L'adoption de géothermique à des échelles multiples en Amérique du Nord

In North America, space heating, hot water, and air conditioning use more secondary energy thanany other activity within buildings, thus emitting the majority of scope 1 and scope 2 GreenhouseGases (GHG). The Ground Source Heat Pump (GSHP) uses one-third the energy of traditionaltechnologies to provide space conditioning and hot water services.While GSHP is a well-established technology, the energy savings and lower GHG emissionshave not translated into their widespread adoption. Public policy measures and financialincentives adopted to promote GSHP have failed to lead to broad adoption or lower costs. Thisthesis examines the adoption of GSHP in response to supportive policies among residential,institutional, and city-scale adopters.Detailed site-level and panel data permit natural experiments on the response of residentialadopters in Canada and the US to changing incentives. At higher scales, regulatory proceedingsconcerning the offering of Thermal Energy Services (TES) has provided a case study for analysisof utility models to finance GSHP for commercial and institutional clients.In Canada and the US, financial incentives failed to sustain the adoption of GSHP throughout orafter the period of subsidy among residential households. Neither did incentives lead to adecrease in price over time. Free-ridership problems in Canada and an inability to make inroadsto areas served by natural gas have stranded GSHP technology. Further, the capital cost ofGSHP results in a higher lifecycle cost than most alternatives. The economy-wide benefits offinancial incentives for GSHP are limited in Canada, where most heat pumps are imported.iiiTES provide compelling innovations to bridge barriers at higher scales. TES overcome balancesheet constraints on debt common to public sector organizations by financing capital equipmentand renovations as utility payments. TES can overcome capital constraints faced by developersby financing equipment inside the building lowering construction costs. However, our casestudy of public procurement reveals TES to be a costly approach in the long run. The insightsfrom this research are translated into best practices and policy advice to improve contracting,increase awareness, and align incentives for greater efficiency.En Amérique du Nord, le chauffage de l'espace, l'eau chaude, et l'utilisation de la climatisation énergie secondaire plus que toute autre activité au sein de bâtiments, émettant ainsi la majorité des gaz périmètres 1 et 2 serre (GES). La pompe à chaleur géothermique (PCG) utilise un tiers de l'énergie des technologies traditionnelles de fournir un espace de services d'eau chaude et de climatisation. Bien géothermique est une technologie bien établie, les économies d'énergie et les émissions de GES ne sont pas traduits dans leur adoption généralisée. Les mesures de politique publique et les incitations financières adoptées pour promouvoir PCG ont échoué à conduire à une large adoption ou de réduire les coûts. Cette thèse examine l'adoption de pompes à chaleur géothermiques en réponse aux politiques de soutien parmi les adopteurs résidentiels, institutionnels, et la ville-échelle. Données au niveau détaillé du site et des panneaux permettent expériences naturelles sur la réponse des adoptants résidentiels au Canada et aux États-Unis à l'évolution des incitations. À des échelles supérieures, les procédures réglementaires relatives à l'offre de services de l'énergie thermique (TES) a fourni une étude de cas pour l'analyse des modèles d'utilité pour financer géothermique pour les clients commerciaux et institutionnels. Au Canada et aux États-Unis, les incitations financières ont échoué à soutenir l'adoption de la pompe à chaleur géothermique à travers ou après la période de la subvention pour les ménages résidentiels. Pas plus que les incitations conduisent à une diminution des prix dans le temps. Problèmes de resquillage au Canada et une incapacité à faire des incursions dans les zones desservies par le gaz naturel ont brin technologie géothermique. En outre, le coût en capital de pompes à chaleur géothermiques en résulte un coût de cycle de vie plus élevé que la plupart des solutions de rechange. Les avantages de l'économie à l'échelle d'incitations financières pour les pompes à chaleur géothermiques sont limitées au Canada, où la plupart des pompes à chaleur sont importés. TES fournissent innovations convaincantes pour combler les obstacles à des échelles supérieures. TES surmonter équilibrer les contraintes de bilan sur la dette commune aux organisations du secteur public par le financement de biens d'équipement et de rénovation que les paiements de services publics. TES peut surmonter les contraintes de capitaux rencontrés par les développeurs en finançant des équipements à l'intérieur du bâtiment en réduisant les coûts de construction. Cependant, notre étude des marchés publics de cas révèle TES être une approche coûteuse dans le long terme. Les perspectives de cette recherche sont traduits dans les meilleures pratiques et des conseils stratégiques pour améliorer la passation des marchés, accroître la sensibilisation, et aligner les incitations pour une plus grande efficacité

