Twitter como herramienta del periodismo de declaraciones con mayor incidencia en las noticias políticas de las plataformas online de medios de comunicación: "Caso Kenji Fujimori en 2017 y 2018”

El presente trabajo analiza la estrategia de comunicación empleada por el entonces congresista de la República Kenji Fujimori en Twitter, así como el uso que los periodistas de medios digitales dieron a sus publicaciones con la mencionada red social. La investigación encuentra que Twitter se convirtió en el único canal de comunicación de Kenji Fujimori, cuya unidireccionalidad, accesibilidad e inmediatez reforzó el desarrollo de un periodismo de declaraciones. El trabajo está acotado desde enero del 2017 hasta marzo del 2018, y a las plataformas digitales de Perú21, El Comercio y La República. En esta tesis, se recurre al análisis de contenido, así como a la entrevista a seis periodistas de las secciones de Política de los referidos medios digitales, quienes brindan detalles sobre la producción de información relacionada a Kenji Fujimori. Asimismo, se entrevistó a Alexei Toledo, quien fue asesor político del ex congresista, para que explique las fases de la estrategia de comunicación en redes sociales. La conclusión del trabajo de investigación es que Twitter es una herramienta inmediata, coyuntural, conflictiva y actualizada, que alienta y refuerza las prácticas de un periodismo de declaraciones y cierta tendencia de los periodistas a utilizar las tendencias de redes sociales al momento de elegir los temas para informar.This research analyzes the communication strategy used by the then Congressman of the Republic Kenji Fujimori on Twitter, as well as the use that digital media journalists gave to their publications with the aforementioned social network. The investigation finds that Twitter became the only communication channel for Kenji Fujimori, whose unidirectionality, accessibility and immediacy reinforced the development of statement journalism. Also, it is limited from January 2017 to March 2018, and to the digital platforms of Perú21, El Comercio and La República. In this thesis, content analysis is used, as well as an interview with six journalists from the Politics sections of the aforementioned digital media, who provide details on the production of information related to Kenji Fujimori. Likewise, Alexei Toledo, who was a political advisor to the former congressman, was interviewed to explain the phases of the communication strategy on social networks. The conclusion of the research work is that Twitter is an immediate, conjunctural, conflictive and up-to-date tool that encourages and reinforces the practices of statement journalism and a certain tendency for journalists to use social media trends when choosing topics to inform

Cartagena como home port para la industria de cruceros

El método a utilizar será la recopilación de información de fuentes secundarias tales como Sociedad Portuaria de Cartagena, Alcaldía Distrital, Corporación Turismo Cartagena, Cámara de Comercio, entes turísticos y demás, de las cuales se analizaran proyectos, ideas e información específica acorde al presente trabajo de investigación y que sean consecuentes con el alcance del objetivo general. Se tendrán en cuenta los proyectos a realizar en la ciudad y los procedimientos que se cumplen para la debida ejecución de estos. Además se observaran estadísticas referentes al movimiento turístico de Cartagena, frecuencia de pasajeros tanto nacionales como internacionales y las fechas en las cuales se presenta la mayor afluencia de personal con la ayuda de un análisis de tendencias con respecto al comportamiento y actitudes que tienen los extranjeros

Midlife Vascular Factors and Prevalence of Mild Cognitive Impairment in Late-Life in Mexico

Objective: To estimate the prevalence of mild cognitive impairment (MCI) and its subtypes and investigate the impact of midlife cardiovascular risk factors on late-life MCI among the aging Mexican population. Method: Analyses included a sample of non-demented adults over the age of 55 living in both urban and rural areas of Mexico (N = 1807). MCI diagnosis was assigned based on a comprehensive cognitive assessment assessing the domains of memory, executive functioning, language, and visuospatial ability. The normative sample was selected by means of the robust norms approach. Cognitive impairment was defined by a 1.5-SD cut-off per cognitive domain using normative corrections for age, years of education, and sex. Risk factors included age, education, sex, rurality, depression, insurance status, workforce status, hypertension, diabetes, stroke, and heart disease. Results: The prevalence of amnestic MCI was 5.9%. Other MCI subtypes ranged from 4.2% to 7.7%. MCI with and without memory impairment was associated with older age (OR = 1.01 [1.01, 1.05]; OR = 1.03 [1.01, 1.04], respectively) and residing in rural areas (OR = 1.49 [1.08, 2.06]; OR = 1.35 [1.03, 1.77], respectively). Depression (OR = 1.07 [1.02, 1.12]), diabetes (OR = 1.37 [1.03, 1.82]), and years of education (OR = 0.94 [0.91, 0.97]) were associated with MCI without memory impairment. Midlife CVD increased the odds of MCI in late-life (OR = 1.76 [1.19, 2.59], which was driven by both midlife hypertension and diabetes (OR = 1.70 [1.18, 2.44]; OR = 1.88 [1.19, 2.97], respectively). Conclusions: Older age, depression, low education, rurality, and midlife hypertension and diabetes were associated with higher risk of late-life MCI among older adults in Mexico. Our findings suggest that the causes of cognitive impairment are multifactorial and vary by MCI subtype

Differential Release and Phagocytosis of Tegument Glycoconjugates in Neurocysticercosis: Implications for Immune Evasion Strategies

