Semiclassical partition function for strings dual to Wilson loops with small cusps in ABJM

We compute the 1-loop partition function for strings in $AdS_4\times\mathbb{CP}^3$, whose worldsheets end along a line with small cusp angles in the boundary of AdS. We obtain these 1-loop results in terms of the vacuum energy for on-shell modes. Our results verify the proposal by Lewkowycz and Maldacena in arXiv:1312.5682 for the exact Bremsstrahlung function up to the next to leading order in the strong coupling expansion. The agreement is observed for cusps distorting either the 1/2 BPS or the 1/6 BPS Wilson line.Comment: 28 page

Strings in AdS_4 x CP^3, Wilson loops in N=6 super Chern-Simons-matter and Bremsstrahlung functions

We find 1/6 BPS string configurations in AdS_4 x CP^3, which we identify as the duals of certain 1/6 BPS circular Wilson loops in N=6 super Chern-Simons-matter gauge theory. We use our results to verify -in the strong coupling limit- a proposal made in arXiv:1402.4128 for a relation between the expectation value of these Wilson loops and the Bremsstrahlung function from deforming 1/2 BPS Wilson lines with a cusp. We also derive an analogous relation between the expectation value of some particular 1/12 BPS Wilson loops and the Bremsstrahlung function from deforming 1/6 BPS Wilson lines with an internal space cusp.Comment: 25 pages, 1 figures; v2 author ordering correcte

The utility of troponin measurement to detect myocardial infarction: review of the current findings

Myocardial infarction (MI) is defined by the presence of myocardial necrosis in combination with clinical evidence of myocardial ischemia. Cardiac troponins are regulatory proteins within the myocardium that are released into the circulation when damage to the myocyte has occurred. Therefore, serum troponin is an exquisitely sensitive marker of myocardial injury and is necessary for establishing the diagnosis of MI. High-sensitivity troponin assays are improving the diagnostic accuracy and rapid detection of myocardial infarction. The early identification of MI is vital for the institution of anti-thrombotic therapy to limit myocardial damage and preserve cardiac function. Troponin has both diagnostic and prognostic significance in the setting of acute coronary syndrome (ACS). Increased troponin levels in the absence of ACS should prompt an evaluation for an alternative, non-thrombotic mechanism of troponin elevation and direct management at the underlying cause. This review describes the role of troponin in the evaluation of patients with suspected myocardial infarction

Morphological and Molecular Changes of the Myocardium After Left Ventricular Mechanical Support

Left ventricular assist devices (LVAD) are currently used to either “bridge” patients with terminal congestive heart failure (CHF) until cardiac transplantation is possible or optionally for patients with contraindications for transplantation (“destination therapy”). Mechanical support is associated with a marked decrease of cardiac dilation and hypertrophy as well as numerous cellular and molecular changes (“reverse cardiac remodeling”), which can be accompanied by improved cardiac function (“bridge to recovery”) in a relatively small subset of patients with heart transplantation no longer necessary even after removal of the device (“weaning”). In the recent past, novel pharmacological strategies have been developed and are combined with mechanical support, which has increased the percentage of patients with improved clinical status and cardiac performance. Gene expression profiles have demonstrated that individuals who recover after LVAD show different gene expression compared to individuals who do not respond to unloading. This methodology holds promise for the future to develop read out frames to identify individuals who can recover after support. Aside from describing the morphological changes associated with “reverse cardiac remodeling”, this review will focus on signal transduction, transcriptional regulation, apoptosis, cell stress proteins, matrix remodeling, inflammatory mediators and aspects of neurohormonal activation in the failing human heart before and after ventricular unloading

Induction of heat shock protein expression in cervical epithelial cells by human semen.

OBJECTIVE: The 70kD heat shock protein (Hsp70), induced when cells are subjected to environmental stress, prevents the denaturation and incorrect folding of polypeptides and may expedite replication and transmission of DNA and RNA viruses. We analyzed whether messenger RNA (mRNA) for Hsp70 was expressed following exposure of a cultured human cervical cell line (HeLa cells) to human semen or in cervical cells from sexually active women. STUDY DESIGN: HeLa cells were co-cultured with a 1:50 dilution of semen from four men or with purified spermatozoa or cell-free seminal fluid. Endocervical swabs were acquired at mid-cycle from 53 women. Heat shock protein 70 mRNA was detected by a reverse transcriptase-polymerase chain reaction utilizing specific primer pairs and analysis on agarose gels. In cervical cells Hsp70 mRNA was measured identically followed by hybridization with an Hsp70-specific internal probe and detection by enzyme-linked immunosorbent assay (ELISA). Cervical immunoglobulin A (IgA) antibodies to the human Hsp70 were determined by ELISA. RESULTS: HeLa cell-semen co-culture resulted in the induction of Hsp70 mRNA. In addition, cell-free seminal plasma and motile sperm incubated individually with HeLa cells also induced this mRNA. Heat shock protein 70 mRNA was detected in 28 (52.8%) of 53 endocervical samples obtained from women at various time points following intercourse. The percentage of samples expressing this mRNA was 37.5% at less than 10 hours, 64.3% at 10 hours, 70% at 11 hours, and between 36% and 50% at later times after semen exposure. The detection of cervical IgA antibodies to the Hsp70 was highly associated with Hsp70 gene transcription. CONCLUSION: Human semen induces transcription of Hsp70 in cervical epithelial cells