Changes in corticospinal drive to spinal motoneurones following tablet-based practice of manual dexterity

The use of touch screens, which require a high level of manual dexterity, has exploded since the development of smartphone and tablet technology. Manual dexterity relies on effective corticospinal control of finger muscles, and we therefore hypothesized that corticospinal drive to finger muscles can be optimized by tablet‐based motor practice. To investigate this, sixteen able‐bodied females practiced a tablet‐based game (3 × 10 min) with their nondominant hand requiring incrementally fast and precise pinching movements involving the thumb and index fingers. The study was designed as a semirandomized crossover study where the participants attended one practice‐ and one control session. Before and after each session electrophysiological recordings were obtained during three blocks of 50 precision pinch movements in a standardized setup resembling the practiced task. Data recorded during movements included electroencephalographic (EEG) activity from primary motor cortex and electromyographic (EMG) activity from first dorsal interosseous (FDI) and abductor pollicis brevis (APB) muscles. Changes in the corticospinal drive were evaluated from coupling in the frequency domain (coherence) between EEG–EMG and EMG–EMG activity. Following motor practice performance improved significantly and a significant increase in EEG‐EMG(APB) and EMG(APB)‐EMG(FDI) coherence in the beta band (15–30 Hz) was observed. No changes were observed after the control session. Our results show that tablet‐based motor practice is associated with changes in the common corticospinal drive to spinal motoneurons involved in manual dexterity. Tablet‐based motor practice may be a motivating training tool for stroke patients who struggle with loss of dexterity

Exercise Oncology and Immuno-Oncology; A (Future) Dynamic Duo

Recent advances in clinical oncology is based on exploiting the capacity of the immune system to combat cancer: immuno-oncology. Thus, immunotherapy of cancer is now used to treat a variety of malignant diseases. A striking feature is that even patients with late-stage disease may experience curative responses. However, most patients still succumb to disease, and do not benefit from treatment. Exercise has gained attention in clinical oncology and has been used for many years to improve quality of life, as well as to counteract chemotherapy-related complications. However, more recently, exercise has garnered interest, largely due to data from animal studies suggesting a striking therapeutic effect in preclinical cancer models; an effect largely mediated by the immune system. In humans, physical activity is associated with a lower risk for a variety of malignancies, and some data suggest a positive clinical effect for cancer patients. Exercise leads to mobilization of cells of the immune system, resulting in redistribution to different body compartments, and in preclinical models, exercise has been shown to lead to immunological changes in the tumor microenvironment. This suggests that exercise and immunotherapy could have a synergistic effect if combined

To be active through indoor-climbing: an exploratory feasibility study in a group of children with cerebral palsy and typically developing children

Background: Cerebral Palsy (CP) is the most common cause of motor disabilities in children and young adults and it is also often associated with cognitive and physiological challenges. Climbing requires a multifaceted repertoire of movements, participants at all levels of expertise may be challenged functionally and cognitively, making climbing of great potential interest in (re) habilitation settings. However, until now only few research projects have investigated the feasibility of climbing as a potential activity for heightening physical activity in children with CP and the possible beneficial effects of climbing activities in populations with functional and/or cognitive challenges. The aim of this study was therefore to test the feasibility of an intensive 3 weeks indoor-climbing training program in children with CP and typically developing (TD) peers. In addition we evaluated possible functional and cognitive benefits of 3 weeks of intensive climbing training in 11 children with cerebral palsy (CP) aged 11-13 years and six of their TD peers.Method: The study was designed as a feasibility and interventional study. We evaluated the amount of time spent being physically active during the 9 indoor-climbing training sessions, and climbing abilities were measured. The participants were tested in a series of physiological, psychological and cognitive tests: two times prior to and one time following the training in order to explore possible effects of the intervention.Results: The children accomplished the training goal of a total of nine sessions within the 3-week training period. The time of physical activity during a 2: 30 h climbing session, was comparably high in the group of children with CP and the TD children. The children with CP were physically active on average for almost 16 h in total during the 3 weeks. Both groups of participants improved their climbing abilities, the children with CP managed to climb a larger proportion of the tested climbing route at the end of training and the TD group climbed faster. For the children with CP this was accompanied by significant improvements in the Sit-to-stand test (p <0.01), increased rate of force development in the least affected hand during an explosive pinch test and increased muscularmuscular coherence during a pinch precision test (p <0.05). We found no improvements in maximal hand or finger strength and no changes in cognitive abilities or psychological well-being in any of the groups.Conclusions: These findings show that it is possible to use climbing as means to make children with CP physically active. The improved motor abilities obtained through the training is likely reflected by increased synchronization between cortex and muscles, which results in a more efficient motor unit recruitment that may be transferred to daily functional abilities

