Electroconvulsive therapy for Patients with Intellectual Disability. When and how?

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Electroconvulsive therapy for Depression in Anorexia Nervosa. A review

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Effects of Fishmeal or Urea Supplementation on Ruminal Fibre Digestion and Passage Kinetics in Bali Cows

Five non-pregnant Bali cows were used in a 5x5 latin square experimental design with the objective to study the effects of supplementation of graded levels of urea or fishmeal on fibre intake and digestion kinetics in Bali cows consuming low quality tropical grass hay. The animals were given ad libitum access to grass hay or supplemented daily with two levels of urea, i.e. 38 and 74 g, or two levels of fishmeal, i.e. 156 and 312 g. The measured parameters included were intake and apparent digestibility of DM and NDF, in sacco ruminal fibre degradation, and in vivo ruminal NDF digestion and passage kinetics. Intakes of DM and NDF were significantly improved by supplementation of both urea and fishmeal with fishmeal exerted a better effect at low level of supplementation. The increase of intake was mainly associated with the significant increase of rumen in sacco degradation of NDF. However, in vivo rumen digestions of NDF and DNDF were not significantly improved by supplementation due to the increased rumen pool of NDF after protein supplementation. As a result, rumen passage and digestion rates were not affected by supplementation. The effective level of fishmeal and urea supplementation to improve the intake of low quality fibrous tropical grass hay in Bali cows were 152 g/d and 74 g/d, respectively. (Animal Production 12(2): 74-81 (2010

KESESUAIAN DAN DAYA DUKUNG KAWASAN EKOWISATA KEBUN KIMA NEGERI MORELLA, KABUPATEN MALUKU TENGAH

Tihlepuai Bay in Morella Village has a protected area called Kebun Kima, which has been developed to become a location for marine ecotourism. An increase in visitor numbers is thought to disrupt conservation activities due to the lack of understanding of local people and tourists regarding the importance of developing marine conservation and tourism. This study aims to analyze the suitability and carrying capacity of the Kebun Kima ecotourism area. The research was conducted in Kebun Kima ecotourism area in Tihlepuai Bay from April to June 2020. Data collection on the suitability of the location designated for the snorkeling and diving categories was obtained from the results of measuring the suitability parameters of the area. Carrying capacity data is intended to determine the number of tourists who can occupy the area. Community social data collection in the form of support for the development of marine ecotourism in the Kebun Kima and tourists' assessment of the coral reef's beauty was obtained from interview results, field observation, and questionnaires. The data obtained were then analyzed descriptively. Based on the study's results, diving and snorkeling activities are suitable for development with a carrying capacity of 4 people per day, both snorkeling and diving. The proportion of people who do not know about the impact of coral reef damage is about 55%, while the proportion of tourists evaluating the coral reef's attractiveness is 60% for the 'very good' category.   ABSTRAK Pantai Teluk Tihlepuai di Negeri Morella memiliki sebuah kawasan yang dilindungi bernama Kebun Kima yang dikembangkan menjadi lokasi ekowisata bahari. Peningkatan jumlah pengunjung di kawasan konservasi Kebun Kima diduga dapat mengganggu kegiatan konservasi. Hal ini disebabkan kurangnya pemahaman masyarakat lokal maupun wisatawan tentang pentingnya pengembangan konservasi dan wisata bahari. Penelitian ini bertujuan untuk menganalisis kesesuaian dan daya dukung kawasan ekowisata kebun kima. Penelitian dilakukan di kawasan ekowisata Kebun Kima di Pantai Teluk Tihlepuai, Negeri Morella, Kabupaten Maluku Tengah pada April-Juni 2020. Pengambilan data kesesuaian lokasi yang diperuntukkan untuk kategori snorkeling dan selam diperoleh dari hasil pengukuran parameter kesesuaian kawasan. Pengambilan data daya dukung diperuntukkan untuk mengetahui jumlah wisatawan yang dapat menempati kawasan tersebut. Pengambilan data sosial masyarakat berupa dukungan terhadap pengembangan ekowisata bahari kebun kima dan penilaian wisatawan terhadap keindahan terumbu karang diperoleh dari hasil wawancara, pengamatan lapangan, dan penyebaran kuesioner. Data yang diperoleh kemudian dianalisis secara deskriptif. Berdasarkan hasil penelitian, kegiatan selam dan snorkeling sesuai untuk dikembangkan serta snorkeling dengan daya dukung mampu melayani 4 orang/hari, dan kategori selam dengan tingkat pelayanan 4 orang wisatawan/hari. Persepsi masyarakat kategori tidak tahu tentang dampak kerusakan terumbu karang sebesar 55%, sedangkan penialian wisatawan terhadap keindangan terumbu karang di kebun kima kategori sangat bagus sebesar 60%. Kata kunci: Ekowisata, kebun kima, kesesuaian, daya dukung, Negeri Morell

