309 research outputs found
Particle image velocimetry measurements of blood flow in a modeled carotid artery bifurcation
Cardiovascular diseases are on of the leading causes of mortality and morbidity in the western world. Amongst these diseases, atherosclerosis, a progressive narrowing of the arterial wall is one of the most severe and if untreated may lead to stroke or ischemic infarction. Fluid mechanic forces are a key player in the early development and progression of atherosclerosis and a better understanding of the interplay between haemodynamic and vascular diseases is needed. The carotid artery (CA) in one of the predominant sites of atherosclerotic plaque formation. In this work a transparent, scaled model of an average human carotid artery (AHCA) bifurcation was constructed and steady blood flow at Re = 290 and Re = 700 was simulated using an aqueous glycerin solution. Particle Image Velocimetry (PIV) measurements were performed in the plane of bifurcation and three axial planes in the carotid sinus. Flow inside the CA bifurcation was found to be three-dimensional with strong secondary currents due to the curvature of the vessel. An accurate method for wall shear stress (WSS) calculation along the outer internal carotid artery (ICA) wall is introduced. The method was tested against synthetically generated particle images and was found to perform best for an 8x8 pix2 interrogation windows. A large low momentum flow region with low WSS along the outer ICA wall exists, posing the potential for atherosclerotic plaque formation. Calculated WSS ranged between 0 and 21. Pa and compared well with in-vivo data
Airflow in a Domestic Kitchen Oven measured by Particle Image Velocimetry
Particle Image Velocimetry (PIV) was used to map the internal airflow of a domestic kitchen oven. Oven cooking performance is dependant on the airflow within the cavity. Previous flow measurement techniques such as hot wire anemometry and pitot probes are very time consuming and prone to error in the hot recirculating flow in an oven. The oven cavity, a commercially available mid-range oven, was modified for optical access. The PIV system consisted of a CCD camera, light sheet illumination from a pulsed Nd:YAG laser, and propanediol droplets and hollow glass spheres with a Stokes number of less than 0.055. Experiments were conducted in an empty oven at room temperature and at 180oC, and at 180oC with a single cooking tray installed. Velocity fields were measured in seven adjacent, coplanar object planes each on four different planes in the oven. The velocity data was averaged to yield mean flow fields, and the seven coplanar data fields were subsequently collaged to produce a full cross-sectional velocity map for each oven plane. In the cold and hot empty cavity a single vortex centred on the fan axis was seen, with strong radial flow. The maximum measured velocity in the cold oven was 1.8ms-1, which compared well with earlier hot-wire measurements. When a tray was introduced, the single vortex was replaced by three circulatory features. Shear flow was seen on both upper and lower sides of the tray, with a lower velocity and a stagnation point on the upper side
Experimental measurement of breath exit velocity and expirated bloodstain patterns produced under different exhalation mechanisms
In an attempt to obtain a deeper understanding of the factors which determine the characteristics of expirated bloodstain patterns, the mechanism of formation of airborne droplets was studied. Hot wire anemometry measured air velocity, 25 mm from the lips, for 31 individuals spitting, coughing and blowing. Expirated stains were produced by the same mechanisms performed by one individual with different volumes of a synthetic blood substitute in their mouth. The atomization of the liquid at the lips was captured with high-speed video, and the resulting stain patterns were captured on paper targets. Peak air velocities varied for blowing (6 to 64 m/s), spitting (1 to 64 m/s) and coughing (1 to 47 m/s), with mean values of 12 m/s (blowing), 7 m/s (spitting) and 4 m/s (coughing). There was a large (55–65%) variation between individuals in air velocity produced, as well as variation between trials for a single individual (25–35%). Spitting and blowing involved similar lip shapes. Blowing had a longer duration of airflow, though it is not the duration but the peak velocity at the beginning of the air motion which appears to control the atomization of blood in the mouth and thus stain formation. Spitting could project quantities of drops at least 1600 mm. Coughing had a shorter range of near 500 mm, with a few droplets travelling further. All mechanisms could spread drops over an angle >45°. Spitting was the most effective for projecting drops of blood from the mouth, due to its combination of chest motion and mouth shape producing strong air velocities. No unique method was found of inferring the physical action (spitting, coughing or blowing) from characteristics of the pattern, except possibly distance travelled. Diameter range in expirated bloodstains varied from very small (<1 mm) in a dense formation to several millimetres. No unique method was found of discriminating expirated patterns from gunshot or impact patterns on stain shape alone. Only 20% of the expirated patterns produced in this study contained identifiable bubble rings or beaded stains
Utility of cardiovascular magnetic resonance in pregnancy
Pregnant women with known or suspected cardiovascular disease (CVD) often require cardiovascular imaging during pregnancy. Decisions about imaging in pregnancy are premised on understanding the physiology of pregnancy, understanding basic concepts of different imaging modalities, the clinical manifestations of existent CVD in pregnancy and features of new CVD. Cardiovascular magnetic resonance (CMR) imaging is safe in pregnancy and is not associated with any adverse foetal effects, provided there are no general contra-indications to magnetic resonance (MR) imaging. CMR also does not involve any ionising radiation. In pregnancy, CMR is useful to confirm diagnosis of CVD, assess disease severity, to stratify risk and prognosticate, to plan appropriate management, and to assess response to therapy. Use of any imaging test in pregnancy needs to have safety considerations balanced against the importance of accurate diagnosis and thorough assessment of the pathological condition. This review summarises the evolving role of CMR in evaluation of known or suspected new CVD in pregnancy
Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.
