User Interface Implementation for Network License Management System

This paper describes a project to understand and enhance a distributed application - the Applied Science Microlab Network License Management System(NLMS1, and to design and implement an improved user interface for that system. The NLMS utilizes a client-server architecture, the TCPIIP network protocol suite, and the Remote Procedure Call (RPC) facility for the program to interface to the network. The new user interface is based on X WindowslMot~foUr NIX client and Microsoft Windows for PC client. In addition, management reports are added to the system and expected to provide the package usage statistics to aid in future software purchase plans. The goals of my project are to do some developmental work in the UNZX environment; to understand more about network programming; to learn how to write distributed applications; and to learn to programming X Windows/Motif and Microsoft Windows. In my opinion, I have accornplished these goals

Coastal Reservoir Strategy and Its Applications

While the world\u27s population tripled in the 20th century, the use of renewable water resources has grown six-fold [1]. It is estimated that the world population will enlarge by another 40 to 50 % in the following fifty years. The demand for water will be increasing resulted by the population growth combined with industrialization and urbanization, which will have serious consequences on the environment. According to WHO/UNICEF Joint Monitoring Programme (JMP) (2012 Update), 780 million people lack access to an improved water source; approximately one in nine people [2]. Water stress causes deterioration of fresh water resources in terms of quantity (aquifer over-exploitation, dry rivers, etc.) and quality (eutrophication, organic matter pollution, saline intrusion, etc.). In the Developing World, women and children walk miles to get water. The UN estimates that the average is 40 pounds of water carried 4 miles (18 kg-6 km). This takes hours, people can’t attend school/ work, deforms the spine and can leave women vulnerable to assault [3]. Figure 1 showed the state of water shortages based on synthetic evaluation of water management using for agriculture in 2007

Intravenous pretreatment with emulsified isoflurane preconditioning protects kidneys against ischemia/reperfusion injury in rats

Ordinal logistic regression models have been developed for analysis of epidemiological studies. However, the adequacy of such models for adjustment has so far received little attention. In this article, we reviewed the most important ordinal regression models and common approaches used to verify goodness-of-fit, using R or Stata programs. We performed formal and graphical analyses to compare ordinal models using data sets on health conditions from the National Health and Nutrition Examination Survey (NHANES II).Los modelos de regresión logística ordinal vienen aplicándose con éxito en el análisis de estudios epidemiológicos. Sin embargo, la verificación de la adecuación de cada modelo ha recibido atención limitada. El artículo presenta un breve análisis de los principales modelos de regresión logística ordinal y las estrategias para ajustes, las técnicas de verificación de calidad de ajuste, así como los comandos para ejecución en los softwares R y Stata. La metodología es ilustrada con la aplicación de los datos del Second Nacional Health and Nutrition Examination Survey (NHANES II), el conocido análisis de salud y nutrición.Os modelos de regressão logística ordinal vêm sendo aplicados com sucesso na análise de estudos epidemiológicos. Entretanto, a verificação da adequação de cada modelo tem recebido atenção limitada. O artigo apresenta uma breve análise dos principais modelos de regressão logística ordinal e as estratégias para ajuste s, as técnicas de verificação de qualidade do ajuste, bem como os comandos para execução nos softwares R e Stata. A metodologia é ilustrada com aplicação dos dados do Second National Health and Nutrition Examination Survey (NHANES II), o conhecido levantamento de saúde e nutrição

Magnet bioreporter device for ecological toxicity assessment on heavy metal contamination of coal cinder sites

