Modified Gravity Makes Galaxies Brighter

We investigate the effect of modifed gravity with screening mechanisms, such as the chameleon or symmetron models, upon the structure of main sequence stars. We find that unscreened stars can be significantly more luminous and ephemeral than their screened doppelgangers. By embedding these stars into dwarf galaxies, which can be unscreened for values of the parameters not yet ruled out observationally, we show that the cumulative effect of their increased luminosity can enhance the total galactic luminosity. We estimate this enhancement and find that it can be considerable given model parameters that are still under experimental scrutiny. By looking for systematic offsets between screened dwarf galaxies in clusters and unscreened galaxies in voids, these effects could form the basis of an independent observational test that can potentially lower the current experimental bounds on the model independent parameters of these theories by and order of magnitude or more.Comment: 16 pages, six figure

The Chiton Radula: A Unique Model for Biomineralization Studies

Advanced Topics in Biomineralization is a compendium of current topics focusing on processes of formation, organization, as well as mineralization of novel structural materials. From enchondral ossification to the application of biomineralized cement, the subject of biomineralization encompasses a range of diverse disciplines including molecular biology, supramolecular chemistry, materials science and engineering. A common theme in all these areas of research in biomineralization is the ability to utilize strategies from Nature to create functional materials. By understanding Nature’s tools to make strong and tough materials, similar properties can be endowed into man-made materials in the near future. [Book Synopsis

Change in urban arterial street design

Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2007.Includes bibliographical references (p. 84-91).The highway-building industry and highway governance was born in the minds of progressive engineers bent on ushering in a new era of efficiency, progress and modern transport. Governance and standards in California heavily influenced other state highway organizations. This research traces the evolution of values in urban arterial street design and standards in the United States and California. For nearly 100 years, the design criteria of geometric street standards have been based on increasing automobility, as if without end. Since the 1960s, liability concerns have guided significant changes in design standards, mostly based on passive driver safety design. Since then, legal action has given rise to bicycle and ADA-based design standards. Right-of-way constraints have lowered minimum widths and "flexibility" has impacted design philosophy and process. However, these latter forces are not driving fundamental or enforceable change to design standards. Change to mandatory standards remains driven by automobility and liability concerns. Despite conventional standards, unconventional values manifest in the design and planning of streets.(cont.) Using the case of El Camino Real in Palo Alto, this research explores the difficulty of implementing unconventional street design through the process of changing standards. It then draws on the case of Santa Monica Boulevard in Los Angeles to demonstrate that individual projects under local jurisdiction are more likely to impact the design of streets. Further research is warranted on state highway relinquishment, the philosophy of context-sensitive design, and methods of selecting design speed.by Jeremy A. Shaw.M.C.P

Sphagnum physiology in the context of changing climate: emergent influences of genomics, modelling and host-microbiome interactions on understanding ecosystem function.

Peatlands harbour more than one-third of terrestrial carbon leading to the argument that the bryophytes, as major components of peatland ecosystems, store more organic carbon in soils than any other collective plant taxa. Plants of the genus Sphagnum are important components of peatland ecosystems and are potentially vulnerable to changing climatic conditions. However, the response of Sphagnum to rising temperatures, elevated CO2 and shifts in local hydrology have yet to be fully characterized. In this review, we examine Sphagnum biology and ecology and explore the role of this group of keystone species and its associated microbiome in carbon and nitrogen cycling using literature review and model simulations. Several issues are highlighted including the consequences of a variable environment on plant-microbiome interactions, uncertainty associated with CO2 diffusion resistances and the relationship between fixed N and that partitioned to the photosynthetic apparatus. We note that the Sphagnum fallax genome is currently being sequenced and outline potential applications of population-level genomics and corresponding plant photosynthesis and microbial metabolic modelling techniques. We highlight Sphagnum as a model organism to explore ecosystem response to a changing climate and to define the role that Sphagnum can play at the intersection of physiology, genetics and functional genomics

A novel adaptation facilitates seed establishment under marine turbulent flows

Seeds of Australian species of the seagrass genus Posidonia are covered by a membranous wing that we hypothesize plays a fundamental role in seed establishment in sandy, wave swept marine environments. Dimensions of the seed and membrane were quantified under electron microscopy and micro-CT scans, and used to model rotational, drag and lift forces. Seeds maintain contact with the seabed in the presence of strong turbulence: the larger the wing, the more stable the seed. Wing surface area increases from P. sinuosa \u3c P. australis \u3c P.coriacea correlating with their ability to establish in increasingly energetic environments. This unique seed trait in a marine angiosperm corresponds to adaptive pressures imposed on seagrass species along 7,500 km of Australia’s coastline, from open, high energy coasts to calmer environments in bays and estuaries

Genetic associations with childhood brain growth, defined in two longitudinal cohorts

