Mixed-fidelity prototyping of user interfaces

This research presents a new technique for user interface prototyping, called mixed-fidelity prototyping. Mixed-fidelity prototyping combines low-, medium-, and high-fidelity interface elements within a single prototype in a lightweight manner, supporting independent refinement of individual elements. The approach allows designers to investigate alternate designs, including more innovative designs, and elicit feedback from stakeholders without having to commit too early in the process. As well, the approach encourages collaboration among a diverse group of stakeholders throughout the design process. For example, individuals who specialize in specific fidelities, such as high-fidelity components, are able to become involved earlier on in the process. We developed a conceptual model called the Region Model and implemented a proof-of-concept system called ProtoMixer. We demonstrated the mixed-fidelity approach by using ProtoMixer to design an example application. ProtoMixer has several benefits over other existing prototyping tools. With ProtoMixer, prototypes can be composed of multiple fidelities, and elements are easily refined and transitioned between different fidelities. Individual elements can be tied into data and functionality, and can be executed inside prototypes. As well, traditional informal practices such as sketching and storyboarding are supported. Furthermore, ProtoMixer is designed for collaborative use on a high-resolution, large display workspace

Intelligent support technologies for older people : an analysis of characteristics and roles

For almost two decades there have been many developments in using intelligent technologies to support older people, with many different terms proposed to describe these technologies including assistive robots, embodied conversational agents and relational agents. Many technologies have been proposed in many different configurations and many assistance roles have been explored. Characteristics of these technologies include tangible or virtual; anthropomorphic, biomorphic, creature or object-like; level of visual realism; paralinguistic abilities; interactivity; adaptability; movement; and positioning. The assistive roles proposed include providing information, advice and reminders, helping with physical tasks, monitoring, providing companionship and emotional support. This paper provides an overview of the characteristics and roles of these technologies and attempts to clarify some of the terminology used. It aims to provide a guide for researchers from the wide range of disciplines working on such technologies for supporting older people

Feeding ancient cities in South Asia: Dating the adoption of rice, millet and tropical pulses in the Indus civilisation

© Antiquity Publications Ltd, 2016.The first direct absolute dates for the exploitation of several summer crops by Indus populations are presented here. These include rice, millets and three tropical pulse species at two settlements in the hinterland of the urban site of Rakhigarhi. The dates confirm the role of native summer domesticates in the rise of Indus cities. They demonstrate that, from their earliest phases, a range of crops and variable strategies, including multi-cropping, were used to feed different urban centres. This has important implications for understanding the development of the earliest cities in South Asia, particularly the organisation of labour and provisioning throughout the year

The Impact of Using Relevant Context on Student Comprehension and Attitude in a Collegiate Introductory Statistics Unit on Probability

The typical collegiate introductory statistics course poses significant challenges for students. Many do not fully comprehend key course skills, and it is common for students to exit the class with a neutral or negative attitude toward statistics. To measure the impact of using relevant contextual examples as an instructional strategy during a probability unit, in-class activities were designed to align with areas of interest for participants as identified by a student interest inventory. It was hypothesized that the use of relevant context would create a significant difference in the comprehension or attitude of students enrolled in an introductory statistics course at an urban midwestern university. Following a quantitative analysis of comprehension and attitude, interviews and focus groups were conducted with students from both the treatment and control groups to better understand the factors that influence student comprehension and attitude. Quantitative results reveal no significant differences in either comprehension or attitude as a result of the relevant context. Qualitative findings suggest other factors such as the instructor, class structure, and previous experiences play a larger role in shaping student comprehension and attitude

Integrating a framework for conducting public health systems research into statewide operations-based exercises to improve emergency preparedness

<p>Abstract</p> <p>Background</p> <p>Due to the uncommon nature of large-scale disasters and emergencies, public health practitioners often turn to simulated emergencies, known as “exercises”, for preparedness assessment and improvement. Under the right conditions, exercises can also be used to conduct original public health systems research. This paper describes the integration of a research framework into a statewide operations-based exercise program in California as a systems-based approach for studying public health emergency preparedness and response.</p> <p>Methods</p> <p>We developed a research framework based on the premise that operations-based exercises conducted by medical and public health agencies can be described using epidemiologic concepts. Using this framework, we conducted a survey of key local and regional medical and health agencies throughout California following the 2010 Statewide Medical and Health Exercise. The survey evaluated: (1) the emergency preparedness capabilities activated and functions performed in response to the emergency scenario, and (2) the major challenges to inter-organizational communications and information management.</p> <p>Results</p> <p>Thirty-five local health departments (LHDs), 24 local emergency medical services (EMS) agencies, 121 hospitals, and 5 Regional Disaster Medical and Health Coordinators/Specialists (RDMHC) responded to our survey, representing 57%, 77%, 26% and 83%, respectively, of target agencies in California. We found two sets of response capabilities were activated during the 2010 Statewide Exercise: a set of core capabilities that were common across all agencies, and a set of agency-specific capabilities that were more common among certain agency types. With respect to one response capability in particular, inter-organizational information sharing, we found that the majority of respondents’ comments were related to the complete or partial failure of communications equipment or systems.</p> <p>Conclusions</p> <p>Using the 2010 Statewide Exercise in California as an opportunity to develop our research framework, we characterized several aspects of the public health and medical system’s response to a standardized emergency scenario. From a research perspective, this study provides a potential new framework for conducting exercise-based research. From a practitioner’s perspective, our results provide a starting point for preparedness professionals’ dialogue about expected and actual organizational roles, responsibilities, and resource capacities within the public health system. Additionally, the identification of specific challenges to inter-organizational communications and information management offer specific areas for intervention.</p

