<em>Helicobacter pylori</em> Genes <em>jhp0940</em>, <em>jhp0945</em>, <em>jhp0947</em> and <em>jhp0949</em> are Associated with Gastroduodenal Disease

The plasticity zone (PZ) of Helicobacter pylori is a genomic region harbouring genes that can be exchanged between strains, contributing to the genetic diversity of this bacterium. The presence or absence of genes reflects the adaptation and coevolution of a pathogen within its host. Among the genes present in PZ, jhp0940, jhp0945, jhp0947 and jhp0949 have gained attention due to their association with gastroduodenal disease, and the prevalence of the latter three among H. pylori isolates from different geographical regions has allowed this association to be understood. With respect to jhp0940, also known as ctkA (cellular translocation kinase A), various results have been obtained regarding its prevalence. However, the presence of jhp0940 in isolates from children seems to be higher than that in isolates from adults, and the product of this gene can induce TNF-α, IL-6 and IL-8 via translocation of NF-κB into macrophages. While little is known about the functions of jhp0945, jhp0947 and jhp0949, their presence in H. pylori strains induces IL-8 and IL-12 expression at higher levels than that in strains lacking these genes. In this chapter, we aim to show a general overview of the prevalence, association with gastroduodenal disease, and currently known function of the H. pylori genes jhp0940, jhp0945, jhp0947 and jhp0949, which are located in PZ

Exploring the mediating effects between transformational leadership and organizational performance

Purpose The purpose of this paper is to study the possible mediating mechanisms (human resource management (HRM), learning and innovation) that could exist in the relationship between transformational leadership and organizational performance. This topic has been studied only by a few groups of researchers and these researchers have not analyzed all these concepts jointly. Design/methodology/approach. This research explores the relationships using partial least squares with data from 200 Spanish industrial companies. Analyzing the mentioned relationships in the Spanish context has been done by few researchers before. Findings. The study reveals that the adoption of transformational leadership styles improves performance when specific systems of HRM practices, learning and innovation are developed in an organization. Originality/value. This study, therefore, contributes to the understanding of the link between transformational leaders and performance by proposing a model in which it is evinced that this leadership style produces synergies between HRM, learning and innovation, which in the end, affect performance.The authors gratefully acknowledge the funding received from the Spanish Ministry for Economy and Competitiveness (Research Project No. ECO2012-37893) and Fundación CajaMurcia-BMN

John's ellipsoid and the integral ratio of a log-concave function

We extend the notion of John’s ellipsoid to the setting of integrable log-concave functions. This will allow us to define the integral ratio of a log-concave function, which will extend the notion of volume ratio, and we will find the log-concave function maximizing the integral ratio. A reverse functional affine isoperimetric inequality will be given, written in terms of this integral ratio. This can be viewed as a stability version of the functional affine isoperimetric inequality.Ministerio de Economía y CompetitividadFondo Europeo de Desarrollo RegionalConsejería de Industria, Turismo, Empresa e Innovación (Comunidad Autónoma de la Región de Murcia)Coordenação de aperfeiçoamento de pessoal de nivel superiorInstituto Nacional de Matemática Pura e Aplicad

INFORME BIBLIOGRÁFICO SOBRE TERMALISMO

Como introducción a la geología de la Región de Murcia y la explicación del termalismo puede verse: FERNÁNDEZ GUTIÉRREZ, J.C., "Síntesis geológica del SE. español", Historia de Cartagena, Murcia 1986, vol. 1, pp. 47-112. MARTÍN, C., "La estructura geológica de la Península Ibérica y sus aguas termales", Aguas mineromedicinales, termas curativas y culto a las aguas en la Península Ibérica, 1992, pp. 23 1-254. (...

