11 research outputs found
Iodinated Aluminum(III) Corroles with Long-Lived Triplet Excited States
The first reported iodination of a corrole leads to selective functionalization of the four C–H bonds on one pole of the macrocycle. An aluminum(III) complex of the tetraiodinated corrole, which exhibits red fluorescence, possesses a long-lived triplet excited state
Tuning the Photophysical and Redox Properties of Metallocorroles by Iodination
Facile procedures
were developed for selective iodination of aluminum
and gallium corroles; crystallographic characterization shows that
the main structural aspects are not changed (the macrocycle remains
planar). Absorption maxima are red-shifted by 3–5 nm/iodine,
singlet lifetimes are reduced to <80 ps, and emissions from long-lived
excited states come into effect. The iodinated corroles display prompt
fluorescence, phosphorescence, and delayed thermal fluorescence, all
at room temperature. The effect on redox potentials appears to be
additive for each additional iodine and, surprisingly, is practically
identical to that of the other three halides. The conclusions of this
work are of large importance for the design of metallocorroles that
are best suited for the various applications where metallocorroles
are used as catalysts and photosensitizers
Tuning the Photophysical and Redox Properties of Metallocorroles by Iodination
Facile procedures
were developed for selective iodination of aluminum
and gallium corroles; crystallographic characterization shows that
the main structural aspects are not changed (the macrocycle remains
planar). Absorption maxima are red-shifted by 3–5 nm/iodine,
singlet lifetimes are reduced to <80 ps, and emissions from long-lived
excited states come into effect. The iodinated corroles display prompt
fluorescence, phosphorescence, and delayed thermal fluorescence, all
at room temperature. The effect on redox potentials appears to be
additive for each additional iodine and, surprisingly, is practically
identical to that of the other three halides. The conclusions of this
work are of large importance for the design of metallocorroles that
are best suited for the various applications where metallocorroles
are used as catalysts and photosensitizers
Intriguing Physical and Chemical Properties of Phosphorus Corroles
The fluorescence intensity of phosphorus
corroles increases upon <i>meso</i>-aryl C–F/C–H
and P–OH/P–F
substitutions, the latter affects corrole-centered redox processes
more than C–H/C–F substitution on the corrole’s
skeleton, and the presence of F atoms allows for the first experimental
insight into the electronic structures of oxidized corroles. Experimental
and theoretical methodologies reveal that mono- but not bis-chlorosulfonation
of the corrole skeleton is under kinetic control. Selective introduction
of heavy atoms leads to complexes that are phosphorescent at room
temperature
Straightforward and Relatively Safe Process for the Fluoride Exchange of Trivalent and Tetravalent Group 13 and 14 Phthalocyanines
To avoid the use of hydrofluoric
acid, a series of fluorinated
trivalent and tetravalent metal-containing phthalocyanines (MPcs)
were synthesized using a straightforward one-step halide substitution
process using cesium fluoride (CsF) as the fluoride source and by
reflux in N,N-dimethylformamide
for less than an hour. The resulting fluoro MPcs were characterized
and compared to the parent chloro MPcs. In some cases, very little
change in properties was observed between the fluoro MPcs and the
chloro MPcs. In other cases, such as fluoro aluminum phthalocyanine,
a blue shift in the absorbance characteristics and an increase in
oxidation and reduction potential of as much as 0.22 V was observed
compared to the chloro derivative. Thermo gravimetric analysis was
performed on all halo-MPcs, indicating that the choice of halo substitution
on the axial position can have an effect on the decomposition or sublimation
temperature of the final compound. After initial establishment and
characterization of the fluoro MPcs, the halide substitution reaction
of difluoro silicon phthalocyanine (F2-SiPc) was further
explored by scaling the reaction up to a gram scale as well as considering
tetrabutylammonium fluoride (TBAF) as an additional safe fluoride
source. The scaled-up reactions producing F2-SiPc using
CsF and TBAF as fluoride exchange sources were successfully reproducible,
resulting in reaction yields of 100 and 73%, respectively. Both processes
led to pure final products but results indicate that CsF, as the fluoride
exchange reagent, appears to be the superior reaction process as it
has a much higher yield
Routescore: Punching the Ticket to More Efficient Materials Development
Self-driving labs, in the form of automated experimentation platforms guided by machine learning algorithms have emerged as a potential solution to the need for accelerated science. While new tools for automated analysis and characterization are being developed at a steady rate, automated synthesis remains the bottleneck in the chemical space accessible to self-driving labs. Combining automated and manual synthesis efforts immediately significantly expands the explorable chemical space. To effectively direct the different capabilities of automated (higher throughput and less labor) and manual synthesis (greater chemical versatility), we describe a protocol, the RouteScore, that quantifies the cost of combined synthetic routes. In this work, the RouteScore is used to determine the most efficient synthetic route to a well-known pharmaceutical (structure-oriented optimization), and to simulate a self-driving lab that finds the most easily synthesizable organic laser molecule with specific photophysical properties from a space of ~3500 possible molecules (property-oriented optimization). These two examples demonstrate the power and generality of our approach in mixed synthetic planning and optimization
Autonomous Chemical Experiments: Challenges and Perspectives on Establishing a Self-Driving Lab
A Materials Acceleration Platform for Organic Laser Discovery
Conventional materials discovery is a laborious and time-consuming process that can take decades from initial conception of the material to commercialization. Recent developments in materials acceleration platforms promise to accelerate materials discovery using automation of experiments coupled with machine learning. However, most of the automation efforts in chemistry focus on synthesis and compound identification, with integrated target property characterization receiving less attention. In this work, we introduce an automated platform for the discovery of molecules as gain mediums for organic semiconductor lasers, a problem that has been challenging for conventional approaches. Our platform encompassed automated lego-like synthesis, product identification, and optical characterization that can be executed in a fully integrated end-to-end fashion. Using this workflow to screen organic laser candidates, we have discovered 8 potential candidates for organic lasers. We tested the lasing threshold of 4 molecules in thin-film devices and found 2 molecules with state-of-the-art performance. These promising results show the potential of automated synthesis and screening for accelerated materials development