Experimental and observational studies find contrasting responses of soil nutrients to climate change

Agraïments: This work was financially supported by The National Key Research and Development Program of China (2016YFA0600801), the National Natural Science Foundation of China (31370455 and 31570438), and One Hundred Person Project of The Chinese Academy of Sciences (K318021405) and of Shaanxi Province.Manipulative experiments and observations along environmental gradients, the two most common approaches to evaluate the impacts of climate change on nutrient cycling, are generally assumed to produce similar results, but this assumption has rarely been tested. We did so by conducting a meta-analysis and found that soil nutrients responded differentially to drivers of climate change depending on the approach considered. Soil carbon, nitrogen, and phosphorus concentrations generally decreased with water addition in manipulative experiments but increased with annual precipitation along environmental gradients. Different patterns were also observed between warming experiments and temperature gradients. Our findings provide evidence of inconsistent results and suggest that manipulative experiments may be better predictors of the causal impacts of short-term (months to years) climate change on soil nutrients but environmental gradients may provide better information for long-term correlations (centuries to millennia) between these nutrients and climatic features. Ecosystem models should consequently incorporate both experimental and observational data to properly assess the impacts of climate change on nutrient cycling

GPT-4 Is Too Smart To Be Safe: Stealthy Chat with LLMs via Cipher

Safety lies at the core of the development of Large Language Models (LLMs). There is ample work on aligning LLMs with human ethics and preferences, including data filtering in pretraining, supervised fine-tuning, reinforcement learning from human feedback, and red teaming, etc. In this study, we discover that chat in cipher can bypass the safety alignment techniques of LLMs, which are mainly conducted in natural languages. We propose a novel framework CipherChat to systematically examine the generalizability of safety alignment to non-natural languages -- ciphers. CipherChat enables humans to chat with LLMs through cipher prompts topped with system role descriptions and few-shot enciphered demonstrations. We use CipherChat to assess state-of-the-art LLMs, including ChatGPT and GPT-4 for different representative human ciphers across 11 safety domains in both English and Chinese. Experimental results show that certain ciphers succeed almost 100% of the time to bypass the safety alignment of GPT-4 in several safety domains, demonstrating the necessity of developing safety alignment for non-natural languages. Notably, we identify that LLMs seem to have a ''secret cipher'', and propose a novel SelfCipher that uses only role play and several demonstrations in natural language to evoke this capability. SelfCipher surprisingly outperforms existing human ciphers in almost all cases. Our code and data will be released at https://github.com/RobustNLP/CipherChat.Comment: 13 pages, 4 figures, 9 table

One-stage coclear implantation via a facial recess approach in children with otitis media with effusion

AbstractObjectiveTo investigate surgical indications, operative techniques, complications and auditory and speech rehabilitation for cochlear implant (CI) in children with otitis media with effusion (OME).Material and methodsThis is a retrospective review of records of 24children with bilateral profound sensorineural hearing loss and OME who were implanted during January 2011 to November 2014 in the Department of Otorhinolaryngology and Head and Neck Surgery at the PLA Hospital, using one-stage implantation via the facial recess approach and round window insertion. The incus was removed in 8 cases during the implantation procedure. Local infiltration of dexamethasone and adrenaline in the middle ear was also performed. Postoperative complications were examined. Preoperative and postoperative questionnaires including Categories of Auditory Performance (CAP), Speech Intelligibility Rating (SIR), and the Meaningful Auditory Integration Scale (MAIS) were collected.ResultsAll electrodes were implanted successfully without any immediate or delayed complications. Inflammatory changes of middle ear mucosa with effusion were noted in all implanted ears. The scores of post-implant CAP and SIR increased significantly in all 24 cases (t = −25.95 and −14.09, respectively for CAP and SIR, p < 0.05).ConclusionsOne-stage CI via the facial recess approach with round window insertion is safe and effective in cochlear implant candidates with OME, as seen in the 24 children in our study who achieved improved auditory performance and speech intelligibility after CI

Tuning anomalous Floquet topological bands with ultracold atoms

The Floquet engineering opens the way to create new topological states without counterparts in static systems. Here, we report the experimental realization and characterization of new anomalous topological states with high-precision Floquet engineering for ultracold atoms trapped in a shaking optical Raman lattice. The Floquet band topology is manipulated by tuning the driving-induced band crossings referred to as band inversion surfaces (BISs), whose configurations fully characterize the topology of the underlying states. We uncover various exotic anomalous topological states by measuring the configurations of BISs which correspond to the bulk Floquet topology. In particular, we identify an unprecedented anomalous Floquet valley-Hall state that possesses anomalous helicallike edge modes protected by valleys and a chiral state with high Chern number

Mesenchymal Stem Cells: A Double-edged Sword in Regulating Immune Responses

Mesenchymal stem cells (MSCs) have been employed successfully to treat various immune disorders in animal models and clinical settings. Our previous studies have shown that MSCs can become highly immunosuppressive upon stimulation by inflammatory cytokines, an effect exerted through the concerted action of chemokines and nitric oxide (NO). Here, we show that MSCs can also enhance immune responses. This immune-promoting effect occurred when proinflammatory cytokines were inadequate to elicit sufficient NO production. When inducible nitric oxide synthase (iNOS) production was inhibited or genetically ablated, MSCs strongly enhance T-cell proliferation in vitro and the delayed-type hypersensitivity response in vivo. Furthermore, iNOS-/- MSCs significantly inhibited melanoma growth. It is likely that in the absence of NO, chemokines act to promote immune responses. Indeed, in CCR5-/- CXCR3-/- mice, the immune-promoting effect of iNOS-/- MSCs is greatly diminished. Thus, NO acts as a switch in MSC-mediated immunomodulation. More importantly, the dual effect on immune reactions was also observed in human MSCs, in which indoleamine 2,3-dioxygenase (IDO) acts as a switch. This study provides novel information about the pathophysiological roles of MSCs. © 2012 Macmillan Publishers Limited All rights reserved