Reflexiones sobre el liberalismo de Ludwig von Mises

The economic liberalism was the organizing principle of a society engaged in the creation of a market system. Born as a mere preference for non-bureaucratic methods, it evolved into a true faith in the secular salvation of man through a regulated market, said Karl Polanyi. This reflection paper, according to the reading of Ludwig von Mises, intends to show the conception of liberalism presented by Ludwig von Mises, and then to propose some elements of debate, not with the pretension of exhausting the discussion or proposing conclusive ideas on the subject, but rather with the intention of contributing ideas to These current thorny issues.El liberalismo económico fue el principio organizador de una sociedad dedicada a la creación de un sistema de mercado. Nacido como una mera preferencia por los métodos no burocráticos, se convirtió en una verdadera fe en la salvación secular del hombre a través de un mercado regulado, dijo Karl Polanyi. Este documento de reflexión, pretende mostrar la concepción del liberalismo presentada por Ludwig von Mises, y luego proponer algunos elementos de debate, no con la pretensión de agotar la discusión o proponer ideas concluyentes sobre su pensamiento, sino más bien con la intención de aportar ideas a estos actuales temas espinosos

A Monte Carlo comparison of three consistent bootstrap procedures

Since bootstrap samples are simple random samples with replacement from the original sample, the information content of some bootstrap samples can be very low. To avoid this fact, some authors have proposed several variants of the classical bootstrap. In this paper we consider two of them: the sequential or Poisson bootstrap and the reduced bootstrap. Both of them, like ordinary bootstrap, can yield second order accurate distribution estimators, that is, the three bootstrap procedures are asymptotically equivalent. The question that naturally arises is which of them should be used in a practical situation, in other words, which of them should be used for finite sample sizes. To try to answer this question, we have carried out a simulation study. Although no method was found to exhibit best performance in all the considered situations, some recommendations are given.Ministerio de Educación y Cienci

On the convergence of quadrature formulas connected with multipoint Padé-type approximants

29 pages, no figures.-- MSC2000 codes: 41A55, 41A21.MR#: MR1408352 (97e:41066)Zbl#: Zbl 0856.41027^aLet $I(F)= \int^1_{- 1} F(x)\omega(x) dx$, where $\omega$ is a complex valued integrable function. We consider quadrature formulas for $I(F)$ which are exact with respect to rational functions with prescribed poles contained in \overline{\bbfC}\backslash [- 1, 1]. Their rate of convergence is studied.The research by the first three authors (P.G.-V., M.J.P., R.O.) was partially supported by the HCM project ROLLS, under Contract CHRX-CT93-0416. Research by the fourth author (G.L.L.) was carried out while on a visit at Universidad de La Laguna. This visit was made possible by a travel grant from CDE-IMU.Publicad

John's ellipsoid and the integral ratio of a log-concave function

We extend the notion of John’s ellipsoid to the setting of integrable logconcave functions. This will allow us to define the integral ratio of a log-concave function, which will extend the notion of volume ratio, and we will find the log-concave function maximizing the integral ratio. A reverse functional affine isoperimetric inequality will be given, written in terms of this integral ratio. This can be viewed as a stability version of the functional affine isoperimetric inequality

Rogers-Shephard inequality for log-concave functions

In this paper we prove different functional inequalities extending the classical Rogers-Shephard inequalities for convex bodies. The original inequalities provide an optimal relation between the volume of a convex body and the volume of several symmetrizations of the body, such as, its difference body. We characterize the equality cases in all these inequalities. Our method is based on the extension of the notion of a convolution body of two convex sets to any pair of log-concave functions and the study of some geometrical properties of these new sets.Comment: 25 page

Frequency Analysis of a 64x64 Pixel Retinomorphic System with AER Output to Estimate the Limits to Apply onto Specific Mechanical Environment

The rods and cones of a human retina are constantly sensing and transmitting the light in the form of spikes to the cortex of the brain in order to reproduce an image in the brain. Delbruck’s lab has designed and manufactured several generations of spike based image sensors that mimic the human retina. In this paper we present an exhaustive timing analysis of the Address-Event- Representation (AER) output of a 64x64 pixels silicon retinomorphic system. Two different scenarios are presented in order to achieve the maximum frequency of light changes for a pixel sensor and the maximum frequency of requested directions on the output AER. Results obtained are 100 Hz and 1.66 MHz in each case respectively. We have tested the upper spin limit and found it to be approximately 6000rpm (revolutions per minute) and in some cases with high light contrast lost events do not exist.Ministerio de Ciencia e Innovación TEC2009-10639- C04-0