PRODUKTIVITAS TENAGA KERJA PADA PEKERJAAN BETON BERTULANG (STUDI KASUS : PEMBANGUNAN GEDUNG RUANG KANTOR DAN RUANG KELAS YAYASAN EBEN HEAZER JALAN 14 FEBRUARI TELING ATAS, MANADO)

Mayoritas pekerjaan bangunan bertingkat pada umumnya adalah pekerjaan struktur beton bertulang. Pekerjaan struktur beton bertulang adalah pekerjaan bekisting, penulangan, dan pengecoran. Salah satu hal yang perlu di manajemen dari pekerjaan struktur beton bertulang adalah pekerja. Hal yang perlu diketahui dalam manajemen pekerja adalah produktivitas pekerja. Tujuan dari penelitian ini adalah untuk menghitung nilai produktivitas pekerja pekerjaan struktur beton betulang,mengetahui faktor-faktor apa yang mempengaruhi produktivitas pekerja pada pekerjaan struktur beton bertulang. Penelitian ditunjang dengan observasi lapangan pada proyek pembangunan gedung kantor dan ruang kelas pada yayasan persekolahan eben heazer manado. Peningkatan produktivitas akan mengurangi waktu pekerjaan, dan itu berarti akan mereduksi biaya, khususnya biaya pekerjaan sehingga diperoleh suatu biaya tenaga kerja minimum untuk mendapatkan harga yang kompetitif baik untuk pelelangan maupun pelaksanaan. Dalam penelitian ini dibahas mengenai produktivitas dilihat dari segi pekerja dan durasi waktu. Kata Kunci : Produktivitas, Pekerja, Beton Bertulang, Bangunan Bertingka

Dor crónica lombar

RESUMO: A Dor Crónica Lombar (DCL) não especifica é entendida como, presença de dor persistente na região lombar, com duração de pelo menos 12 semanas ou presença de recorrências de dor por um período de seis meses, sem causa física específica, isto é, de origem desconhecida (Airaksinen, et al., 2006; Bekkering et al., 2003; Krismer & van Tulder, 2007). Em Portugal, 36% de pessoas referem dor crónica, sendo que em 40% destes casos são relativos a dor crónica lombar (Faculdade de Medicina da Universidade do Porto, 2007 cit. por APED, 2007 e Castro-Lopes, Saramago, Romão & Paiva, 2010). A frequência de DCL não é só elevada em Portugal como em todos os países desenvolvidos, estimando-se que a sua prevalência varie entre 23 a 30% (Walker, 2000; Cassidy, Cote, Carroll & Kristman, 2005). É também conhecido, que esta condição representa elevadas taxas de absentismo laboral e incapacidade funcional (Nakamura, Nishiwaki, Ushida & Toyama, 2011; Webb et al., 2003; Sá, Baptista, Matos & Lessa, 2008), afigurando cerca de 80% dos custos dos cuidados de saúde (Waddell, 1998). A fisioterapia é uma intervenção comunmente utilizada na DCL (Airaksinen et al., 2006; Savigny et al., 2009). Esta considera variadíssimas modalidades e múltiplos procedimentos de intervenção, com enorme diversidade na conjugação dos mesmos (Airaksinen et al., 2006; Savigny et al., 2009; Moníz & Cruz, 2012), assim como no número de sessões realizadas por episódio de cuidados (Moníz & Cruz, 2012), tornando quase impossível determinar um qualquer padrão de tratamentos (Gil, Cabri & Ferreira, 2009)

