Awareness, knowledge and acceptance of community on a non-communicable disease intervention – findings from the “Healthy Community, Developed Nation” (KOSPEN) in the Southern Zone of Peninsular Malaysia

Introduction Community-based health promotion programme has been recognised to reduce modifiable lifestyle risk behaviours for non-communicable diseases. The aim of this study was to evaluate the proportion of the awareness, knowledge and acceptance of a community-based intervention programme, “Komuniti Sihat, Pembina Negara“ (KOSPEN) (Healthy Community, Developed Nation). Methods This cross-sectional study employed a two-stage proportionate sampling method to select a representative sample of communities in the Southern states of Peninsular Malaysia, Negeri Sembilan, Malacca, and Johor. Face-to-face interviews by trained research assistants using pre-validated questionnaires was the study tool applied. Results The study revealed that approximately two thirds of respondents were aware of the KOSPEN programme (65.5%) and almost half (45.4%) of them were involved in the health promotion activities, namely health screenings (84.8%), health talks (66.4%), and providing plain water in formal occasion (52.9%). About two thirds and one-quarter of them have a very good (73.4%) and good (24.1%) general view on this programme. Four out of ten respondents faced difficulties joining the activities. Lack of time (83.0%) was reported as the main barrier. Conclusions The KOSPEN programme in overall was moderately accepted by the community. However, the need for future improvement has to be highlighted in order to enhance the involvement and participation of the communities

Support of smoking restriction in public areas among adolescents in Malaysia-the findings from tobacco and e-cigarette survey among adolescents in Malaysia (TECMA)

Adolescents are the future generation, and their support for smoke-free policies might create momentum for future stringent smoke-free initiatives. This study aimed to determine the levels and factors associated with support for smoking in public areas among Malaysian school-going adolescents aged 10-19 years. The data were derived from the Tobacco and E-cigarettes among adolescents in Malaysia (TECMA), which employed the cross-sectional study design and multistage sampling to select the representative samples of school-going adolescents. Data was obtained through self-administered of pre-validated questionnaire. Descriptive study, cross-tabulation and multivariable analysis were used for analysis. Majority of respondents supported smoking restriction in public areas (86.3%, 95 CI 85.4-87.1). The proportion and likelihood of support of smoke-free initiative were higher among respondents with better knowledge of the harmful effects of second-hand smoke (SHS), been taught in school about the health effects of smoking, older age group (16-19 years), female, those students schooling in urban areas, Malay and other Bumiputras from Sabah and Sarawak. However, current smokers and ECV users were less likely to support smoke-free initiatives in public areas. The level of support for smoke-free initiative in public areas was high among youths in Malaysia, and this might offer promising prospects to expand the non-smoking areas to more public areas in the future

Targeted drug delivery system:- formulation and evaluation of chitosan nanospheres containing doxorubicin hydrochloride

A chitosan molecule form self-assembled nanoparticles that can encapsulate a quantity of drugs and deliver them to a specific site. Chemical attachment of drug to chitosan throughout the functional linker has possibility to produce useful prodrugs, exhibiting biological activity at target site. In vivo residence time of the dosage form in the gastrointestinal tract and bioavailability of various drugs increases by mucoadhesive and absorption enhancement properties of chitosan. Antitumour activity of doxorubicin(DOX)-incorporated nanoparticles in vitro on DOX- resistant C6 glioma cells. Nanoparticles showed increased cytotoxicity compared to DOX alone. These results suggest that doxorubicin (DOX) was unable to penetrate into cells and did not effectively inhibit cell proliferation. In contrast, nanoparticles can penetrate into cells and effectively inhibit cell proliferation. There are 3 batches of drug loaded nanospheres in which 2.5mg,5mg and 10mg of DOX were loaded into nanospheres where the concentration of chitosan is 1%w/v. Anticancer drugs without targeting a specific site cause side effects. The objective of this research is to reduce side effects. HPLC device was used to quantitatively analyze amount of doxorubicin loaded in nanospheres. The result had showed concentration of anticancer drug loaded in nanospheres is directly proportional to the drug payload capacity until saturation point. The in vitro drug release studies was carried out for 48 hours to obtain a more precise result by carrying out this studies in a medium resembling our body environment such as pH7.4, 37ºC with analytical grade water for this studies. In vitro release of doxorubicin is of zero order kinetic. This shows that release is independent of the concentration of drug loaded in the nanospheres. Besides that, the graphs also show a sustained release manner, indicating these nanospheres formulation are suitable for targeting drug delivery system and for efficient treatment of cancerous cells

Prevalence and factors associated with smoking cessation among elderly in Malaysia- A findings from the population-based study

