The Era of Radiogenomics in Precision Medicine: An Emerging Approach to Support Diagnosis, Treatment Decisions, and Prognostication in Oncology

With the rapid development of new technologies, including artificial intelligence and genome sequencing, radiogenomics has emerged as a state-of-the-art science in the field of individualized medicine. Radiogenomics combines a large volume of quantitative data extracted from medical images with individual genomic phenotypes and constructs a prediction model through deep learning to stratify patients, guide therapeutic strategies, and evaluate clinical outcomes. Recent studies of various types of tumors demonstrate the predictive value of radiogenomics. And some of the issues in the radiogenomic analysis and the solutions from prior works are presented. Although the workflow criteria and international agreed guidelines for statistical methods need to be confirmed, radiogenomics represents a repeatable and cost-effective approach for the detection of continuous changes and is a promising surrogate for invasive interventions. Therefore, radiogenomics could facilitate computer-aided diagnosis, treatment, and prediction of the prognosis in patients with tumors in the routine clinical setting. Here, we summarize the integrated process of radiogenomics and introduce the crucial strategies and statistical algorithms involved in current studies

Interference-aware coordinated power allocation in autonomous Wi-Fi environment

Self-managed access points (APs) with growing intelligence can optimize their own performances but pose potential negative impacts on others without energy ef ciency. In this paper, we focus on modeling the coordinated interaction among interest-independent and self-con gured APs, and conduct the power allocation case study in the autonomous Wi-Fi scenario. Speci cally, we build a `coordination Wi-Fi platform (CWP), a public platform for APs interacting with each other. OpenWrt-based APs in the physical world are mapped to virtual agents (VAs) in CWP, which communicate with each other through a standard request-reply process de ned as AP talk protocol (ATP).With ATP, an active interference measurement methodology is proposed re ecting both in-range interference and hidden terminal interference, and the Nash bargaining-based power control is further formulated for interference reductions. CWP is deployed in a real of ce environment, where coordination interactions between VAs can bring a maximum 40-Mb/s throughput improvement with the Nash bargaining-based power control in the multi-AP experiments

Rotective effect of Fengliao-Changweikang extracts, a traditional Chinese herbal medicine formula,on mucosa in rat with chronic gastritis

Background: Fengliao-Changwei-Kang(FCK), the Chinese patent drug, is a famous traditional Chinese herbal medicine formula. It has a significant effect on the clinic treatment of gastrointestinal diseases  including gastritis, enteritis and diarrhea for many years. However, there is few research on the  protective effects of FCK on the gastric mucosa of chronic gastritis (CG) model rat. Objective: The present study aimed to explore the effects of FCK extract on mucosa in rats with Chronic Gastritis.Materials and Methods: 50 SD mice were randomly divided into 5 groups with 10 in each group（five per sex). The groups are respectively control group, model group, low, middle and high FCK extracts (FCK I, II and III) group. The CG rat model was induced by synthetic methods. FCK I, II and III group were  administrated with FCK extracts at 2.16g• kg, 4.32g• kg, 8.94g• kg once per day for 21 consecutive  days, and the control group and model group were administrated the same volume of distilled water at 10mL/kg once per day. 16 hours after the last administration, the rats were anesthetized and their blood and stomach were drawn from vena cava and abdominal cavity. The serum levels of EGF was measured by enzyme linked immunosorbent assay(ELISA) method, the expression of growth factor receptor (EGFR) in gastric mucosa was detected by immunohistochemical method, and the mRNA expressions of NF-κB p65 was detected in-situ hybridization.Results: The inflammation grades and the expressions of NF-κB p65 mRNA in gastric mucosa of the model group were markedly higher than those of the control group (P<0.05). The inflammation grades of gastric mucosa and the expressions of NF-κB p65 mRNA in gastric mucosa the FCK extract group are significantly lower than those of the model group, and the FCK extract group at 8.64g/kg could greatly increase the serum levels of EGF and the expressions of EGFR in gastric mucosa. High EGF level was found in FCK extract group at 4.32g/kg, but low in FCK extract groups at 2.16g/kg. There were no marked differences among the rats from control group, model group and FCK extract group on ratio of Ll/L2 (P>0.05).Conclusions: FCK extract could alleviate mucosal inflammation by down regulating the expressions of NF-κB p65 mRNA and promote tissue repair by up regulating EGFR expression in gastric mucosa cell.Keywords: chronic gastritis; fengliao-changwei-kang extract; epidermal growth factor receptor; nuclear factor kappa B

Geographical, meteorological and vectorial factors related to malaria re-emergence in Huang-Huai River of central China

<p/> <p>Background</p> <p>Malaria still represents a significant public health problem in China, and the cases dramatically increased in the areas along the Huang-Huai River of central China after 2001. Considering spatial aggregation of malaria cases and specific vectors, the geographical, meteorological and vectorial factors were analysed to determine the key factors related to malaria re-emergence in these particular areas.</p> <p>Methods</p> <p>The geographic information of 357 malaria cases and 603 water bodies in 113 villages were collected to analyse the relationship between the residence of malaria cases and water body. Spearman rank correlation, multiple regression, curve fitting and trend analysis were used to explain the relationship between the meteorological factors and malaria incidence. Entomological investigation was conducted in two sites to get the vectorial capacity and the basic reproductive rate to determine whether the effect of vector lead to malaria re-emergence.</p> <p>Results</p> <p>The distances from household of cases to the nearest water-body was positive-skew distributed, the median was 60.9 m and 74% malaria cases were inhabited in the extent of 60 m near the water body, and the risk rate of people live there attacked by malaria was higher than others(<it>OR </it>= 1.6, 95%<it>CI </it>(1.042, 2.463), <it>P </it>< 0.05). The annual average temperature and rainfall may have close relationship with annual incidence. The average monthly temperature and rainfall were the key factors, and the correlation coefficients are 0.501 and 0.304(<it>P </it>< 0.01), respectively. Moreover, 75.3% changes of monthly malaria incidence contributed to the average monthly temperature (T_mean), the average temperature of last two months(T_mean01) and the average rainfall of current month (R_mean) and the regression equation was Y = -2.085 + 0.839I₁+ 0.998T_mean0- 0.86T_mean01+ 0.16R_mean0. All the collected mosquitoes were <it>Anopheles sinensis</it>. The vectorial capacity and the basic reproductive rate of <it>An. sinensis </it>in two sites were 0.6969, 0.4983 and 2.1604, 1.5447, respectively.</p> <p>Conclusion</p> <p>The spatial distribution between malaria cases and water-body, the changing of meteorological factors, and increasing vectorial capacity and basic reproductive rate of <it>An. sinensis </it>leaded to malaria re-emergence in these areas.</p

A study of the fire smoke propagation in subway station under the effect of piston wind

A running traffic train induces piston wind in the subway. The influence of piston wind on fire smoke propagation in subway is investigated numerically. The flow field structure in fire platform, temperature contours and velocity profiles at certain positions are obtained at various scenarios respectively. Three methods are adopted to reduce the impact of piston wind on smoke layers. Results show that large-scale vortexes and tremendous horizontal inertial force would be produced under the influence of piston wind; and that smoke stratification would be broken totally under its influence, therefore toxic gas would spread to subway hall through stairs. So the former smoke management system in a subway station becomes less effective. Results also show that combination of enhanced the volume flux of pressurization at the subway hall and lowering the height of smoke screens around stairs are necessary to restrict hazard smoke on the floor on fire. The bypass wind tunnel and ventilation shaft are useful to attenuate the magnitude of piston wind