Sub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regions

BACKGROUND: The variant surface antigen family Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) is an important target for protective immunity and is implicated in the pathology of malaria through its ability to adhere to host endothelial receptors. The sequence diversity and organization of the 3D7 PfEMP1 repertoire was investigated on the basis of the complete genome sequence. METHODS: Using two tree-building methods we analysed the coding and non-coding sequences of 3D7 var and rif genes as well as var genes of other parasite strains. RESULTS: var genes can be sub-grouped into three major groups (group A, B and C) and two intermediate groups B/A and B/C representing transitions between the three major groups. The best defined var group, group A, comprises telomeric genes transcribed towards the telomere encoding PfEMP1s with complex domain structures different from the 4-domain type dominant of groups B and C. Two sequences belonging to the var1 and var2 subfamilies formed independent groups. A rif subgroup transcribed towards the centromere was found neighbouring var genes of group A such that the rif and var 5' regions merged. This organization appeared to be unique for the group A var genes CONCLUSION: The grouping of var genes implies that var gene recombination preferentially occurs within var gene groups and it is speculated that the groups reflect a functional diversification evolved to cope with the varying conditions of transmission and host immune response met by the parasite

HUBUNGAN ANTARA KOMITMEN BERPACARAN DENGAN KUALITAS PERSAHABATAN PADA REMAJA AKHIR DI UNIVERSITAS PENDIDIKAN INDONESIA

Penelitian ini memiliki beberapa tujuan, yaitu untuk mengetahui (1) gambaran komitmen berpacaran, (2) gambaran kualitas persahabatan, (3) hubungan antara komitmen berpacaran dengan kualitas persahabatan pada remaja akhir di Universitas Pendidikan Indonesia (UPI). Responden pada penelitian ini ialah mahasiswa di UPI yang berada pada usia remaja akhir yang memiliki pasangan (pacar) dan juga teman dekat (sahabat). Terdapat 200 orang responden sesuai kriteria yang telah ditentukan dalam penelitian ini. Penelitian ini menggunakan metode kuantitatif dan menggunakan teknik purposive sampling. Pengumpulan data dilakukan melalui penyebaran kuesioner dengan memanfaatkan aplikasi google docs. Kuesioner berisikan skala komitmen berpacaran yang peneliti adaptasi dan modifikasi dari Commitment Measurenment milik Rusbult (1983) dan skala kualitas persahabatan yang juga peneliti adaptasi dan modifikasi dari Friendship Quality Scale (FQS) milik Bukowski, Hoza, dan Bovin (Ponti, dkk, 2010). Data yang diperoleh dianalisis menggunakan teknik korelasi Spearman Rho. Hasil penelitian menunjukkan (1) remaja akhir di UPI memiliki komitmen berpacaran yang cenderung rendah yaitu sebanyak 41% dari 200 orang responden, (2) remaja akhir di UPI memiliki kualitas persahabatan yang cenderung rendah yaitu sebanyak 36,5% dari 200 orang responden, dan (3) terdapat hubungan yang antara komitmen berpacaran dengan kualitas persahabatan pada remaja akhir di Universitas Pendidikan Indonesia.---------This study aims to describe (1) the image of commitment dating (2) the big picture of quality of friendship, and (3) relationship between Commitment Dating with the quality of friendship late adolescence at Indonesia University of Education (UPI). Responders of this study are late adolescence at Indonesia University of Education who are in commitment relationship and having close friends. There are around 200 people with the appropriate criteria have been determined in this study. This study uses quantitative methods and using purposive sampling technique. Data collected through questionnaires by using google docs app. The questionnaire contains of a commitment dating scale that is adapted by researcher and modification of Commitment Measurenment owned by Rusbult (1983) and so is Quality Scale (FQS) belongs to Bukowski, Hoza, and Bovin (Ponti et al, 2010). Data was analyzed by using Spearman Rho correlation techniques. The result showed that (1) late adolescence of UPI who are in committed relationship that tends to lower as many as 41% of the 200 respondents, (2) late adolescence of UPI have a rather low quality friendships as many as 36.5% of the 200 respondents, and (3) there is a relationship between commitment dating with the quality of friendship in late teens at UPI