Mit Musik gebären - es ist Zeit aufzuklären : die Wirkung von Musiktherapie auf das Schmerz- und Angsterleben der Gebärenden

Darstellung des Themas: Frauen werden bei der Geburt mit starken Schmerzen und Ängsten konfrontiert. Da jedoch kein Medikament vollkommen frei von Risiken und Nebenwirkungen für Mutter und Kind ist, besteht eine grosse Nachfrage an alternativen Linderungsmitteln. Trotzdem rücken einige alternative Bewältigungsstrategien, mitunter der Musiktherapie, in der Hebammenarbeit in den Hintergrund. Ziel: Das Ziel ist es aufzuzeigen, welche Wirkung die individuell ausgewählte Musik der Erstgebärenden auf ihr Schmerz- und Angsterleben während ihrer Eröffnungsperiode hat. Des Weiteren soll dieser Mehrwert an Erkenntnissen in der Hebammenarbeit umgesetzt werden. Folglich kann die Erstgebärende über eine zusätzliche alternative Methode unter der Geburt informiert und beraten werden. Methode: Diese Arbeit hat das Design eines Literaturreviews. Nach ausgiebiger Literaturrecherche werden fünf Publikationen miteinander verglichen, kritisch gewürdigt und diskutiert. Relevante Ergebnisse: Das Angsterleben sowie die Schmerzintensität der Erstgebärenden werden in der Eröffnungsperiode durch die Musiktherapie gesenkt. Schlussfolgerung: Durch diese Resultate können Frauen durch Hebammen über eine zusätzliche alternative Methode in der Geburtshilfe evidenzbasiert beraten und aufgeklärt werden. Zudem ist die Musiktherapie einfach anzuwenden und kostengünstig. Es benötigt weiterführende Forschung, um die Wirkung der Musik bei Frauen zu ermitteln, welche ihre eigene Musikauswahl zur Geburt mitbringen

Distance estimation of howling golden jackals (Canis aureus) using relative sound level

Golden jackals (Canis aureus) display a complex repertoire of calls, utilized in different communication types (e.g., marking territories, attraction of mating partners). Resident golden jackal groups can successfully be detected by active bioacoustic stimulation, as well as with passive recording devices. For monitoring, basic knowledge of the calls of the focal species and potential restrictions and strengths of the monitoring devices should be considered. We therefore tested possible applications of a low-budget autonomous recording unit for bioacoustic golden jackal monitoring and examined the following research questions: How far can group calls be detected? Can the distance to the recording device be estimated? To answer these questions, we placed 11 AudioMoth recording devices in a linear transect to record live imitated and replayed howls. For the estimation of the number of responding animals, the number of howling individuals was determined based on the maximum number of simultaneously visible fundamental frequencies in a spectrogram. To predict the distance of the playback howls to the recording devices, the relative sound level (RSL) of each call was measured and fitted in linear models. Reliable distance estimations using RSL were possible up to 400 m. Estimated number of responding animals showed a negative relationship with distance. Our results present a baseline for future studies and show that AudioMoths can be a helpful asset in distance estimation of golden jackal packs—both in passive but also active monitoring.Peer reviewe

Success for People with Disabilities after Postsecondary Education

Success may be defined in numerous ways and may be linked to quality of life. Individuals with disabilities often find success difficult to achieve. Postsecondary education has been shown to improve individual quality of life. Does a professional life obtained through postsecondary education provide individuals with disabilities entree to a better quality of life? How does this play out in the life of a person with a disability? This study reports on interviews with both people with and without disabilities and their perceptions of both success and quality of life. The findings stress how important it is to facilitate access and support in the pursuit of a postsecondary education for individuals with disabilities

Manufacturing Change Management - A Survey On Current Challenges, The State Of Digitalization And The Application Of Change Impact Analysis In Industrial Practice