Exclusive breastfeeding and its effect on growth of Malawian infants: results from a cross-sectional study

Abstract Background: For the optimal nutrition of children under 2 years of age, it is considered important that they be exclusively breastfed for the first 6 months before being given complementary food. Aims and Objectives: A cross-sectional nutritional baseline survey was undertaken in 2011 in the Kasungu and Mzimba Districts of Malawi to assess the nutritional status of children under 2 years of age and its determinants in order to prepare a nutrition education intervention programme. The intention of this study was to assess the nutritional status of infants aged 0–<6 months with regard to food intake. Methods: Interviews were conducted on randomly selected families with children under 2 years; anthropometric measurements were obtained from mothers and their children. Only infants between 0 and <6 months were selected for analysis (n  =  196). An ANCOVA test was performed on age of the infant with mothers’ height and weight as covariates. Results: Prevalence of stunting (infants’ length-for-age Z-score (LAZ) <−2SD) was 39%, wasting (WLZ <−2SD) 2%, and underweight (WAZ <−2SD) 13%. Of the infants under 6 months, 43% were exclusively breastfed. Predominant breastfeeding and mixed breastfeeding were less common (21% and 36%, respectively). The ANCOVA confirmed the association between exclusive breastfeeding and LAZ and WAZ: exclusively breastfed infants had a higher mean (SE) LAZ (−1·13, 0·12) and WAZ (−0·41, 0·13) than infants not being exclusively breastfed (−1·59, 0·11, and −0·97, 0·11, respectively). There was no overall significant association between breastfeeding practice and WLZ. Conclusion: Exclusive breastfeeding of infants under 6 months is associated with higher mean LAZ and WAZ. Promotion of exclusive breastfeeding in low-income countries is important in preventing growth retardation

Chlamydia trachomatis Infection, Immunity, and Pregnancy Outcome

Chlamydia trachomatis can ascend from the cervix to the fallopian tubes and survive for long periods of time without causing symptoms. The immune response to infection clears the extracellular organisms but leads to development of a persistent intracellular infection. Repeated cycles of productive infection and persistence eventually induce tubal occlusion and infertility. Persistently infected cells continue to synthesize the chlamydial 60 kD heat shock protein (hsp60). Immunity to conserved regions of hsp60 may result in autoimmunity to human hsp60. Expression of hsp60 by the embryo and decidua during early pregnancy may reactivate hsp60-sensitized lymphocytes, disturb pregnancy-induced immune regulatory mechanisms, and lead to immune rejection of the embryo. Due to this mechanism women with tubal infertility who are sensitized to the human hsp60 may have a decreased probability of successful outcome after undergoing in vitro fertilization and embryo transfer

Heat shock protein expression during gametogenesis and embryogenesis.

When cells are subjected to various stress factors, they increase the production of a group of proteins called heat shock proteins (hsp). Heat shock proteins are highly conserved proteins present in organisms ranging from bacteria to man. Heat shock proteins enable cells to survive adverse environmental conditions by preventing protein denaturation. Thus the physiological and pathological potential of hsps is enormous and has been studied widely over the past two decades. The presence or absence of hsps influences almost every aspect of reproduction. They are among the first proteins produced during mammalian embryo development. In this report, the production of hsps in gametogenesis and early embryo development is described. It has been suggested that prolonged and asymptomatic infections trigger immunity to microbial hsp epitopes that are also expressed in man. This may be relevant for human reproduction, since many couples with fertility problems have had a previous genital tract infection. Antibodies to bacterial and human hsps are present at high titers in sera of many patients undergoing in vitro fertilization. In a mouse embryo culture model, these antibodies impaired the mouse embryo development at unique developmental stages. The gross morphology of these embryos resembled cells undergoing apoptosis. The TUNEL (terminal deoxynucleotidyl transferase-mediated X-dUTP nick end labeling) staining pattern, which is a common marker of apoptosis, revealed that embryos cultured in the presence of hsp antibodies stained TUNEL-positive more often than unexposed embryos. These data extend preexisting findings showing the detrimental effect of immune sensitization to hsps on embryo development