Dor crónica lombar: modelo preditivo dos resultados da fisioterapia

Dissertação de mestrado em Fisioterapia.Objetivo: O estudo pretendeu determinar se um modelo baseado nos fatores de prognóstico, identificados na literatura, pode prever os resultados da intervenção em Fisioterapia, a curto prazo, em utentes com DLC, ao nível da incapacidade funcional, intensidade da dor e perceção global de melhoria. Introdução: Estima-se elevada prevalência e incidência de dor crónica lombar tanto em Portugal como em todos os países desenvolvidos. Esta é responsável por elevados índices incapacidade funcional, absentismo laboral e pela maioria dos custos do sistema de saúde. A fisioterapia é das intervenções a que mais se recorre, no entanto os efeitos reportados são diversificados. A obtenção de “bons/ maus” resultados tem sido associada à tipologia de tratamento, mas também a características intrínsecas aos indivíduos ou à forma como a DCL está presente nas pessoas. No que respeita às características intrínsecas aos indivíduos, tem sido estudada a capacidade preditiva de fatores de natureza sócio demográfica e clínica na antecipação desses resultados. Contudo, parece não existir consenso acerca dos mesmos, com os modelos preditivos resultantes a demonstrar reduzida capacidade de explicação da variância dos “bons/ maus” resultados obtidos. Metodologia: Tratou-se de uma coorte prospetiva não probabilística, com dois momentos de avaliação, num período de 6 semanas. Selecionou-se uma amostra por conveniência a partir dos indivíduos que recorreram a serviços de Fisioterapia em Portugal e que cumpriam os critérios de inclusão definidos á priori. Os resultados foram analisados segundo um modelo de regressão logística multivariada, sendo sintetizados de um modo quantitativo. Resultados: A amostra final foi de 171 pessoas com dor crónica lombar e idade média de 48 anos. O curso clínico observado foi, a redução significativa na QBPDS-PT (p=0,000; z= -7,994) e EVA (p=0,000; z= -8,742). O modelo de regressão logística analisado para o outcome incapacidade funcional, revelou ser estatisticamente significativo [X²(2)=22,628 (p<0,001)], explicando 16,6% (Nagelkerke R2 value) da variância da probabilidade de obter “bons” resultados. E evidenciou capacidade preditiva razoável (sensibilidade é de 76,8% e a especificidade de 60,5%) assim como boa capacidade discriminativa (ROC c=0.712, p<0.001).Também o modelo de regressão logística para o outcome intensidade da dor, demonstrou ser estatisticamente significativo [X²(2)=25,731 (p<0,001)], explicando 18,7% (Nagelkerke R2 value) da variância da probabilidade de obter “bons” resultados. E registou boa capacidade discriminativa (ROC c=0,713; p<0.001) e preditiva (sensibilidade é de 75% e a especificidade de 51,9%). Verificou-se ainda, que à semelhança dos anteriores, o modelo de regressão logística, para o outcome perceção global de melhoria, é estatisticamente significativo [X²(2)= 14,936 (p<0,001)], explicando 11,4% (Nagelkerke R2 value) da variância da probabilidade de obter “bons” resultados. Demonstrou também, moderada capacidade discriminativa (habilitações literárias ROC c=0.665, p<0.001) e preditiva (sensibilidade é de 73,1% e a especificidade de 58,7%). Conclusão: Os dados do estudo sugerem que ao fim de 6 semanas de fisioterapia, o nível da incapacidade funcional e de intensidade da dor diminuem significativamente. Indicam ainda que, os modelos determinados são significativos e possuem capacidade preditiva e discriminativa razoável dos “bons” resultados da fisioterapia, em termos de incapacidade funcional, intensidade da dor e perceção global de melhoria.Abstract: Aim: The aim of this study was to determine if short-term successful outcomes following Physical Therapy treatment could be predicted from prognostic factors at baseline, in patients with chronic low back pain (CLBP). Introduction: Prevalence and incidence of chronic low back pain is estimated to be as high in Portugal as in every developed country. This condition is responsible for high functional disability indexes, increased work absence and for the largest amount of money spent by the health care system. Physical therapy is a common intervention for CLBP, however the reported effects are diverse. The “good/bad” results have been connected with the treatments typology as well as the internal characteristics of the patients or how CLBP affects their life. Concerning the internal characteristics of the patients, the predictive capacity of socio demographic and clinical factors have been studied, in the way they can anticipate the results. However, there seems to be no consensus about them, with the resulting predictive models to demonstrate reduced ability to explain the variance of the "good / bad" results obtained. Methodology: It was used a non-probabilistic prospective cohort, with two assessment moments, on a period of 6 weeks. A sample group was chosen from patients that use the Physical therapy services in Portugal following the criteria previously defined. Results were analyzed according to a multivariate logistic regression model and synthesized in a quantitative way. Results: The final sample was composed by 171 patients with an average age of 48 years old, which presented CLBP. Was observed that, significant decrease in QBPDS-PT (p=0,000; z= -7,994) and VAS (p=0,000; z= -8,742). The multivariate logistic regression model for the outcome related to the functional disability, showed to be statistically significant [X²(2)=22,628 (p<0,001)], managing to explain 16,6% (Nagelkerke R2 value) of the “good” results variance probability. Showed a reasonable predictive capacity (76,8% sensibility and 60,5% specificity) as well as a good discriminative competence (ROCcurve=0.712, p<0.001). Also the multivariate logistic regression model for the outcome for pain intensity also demonstrated to be statistically significant [X²(2)=25,731 (p<0,001)], explaining 18,7% (Nagelkerke R2 value) of the “good” results variance probability. It registered likewise a good discriminative (ROC c=0,713; p<0.001) and predictive competence (75% sensibility and 51,9% specificity). Like the mentioned previously for the others models, it was shown that the multivariate logistic regression model for the general improvement perception outcome is statistically significant [X²(2)= 14,936 (p<0,001)], being able to explain 11,4% (Nagelkerke R2 value) of the “good” results variance probability. Showed moderate discriminative (literary qualifications ROC c=0.665, p<0.001) and predictive capacity (73,1% sensibility and 58,7% specificity). Conclusion: Data received from the study suggest that after 6 weeks of physical therapy intervention, the level of functional disability and pain intensity decreased significantly. Also indicate that the models are significant and have reasonable predictive and discriminative ability of "good" physical therapy results in terms of functional disability, pain intensity and global perception of improvement

Shame and psychopathology. Its role in the genesis and perpetuation of different disorders

publishersversionpublishe