Consolidation of Schools and Districts: What the Research Says and What it Means

Arguments for consolidation, which merges schools or districts and centralizes their management, rest primarily on two presumed benefits: (1) fiscal efficiency and (2) higher educational quality. The extent of consolidation varies across states due to their considerable differences in history, geography, population density, and politics. Because economic crises often provoke calls for consolidation as a means of increasing government efficiency, the contemporary interest in consolidation is not surprising. However, the review of research evidence detailed in this brief suggests that a century of consolidation has already produced most of the efficiencies obtainable. Research also suggests that impoverished regions in particular often benefit from smaller schools and districts, and they can suffer irreversible damage if consolidation occurs. For these reasons, decisions to deconsolidate or consolidate districts are best made on a case-by-case basis. While state-level consolidation proposals may serve a public relations purpose in times of crisis, they are unlikely to be a reliable way to obtain substantive fiscal or educational improvement

A cell-based assay system for activators of the environmental cell stress response

This work was funded by The Scottish Government Rural and Environment Science and Analytical Services Division (RESAS), Scotland, United Kingdom and the Biotechnology and Biological Sciences Research Council (BBSRC; East-Bio Doctoral Training Partnership), United Kingdom. The funders had no role in the design of the study, the analysis and interpretation of the data, or the publication process. The authors wish to thank Prof. John Hayes, University of Dundee, for the NQO1-luciferase construct and Prof. Gary Felsenfeld, NIH, Bethesda for the plasmid pJC13-1.Peer reviewedPostprin

Developing Global Competency and Ethical Leadership through Global Service Learning: Exploring Innovations in Process, Assessment, and Student Experience

The main objective of the “Developing Global Competency “workshop as described in the proposal is to educate participants on how to integrate the global service learning model effectively to teach students about ethics and leadership. This session describes the Pitt Business global service learning model, presenting innovations in the process, assessment, and student experience. The intention is to create awareness among participants on ways to use the global service learning teaching model to promote students’ development of ethical and transferable skills necessary for a global workforce

MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells

<p>Abstract</p> <p>Background</p> <p>Cancer cells utilize a variety of mechanisms to evade immune detection and attack. Effective immune detection largely relies on the formation of an immune synapse which requires close contact between immune cells and their targets. Here, we show that MUC16, a heavily glycosylated 3-5 million Da mucin expressed on the surface of ovarian tumor cells, inhibits the formation of immune synapses between NK cells and ovarian tumor targets. Our results indicate that MUC16-mediated inhibition of immune synapse formation is an effective mechanism employed by ovarian tumors to evade immune recognition.</p> <p>Results</p> <p>Expression of low levels of MUC16 strongly correlated with an increased number of conjugates and activating immune synapses between ovarian tumor cells and primary naïve NK cells. MUC16-knockdown ovarian tumor cells were more susceptible to lysis by primary NK cells than MUC16 expressing controls. This increased lysis was not due to differences in the expression levels of the ligands for the activating receptors DNAM-1 and NKG2D. The NK cell leukemia cell line (NKL), which does not express KIRs but are positive for DNAM-1 and NKG2D, also conjugated and lysed MUC16-knockdown cells more efficiently than MUC16 expressing controls. Tumor cells that survived the NKL challenge expressed higher levels of MUC16 indicating selective lysis of MUC16^lowtargets. The higher csMUC16 levels on the NKL resistant tumor cells correlated with more protection from lysis as compared to target cells that were never exposed to the effectors.</p> <p>Conclusion</p> <p>MUC16, a carrier of the tumor marker CA125, has previously been shown to facilitate ovarian tumor metastasis and inhibits NK cell mediated lysis of tumor targets. Our data now demonstrates that MUC16 expressing ovarian cancer cells are protected from recognition by NK cells. The immune protection provided by MUC16 may lead to selective survival of ovarian cancer cells that are more efficient in metastasizing within the peritoneal cavity and also at overcoming anti-tumor innate immune responses.</p