322 research outputs found
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Courtesan, Concubine, Whore: Apollodorus' Deliberate Use Of Terms For Prostitutes
This article examines Apollodorus' use of the terms 'hetaira', 'pallake', and 'porne' in the speech >Against Neaira>. It argues that he employs these terms with consistency and with attention to differences among them rather than haphazardly or interchangeably as was previously believed. Apollodorus' distinctions among types of prostitutes are further clarified through comparisons with his use of the terms in other speeches. Finally there is a reexamination of the famous statement on the existence of three types of women in society. By resituating this claim in its oratorical context, I show that it is not an all-inclusive remark on women's roles but rather a statement quite specific to Apollodorus' attack on Neaira.Classic
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Crowning Thersites : the relevance of invective in Athenian forensic oratory
textThis dissertation examines the function and relevance of invective in late 4th century oratory. I bring together recent approaches to performance, humor, and legal studies in order to reevaluate the role of character depiction, and especially character assassination, in forensic rhetoric. Both on the comic stage and in the courts, evoking derisive laughter from the audience was an important mechanism for effecting social control. I demonstrate how the orators draw from Old and Middle Comedy to depict opponents as character types, like braggarts (alazones), flatterers (kolakes), and comic prostitutes (male hetairai/pornoi). I argue further that speakers do not use invective to skirt legal issues; rather, they tailor their arguments about character to the legal charge. In the Athenian system, the concept of legal relevance was broad and subject to manipulation. The only mechanism of restraint on a speaker was the threat of being shouted down (thorubos) by the jury. Invective, therefore, was not automatically âout of boundsâ. Moreover, issues of character and morality were of increasing public concern in 4th-century Athens (as evidenced by Xenophon, Middle Comedy, and oratory alike). To the minds of Athenian jurors, information about character provided important evidence for reaching a just verdict.Classic
Epithelial laminin α5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung
AbstractLaminin α5 is prominent in the basement membrane of alveolar walls, airways, and pleura in developing and adult lung. Targeted deletion of laminin α5 in mice causes developmental defects in multiple organs, but embryonic lethality has precluded examination of the latter stages of lung development. To identify roles for laminin α5 in lung development, we have generated an inducible lung epithelial cell-specific Lama5 null (SP-CLama5fl/â) mouse through use of the Cre/loxP system, the human surfactant protein C promoter, and the reverse tetracycline transactivator. SP-CLama5fl/â embryos exposed to doxycycline from E6.5 died a few hours after birth. Compared to control littermates, SP-CLama5fl/â lungs had dilated, enlarged distal airspaces, but basement membrane ultrastructure was preserved. Distal epithelial cell differentiation was perturbed, with a marked reduction of alveolar type II cells and a virtual absence of type I cells. Cell proliferation was reduced and apoptosis was increased. Capillary density was diminished, and this was associated with a decrease in total lung VEGF production. Overall, these findings indicate that epithelial laminin α5, independent of its structural function, is necessary for murine lung development, and suggest a role for laminin α5 in signaling pathways that promote alveolar epithelial cell differentiation and VEGF expression
High asymptomatic carriage with the Omicron variant in South Africa
We report a 23% asymptomatic severe acute respiratory syndrome
coronavirus 2 (SARS CoV-2) Omicron carriage rate in
participants being enrolled into a clinical trial in South Africa,
15-fold higher than in trials before Omicron. We also found
lower CD4 + T-cell counts in persons with human immunodeficiency
virus (HIV) strongly correlated with increased odds of
being SARS-CoV-2 polymerase chain reaction (PCR) positive.The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) grants. The Sisonke study was funded by the National Treasury of South Africa; the National Department of Health; Solidarity Response Fund NPC; The Michael & Susan Dell Foundation; The Elma Vaccines and Immunization Foundation; and the Bill & Melinda Gates Foundation.https://academic.oup.com/cidam2023Paediatrics and Child Healt
Initial sequencing and analysis of the human genome
The human genome holds an extraordinary trove of information about human development, physiology, medicine and evolution. Here we report the results of an international collaboration to produce and make freely available a draft sequence of the human genome. We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62798/1/409860a0.pd
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