Computing on Masked Data to improve the Security of Big Data

Organizations that make use of large quantities of information require the ability to store and process data from central locations so that the product can be shared or distributed across a heterogeneous group of users. However, recent events underscore the need for improving the security of data stored in such untrusted servers or databases. Advances in cryptographic techniques and database technologies provide the necessary security functionality but rely on a computational model in which the cloud is used solely for storage and retrieval. Much of big data computation and analytics make use of signal processing fundamentals for computation. As the trend of moving data storage and computation to the cloud increases, homeland security missions should understand the impact of security on key signal processing kernels such as correlation or thresholding. In this article, we propose a tool called Computing on Masked Data (CMD), which combines advances in database technologies and cryptographic tools to provide a low overhead mechanism to offload certain mathematical operations securely to the cloud. This article describes the design and development of the CMD tool.Comment: 6 pages, Accepted to IEEE HST Conferenc

Rural masters and urban militants in early twentieth-century South Africa

White farmers in South Africa, a landowning class that subordinated black tenants and workers, also participated in the suppression of white workers’ movements before and after the First World War. This article explores how class interest limited and then overrode the farmers’ expected ethnic and political solidarities. It focuses especially on the contradictory ways in which farmers related to the great mineworkers’ strike and rebellion of 1922. Some contemporaries expected that racial solidarity, Afrikaner nationalism, and familial links would lead landowners to side, even militarily, with the white workers. Appeals were made to farmers by both sides of the struggle in 1922, and there was some significant support for the strikers from them. But the upheaval ran counter to landowners’ interests, notably by dislocating their primary urban market at a time of severe economic difficulty. In the end, farmers rode once more into the towns against the workers

Parallel Vectorized Algebraic AES in MATLAB for Rapid Prototyping of Encrypted Sensor Processing Algorithms and Database Analytics

The increasing use of networked sensor systems and networked databases has led to an increased interest in incorporating encryption directly into sensor algorithms and database analytics. MATLAB is the dominant tool for rapid prototyping of sensor algorithms and has extensive database analytics capabilities. The advent of high level and high performance Galois Field mathematical environments allows encryption algorithms to be expressed succinctly and efficiently. This work leverages the Galois Field primitives found the MATLAB Communication Toolbox to implement a mode of the Advanced Encrypted Standard (AES) based on first principals mathematics. The resulting implementation requires 100x less code than standard AES implementations and delivers speed that is effective for many design purposes. The parallel version achieves speed comparable to native OpenSSL on a single node and is sufficient for real-time prototyping of many sensor processing algorithms and database analytics.Comment: 6 pages; accepted to IEEE High Performance Extreme Computing Conference (HPEC) 201

The Waste Isolation Pilot Plant: How Well is Accelerated Cleanup Working?

This report examines the Performance Management Plans (PMPs) of the six transuranic (TRU) waste sites (Rocky Flats Plant, Hanford, Idaho National Lab, Los Alamos National Lab, the Oak Ridge Reservation, and the Savannah River Site) to the PMP of the Waste Isolation Pilot Plant\u27s (WIPP) (located in southeastern New Mexico) , to see how the WIPP Plan and the major individual site plans relate. The report also analyzes how well each site and WIPP are meeting the goals and milestones of the plans, discusses how well projected cost savings are justified, and reviews regulatory and other relevant issues. The analysis primarily covers the first two+ years of the plans, updating the information through at least 2004, and in some cases, up to July 2005. The report includes separate chapters on each of the seven sites and its PMP. Each chapter includes six sections: * A background briefly describes the site and its mission and role regarding TRU waste. * The TRU waste inventory is examined by comparing the WIPP PMP with the site PMP, as well as comparing the inventory in other site or official documents. * Waste shipment projections are compared with the WIPP PMP, the site PMP, and DOE’s Budget Requests to Congress. * Cost savings provided in the PMP are reviewed and analyzed. * Regulatory compliance issues regarding TRU waste management are identified and analyzed. * Other relevant issues are discussed.https://commons.clarku.edu/swresearch/1001/thumbnail.jp

Unexpected patterns of global population structure in melon-headed whales Peponocephala electra

Foraging specialization, environmental barriers, and social structure have driven the development of strong genetic differentiation within many marine species, including most of the large dolphin species commonly referred to as ‘blackfish’ (subfamily Globicephalinae). We used mitochondrial sequence data (mtDNA) and genotypes from 14 nuclear microsatellite loci (nDNA) to examine patterns of genetic population structure in melon-headed whales Peponocephala electra (MHWs), poorly known members of the blackfish family for which genetic structuring is unknown. MHWs are globally distributed in tropical and subtropical waters, and have formed resident populations around oceanic islands. They frequently mass strand, suggesting strong social cohesion within groups. Based on these characteristics, we hypothesized that MHWs would exhibit strong regional genetic differentiation, similar to that observed in other members of the Globicephalinae subfamily. Instead we found only moderate differentiation (median mtDNA ΦST = 0.204, median nDNA FST = 0.012) among populations both within and between ocean basins. Our results suggest that populations of MHWs that are resident to oceanic islands maintain a higher level of genetic connectivity than is seen in most other blackfish. MHWs may be more behaviorally similar to delphinids from the Delphininae subfamily (particularly the spinner dolphin Stenella longirostris), which are known to form coastal and island-associated resident populations that maintain genetic connectivity either through occasional long-distance dispersal or gene flow with larger pelagic populations. Our results suggest that differences in social organization may drive different patterns of population structure in social odontocete

