaviours of young people aged 15-29 in Melilla (Spain): a cross-sectional study

Background: Research confirms the existence of gender-based differences regarding the high-risk sexual behaviour (non-use of condoms and casual partners) of young men and women. The objectives were to provide evidence for this association; to analyse the reasons why both sexes have sexual relations with casual partners and to ascertain the motives for condom use or non-use during casual sex. Methods: A cross-sectional study was performed on a sample of 900 participants, 524 males and 376 females. All participants were 15-29 (20.93 ± 4.071) years of age and came from four different centres (a university, two secondary schools, and a military base) in Melilla (Spain). The participants were given a socio-demographic survey as well as a psychometric text on high-risk sexual behaviour. Results: The results found gender-based significant differences for sexual relations with penetration (p = 0.001), number of sexual partners (p = 0.001), and sexual relations with casual partners (p = 0.001). In all of these variables, male participants had higher percentages than female participants. Reasons for having casual sexual relations were also different for men and women, differences were found for the items, opportunity (p = 0.001), interest in knowing the other person (p = 0.015), physical excitement (p = 0.056) and drug consumption (p = 0.059). Regarding the reasons for consistent condom use with casual partners, there were differences for the item, my demand of a condom (p = 0.002). For the non-use of condoms with casual partners, differences were found for the items, I do not like to use condoms (p = 0.001) and condoms lessen sensitivity and reduce pleasure (p = 0.009). Conclusions: Men and women were found to have different high-risk sexual behaviours and practices. Of the motives for having sexual relations with casual partners, male participants considered opportunity and interest in knowing the other person to be more important than the female participants. Regarding condom use, the female participants’ demand to use a condom was a significant gender-based difference. In contrast to the young women, the male participants mostly justified not using a condom because it lessened sensitivity and reduced pleasure

Aprendizaje integrado de contenidos y lenguas extranjeras (AICLE) para enseñar psicología en la universidad

A lesson in a psychology course given to university students is presented, using the Content and Language Integrated Learning (CLIL) approach. A total of 78 psychology freshmen college students participated in this experiment. All participants received four lessons in a regular university class. The lessons were about general concepts on psychological disorders. The lessons were taught in English. Different quantitative and qualitative aspects of content acquisition were assessed. In addition, attitudes about and motivation to participate in this bilingual learning practice at the university were evaluated. Results showed a high level of approval and motivation for this methodology, along with a significant assimilation of the content taught. In conclusion, intensifying interaction and diversifying of linguistic skills, as well as adjusting the lecturing time to match the students’ learning capacity and the professor’s second language proficiency, could potentially improve this CLIL experience. Keywords: CLIL

Impact of Problematic Smartphone Use and Instagram Use Intensity on Self-Esteem with University Students from Physical Education

Mobile devices are a revolutionary element that offer many possibilities, although they can also cause problems for users. This is the case with the development of addictive behaviors that can affect personal well-being. The purpose of this paper has been to analyze the influence of smartphone addiction and Instagram use intensity on the self-esteem of Physical Education students. A cross-sectional research design was adopted by applying an online survey to a sample of undergraduate students (n = 385). The results showed that gender and age were factors that influenced the problematic use of the smartphone. In turn, there was a significant positive correlation between smartphone addiction and Instagram use intensity. The influence of smartphone addiction on students’ self-esteem was also highlighted. In contrast, Instagram use intensity did not affect self-esteem. Finally, the findings are discussed, and the main implications of the study are established, where physical education students take on a special role in order to avoid the improper use of smartphones and Instagram through sport.University of Granada (Spain) PPJIB2019-0

Aproximación arqueológica al yacimiento de Ategua (Córdoba)

Romula nº 10 (2011) p. 135-198El artículo que se presenta se inicia con un objetivo principal: la puesta al día de la documentación arqueológica relativa al yacimiento de Ategua. Por un lado hemos centrado el estudio en la morfología del sitio y su evolución a través de las herramientas SIG, especialmente de aquellas derivadas del Modelo Digital del Terreno, como son el análisis de la altitud, de las pendientes, el estudio de la accesibilidad, del drenaje del sitio y de la visibilidad. Todo ello ha permitido establecer las distintas áreas morfológicas que componen el yacimiento; ha ayudado a plantear hipótesis fehacientes sobre la estructura urbana de la ciudadela, fundamentalmente durante sus etapas romana y medieval. La aplicación del MDT ha permitido señalar los perímetros murados así como conocer los posibles puntos de acceso al recinto y determinar las relaciones visuales de Ategua con los yacimientos del entorno. La segunda parte del trabajo se ha centrado en el análisis arquitectónico y urbanístico (descriptivo y estratigráfico) de las diferentes estructuras que configuran los sectores ¿domus¿ y ¿castillo¿.Palabras clave: Ategua, BIC, caminos, castillo, domus, Modelo Digital del Terreno (MDT), SIG, topografía, visibilidad, yacimientoThe present article starts with one main objective: the updating of the documentation relating to the archaeological site of Ategua. On the one hand we have focused the study on the morphology of the site and its evolution through GIS tools, especially those derived from digital terrain model, such as the analysis of the altitude, slope, the study of accessibility, Site drainage and visibility. This has helped establish the distinct morphological areas that make up the site, helped reliable hypotheses on the urban structure of the citadel, mainly during Roman and medieval stages. The implementation of MDT has noted the walled perimeter and identifies possible points of access to the site and to determine relationships with visual fields Ategua environment. The second part of the work has focused on architectural and urban analysis (descriptive and stratigraphic) of the different structures that make up the sectors ¿domus¿ and ¿castle¿. Keywords: Ategua, BIC, roads, castles, domus, Digital Terrain Model (DTM), GIS, topography, visibility, site.Versión del edito

