417 research outputs found
Ordered GeSi nanorings grown on patterned Si (001) substrates
An easy approach to fabricate ordered pattern using nanosphere lithography and reactive iron etching technology was demonstrated. Long-range ordered GeSi nanorings with 430 nm period were grown on patterned Si (001) substrates by molecular beam epitaxy. The size and shape of rings were closely associated with the size of capped GeSi quantum dots and the Si capping processes. Statistical analysis on the lateral size distribution shows that the high growth temperature and the long-term annealing can improve the uniformity of nanorings
Comparative studies of the anti-thrombotic effects of saffron and HongHua based on network pharmacology
Purpose: To investigate the comparative anti-thrombotic effects of saffron and Honghua, and also to explore possible mechanisms in thrombosis based on network pharmacology.
Methods: A network pharmacology model was used for bioactive components, targets and pathways for saffron and HongHua via Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), PharmMapper, Genecard, Uniprot and KEGG databases. In animal experiments, 72 rats were randomly divided into 9 groups: normal control group (NC), model control group (MC), crocetin groups (80, 40, 20 mg/kg), hydroxysafflor yellow A(HSYA) groups (80, 40, 20 mg/kg), and aspirin group (40 mg/kg). Using in vitro thrombosis models and an acute blood stasis model in vivo, the anti-thrombotic effects of these treatments on clotting time, hemorheology parameters, Thromboxane B2 (TXB2), plasmin activator inhibitor (PAI), protein C (PC), protein S (PS), and thrombinantithrombin complex (TAT) were determined and comparisons made for saffron and HongHua.
Results: Five potential compounds, 16 anti-thrombotic targets and 27 pathways were predicted for saffron, while 22 compounds, 37 disease targets and 35 pathways were found for HongHua (p < 0.05). Pharmacological experiments revealed that crocetin and HSYA had significant effects on thrombus length, thrombus wet/dry mass, whole blood viscosity (WBV), erythrocyte aggregation index (EAI), clotting time and D-dimer for the high and middle groups. Unlike HSYA, crocetin also had significant and dose-dependent effects on PAI, prothrombin fragment 1+2 (F1+2) and PS and had highly significant effects on TXB2 and TAT.
Conclusion: This research provides a systematic, comprehensive and comparative analysis of component, target and anti-thrombotic pathways of saffron and HongHua based on network pharmacology, and also shows that saffron has more significant anti-thrombotic effect than HongHua.
Keywords: Saffron; HongHua; Network pharmacology; Anti-thrombosis; Network mode
A promising routine to fabricate GeSi nanowires via self-assembly on miscut Si (001) substrates
Photometric Metallicity Calibration with SDSS and SCUSS and its Application to distant stars in the South Galactic Cap
Based on SDSS g, r and SCUSS (South Galactic Cap of u-band Sky Survey)
photometry, we develop a photometric calibration for estimating the stellar
metallicity from and colors by using the SDSS spectra of 32,542 F-
and G-type main sequence stars, which cover almost deg in the
south Galactic cap. The rms scatter of the photometric metallicity residuals
relative to spectrum-based metallicity is dex when , and
dex when . Due to the deeper and more accurate magnitude of SCUSS
band, the estimate can be used up to the faint magnitude of . This
application range of photometric metallicity calibration is wide enough so that
it can be used to study metallicity distribution of distant stars. In this
study, we select the Sagittarius (Sgr) stream and its neighboring field halo
stars in south Galactic cap to study their metallicity distribution. We find
that the Sgr stream at the cylindrical Galactocentric coordinate of
kpc, kpc exhibits a relative rich metallicity
distribution, and the neighboring field halo stars in our studied fields can be
modeled by two-Gaussian model, with peaks respectively at [Fe/H] and
[Fe/H].Comment: 8 pages, 7 figures, Accepted for publication in MNRA
Plasmon-gating photoluminescence in graphene/GeSi quantum dots hybrid structures
