An Investigation into the relationship between the gender binary and occupational discrimination using the implicit relational assessment procedure

The social construction of gender-as-binary plays an important role within many contemporary theories of gender inequality. However, to date, the field of psychology has struggled with the operationalization and assessment of binarist ideologies. The current article proposes a technical framework for the analysis of the gender binary and assesses the suitability of the Implicit Relational Assessment Procedure (IRAP) as a measure of binarist gender beliefs. Forty-seven undergraduate students (26 female; M-age = 23.84) completed two IRAPs assessing the coordination of certain traits exclusively with women and others exclusively with men. Effects found on the IRAP were in the expected direction (i.e., relating men but not women with certain traits and women but not men with other traits). In addition, the traits ascribed to men within the IRAP were evaluated as more hirable by a large majority of participants (83%) on an explicit preference task. The results therefore support the arguments that, first, gender traits do seem to be framed oppositionally in language and, second, this binary may underpin existing gender hierarchies in certain contexts

Evidence synthesis on the occurrence, causes, consequences, prevention and management of bullying and harassment behaviours to inform decision making in the NHS

Background Workplace bullying is a persistent problem in the NHS with negative implications for individuals, teams, and organisations. Bullying is a complex phenomenon and there is a lack of evidence on the best approaches to manage the problem. Aims Research questions What is known about the occurrence, causes, consequences and management of bullying and inappropriate behaviour in the workplace? Objectives Summarise the reported prevalence of workplace bullying and inappropriate behaviour. Summarise the empirical evidence on the causes and consequences of workplace bullying and inappropriate behaviour. Describe any theoretical explanations of the causes and consequences of workplace bullying and inappropriate behaviour. Synthesise evidence on the preventative and management interventions that address workplace bullying interventions and inappropriate behaviour. Methods To fulfil a realist synthesis approach the study was designed across four interrelated component parts: Part 1: A narrative review of the prevalence, causes and consequences of workplace bullying Part 2: A systematic literature search and realist review of workplace bullying interventions Part 3: Consultation with international bullying experts and practitioners Part 4: Identification of case studies and examples of good practic

Comparing impingement boiling vs. pool boiling to improve technological insight into liquid cooling in electronics [abstract]

Abstract only availableWith the field of technology advancing at a rapid pace so must the technology behind cooling these electronic parts. My research compares two completely different of cooling operations and compares many different fluids in each method. This research will help lead the electronics industry into the future of liquid cooling. The first method is impingement boiling where jets of fluid spray a heated copper coupon and as the fluid rapidly boils it removes large amounts of heat. Jet arrays will be tested for one jet, four jets, and nine jets. Also we will experiment with different sorts of surface finishes on the heated copper coupon to see how this affects heat transfer. The three fluids that will be tested in this experiment are Water, Ethanol, and HFE7000. With these fluid's contrasting properties we should obtain great insight into what properties are most desired for this form of cooling. The second method of removing heat will be by pool boiling. For these tests will have a similar copper coupon, but in this case the fluid is allowed to gather in a pool completely submersing the copper coupon. We will be testing the fluids listed above plus some additional nanofluids. This is a very simple form of boiling that yields great amounts of heat transfer. Pool boiling as well as impingement boiling both have a very positive outlook for the future of liquid cooling and I hope to offer more insight though my research

Lean Healthcare: en studie av implementering och organisatoriskt lärande

I dag är Lean som verksamhetsfilosofi populärt och det an-vänds i både privat och offentlig sektor. Detta väckte vårt intresse som pedagoger för huruvida ett lärande gynnas av denna verksamhetsfilosofi. Vi fick tillgång till en stor orga-nisation som jobbar med implementering av Lean Health-care. Syftet med studien var att genom Leanstrategernas förståelse av verksamhetsfilosofin utröna möjligheterna för ett organisatoriskt lärande vid implementeringen av Lean. För att undersöka detta har vi använt oss av en hermeneutisk kvalitativ studie där datainsamlingen har skett i form av intervjuer och dokumentation från organisationen. Vidare har tolkningen skett med hjälp av relevanta teorier kring organisatoriskt lärande, ledarskap och makt. Vår slutsats är att det finns förutsättningar för organisato-riskt lärande men det kräver dock att detta synsätt genomsy-rar hela organisationen

Ensayos a cortante de vigas de hormigón estructural autocompactable

En el presente trabajo se presenta una serie de ensayos realizados en el Laboratorio de Tecnología de Estructuras de la Escuela de Ingenieros de Caminos, Canales y Puertos de Barcelona (Departamento de Ingeniería de la Construcción) de la Universidad Politécnica de Cataluña. La campaña de ensayos incluía una serie de vigas de sección “doble T” de hormigón autocompactable de resistencia media (HAC-RM) y una serie paralela realizada con hormigón convencional (HC) de la misma resistencia mecánica. Se verificó el comportamiento estructural frente al esfuerzo cortante de vigas de hormigón armado y pretensado con armadura pretesa y postesa, y tanto estructuras continuas como isostáticas. Los resultados muestran una menor resistencia a cortante en las vigas con HAC y armadura pasiva y activa. Para las vigas pretensadas con HAC y HC los valores de resistencia a cortante fueron similares.Peer ReviewedPostprint (published version