Genome-wide association studies (GWASs) are unraveling the genetics of adult brain neuroanatomy as measured by cross-sectional anatomic magnetic resonance imaging (aMRI). However, the genetic mechanisms that shape childhood brain development are, as yet, largely unexplored. In this study we identify common genetic variants associated with childhood brain development as defined by longitudinal aMRI. Genome-wide single nucleotide polymorphism (SNP) data were determined in two cohorts: one enriched for attention-deficit/hyperactivity disorder (ADHD) (LONG cohort: 458 participants; 119 with ADHD) and the other from a population-based cohort (Generation R: 257 participants). The growth of the brain's major regions (cerebral cortex, white matter, basal ganglia, and cerebellum) and one region of interest (the right lateral prefrontal cortex) were defined on all individuals from two aMRIs, and a GWAS and a pathway analysis were performed. In addition, association between polygenic risk for ADHD and brain growth was determined for the LONG cohort. For white matter growth, GWAS meta-analysis identified a genome-wide significant intergenic SNP (rs12386571, P = 9.09 × 10-9 ), near AKR1B10. This gene is part of the aldo-keto reductase superfamily and shows neural expression. No enrichment of neural pathways was detected and polygenic risk for ADHD was not associated with the brain growth phenotypes in the LONG cohort that was enriched for the diagnosis of ADHD. The study illustrates the use of a novel brain growth phenotype defined in vivo for further study

Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature

Abstract The renal mesenchyme contains heterogeneous cells, including interstitial fibroblasts and pericytes, with key roles in wound healing. Although healing is impaired in aged kidneys, the effect of age and injury on the mesenchyme remains poorly understood. We characterized renal mesenchymal cell heterogeneity in young vs old animals and after ischemia‐reperfusion‐injury (IRI) using multiplex immunolabeling and single cell transcriptomics. Expression patterns of perivascular cell markers (α‐SMA, CD146, NG2, PDGFR‐α, and PDGFR‐β) correlated with their interstitial location. PDGFR‐α and PDGFR‐β co‐expression labeled renal myofibroblasts more efficiently than the current standard marker α‐SMA, and CD146 was a superior murine renal pericyte marker. Three renal mesenchymal subtypes; pericytes, fibroblasts, and myofibroblasts, were recapitulated with data from two independently performed single cell transcriptomic analyzes of murine kidneys, the first dataset an aging cohort and the second dataset injured kidneys following IRI. Mesenchymal cells segregated into subtypes with distinct patterns of expression with aging and following injury. Baseline uninjured old kidneys resembled post‐ischemic young kidneys, with this phenotype further exaggerated following IRI. These studies demonstrate that age modulates renal perivascular/interstitial cell marker expression and transcriptome at baseline and in response to injury and provide tools for the histological and transcriptomic analysis of renal mesenchymal cells, paving the way for more accurate classification of renal mesenchymal cell heterogeneity and identification of age‐specific pathways and targets

The impact of sequencing depth on the inferred taxonomic composition and AMR gene content of metagenomic samples

Shotgun metagenomics is increasingly used to characterise microbial communities, particularly for the investigation of antimicrobial resistance (AMR) in different animal and environmental contexts. There are many different approaches for inferring the taxonomic composition and AMR gene content of complex community samples from shotgun metagenomic data, but there has been little work establishing the optimum sequencing depth, data processing and analysis methods for these samples. In this study we used shotgun metagenomics and sequencing of cultured isolates from the same samples to address these issues. We sampled three potential environmental AMR gene reservoirs (pig caeca, river sediment, effluent) and sequenced samples with shotgun metagenomics at high depth (~ 200 million reads per sample). Alongside this, we cultured single-colony isolates of Enterobacteriaceae from the same samples and used hybrid sequencing (short- and long-reads) to create high- quality assemblies for comparison to the metagenomic data. To automate data processing, we developed an open- source software pipeline, ‘ResPipe’

Surgical site infection following surgery for hand trauma: a systematic review and meta-analysis

Surgical site infection is the most common healthcare-associated infection. Surgical site infection after surgery for hand trauma is associated with increased antibiotic prescribing, re-operation, hospital readmission and delayed rehabilitation, and in severe cases may lead to amputation. As the risk of surgical site infection after surgery for hand trauma remains unclear, we performed a systematic review and meta-analysis of all primary studies of hand trauma surgery, including randomized controlled trials, cohort studies, case-control studies and case series. A total of 8836 abstracts were screened, and 201 full studies with 315,618 patients included. The meta-analysis showed a 10% risk of surgical site infection in randomized control trials, with an overall risk of 5% when all studies were included. These summary statistics can be used clinically for informed consent and shared decision making, and for power calculations for future clinical trials of antimicrobial interventions in hand trauma