There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an understanding of preclinical causal biomarkers to help target disease pathogenesis in the earliest phases remains elusive. Here, we investigated whether 19 metabolites previously associated with midlife cognition-a preclinical predictor of AD-translate to later clinical risk, using Mendelian randomization (MR) to tease out AD-specific causal relationships. Summary statistics from the largest genome-wide association studies (GWASs) for AD and metabolites were used to perform bidirectional univariable MR. Bayesian model averaging (BMA) was additionally performed to address high correlation between metabolites and identify metabolite combinations that may be on the AD causal pathway. Univariable MR indicated four extra-large high-density lipoproteins (XL.HDL) on the causal pathway to AD: free cholesterol (XL.HDL.FC: 95% CI = 0.78 to 0.94), total lipids (XL.HDL.L: 95% CI = 0.80 to 0.97), phospholipids (XL.HDL.PL: 95% CI = 0.81 to 0.97), and concentration of XL.HDL particles (95% CI = 0.79 to 0.96), significant at an adjusted P < 0.009. MR-BMA corroborated XL.HDL.FC to be among the top three causal metabolites, in addition to total cholesterol in XL.HDL (XL.HDL.C) and glycoprotein acetyls (GP). Both XL.HDL.C and GP demonstrated suggestive univariable evidence of causality (P < 0.05), and GP successfully replicated within an independent dataset. This study offers insight into the causal relationship between metabolites demonstrating association with midlife cognition and AD. It highlights GP in addition to several XL.HDLs-particularly XL.HDL.FC-as causal candidates warranting further investigation. As AD pathology is thought to develop decades prior to symptom onset, expanding on these findings could inform risk reduction strategies
The Impact of Natural Ventilation During Winter on Thermal Comfort: A systematic literature review
The COVID-19 pandemic has highlighted the importance of ventilation as a transmission mitigation
strategy. However, there is a widely-held concern that a drop in outdoor temperatures during
wintertime may impact thermal comfort in the context of naturally ventilated classrooms. This is a
concern which has not been widely investigated by peer-reviewed empirical studies. The aim of this
paper is to review the available literature on the impact of natural ventilation during winter on thermal
comfort. Using the replicable search processes of a systematic literature review adopted from medical
research practice, 142 articles were retrieved from four search databases (Science direct, Scopus,
PubMed, and Google Scholar). Analysis of these 142 articles revealed that most studies have
particularly focused on the assessment of ventilation conditions, especially in non-naturally ventilated
spaces, and that there were only 5 articles that empirically investigated the impact of natural
ventilation on thermal comfort during winter in sufficient detail. This shows a significant gap within
the body of literature, meaning that the findings from this study can only be treated as tentative, with
further research required
Assessment of dispersion of airborne particles of oral/nasal fluid by high flow nasal cannula therapy
Background
Nasal High Flow (NHF) therapy delivers flows of heated humidified gases up to 60 LPM (litres per minute) via a nasal cannula. Particles of oral/nasal fluid released by patients undergoing NHF therapy may pose a cross-infection risk, which is a potential concern for treating COVID-19 patients.
Methods
Liquid particles within the exhaled breath of healthy participants were measured with two protocols: (1) high speed camera imaging and counting exhaled particles under high magnification (6 participants) and (2) measuring the deposition of a chemical marker (riboflavin-5-monophosphate) at a distance of 100 and 500 mm on filter papers through which air was drawn (10 participants). The filter papers were assayed with HPLC. Breathing conditions tested included quiet (resting) breathing and vigorous breathing (which here means nasal snorting, voluntary coughing and voluntary sneezing). Unsupported (natural) breathing and NHF at 30 and 60 LPM were compared.