A novel magnet bioreporter device was developed in this research for soil toxicity assessment, via magnetic nanoparticles functionalized whole-cell bioreporters. The whole-cell bioreporter ADPWH-recA kept response capability to DNA damage after magnetic nanoparticles (MNPs) functionalization, and could be harvested from soil samples by permanent magnet to reduce the soil particle disturbance. Compared to conventional treatments applying bioreporter directly in soil-water mixture (SW-M treatment) or supernatant (SW-S treatment), MNPs functionalized bioreporter via the magnet device (MFB) treatment achieved high sensitivity to evaluate the toxicity and bioavailability of chromium contamination in soils from 10 mg/kg to 5000 mg/kg soil dry weight. The MNPs functionalized bioreporter also achieved high reproducibility with pH value from 5.0 to 9.0, salinity from 0% to 3% and temperature from 20 °C to 37 °C. A case study was carried out on the ecological toxicity assessment of heavy metal contamination at the coal cinder site via the magnet bioreporter device. The heavy metal toxicity declined with the increasing distance to the coal cinder point, and a significant accumulation of heavy metal toxicity was observed along the vertical distribution. No direct link was found between the pollution load index (PLI) and heavy metal toxicity, and the results suggested the bioreporter test monitored the toxicity of heavy metals in soils and was an important approach for ecological risk assessment. Magnet bioreporter device also offered the high throughput biological measurement and was feasible for in situ monitoring

The Availability of Essential Medicines and Diagnostic Devices for Chronic Obstructive Pulmonary Disease in Primary Care

BackgroundChina has seen a significantly increased prevalence of chronic obstructive pulmonary disease (COPD) recently. But primary care institutions, the main "battlefield" for containing COPD, have shown relatively weak capabilities for the diagnosis and treatment of disease. As there are relatively few large-scale investigations and studies on medicines and diagnostic devices for COPD in primary care, we conducted this study to further understand the weaknesses of current COPD containment in primary care, by which the gap in related research may be made up.ObjectiveTo understand the allocation and availability rate of essential medicines for COPD, and availability rate of spirometer as well as the implementation of pulmonary function tests in primary care.MethodsFrom February to March 2021, a multi-stage cluster sampling was adopted to select 8 176 community (township) health centers from 31 provinces of China to attend a survey. The rates of availability and allocation of each of the 16 essential medicines for COPD in the 2018 National Essential Medicines List were calculated to estimate the categories and number of these medicines in primary care institutions. The rate of availability of spirometer in these institutions was estimated. And the rate of implementation of pulmonary function tests in these institutions was estimated.ResultsAltogether, 7 458 (91.22%) institutions who gave effective responses to the survey were included for analysis, including 5 901 (79.12%) township health centers, and 1 557 (20.88%) community health centers. Among the 16 essential medicines for COPD, less than 8 were available in 6 538 (87.66%) institutions, at least 1 inhaled antiasthmatic medicines were available in 4 992 (66.00%) institutions, and long-acting inhaled antiasthmatic medicines were available in 814 (10.91%) institutions. The average availability rate of 16 essential medicines for COPD was 33.30%. The highest ranked three medicines in terms of availability rate were ambroxol〔85.28% (6 360/7 458) 〕, aminophylline〔81.17% (6 054/7 458) 〕 and compound licorice〔74.48% (5 555/7 458) 〕. And the relatively low-ranked three were fluticasone propionate 〔4.89% (365/7 458) 〕, tiotropium bromide〔6.25% (466/7 458) 〕, budesonide forterol〔8.61% (642/7 458) 〕. The average availability rate of 6 inhaled antiasthmatic medicines in community health centers was 28.31%, and that in township health centers was 4.81%. The average availability rate of 2 long-acting inhaled antiasthmatic medicines in community health centers was 16.18%, and that in township health centers was 5.12%. The average availability rate of spirometers in primary care institutions was 8.94% (667/7 458) . The average availability rate of spirometers in community health centers was higher than that of township health centers〔18.56% (289/1 557) vs 6.41% (378/5 901) , P<0.05〕. Pulmonary function tests were implemented in 10.82% (807/7 458) of the institutions. The rate of community health centers was higher than that of township health centers in terms of offering pulmonary function testing services〔13.81% (215/1 557) vs 10.03% (592/5 901) , P<0.05〕.ConclusionThe available essential medicines for COPD in these primary care institutions were insufficient with unbalanced distribution. Most of available medicines were oral preparations, and inhaled antiasthmatic medicines, especially long-acting inhaled antiasthmatic medicines, were poorly available. Moreover, the availability rate of spirometers and the implementation rate of pulmonary function tests were both relatively low. All these factors negatively influence early screening for and management of COPD in primary care. In view of this, it is recommended that increasing the availability levels of inhaled antiasthmatic medicines and portable spirometers, and the application of pulmonary function tests in primary care, as well as primary care physicians asompetencies and initiatives for the prevention, diagnosis, treatment and rehabilitation of COPD with the delivery of the national essential publish health services for COPD as the starting point of enhancement trainings