Neurocysticercosis (NCC) is an infection of the central nervous system (CNS) by the metacestode of the helminth Taenia solium. The severity of the symptoms is associated with the intensity of the immune response. First, there is a long asymptomatic period where host immunity seems incapable of resolving the infection, followed by a chronic hypersensitivity reaction. Since little is known about the initial response to this infection, a murine model using the cestode Mesocestoides corti (syn. Mesocestoides vogae) was employed to analyze morphological changes in the parasite early in the infection. It was found that M. corti material is released from the tegument making close contact with the nervous tissue. These results were confirmed by infecting murine CNS with ex vivo–labeled parasites. Because more than 95% of NCC patients exhibit humoral responses against carbohydrate-based antigens, and the tegument is known to be rich in glycoconjugates (GCs), the expression of these types of molecules was analyzed in human, porcine, and murine NCC specimens. To determine the GCs present in the tegument, fluorochrome-labeled hydrazides as well as fluorochrome-labeled lectins with specificity to different carbohydrates were used. All the lectins utilized labeled the tegument. GCs bound by isolectinB4 were shed in the first days of infection and not resynthesized by the parasite, whereas GCs bound by wheat germ agglutinin and concavalinA were continuously released throughout the infectious process. GCs bound by these three lectins were taken up by host cells. Peanut lectin-binding GCs, in contrast, remained on the parasite and were not detected in host cells. The parasitic origin of the lectin-binding GCs found in host cells was confirmed using antibodies against T. solium and M. corti. We propose that both the rapid and persistent release of tegumental GCs plays a key role in the well-known immunomodulatory effects of helminths, including immune evasion and life-long inflammatory sequelae seen in many NCC patients

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Propuesta de plan estratégico de mercado para la empresa Tisei

Presenta un plan estratégico de mercado para la empresa TISEY, contiene diagnostico de la situación actual de mercado, propuesta de estrategias de posicionamiento que fortalezcan el desarrollo de TISE

Anti-microbiota vaccine reduces avian malaria infection within mosquito vectors

Animal and human pathogens that are transmitted by arthropods are a global concern, particularly those vectored by mosquitoes (e.g., Plasmodium spp. and dengue virus). Vector microbiota may hold the key to vector-borne pathogen control, as mounting evidence suggests that the contributions of the vector microbiota to vector physiology and pathogen life cycle are so relevant that vectorial capacity cannot be understood without considering microbial communities within the vectors. Anti-tick microbiota vaccines targeting commensal bacteria of the vector microbiota alter vector feeding and modulate the taxonomic and functional profiles of vector microbiome, but their impact on vector-borne pathogen development within the vector has not been tested. In this study, we tested whether anti-microbiota vaccination in birds targeting Enterobacteriaceae within mosquito midguts modulates the mosquito microbiota and disrupt Plasmodium relictum development in its natural vector Culex quinquefasciatus. Domestic canaries (Serinus canaria domestica) were experimentally infected with P. relictum and/or immunized with live vaccines containing different strains of Escherichia coli. Immunization of birds induced E. coli-specific antibodies. The midgut microbial communities of mosquitoes fed on Plasmodium-infected and/or E. coli-immunized birds were different from those of mosquitoes fed on control birds. Notably, mosquito midgut microbiota modulation was associated with a significant decrease in the occurrence of P. relictum oocysts and sporozoites in the midguts and salivary glands of C. quinquefasciatus, respectively. A significant reduction in the number of oocysts was also observed. These findings suggest that anti-microbiota vaccines can be used as a novel tool to control malaria transmission and potentially other vector-borne pathogens

Midlife Vascular Factors and Prevalence of Mild Cognitive Impairment in Late-Life in Mexico

OBJECTIVE: To estimate the prevalence of mild cognitive impairment (MCI) and its subtypes and investigate the impact of midlife cardiovascular risk factors on late-life MCI among the aging Mexican population. METHOD: Analyses included a sample of non-demented adults over the age of 55 living in both urban and rural areas of Mexico (N = 1807). MCI diagnosis was assigned based on a comprehensive cognitive assessment assessing the domains of memory, executive functioning, language, and visuospatial ability. The normative sample was selected by means of the robust norms approach. Cognitive impairment was defined by a 1.5-SD cut-off per cognitive domain using normative corrections for age, years of education, and sex. Risk factors included age, education, sex, rurality, depression, insurance status, workforce status, hypertension, diabetes, stroke, and heart disease. RESULTS: The prevalence of amnestic MCI was 5.9%. Other MCI subtypes ranged from 4.2% to 7.7%. MCI with and without memory impairment was associated with older age (OR = 1.01 [1.01, 1.05]; OR = 1.03 [1.01, 1.04], respectively) and residing in rural areas (OR = 1.49 [1.08, 2.06]; OR = 1.35 [1.03, 1.77], respectively). Depression (OR = 1.07 [1.02, 1.12]), diabetes (OR = 1.37 [1.03, 1.82]), and years of education (OR = 0.94 [0.91, 0.97]) were associated with MCI without memory impairment. Midlife CVD increased the odds of MCI in late-life (OR = 1.76 [1.19, 2.59], which was driven by both midlife hypertension and diabetes (OR = 1.70 [1.18, 2.44]; OR = 1.88 [1.19, 2.97], respectively). CONCLUSIONS: Older age, depression, low education, rurality, and midlife hypertension and diabetes were associated with higher risk of late-life MCI among older adults in Mexico. Our findings suggest that the causes of cognitive impairment are multifactorial and vary by MCI subtype