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia

PURPOSE: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF).METHODS: We studied all cases of T-ALL IF on two consecutive multinational randomized trials, UKALL2003 and UKALL2011, to define risk factors, treatment, and outcomes. We performed multiomic profiling to characterize the genomic landscape.RESULTS: IF occurred in 10.3% of cases and was significantly associated with increasing age, occurring in 20% of patients age 16 years and older. Five-year overall survival (OS) rates were 52.1% in IF and 90.2% in responsive patients (P &lt; .001). Despite increased use of nelarabine-based chemotherapy consolidated by hematopoietic stem-cell transplant in UKALL2011, there was no improvement in outcome. Persistent end-of-consolidation molecular residual disease resulted in a significantly worse outcome (5-year OS, 14.3% v 68.5%; HR, 4.10; 95% CI, 1.35 to 12.45; P = .0071). Genomic profiling revealed a heterogeneous picture with 25 different initiating lesions converging on 10 subtype-defining genes. There was a remarkable abundance of TAL1 noncoding lesions, associated with a dismal outcome (5-year OS, 12.5%). Combining TAL1 lesions with mutations in the MYC and RAS pathways produces a genetic stratifier that identifies patients highly likely to fail conventional therapy (5-year OS, 23.1% v 86.4%; HR, 6.84; 95% CI, 2.78 to 16.78; P &lt; .0001) and who should therefore be considered for experimental agents.CONCLUSION: The outcome of IF in T-ALL remains poor with current therapy. The lack of a unifying genetic driver suggests alternative approaches, particularly using immunotherapy, are urgently needed.</p

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia

PURPOSE: Failure to respond to induction chemotherapy portends a poor outcome in childhood acute lymphoblastic leukemia (ALL) and is more frequent in T-cell ALL (T-ALL) than B-cell ALL. We aimed to address the limited understanding of clinical and genetic factors that influence outcome in a cohort of patients with T-ALL induction failure (IF). METHODS: We studied all cases of T-ALL IF on two consecutive multinational randomized trials, UKALL2003 and UKALL2011, to define risk factors, treatment, and outcomes. We performed multiomic profiling to characterize the genomic landscape. RESULTS: IF occurred in 10.3% of cases and was significantly associated with increasing age, occurring in 20% of patients age 16 years and older. Five-year overall survival (OS) rates were 52.1% in IF and 90.2% in responsive patients (P < .001). Despite increased use of nelarabine-based chemotherapy consolidated by hematopoietic stem-cell transplant in UKALL2011, there was no improvement in outcome. Persistent end-of-consolidation molecular residual disease resulted in a significantly worse outcome (5-year OS, 14.3% v 68.5%; HR, 4.10; 95% CI, 1.35 to 12.45; P = .0071). Genomic profiling revealed a heterogeneous picture with 25 different initiating lesions converging on 10 subtype-defining genes. There was a remarkable abundance of TAL1 noncoding lesions, associated with a dismal outcome (5-year OS, 12.5%). Combining TAL1 lesions with mutations in the MYC and RAS pathways produces a genetic stratifier that identifies patients highly likely to fail conventional therapy (5-year OS, 23.1% v 86.4%; HR, 6.84; 95% CI, 2.78 to 16.78; P < .0001) and who should therefore be considered for experimental agents. CONCLUSION: The outcome of IF in T-ALL remains poor with current therapy. The lack of a unifying genetic driver suggests alternative approaches, particularly using immunotherapy, are urgently needed

"Bibliocircuitry and the Design of the Alien Everyday"

Curatorial note from Digital Pedagogy in the Humanities: “Bibliocircuitry and the Design of the Alien Everyday” details student exploration of the concept of reflective design through projects that investigate the book as interface. This activity perfectly highlights the way that exposure to and emphasis on process leads to unforeseen insight. These student authors also emphasize that digital work requires consideration of hardware and physical and tactile design. Instructors inspired by this article might select a particular type of object and ask students to devise ways to alter or enhance users’ interaction with it. Students would demonstrate learning not only through their work in designing and redesigning objects but also through oral or written presentations of them (much as the student authors of this journal article have done)

Conditional Ablation of Macrophages Halts Progression of Crescentic Glomerulonephritis

The presence of macrophages in inflamed glomeruli of rat kidney correlates with proliferation and apoptosis of resident glomerular mesangial cells. We assessed the contribution of inflammatory macrophages to progressive renal injury in murine crescentic glomerulonephritis (GN). Using a novel transgenic mouse (CD11b-DTR) in which tissue macrophages can be specifically and selectively ablated by minute injections of diphtheria toxin, we depleted renal inflammatory macrophages through days 15 and 20 of progressive crescentic GN. Macrophage depletion reduced the number of glomerular crescents, improved renal function, and reduced proteinuria. Morphometric analysis of renal tubules and interstitium revealed a marked attenuation of tubular injury that was associated with reduced proliferation and apoptosis of tubular cells. The population of interstitial myofibroblasts decreased after macrophage depletion and interstitial fibrosis also decreased. In the presence of macrophages, interstitial myofibroblasts exhibited increased levels of both proliferation and apoptosis, suggesting that macrophages act to support a population of renal myofibroblasts in a high turnover state and in matrix deposition. Finally, deletion of macrophages reduced CD4 T cells in the diseased kidney. This study demonstrates that macrophages are key effectors of disease progression in crescentic GN, acting to regulate parenchymal cell populations by modulating both cell proliferation and apoptosis