Evidence of a Large Novel Gene Pool Associated with Prokaryotic Genomic Islands

Microbial genes that are “novel” (no detectable homologs in other species) have become of increasing interest as environmental sampling suggests that there are many more such novel genes in yet-to-be-cultured microorganisms. By analyzing known microbial genomic islands and prophages, we developed criteria for systematic identification of putative genomic islands (clusters of genes of probable horizontal origin in a prokaryotic genome) in 63 prokaryotic genomes, and then characterized the distribution of novel genes and other features. All but a few of the genomes examined contained significantly higher proportions of novel genes in their predicted genomic islands compared with the rest of their genome (Paired t test = 4.43E-14 to 1.27E-18, depending on method). Moreover, the reverse observation (i.e., higher proportions of novel genes outside of islands) never reached statistical significance in any organism examined. We show that this higher proportion of novel genes in predicted genomic islands is not due to less accurate gene prediction in genomic island regions, but likely reflects a genuine increase in novel genes in these regions for both bacteria and archaea. This represents the first comprehensive analysis of novel genes in prokaryotic genomic islands and provides clues regarding the origin of novel genes. Our collective results imply that there are different gene pools associated with recently horizontally transmitted genomic regions versus regions that are primarily vertically inherited. Moreover, there are more novel genes within the gene pool associated with genomic islands. Since genomic islands are frequently associated with a particular microbial adaptation, such as antibiotic resistance, pathogen virulence, or metal resistance, this suggests that microbes may have access to a larger “arsenal” of novel genes for adaptation than previously thought

Evolution or revolution: Where next for impact assessment?

Impact assessment (IA) has become one of the most prevalent environmental policy instruments today. Its introduction under the National Environmental Policy Act (US) in 1969 was revolutionary. Perhaps it is not surprising, then, that such a widely used tool has received its share of criticism, including that it fails to meet some of its fundamental goals. Over the last fifty years, IA has broadened in scope and application and embraced new techniques. It has followed evolved, but has not changed fundamentally. We believe that IA must continue to change to meet the societal and environmental challenges of the 21st century. But will it be enough for IA to progress through incremental change (evolution), or is a complete overhaul of impact assessment (revolution) needed? We provide some ideas as to what ‘evolution’ and ‘revolution’ may look like, but rather then offering a definitive way forward now, we invite stakeholders to present their thoughts and suggestions at the IAIA19 Annual Conference in Brisbane, which carries the same theme as the title of this article

Development of the morpholino gene knockdown technique in Fundulus heteroclitus : a tool for studying molecular mechanisms in an established environmental model

Author Posting. © Elsevier B.V., 2008. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Aquatic Toxicology 87 (2008): 289-295, doi:10.1016/j.aquatox.2008.02.010.A significant challenge in environmental toxicology is that many genetic and genomic tools available in laboratory models are not developed for commonly used environmental models. The Atlantic killifish (Fundulus heteroclitus) is one of the most studied teleost environmental models, yet few genetic or genomic tools have been developed for use in this species. The advancement of genetic and evolutionary toxicology will require that many of the tools developed in laboratory models be transferred into species more applicable to environmental toxicology. Antisense morpholino oligonucleotide (MO) gene knockdown technology has been widely utilized to study development in zebrafish and has been proven to be a powerful tool in toxicological investigations through direct manipulation of molecular pathways. To expand the utility of killifish as an environmental model, MO gene knockdown technology was adapted for use in Fundulus. Morpholino microinjection methods were altered to overcome the significant differences between these two species. Morpholino efficacy and functional duration were evaluated with molecular and phenotypic methods. A cytochrome P450-1A (CYP1A) MO was used to confirm effectiveness of the methodology. For CYP1A MO-injected embryos, a 70% reduction in CYP1A activity, a 86% reduction in total CYP1A protein, a significant increase in β-naphthoflavone-induced teratogenicity, and estimates of functional duration (50% reduction in activity 10 dpf, and 86% reduction in total protein 12 dpf) conclusively demonstrated that MO technologies can be used effectively in killifish and will likely be just as informative as they have been in zebrafish.This work was funded in part by the National Institute of Environmental Health Sciences through the Duke Superfund Basic Research Center (P42ES010356), the Boston University Superfund Basic Research Program (P42ES007381), and the Duke Integrated Toxicology and Environmental Health Program (ES-T32-0007031). Additional support was provided by a U.S. Environmental Protection Agency STAR fellowship awarded to C.R.F

MAID : An effect size based model for microarray data integration across laboratories and platforms

<p>Abstract</p> <p>Background</p> <p>Gene expression profiling has the potential to unravel molecular mechanisms behind gene regulation and identify gene targets for therapeutic interventions. As microarray technology matures, the number of microarray studies has increased, resulting in many different datasets available for any given disease. The increase in sensitivity and reliability of measurements of gene expression changes can be improved through a systematic integration of different microarray datasets that address the same or similar biological questions.</p> <p>Results</p> <p>Traditional effect size models can not be used to integrate array data that directly compare treatment to control samples expressed as log ratios of gene expressions. Here we extend the traditional effect size model to integrate as many array datasets as possible. The extended effect size model (MAID) can integrate any array datatype generated with either single or two channel arrays using either direct or indirect designs across different laboratories and platforms. The model uses two standardized indices, the standard effect size score for experiments with two groups of data, and a new standardized index that measures the difference in gene expression between treatment and control groups for one sample data with replicate arrays. The statistical significance of treatment effect across studies for each gene is determined by appropriate permutation methods depending on the type of data integrated. We apply our method to three different expression datasets from two different laboratories generated using three different array platforms and two different experimental designs. Our results indicate that the proposed integration model produces an increase in statistical power for identifying differentially expressed genes when integrating data across experiments and when compared to other integration models. We also show that genes found to be significant using our data integration method are of direct biological relevance to the three experiments integrated.</p> <p>Conclusion</p> <p>High-throughput genomics data provide a rich and complex source of information that could play a key role in deciphering intricate molecular networks behind disease. Here we propose an extension of the traditional effect size model to allow the integration of as many array experiments as possible with the aim of increasing the statistical power for identifying differentially expressed genes.</p