The clinical and biological implications of the focal adhesion kinase pathway in ShenLingLan mediated suppression of cellular migration of ovarian cancer cells

The incidence of ovarian cancer in the UK has increased by almost twenty percent since the 1970’s and the majority of cases are not diagnosed until the late stages, when metastasis is more likely to have occurred. Focal Adhesion Kinase (FAK) is one of the key protein complexes which is integral to cell migration and has been linked to a variety of solid tumours. ShenLingLan (SLDM) is a traditional herbal medicine which has been formulated for the treatment of solid tumours. This study aimed to establish the impact of SLDM on FAK in ovarian cancer cells in vitro and transcript levels of FAK in an ovarian cancer cohort. FAK and paxillin phosphorylation events stimulated by SLDM treatment were identified using a Kinexus™ antibody based protein array. The impact of SLDM on cell attachment and migration was evaluated using Electric cell-substrate impedance sensing (ECIS), whilst the changes in focal adhesion complex localisation were assessed using immunofluorescence. In an ovarian cancer cohort, differences in FAK and paxillin transcript levels were assessed against key clinical parameters such as differentiation, stage and survival outcome. SLDM treatment of ovarian cancer cells in vitro resulted in the suppression of FAK and paxillin phosphorylation at several sites, which appeared to manifest as decreased cellular attachment and migration in a range of immortalised ovarian cancer cells. Increased FAK and paxillin transcript copies were observed in high grade and poorly differentiated ovarian tumours as well as in tumours from patients with ovarian cancer related incidence. SLDM has a profound effect on the migratory and adhesive properties of ovarian cancer cells, potentially via inhibitory effects on the activation of the FAK pathway, which is aberrant in clinical ovarian cancers

Millennial-Scale Asian Monsoon Influenced Longjie Lake Evolution during Marine Isotope Stage 3, Upper Stream of Changjiang (Yangtze) River, China

Millennial-scale climate change in Asian monsoon region during MIS 3 has been studied using stalagmite, loess, and peat sediments. However, records from more materials are essential to further illustrate dynamics of these events. In the present study, a time-series of grain size covering 60–30 ka was reconstructed from lake sediments in the Yunnan Province, southwestern China. The time-series contains 14 obvious millennial-scale events during the period. On millennial-scale, the grain size record is generally consistent with mean stalagmite δ18O from Hulu Cave, grain size of Gulang loess sequence, Chinese Loess Plateau, and Greenland ice core δ18O. The results show that the millennial-scale variation was well compared with the Dansgaard-Oeschger (DO) events, indicating that those global events were well documented in lake sediments in the Asian monsoon region. Because the grain size can be used as a proxy for water discharge, we suggest that signal of the DO events might be transmitted to lake evolution by Asian monsoon

Analysis of the fine-mesh subgroup method and its feasible improvement

The fine-mesh subgroup method (FSM) is proposed to treat the significant resonance self-shielding effect both effectively and accurately. Similar to the ultra-fine group method, the fine-mesh subgroup method adopts a fine group structure on the resonance energy range to avoid the extra resonance interference effect correction. To improve the efficiency, on the one hand, the one-group micro-level optimization is adopted, so the subgroup fixed-source equations will be only calculated on a certain number of pre-determined subgroup levels, and an interpolation process is employed to obtain the actual subgroup flux. On the other hand, the slowing-down calculation is carried out for group condensation for multigroup transport calculation. The main theory and feasible improvements of the fine-mesh subgroup method are analyzed in this paper. Several pin cell and lattice problems are applied to test the performance of the fine-mesh subgroup method, and the particle swarm optimization method is adopted to find the better group structure. The numerical results indicate a good performance both for accuracy and efficiency