How to address vaccine hesitancy? Lessons from National Hepatitis B Immunization Program in China

China, with the severe burden of hepatitis B, plays a significant role in the global efforts towards eliminating hepatitis B disease by 2030. Vaccination is recognized as the most effective measure to prevent infectious diseases. However, vaccine hesitancy remains a significant barrier to achieving herd immunity across diverse populations. To address this issue, the health ministries and public health authorities in China have implemented various measures to encourage hepatitis B vaccination. China’s National Hepatitis B Immunization Program, initiated in 1985, has been successful in controlling this vaccine-preventable disease. Given the challenges in eliminating hepatitis B, strengthening the National Hepatitis Immunization Program in China is of utmost importance. Through an analysis of policy documents, reports, and scientific papers, the history of the program was summarized, and effective approaches to address vaccine hesitancy were identified. This will help achieve universal health coverage of vaccines and effectively work towards meeting the goals set for 2030

Numerical simulation of the fluid dynamics within the tissue engineering scaffolds micro-tubes

The core of tissue engineering is the fabrication of a complex three-dimensional space with cells and biomaterials. In the development of porous scaffolds in vitro, no matter the seed cells ran into the scaffold, or its excretion of waste discharged scaffolds, they both need the nutrient solution to be brought into or taken out. Therefore, the flow of the nutrient solution, cells and metabolic waste for the profitable living in vitro culture plays a significant role. the paper constructed bone scaffold models of different geometric parameters, analog cells, and nutrient solution flow conditions in the scaffolds using the FLUENT software. By making a contrastive analysis with the simulated result, the internal organizational design parameters of scaffold for tissue engineering is optimized and a certain amount of data and a theoretical basis for the internal bone scaffold structure design is provided

Open Science Saves Lives: Lessons from the COVID-19 Pandemic

In the last decade Open Science principles, such as Open Access, study preregistration, use of preprints, making available data and code, and open peer review, have been successfully advocated for and are being slowly adopted in many different research communities. In response to the COVID-19 pandemic many publishers and researchers have sped up their adoption of some of these Open Science practices, sometimes embracing them fully and sometimes partially or in a sub-optimal manner. In this article, we express concerns about the violation of some of the Open Science principles and its potential impact on the quality of research output. We provide evidence of the misuses of these principles at different stages of the scientific process. We call for a wider adoption of Open Science practices in the hope that this work will encourage a broader endorsement of Open Science principles and serve as a reminder that science should always be a rigorous process, reliable and transparent, especially in the context of a pandemic where research findings are being translated into practice even more rapidly

Synthesis and White-Light Emission of ZnO/HfO2: Eu Nanocables

ZnO/HfO2:Eu nanocables were prepared by radio frequency sputtering with electrospun ZnO nanofibers as cores. The well-crystallized ZnO/HfO2:Eu nanocables showed a uniform intact core–shell structure, which consisted of a hexagonal ZnO core and a monoclinic HfO2 shell. The photoluminescence properties of the samples were characterized. A white-light band emission consisted of blue, green, and red emissions was observed in the nanocables. The blue and green emissions can be attributed to the zinc vacancy and oxygen vacancy defects in ZnO/HfO2:Eu nanocables, and the yellow–red emissions are derived from the inner 4f-shell transitions of corresponding Eu3+ ions in HfO2:Eu shells. Enhanced white-light emission was observed in the nanocables. The enhancement of the emission is ascribed to the structural changes after coaxial synthesis

Rural–Urban Inequalities in Poor Self-Rated Health, Self-Reported Functional Disabilities, and Depression among Chinese Older Adults: Evidence from the China Health and Retirement Longitudinal Study 2011 and 2015

The household registration system (Hukou) in China classifies persons into rural or urban citizens and determines eligibility for state-provided services and welfare. Not taking actual residence into account may underestimate rural–urban differences. This study investigates rural–urban inequalities in self-reported health outcomes among older adults aged 60+, taking into account both Hukou and actual residence, adjusting for sociodemographic determinants, based on the China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Self-Rated Health (SRH) was assessed with a single question, functional abilities were assessed with the Basic Activities of Daily Living (BADLs) and Instrumental Activities of Daily Living (IADLs) scales, and depression was assessed with the 10-item version of the Center for Epidemiologic Studies Depression Scale. Rural respondents had poorer socioeconomic status and higher prevalence of poor SRH, functional disabilities, and depression than urban respondents in both years, which were closely related to rural–urban differences in educational level and income. Impairments appeared at a younger age among rural respondents. Analyses using only Hukou registration and not actual residence resulted in underestimation of rural–urban differences. This study may serve as a basis for interventions to address rural–urban differences in health and social services and reduce health inequalities among Chinese older adults

