The Quadratic Shortest Path Problem and its Genetic Algorithm

The quadratic shortest path (QSP) problem is to find a path from a node to another node in a given network such that the total cost includes two kinds of costs, say direct cost and interactive cost, is minimum. The direct cost is the cost associated with each arc and the interactive cost occurs when two arcs appear simultaneously in the shortest path. In this paper, the concept of the quadratic shortest path is initialized firstly. Then a spanning tree-based genetic algorithm is designed for solving the quadratic shortest path problem. Finally, a numerical example is given

The level of circulating endothelial progenitor cells may be associated with the occurrence and recurrence of chronic subdural hematoma

OBJECTIVES: The onset of chronic subdural hematoma may be associated with direct or indirect minor injuries to the head or a poorly repaired vascular injury. Endothelial progenitor cells happen to be one of the key factors involved in hemostasis and vascular repair. This study was designed to observe the levels of endothelial progenitor cells, white blood cells, platelets, and other indicators in the peripheral blood of patients diagnosed with chronic subdural hematoma to determine the possible relationship between the endothelial progenitor cells and the occurrence, development, and outcomes of chronic subdural hematoma. METHOD: We enrolled 30 patients with diagnosed chronic subdural hematoma by computer tomography scanning and operating procedure at Tianjin Medical University General Hospital from July 2009 to July 2011. Meanwhile, we collected 30 cases of peripheral blood samples from healthy volunteers over the age of 50. Approximately 2 ml of blood was taken from veins of the elbow to test the peripheral blood routine and coagulation function. The content of endothelial progenitor cells in peripheral blood mononuclear cells was determined by flow cytometry. RESULTS: The level of endothelial progenitor cells in peripheral blood was significantly lower in preoperational patients with chronic subdural hematomas than in controls. There were no significant differences between the two groups regarding the blood routine and coagulation function. However, the levels of circulating endothelial progenitor cells were significantly different between the recurrent group and the non-recurrent group. CONCLUSIONS: The level of circulating endothelial progenitor cells in chronic subdural hematoma patients was significantly lower than the level in healthy controls. Meanwhile, the level of endothelial progenitor cells in recurrent patients was significantly lower than the level in patients without recurrence. Endothelial progenitor cells may be related to the occurrence and recurrence of chronic subdural hematoma

Stellar Parameters of Main Sequence Turn-off Star Candidates Observed with the LAMOST and Kepler

Main sequence turn-off (MSTO) stars have advantages as indicators of Galactic evolution since their ages could be robustly estimated from atmospheric parameters. Hundreds of thousands of MSTO stars have been selected from the LAMOST Galactic sur- vey to study the evolution of the Galaxy, and it is vital to derive accurate stellar parameters. In this work, we select 150 MSTO star candidates from the MSTO stars sample of Xiang that have asteroseismic parameters and determine accurate stellar parameters for these stars combing the asteroseismic parameters deduced from the Kepler photometry and atmospheric parameters deduced from the LAMOST spectra.With this sample, we examine the age deter- mination as well as the contamination rate of the MSTO stars sample. A comparison of age between this work and Xiang shows a mean difference of 0.53 Gyr (7%) and a dispersion of 2.71 Gyr (28%). The results show that 79 of the candidates are MSTO stars, while the others are contaminations from either main sequence or sub-giant stars. The contamination rate for the oldest stars is much higher than that for the younger stars. The main cause for the high contamination rate is found to be the relatively large systematic bias in the LAMOST surface gravity estimates.Comment: accepted by RA

Direct Interaction between AR and PAK6 in Androgen-Stimulated PAK6 Activation

A p21-activated kinase 6 (PAK6) was previously identified to be an androgen receptor (AR) interacting protein through a yeast two-hybrid screening. We used hormone responsive prostate cancer LAPC4 and LNCap cell lines as models to study the signaling events associated with androgen stimulation and PAK6. An androgen-stimulated PAK6 kinase activation was observed in LAPC4 cells expressing endogenous PAK6 and in LNCap cells ectopically expressing a wild type PAK6. This activation was likely mediated through a direct interaction between AR and PAK6 since siRNA knock-down of AR in LAPC4 cells downregulated androgen-stimulated PAK6 activation. In addition, LNCap cells expressing a non-AR-interacting PAK6 mutant exhibited dampened androgen-stimulated kinase activation. As a consequence of androgen-stimulated activation, PAK6 was phosphorylated at multiple serine/threonine residues including the AR-interacting domain of PAK6. Furthermore, androgen-stimulation promoted prostate cancer cell motility and invasion were demonstrated in LNCap cells ectopically expressing PAK6-WT. In contrast, LNCap expressing non-AR-interacting mutant PAK6 did not respond to androgen stimulation with increased cell motility and invasion. Our results demonstrate that androgen-stimulated PAK6 activation is mediated through a direct interaction between AR and PAK6 and PAK6 activation promotes prostate cancer cells motility and invasion

Coordination Game Analysis through Penalty Scheme in Freight Intermodal Service

We study coordination mechanisms through penalty schemes to cooperate the behavior of two firms as successive segment carriers to make transport plan separate in freight intermodal market. Based on the different cost structure and service level constraint to two firms, we compare the decision making in two possible decision systems, that is, centralized system and decentralized system. In a centralized system-the first best case as a benchmark is contrasted with decentralized system. In the decentralized system, a Stackelberg game model is formulated between two firms. Some discordant decisions would be made by firm I's overestimate motivation and firm II's undersupply motivation. Our primary objective is to design penalty schemes to coordinate the interactions for two firms. The study shows in a decentralized system, setting suitable penalty schemes can coordinate the two firms' decision. We also study the feasible range of penalty parameters, and some important managerial insights are then deduced. In the end, a numerical example is provided to verify the validity of results, some concluding remarks are presented subsequently