Results
Imaging: During quiet breathing, no particles were recorded with unsupported breathing or 30 LPM NHF (detection limit for single particles 33 μm). Particles were detected from 2 of 6 participants at 60 LPM quiet breathing at approximately 10% of the rate caused by unsupported vigorous breathing. Unsupported vigorous breathing released the greatest numbers of particles. Vigorous breathing with NHF at 60 LPM, released half the number of particles compared to vigorous breathing without NHF.
Chemical marker tests: No oral/nasal fluid was detected in quiet breathing without NHF (detection limit 0.28 μL/m3). In quiet breathing with NHF at 60 LPM, small quantities were detected in 4 out of 29 quiet breathing tests, not exceeding 17 μL/m3. Vigorous breathing released 200–1000 times more fluid than the quiet breathing with NHF. The quantities detected in vigorous breathing were similar whether using NHF or not.
Conclusion
During quiet breathing, 60 LPM NHF therapy may cause oral/nasal fluid to be released as particles, at levels of tens of μL per cubic metre of air. Vigorous breathing (snort, cough or sneeze) releases 200 to 1000 times more oral/nasal fluid than quiet breathing (p < 0.001 with both imaging and chemical marker methods). During vigorous breathing, 60 LPM NHF therapy caused no statistically significant difference in the quantity of oral/nasal fluid released compared to unsupported breathing. NHF use does not increase the risk of dispersing infectious aerosols above the risk of unsupported vigorous breathing. Standard infection prevention and control measures should apply when dealing with a patient who has an acute respiratory infection, independent of which, if any, respiratory support is being used
Classroom Ventilation: The Effectiveness of Preheating and Refresh Breaks: An analysis of 169 spaces at 43 schools across New Zealand
The COVID-19 pandemic has highlighted the importance of ventilation as a transmission mitigation strategy. However,
there was a widely held concern that a drop in outdoor temperatures during winter may impact thermal comfort in the
context of naturally ventilated classrooms. This concern has not been widely investigated by peer-reviewed empirical
studies (Sutherland et al., 2022b).
The aim of the Ministry’s ventilation monitoring initiative was to assess ventilation performance and thermal comfort
by continuously measuring indoor CO2 levels, air temperature, and relative humidity in classrooms during winter,
without obstructing teaching activities.
A total of 43 schools, which represent a broad mix of property attributes and located across the 6 Climate Zones in New
Zealand, were selected for the monitoring initiative. The CO2 monitors were deployed in about 4-6 pre-selected and
representative spaces in each school. Data was retrieved from 213 spaces; of these, 44 spaces were excluded, because
the initiative concentrated on teaching environments (classrooms) and those spaces were categorised as non-teaching
environments (e.g., staff rooms, meeting rooms, etc.).
From the 213 spaces, the data from 169 teaching spaces retrieved for the period 23 May to 26 August 2022 were
analysed to ascertain the impacts of inferred human behaviours considered to be able to improve natural ventilation
and detected from features of CO2 and temperature data. This analysis does not (and did not intend to) corroborate
independent observation of behaviours
Evaluation of natural and tracer fluorescent emission methods for droplet size measurements in a diesel spray
The final publication is available at Springer via http://dx.doi.org/10.1007/s12239-012-0070-zSpray sizing that records fluorescent emission and scattered light has been widely applied to spray diagnostics over the last two decades. Different experimental strategies have been developed, but comparing the different solutions offered has remained of interest to experimentalists. In this work, a comparison of two fluorescence strategies for measuring droplet size in the liquid phase of a last-generation DI diesel spray is conducted. The natural fluorescent emission of a commercial diesel fuel and the fluorescence emitted by a tracer (Rhodamine B) are compared using theoretical and experimental approaches. The LIF/Mie ratio commonly called Planar Droplet Sizing (PDS) technique is applied in two different ways to elucidate the possible advantages of using a fluorescent dopant. The sprays were injected under non-evaporative conditions into a constant pressure vessel that simulates densities present at the moment of injection in currently used passenger car diesel engines. Characterization of the signal properties was performed by measuring the absorption coefficient, fluorescence emission spectrum, quantum yield and lifetime of both configurations. The scattered light and fluorescence intensities were calculated to verify the dependencies of the droplet surface and volume. When applying the two techniques to quantify droplet size in dense diesel sprays, the results show that signal weakness and lack of control over the properties of natural fluorescence produce distortion in the shape of the spray and cause measurements to be unreliable. © 2012 The Korean Society of Automotive Engineers and Springer-Verlag Berlin Heidelberg.This research has been funded in the frame of the project PROFUEL reference TRA2011-26293 from Ministerio de Ciencia e Innovacion. 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Misoprostol and termination of pregnancy: is there a need for ultrasound screening in a general population to assess the risk for adverse outcome in cases of uterine anomaly?
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