Numerical simulation of the fluid dynamics within the tissue engineering scaffolds micro-tubes

The core of tissue engineering is the fabrication of a complex three-dimensional space with cells and biomaterials. In the development of porous scaffolds in vitro, no matter the seed cells ran into the scaffold, or its excretion of waste discharged scaffolds, they both need the nutrient solution to be brought into or taken out. Therefore, the flow of the nutrient solution, cells and metabolic waste for the profitable living in vitro culture plays a significant role. the paper constructed bone scaffold models of different geometric parameters, analog cells, and nutrient solution flow conditions in the scaffolds using the FLUENT software. By making a contrastive analysis with the simulated result, the internal organizational design parameters of scaffold for tissue engineering is optimized and a certain amount of data and a theoretical basis for the internal bone scaffold structure design is provided

Study on heat transfer enhancing performance of spiral groove tube in phase change heat storage for solar energy

Based on the energy storage problems for solar energy utilization and the advantages of spiral groove tube heat exchanger, spiral groove tubes are used in the solar energy phase change heat storage, with numerical simulation of the thermal storage process of heat reservoir. Firstly, the simulation method and the reliability of the used model are verified experimentally with smooth tube. Using spiral groove tube as water flow pipe and phase change material as heat storage medium, building the three-dimensional model by Gambit software and meshing by ICEM, the heat storage process in the spiral groove tube and smooth tube heat storage are numerically simulated while the heat transfer enhancing effect is investigated. The influence of structural parameters such as groove pitch and groove depth on the heat storage process is simulated numerically and the influence rules are analyzed. The results show that the convective heat transfer intensity and heat transfer capability are enhanced when the smooth tubes are substituted by spiral groove tubes in the phase change heat storage and the heat storage time become shorter. In the range of simulation, the optimal structural parameters of spiral groove tube is that the groove pitch p=7 mm and groove depth e=0.4 mm. The further improved design of phase change thermal storage can be realized in later research in-depth

Numerical simulation of the fluid dynamics within the tissue engineering scaffolds micro-tubes

The core of tissue engineering is the fabrication of a complex three-dimensional space with cells and biomaterials. In the development of porous scaffolds in vitro, no matter the seed cells ran into the scaffold, or its excretion of waste discharged scaffolds, they both need the nutrient solution to be brought into or taken out. Therefore, the flow of the nutrient solution, cells and metabolic waste for the profitable living in vitro culture plays a significant role. the paper constructed bone scaffold models of different geometric parameters, analog cells, and nutrient solution flow conditions in the scaffolds using the FLUENT software. By making a contrastive analysis with the simulated result, the internal organizational design parameters of scaffold for tissue engineering is optimized and a certain amount of data and a theoretical basis for the internal bone scaffold structure design is provided

A CC-Type IPT System Based on S/S/N Three-Coil Structure to Realize Low-Cost and Compact Receiver

The characteristics of load-independent constant current (CC) output and zero phase angle (ZPA) operation are required in many scenarios of inductive power transfer (IPT) applications. However, the existing topologies with CC output characteristics usually need to introduce additional compensation components on the receiving side to compensate for reactive power and achieve the preset function. This not only increases the occupied space of the receiving side, but also increases the cost and weight. Therefore, this study proposes a new IPT system based on an S/S/N three-coil structure. The proposed system can achieve the CC output function and an operation nearly ZPA and zero-voltage switching (ZVS) through flexible parameter design. Moreover, there are no compensation components on the receiving side of the proposed system, which guarantees a low-cost, lightweight, and compact receiver. Firstly, a comprehensive analysis of the proposed S/S/N three-coil structure IPT system that implements CC output characteristics and ZPA operation is provided. Then, the conditions for realizing ZVS are discussed in terms of parameter design and the sensitivity of CC output characteristics to the changes in compensation capacitance parameters. Furthermore, the proposed S/S/N three-coil structure IPT system is compared with previous related studies to reflect its advantages. Finally, the correctness of the theory is verified by simulation and experiment