Dynamical nucleus-nucleus potential at short distances

The dynamical nucleus-nucleus potentials for fusion reactions 40Ca+40Ca, 48Ca+208Pb and 126Sn+130Te are studied with the improved quantum molecular dynamics (ImQMD) model together with the extended Thomas-Fermi approximation for the kinetic energies of nuclei. The obtained fusion barrier for 40Ca+40Ca is in good agreement with the extracted fusion barrier from the measured fusion excitation function, and the depth of the fusion pockets are close to the results of time-dependent Hartree-Fock calculations. The energy dependence of fusion barrier is also investigated. For heavy fusion system, the fusion pocket becomes shallow and almost disappears for symmetric systems and the obtained potential at short distances is higher than the adiabatic potential.Comment: 6 figures, accepted for publication in Phys. Rev.

Experimental Investigation for Fault Diagnosis Based on a Hybrid Approach Using Wavelet Packet and Support Vector Classification

To deal with the difficulty to obtain a large number of fault samples under the practical condition for mechanical fault diagnosis, a hybrid method that combined wavelet packet decomposition and support vector classification (SVC) is proposed. The wavelet packet is employed to decompose the vibration signal to obtain the energy ratio in each frequency band. Taking energy ratios as feature vectors, the pattern recognition results are obtained by the SVC. The rolling bearing and gear fault diagnostic results of the typical experimental platform show that the present approach is robust to noise and has higher classification accuracy and, thus, provides a better way to diagnose mechanical faults under the condition of small fault samples

New contributions to the knowledge of Chinese flea beetle fauna (III): revision of Meishania Chen & Wang with description of five new species (Coleoptera: Chrysomelidae: Galerucinae)

The flea beetle genus Meishania Chen & Wang is revised and five new species—M. cangshanensis sp. nov., M. flavipen- nis sp. nov., M. fulvotigera sp. nov., and M. sichuanica sp. nov. from China and M. bhutanensis sp. nov. from Bhutan— are described. All species of Meishania are illustrated and a key to species is provided

New contributions to the knowledge of Chinese flea beetle fauna (III): revision of Meishania Chen & Wang with description of five new species (Coleoptera: Chrysomelidae: Galerucinae)

The flea beetle genus Meishania Chen & Wang is revised and five new species—M. cangshanensis sp. nov., M. flavipen- nis sp. nov., M. fulvotigera sp. nov., and M. sichuanica sp. nov. from China and M. bhutanensis sp. nov. from Bhutan— are described. All species of Meishania are illustrated and a key to species is provided

Multi-disciplinary efforts to evaluate the therapeutic potential of CDK11, a novel transcription associated cyclin dependent kinase.

View full abstracthttps://openworks.mdanderson.org/leading-edge/1043/thumbnail.jp

An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

Metabolic reprograming is an emerging hallmark of tumor biology and an actively pursued opportunity in discovery of oncology drugs. Extensive efforts have focused on therapeutic targeting of glycolysis, whereas drugging mitochondrial oxidative phosphorylation (OXPHOS) has remained largely unexplored, partly owing to an incomplete understanding of tumor contexts in which OXPHOS is essential. Here, we report the discovery of IACS-010759, a clinical-grade small-molecule inhibitor of complex I of the mitochondrial electron transport chain. Treatment with IACS-010759 robustly inhibited proliferation and induced apoptosis in models of brain cancer and acute myeloid leukemia (AML) reliant on OXPHOS, likely owing to a combination of energy depletion and reduced aspartate production that leads to impaired nucleotide biosynthesis. In models of brain cancer and AML, tumor growth was potently inhibited in vivo following IACS-010759 treatment at well-tolerated doses. IACS-010759 is currently being evaluated in phase 1 clinical trials in relapsed/refractory AML and solid tumors

The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism

林圣彩教授课题组长期致力于细胞信号转导的研究。近年来，该课题组潜心研究，不断攻关，取得了一系列重大成果，如揭示细胞如何应对生长因子缺乏的内在机理，发现了细胞自噬“路线图”、还发现了细胞如何感应“饥饿”信号AMP的信号传导通路等。其中，“发现细胞自噬‘路线图’”成果曾登上《科学》杂志，并入选2012年度“中国科学十大进展”。AMPK and mTOR play principal roles in governing metabolic programs; however, mechanisms underlying the coordination of the two inversely regulated kinases remain unclear. In this study we found, most surprisingly, that the late endosomal/lysosomal protein complex v-ATPase-Ragulator, essential for activation of mTORC1, is also required for AMPK activation. We also uncovered that AMPK is a residential protein of late endosome/lysosome. Under glucose starvation, the v-ATPase-Ragulator complex is accessible to AXIN/LKB1 for AMPK activation. Concurrently, the guanine nucleotide exchange factor (GEF) activity of Ragulator toward RAG is inhibited by AXIN, causing dissociation from endosome and inactivation of mTORC1. We have thus revealed that the v-ATPase-Ragulator complex is also an initiating sensor for energy stress and meanwhile serves as an endosomal docking site for LKB1-mediated AMPK activation by forming the v-ATPase-Ragulator-AXIN/LKB1-AMPK complex, thereby providing a switch between catabolism and anabolism. Our current study also emphasizes a general role of late endosome/lysosome in controlling metabolic programs

Pose Estimation of Automatic Battery-Replacement System Based on ORB and Improved Keypoints Matching Method

This paper presents an improved Oriented Feature from Accelerated Segment Test (FAST) and Rotated BRIEF (ORB) keypoints matching method for pose estimation of automatic battery-replacement systems. The key issue of the system is how to precisely estimate the pose of the camera in respect to the battery. In our system, the pose-estimation hardware module is mounted onto the robot manipulator, composed of double high brightness LED light source, one monocular camera, and two laser rangefinders. The camera is utilized to take an image of the battery, the laser rangefinders on both sides of the camera are utilized to detect the real-time distance between the battery and the pose-estimation system. The estimation result is significantly influenced by the matching result of the keypoints detected by the ORB technique. The modified matching procedure, based on spatial consistency nearest hamming distance searching method, is used to determine the correct correspondences. Meanwhile, the iterative reprojection error minimization algorithm is utilized to discard incorrect correspondences. Verified by the experiments, the results reveal that this method is highly reliable and able to achieve the required positioning accuracy. The positioning error is lower than 1 mm