429 research outputs found

    Branes and Calibrated Geometries

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    The fivebrane worldvolume theory in eleven dimensions is known to contain BPS threebrane solitons which can also be interpreted as a fivebrane whose worldvolume is wrapped around a Riemann surface. By considering configurations of intersecting fivebranes and hence intersecting threebrane solitons, we determine the Bogomol'nyi equations for more general BPS configurations. We obtain differential equations, generalising Cauchy-Riemann equations, which imply that the worldvolume of the fivebrane is wrapped around a calibrated geometry.Comment: Latex, 35 pages. References added, minor change

    Smart Wheelchair with Dual Control using Touchpad and Android Mobile Device

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    The general objective of the design was to develop a touchpad controlled Android-based electronic wheelchair. It aimed to construct the Android-based circuitry and program for the path finding mechanism of the drive system and interface the Arduino-based circuit to the electronic wheelchair setup. It was designed to evaluate the system in terms of the speed of the electronic wheelchair, reliability of the sensors to avoid obstacle, and ease of use of the wheelchair. C Programming Language was used by the system to control and manipulate the microcontroller, Gizduino AtMega644. The Android application was programmed using the Java Language and Eclipse as the IDE. Its ports were used to interface input and output devices such as the ultrasonic sensors, infrared proximity sensor, touchpad, Bluetooth module, motor and motor driver. There was a satisfactory rating for the evaluation of the system while the Android software was rated excellent as a navigational controller

    Orexin receptors in GtoPdb v.2021.3

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    Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [42]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [109]. Currently the only orexin receptor ligands in clinical use are suvorexant and lemborexant, which are used as hypnotics. Orexin receptor crystal structures have been solved [134, 133, 54, 117, 46]

    SPECIAL COMMUNICATION Health Industry Practices That Create Conflicts of Interest A Policy Proposal for Academic Medical Centers

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    market incentives in the United States is posing extraordinary challenges to the principles of medical professionalism. Physicians’ commitment to altruism, putting the interests of the patients first, scientific integrity, and an absence of bias in medical decision making now regularly come up against financial conflicts of interest. Arguably, the most challenging and extensive of these conflicts emanate from relationships between physicians and pharmaceutical companies and medical device manufacturers. 1 As part of the health care industry

    Orexin receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

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    Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [39]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [102]. Currently the only orexin receptor ligand in clinical use is suvorexant, which is used as a hypnotic. Orexin receptor crystal structures have been solved [124, 123]

    Orexin receptors in GtoPdb v.2023.1

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    Orexin receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Orexin receptors [43]) are activated by the endogenous polypeptides orexin-A and orexin-B (also known as hypocretin-1 and -2; 33 and 28 aa) derived from a common precursor, preproorexin or orexin precursor, by proteolytic cleavage and some typical peptide modifications [117]. Orexin signaling has been associated with regulation of sleep and wakefulness, reward and addiction, appetite and feeding, pain gating, stress response, anxiety and depression. Currently the orexin receptor ligands in clinical use are the dual orexin receptor antagonists suvorexant and lemborexant and daridorexant, which are used as hypnotics, and several dual and OX2-selective antagonists are under development. Multiple orexin agonists are in development for the treatment of narcolepsy and other sleep disorders. Orexin receptor 3D structures have been solved [146, 144, 55, 126, 47, 109, 7, 145]

    Distress Signal Tracker Using GPS and SMS Technology: A Prototype

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    There is no time in history that tracking has become a part and parcel of almost everyone’s lives than it is today. Due to the need of a device that enables easy access in locating a particular person, things or vehicles, the proponents aim to develop a study which comprises of the communication between a distress signal tracker incorporated in a server through mobile communication (SMS) that contributes to public safety, delivers accurate location of the user to the corresponding recipients and provides a real-time monitoring system using VB.Net and MySQL. The method of research used, in this study, is experimental method which involves the identification of response time and availability of the network signal. A series of testing was performed in 30 different locations in Calamba, Laguna demonstrating the versatility and accuracy of the device and server under various circumstances. Based from the evaluation of the data gathered, the results are proved to satisfy the required objectives and specifications of the study
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