The ability to control light-matter interaction is central to several potential applications in lasing, sensing, and communication. Graphene plasmons provide a way of strongly enhancing the interaction and realizing ultrathin optoelectronic devices. Here, we find that photoluminescence (PL) intensities of the graphene/GeSi quantum dots hybrid structures are saturated and quenched under positive and negative voltages at the excitation of 325 nm, respectively. A mechanism called plasmon-gating effect is proposed to reveal the PL dependence of the hybrid structures on the external electric field. On the contrary, the PL intensities at the excitation of 405 and 795 nm of the hybrid structures are quenched due to the charge transfer by tuning the Fermi level of graphene or the blocking of the excitons recombination by excitons separation effect. The results also provide an evidence for the charge transfer mechanism. The plasmon gating effect on the PL provides a new way to control the optical properties of graphene/QD hybrid structures
Crustal Deformation in Southern California Constrained by Radial Anisotropy From Ambient Noise Adjoint Tomography
We build a new radially anisotropic shear wave velocity model of Southern California based on ambient noise adjoint tomography to investigate crustal deformation associated with Cenozoic evolution of the Pacific‐North American plate boundary. Pervasive positive radial anisotropy (4%) is observed in the crust east of the San Andreas Fault (SAF), attributed to subhorizontal alignment of mica/amphibole foliation planes resulting from significant crustal extension. Substantial negative anisotropy (6%) is revealed in the middle/lower crust west of the SAF, where high shear wave speeds are also observed. The negative anisotropy could result from steeply dipping amphibole schists in a shear zone developed during Laramide flat slab subduction. Alternatively, it could be caused by the crystal preferred orientation (CPO) of plagioclase, whose fast axis aligns orthogonally to a presumed subhorizontal foliation. The latter new mechanism highlights potentially complex CPO patterns resulting from different lithospheric mineralogy, as suggested by laboratory experiments on xenoliths from the region.K. Wang and Q. Liu are
supported by the NSERC Discovery
Grant 487237. Computations for this
study were performed on hardware
acquired through the combined
funding of Canada Foundation for
Innovation (CFI), Ontario Research
Fund (ORF), and University of Toronto
Startup Fund and partly hosted by the
SciNet HPC Consortium. Y. Yang is
supported by Australian Research
Council Future Fellowship
(FT130101220) and Discovery Project
(DP190102940). Schulte‐Pelkum's contribution was supported by NSF Grants
EAR‐1251193, 1735890, and 1927246,
and SCEC Grant 17097. This is contribution 1509 from the ARC Centre of
Excellence for Core to Crust Fluid
Systems (http://www.ccfs.mq.edu.au)
and 1393 in the GEMOC Key Centre
(http://www.gemoc.mq.edu.au)
Fatigue Analysis of Hybrid Wind Turbine Towers
Fatigue analysis of hybrid wind turbine towers between cut in wind speed and cut out wind speed are demonstrated. Nominal stress method and miner liner accumulated damage theory are adopted. Through the analysis of the results, comparative research on effect of parameters of aspect ratio, height ratio and unequal legs for fatigue properties of hybrid wind turbine towers. The results show that the optimal range of aspect ratio of hybrid towers is 1/6~1/4, the optimal range of height ratio of hybrid towers is 0.60~0.67. Fatigue analysis of hybrid towers, should select the right junction of leeward towers and the S-N curve from EN 1993-1-9.The effect of unequal legs for fatigue properties of hybrid towers can be neglected
Non-overlap subaperture interferometric testing for large optics
It has been shown that the number of subapertures and the amount of overlap has a significant influence on the stitching accuracy. In this paper, a non-overlap subaperture interferometric testing method (NOSAI) is proposed to inspect large optical components. This method would greatly reduce the number of subapertures and the influence of environmental interference while maintaining the accuracy of reconstruction. A general subaperture distribution pattern of NOSAI is also proposed for the large rectangle surface. The square Zernike polynomial is employed to fit such wavefront. The effect of the minimum fitting terms on the accuracy of NOSAI and the sensitivities of NOSAI to subaperture’s alignment error, power systematic error, and random noise are discussed. Experimental results validate the feasibility and accuracy of the proposed NOSAI in comparison with wavefront obtained by a large aperture interferometer and stitching surface by multi-aperture overlap-scanning technique (MAOST)
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