On the single and multiple associations of COVID‑19 post‑acute sequelae: 6‑month prospective cohort study

Medical research is progressing to clarify the full spectrum of sub-acute and long-term effects of the post-COVID-19 syndrome. However, most manuscripts published to date only analyze the effects of post-COVID-19 in patients discharged from hospital, which may induce significant bias. Here, we propose a pioneering study to analyze the single and multiple associations between post-COVID-19 characteristics with up to 6-months of follow-up in hospitalized and non-hospitalized COVID-19 patients. The cohort study was conducted from May to October 2020 at the University Hospital Virgen de la Nieves, the leading hospital assigned for patients with COVID-19 in Granada, Spain. A total of 372 and 217 patients—with 217 and 207 included in the first and second follow-up visits—were referred 2 and 6 months after diagnosing COVID-19, respectively. We find out that post-COVID-19 clinical and mental health impairment symptoms are correlated with patient gender. Logistic adjustments showed strong statistically robust single and multiple associations of demographic, clinical, mental health, X-ray, laboratory indices, and pulmonary function variables. The functional lung tests are good predictors of chest CT imaging abnormalities in elderly patients. Bilateral lung involvement, subpleural reticulum, ground-glass opacity, peripheral lung lesions, and bronchiectasis were the most common findings of the high-resolution computed tomography images. Nonhospitalized patients suffer more severe thromboembolic events and fatigue than those hospitalized

Hibridaciones de la hipertelevisión : información y entretenimiento en los modelos de infoentertaiment

La actualidad informativa, organizada en espacios cerrados durante la paleotelevisión, se introduce en programas ficcionales a partir de los 90. En el siglo XXI, con la hipertelevisión, también el entretenimiento se mezclará con contenidos periodísticos estableciendo formatos diferentes. Por un lado, el infoshow consigue que el discurso informativo se nutra de claves estilísticas y de contenido provenientes de programas ficcionales y de entretenimiento. Por otro, el infoentertaiment, coloca temáticas informativas en formatos de entretenimiento. El presente artículo se plantea un análisis de la nueva creatividad dentro del género del entretenimiento, así como la constitución de una tipología de modelosThe information of the news, organized in closed spaces during the paleotelevision, is gradually introduced in fictional programs since the nineties. However, in the 21st century, with the hypertelevision, entertainment programs and informational contents converge in new formats. On the one hand, the infoshow allows the informative discourse to absorb stylistic and content features from entertainment and fictional programs. On the other, the infoentertainment introduces informational topics in entertainment formats. The present article offers an analysis of the new creativity in the genre of the entertainment as well as the organization of a typology of models

The hybridizations of the hypertelevision: information and entertainment in the models of infoentertainment

La actualidad informativa, organizada en espacios cerrados durante la paleotelevisión, se introduce en programas ficcionales a partir de los 90. En el siglo XXI, con la hipertelevisión, también el entretenimiento se mezclará con contenidos periodísticos estableciendo formatos diferentes. Por un lado, el infoshow consigue que el discurso informativo se nutra de claves estilísticas y de contenido provenientes de programas ficcionales y de entretenimiento. Por otro, el infoentertaiment, coloca temáticas informativas en formatos de entretenimiento. El presente artículo se plantea un análisis de la nueva creatividad dentro del género del entretenimiento, así como la constitución de una tipología de modelos.The information of the news, organized in closed spaces during the paleotelevision, is gradually introduced in fictional programs since the nineties. However, in the 21st century, with the hypertelevision, entertainment programs and informational contents converge in new formats. On the one hand, the infoshow allows the informative discourse to absorb stylistic and content features from entertainment and fictional programs. On the other, the infoentertainment introduces informational topics in entertainment formats. The present article offers an analysis of the new creativity in the genre of the entertainment as well as the organization of a typology of models

El eportfolio en la Ingeniería del Software como una herramienta de reflexión en el proceso de aprendizaje

La aplicación de nuevas metodologías de enseñanzaaprendizaje y sistemas de evaluación, basados principalmente en los contratos de aprendizaje, ha conseguido mejorar visiblemente los resultados de los alumnos en la superación de la asignatura ‘Ingeniería del Software’. Sin embargo, el profesorado de dicha asignatura se plantea, con el ánimo de mejorar, si estos cambios hacen que realmente los alumnos estén aprendiendo más. Para dar respuesta a esta cuestión se ha utilizado el eportfolio como una herramienta de evaluación enfocada a la reflexión sobre el propio proceso de aprendizaje. En este artículo, se explica esta experiencia docente, detallando la situación de partida, la planificación, ejecución y evaluación de la misma, así como los resultados obtenidos

The hybridizations of the hypertelevision: information and entertainment in the models of infoentertainment

La actualidad informativa, organizada en espacios cerrados durante la paleotelevisión, se introduce en programas ficcionales a partir de los 90. En el siglo XXI, con la hipertelevisión, también el entretenimiento se mezclará con contenidos periodísticos estableciendo formatos diferentes. Por un lado, el infoshow consigue que el discurso informativo se nutra de claves estilísticas y de contenido provenientes de programas ficcionales y de entretenimiento. Por otro, el infoentertaiment, coloca temáticas informativas en formatos de entretenimiento. El presente artículo se plantea un análisis de la nueva creatividad dentro del género del entretenimiento, así como la constitución de una tipología de modelos.The information of the news, organized in closed spaces during the paleotelevision, is gradually introduced in fictional programs since the nineties. However, in the 21st century, with the hypertelevision, entertainment programs and informational contents converge in new formats. On the one hand, the infoshow allows the informative discourse to absorb stylistic and content features from entertainment and fictional programs. On the other, the infoentertainment introduces informational topics in entertainment formats. The present article offers an analysis of the new creativity in the genre of the entertainment as well as the organization of a typology of models