Exclusive breastfeeding and its effect on growth of Malawian infants: results from a cross-sectional study

Background: For the optimal nutrition of children under 2 years of age, it is considered important that they be exclusively breastfed for the first 6 months before being given complementary food. Aims and Objectives: A cross-sectional nutritional baseline survey was undertaken in 2011 in the Kasungu and Mzimba Districts of Malawi to assess the nutritional status of children under 2 years of age and its determinants in order to prepare a nutrition education intervention programme. The intention of this study was to assess the nutritional status of infants aged 0-,6 months with regard to food intake. Methods: Interviews were conducted on randomly selected families with children under 2 years; anthropometric measurements were obtained from mothers and their children. Only infants between 0 and ,6 months were selected for analysis (n 5 196). An ANCOVA test was performed on age of the infant with mothers&apos; height and weight as covariates. Results: Prevalence of stunting (infants&apos; length-for-age Z-score (LAZ) ,22SD) was 39%, wasting (WLZ ,22SD) 2%, and underweight (WAZ ,22SD) 13%. Of the infants under 6 months, 43% were exclusively breastfed. Predominant breastfeeding and mixed breastfeeding were less common (21% and 36%, respectively). The ANCOVA confirmed the association between exclusive breastfeeding and LAZ and WAZ: exclusively breastfed infants had a higher mean (SE) LAZ (21.13, 0.12) and WAZ (20.41, 0.13) than infants not being exclusively breastfed (21.59, 0.11, and 20.97, 0.11, respectively). There was no overall significant association between breastfeeding practice and WLZ. Conclusion: Exclusive breastfeeding of infants under 6 months is associated with higher mean LAZ and WAZ. Promotion of exclusive breastfeeding in low-income countries is important in preventing growth retardation

Influence of Lung Reconstruction Algorithms on Interstitial Lung Pattern Recognition on CT.

BACKGROUND  Despite current recommendations, there is no recent scientific study comparing the influence of CT reconstruction kernels on lung pattern recognition in interstitial lung disease (ILD). PURPOSE  To evaluate the sensitivity of lung (i70) and soft (i30) CT kernel algorithms for the diagnosis of ILD patterns. MATERIALS AND METHODS  We retrospectively extracted between 15-25 pattern annotations per case (1 annotation = 15 slices of 1 mm) from 23 subjects resulting in 408 annotation stacks per lung kernel and soft kernel reconstructions. Two subspecialized chest radiologists defined the ground truth in consensus. 4 residents, 2 fellows, and 2 general consultants in radiology with 3 to 13 years of experience in chest imaging performed a blinded readout. In order to account for data clustering, a generalized linear mixed model (GLMM) with random intercept for reader and nested for patient and image and a kernel/experience interaction term was used to analyze the results. RESULTS  The results of the GLMM indicated, that the odds of correct pattern recognition is 12 % lower with lung kernel compared to soft kernel; however, this was not statistically significant (OR 0.88; 95%-CI, 0.73-1.06; p = 0.187). Furthermore, the consultants' odds of correct pattern recognition was 78 % higher than the residents' odds, although this finding did not reach statistical significance either (OR 1.78; 95%-CI, 0.62-5.06; p = 0.283). There was no significant interaction between the two fixed terms kernel and experience. Intra-rater agreement between lung and soft kernel was substantial (κ = 0.63 ± 0.19). The mean inter-rater agreement for lung/soft kernel was κ = 0.37 ± 0.17/κ = 0.38 ± 0.17. CONCLUSION  There is no significant difference between lung and soft kernel reconstructed CT images for the correct pattern recognition in ILD. There are non-significant trends indicating that the use of soft kernels and a higher level of experience lead to a higher probability of correct pattern identification. KEY POINTS   · There is no significant difference between lung and soft kernel reconstructed CT images for the correct pattern recognition in interstitial lung disease.. · There are even non-significant tendencies that the use of soft kernels lead to a higher probability of correct pattern identification.. · These results challenge the current recommendations and the routinely performed separate lung kernel reconstructions for lung parenchyma analysis.. CITATION FORMAT · Klaus JB, Christodoulidis S, Peters AA et al. Influence of Lung Reconstruction Algorithms on Interstitial Lung Pattern Recognition on CT. Fortschr Röntgenstr 2022; DOI: 10.1055/a-1901-7814