Introduction: The information of prevalence and associated factor(s) with smoking cessation among the elderly will assist in formulating the suitable policies and reducing the mortality among Malaysian elderly due to smoking-related diseases. This paper aims to describe the prevalence and factor(s) associated with smoking cessation among Malaysian elderly. Methods: We carried out the population-based study using the cross-sectional study design and a sample size of 2,674 respondents obtained via a multistage sampling method. Validated questionnaire and face-to-face interviews approach were the methodologies employed to collect data from the selected respondents. The interview was conducted by trained enumerator using a standardized and validated questionnaire. Descriptive and multiple logistic regression were used in data analysis. Results: The present findings demonstrated that almost 1 out of 10 of Malaysian elderly are current smokers. The prevalence of smoking was significantly higher among men (28.1%) compared to women (2.9%). Multivariable analysis showed that males and other ethnicities were less likely to cease smoking, while those with advancing age were more likely to stop smoking compared to the younger-aged elderly. Based on multivariate analysis, diabetes, hypertension and hypercholesterolemia were not significant factors associated with smoking cessation. Conclusions: The study has shown a low proportion of Malaysian elderly is ex- smoker. Suitable measures and programmes should be formulated and implemented to increase the quit smoking rate among them and subsequently to increase the quality of life by reducing the burden of smoking-related disease among the Malaysian elderly

ASIC Layout Design-Space Exploration of Pan-and-Tompkins Pre-Processing Algorithm for High Efficiency Electrocardiogram Monitor

Cardiovascular diseases (CVDs) is the leading cause of the death globally. Ambulatory Electrocardiogram (ECG) and mobile monitoring is very important for early heart disease detection and prevention, but its measurement normally contains various types of noise which affect the analysis accuracy. Moreover, long hour ECG monitoring requires an efficient architecture to support real-time processing and low power consumption. This paper presents an application specific integrated circuit (ASIC) design of Pan-and-Tompkins ECG pre-processing algorithm which aims to remove several unwanted noise to increase analysis accuracy. The complete design flow covers high-level algorithm modelling in Matlab, followed by synthesizable design at Register Transfer Level (RTL) until logic synthesis, physical synthesis and static timing analysis to produce VLSI layout. Several power optimization techniques as well as different ASIC process technology libraries in terms of SilTerra’s 180nm CMOS Logic Generic Library (CL180G) and Synopsys 32nm Generic Library (SAED32) are deployed for design-space exploration to study the design trade-off in terms of power consumption, timing performance, and the logic area usage. Results show that the clock gating technique is able to reduce 32.4% of dynamic power in design using CL180G generic library, whereas the integration of several power optimization techniques using SAED32 generic library is able to reduce 43.82% of dynamic power, 91.21% of leakage power and 91.25% of total power

Construct validity and reliability of Malay language-perception towards smoking questionnaire (BM-PTSQ) among secondary school adolescents

Multitude studies have demonstrated that perception is an integral factor associated with smoking. However, no such tool was available in the Malay language. In this study, we established a Bahasa Malaysia version of PTSQ (BM-PTSQ) and tested the validity and reliability among secondary school adolescents. The English version of PTSQ originally consists of 12 items. It was translated into Bahasa Malaysia and back-translated again into English to check for consistency. After face validity (face-to-face query) was determined among 20 secondary school adolescents, only 10 items were included in the survey. Construct validity was established from 407 school adolescents through random selection in the same locality. More than 60% of the respondents were female, while the majority of them (67.3%) were schooling in rural areas. Then, the reliability of the questionnaire was determined with Cronbach’s alpha. The Exploratory Factor Analysis (EFA) has grouped PTSQ into two components associated with either knowledge or attitude towards smoking. The variance and Cronbach’s alpha for the first and second components were 38.24% and 0.861 (7 items), 21.62% and 0.661 (3 items), respectively. The PTSQ showed good validity and reliability for measuring perception of smoking among secondary school-going adolescents in Malaysia. Hence, this is a viable measurement tool. But, more importantly, this study showed an urgent need to improve smoking education among adolescents in Malaysia

3,4-Diaminopyrazolo[3,4-d]pyrimidines: a new three-component microwave-assisted synthesis and anti-leukemic properties

A convenient method for the synthesis of N3,N4-disubstituted 3,4-diaminopyrazolo[3,4-d]pyrimidines was developed using a three-component reaction of 3,5-diaminopyrazole-4-carbonitriles with primary amines and orthoesters. The preparation of 114 examples demonstrated the good scope of the reaction, which tolerated variations in the substrate structure and was particularly efficient under microwave irradiation. The short reaction time and chromatographyfree product isolation add practicality to this method. The anti-leukemic activity was assessed in vitro using K562 and Jurkat T cells, and the selectivity of the most active compounds was 3 evaluated using non-cancerous MRC5 cells. The most promising compound inhibited Jurkat T cells with a GI50 value of 0.5 µM and a selectivity index of 64

Controlling the Assembly of Cellulose-Based Oligosaccharides through Sequence Modifications

Peptides and nucleic acids with programmable sequences are widely explored for the production of tunable, self-assembling functional materials. Herein we demonstrate that the primary sequence of oligosaccharides can be designed to access materials with tunable shapes and properties. Synthetic cellulose-based oligomers were assembled into 2D or 3D rod-like crystallites. Sequence modifications within the oligosaccharide core influenced the molecular packing and led to the formation of square-like assemblies based on the rare cellulose IVII allomorph. In contrast, modifications at the termini generated elongated aggregates with tunable surfaces, resulting in self-healing supramolecular hydrogels