Determinative developmental cell lineages are robust to cell deaths

All forms of life are confronted with environmental and genetic perturbations, making phenotypic robustness an important characteristic of life. Although development has long been viewed as a key component of phenotypic robustness, the underlying mechanism is unclear. Here we report that the determinative developmental cell lineages of two protostomes and one deuterostome are structured such that the resulting cellular compositions of the organisms are only modestly affected by cell deaths. Several features of the cell lineages, including their shallowness, topology, early ontogenic appearances of rare cells, and non-clonality of most cell types, underlie the robustness. Simple simulations of cell lineage evolution demonstrate the possibility that the observed robustness arose as an adaptation in the face of random cell deaths in development. These results reveal general organizing principles of determinative developmental cell lineages and a conceptually new mechanism of phenotypic robustness, both of which have important implications for development and evolution

Before the Morning After

This paper presents a wearable biopatch prototype for body surface potential measurement. It combines three key technologies, including mixed-signal system on chip (SoC) technology, inkjet printing technology, and anisotropic conductive adhesive (ACA) bonding technology. An integral part of the biopatch is a low-power low-noise SoC. The SoC contains a tunable analog front end, a successive approximation register analog-to-digital converter, and a reconfigurable digital controller. The electrodes, interconnections, and interposer are implemented by inkjet-printing the silver ink precisely on a flexible substrate. The reliability of printed traces is evaluated by static bending tests. ACA is used to attach the SoC to the printed structures and form the flexible hybrid system. The biopatch prototype is light and thin with a physical size of 16 cm x 16 cm. Measurement results show that low-noise concurrent electrocardiogram signals from eight chest points have been successfully recorded using the implemented biopatch.QC 20130805. Updated from accepted to published.</p

STUDY ON A MODEL OF THE EQUIPMENT MRO SERVICE INFORMATION SYSTEMS

The MRO(Maintenance、Repair and Operations) System for the Large Equipment has been becoming a strong support pattern for the agile service support. To build agile service system and identify a portfolio of computer-based integrated applications, a cross-enterprise strategic information systems planning (SISP) is a key concern. An integrated framework for a large equipment support system service chain is analyzed and Strategic information systems planning task is discussed. Integrated the cross-enterprise business process component and inter-organization management policy, the strategic information systems model for a large equipment MRO service support system is proposed. Key words: Strategic information systems, MRO, Service chai

Final stage of merging binaries of supermassive black holes: observational signatures

There are increasing interests in binary supermassive black holes (SMBHs), but merging binaries with separations smaller than ~1 light days (~10^2 gravitational radii for 10^8 Msun), which are rapidly evolving under control of gravitational waves, are elusive in observations. In this paper, we discuss fates of mini-disks around component SMBHs for three regimes: 1) low rates (advection-dominated accretion flows: ADAFs); 2) intermediate rates; 3) super-Eddington accretion rates. Mini-disks with intermediate rates are undergoing evaporation through thermal conduction of hot corona forming a hybrid radial structure. When the binary orbital periods are shorter than sound propagation timescales of the evaporated mini-disks, a new instability, denoted as sound instability, arises because the disks will be highly twisted so that they are destroyed. We demonstrate a critical separation of A_{crit}~10^2 Rg from the sound instability of the mini-disks and the cavity is full of hot gas. For those binaries, component SMBHs are accreting with Bondi mode in the ADAF regime, showing periodic variations resulting from Doppler boosting effects in radio from the ADAFs due to orbital motion. In the mean while, the circumbinary disks (CBDs) are still not hot enough (ultraviolet deficit) to generate photons to ionize gas for broad emission lines. For slightly super-Eddington accretion of the CBDs, MgII line appears with decreases of UV deficit, and for intermediate super-Eddington Balmer lines appear, but CIV line never unless CBD accretion rates are extremely high. Moreover, if the CBDs are misaligned with the binary plane, it is then expected to have optical periodical variations with about ten times radio periods.Comment: 10 pages, 3 figures; accepted to MNRA