Modern manufacturing companies operate in a complex and highly dynamic environment. External factors such as new legislations and customer demands, as well as internal factors such as fluctuations in production rates and frequent product changes, make it essential for companies to respond quickly and effectively to changes of all kinds. Scientific literature already provides various processes and methods to manage Manufacturing Changes (MCs) efficiently and to precisely assess their possible impacts. Building upon the existing literature, this survey-based study aims to gain practical insights into the implementation of Manufacturing Change Management (MCM) and Change Impact Analysis (CIA) in real-world industrial settings. By examining the current challenges and exploring the state of digitalization, this research provides valuable insights to complement and further develop the existing theoretical frameworks. In order to gather diverse knowledge from experts across various industries, a web-based survey was conducted, with 99 participants representing 15 different industries. After introducing the necessary theoretical foundations and the current state of research in MCM literature, this contribution describes in detail the methodology of the survey development. The survey findings are then outlined and discussed thoroughly. Finally, the contribution concludes by offering an outlook on future research perspectives based on the identified industry challenges

Gender-specific outcomes in immune checkpoint inhibitor therapy for advanced or metastatic urothelial cancer: a systematic review and meta-analysis.

PURPOSE To analyze gender-specific differences in survival parameters in advanced or metastatic urothelial cancer patients undergoing immune checkpoint inhibition. METHODS The primary aim of this systematic review and meta-analysis was to evaluate gender-specific differences in disease-free (DFS), progression-free (PFS), cancer-specific survival (CSS), event-free survival (EFS), overall survival (OS) and objective response rate (ORR). The sources MEDLINE, Embase and Cochrane Library were systematically searched from January 2010 to June 2022. No restrictions were made concerning language, study region or publication type. A comparison of gender-specific differences in survival parameters was performed using a random-effects meta-analysis. A risk of bias assessment was done using the ROBINS-I tool. RESULTS Five studies were included. In a random-effect meta-analysis of the studies, PCD4989g and IMvigor 211 with both using atezolizumab, females were more likely to have better objective response rate (ORR) than men (OR 2.24; 95% CI 1.20-4.16; p = 0.0110). In addition, females had a comparable median OS to men (MD 1.16; 95% CI - 3.15-5.46; p = 0.598). In summary, comparing all results, a tendency was seen toward better response rates and survival parameters in female patients. The risk of bias assessment yielded an overall low risk of bias. CONCLUSIONS There is a tendency toward better outcomes in women for immunotherapy in advanced or metastatic urothelial cancer, but only for the antibody atezolizumab women have a significantly better ORR. Unfortunately, many studies fail to report gender-specific outcomes. Therefore, further research is essential when aiming for individualized medicine. This research should address immunological confounders

Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs.

OBJECTIVES: Trypanosoma brucei drug transporters include the TbAT1/P2 aminopurine transporter and the high-affinity pentamidine transporter (HAPT1), but the genetic identity of HAPT1 is unknown. We recently reported that loss of T. brucei aquaglyceroporin 2 (TbAQP2) caused melarsoprol/pentamidine cross-resistance (MPXR) in these parasites and the current study aims to delineate the mechanism by which this occurs. METHODS: The TbAQP2 loci of isogenic pairs of drug-susceptible and MPXR strains of T. brucei subspecies were sequenced. Drug susceptibility profiles of trypanosome strains were correlated with expression of mutated TbAQP2 alleles. Pentamidine transport was studied in T. brucei subspecies expressing TbAQP2 variants. RESULTS: All MPXR strains examined contained TbAQP2 deletions or rearrangements, regardless of whether the strains were originally adapted in vitro or in vivo to arsenicals or to pentamidine. The MPXR strains and AQP2 knockout strains had lost HAPT1 activity. Reintroduction of TbAQP2 in MPXR trypanosomes restored susceptibility to the drugs and reinstated HAPT1 activity, but did not change the activity of TbAT1/P2. Expression of TbAQP2 sensitized Leishmania mexicana promastigotes 40-fold to pentamidine and >1000-fold to melaminophenyl arsenicals and induced a high-affinity pentamidine transport activity indistinguishable from HAPT1 by Km and inhibitor profile. Grafting the TbAQP2 selectivity filter amino acid residues onto a chimeric allele of AQP2 and AQP3 partly restored susceptibility to pentamidine and an arsenical. CONCLUSIONS: TbAQP2 mediates high-affinity uptake of pentamidine and melaminophenyl arsenicals in trypanosomes and TbAQP2 encodes the previously reported HAPT1 activity. This finding establishes TbAQP2 as an important drug transporter

On the complex and dimensional relationship of maternal PTSD during early childhood and child outcomes at school-age.

Several studies have shown associations between maternal interpersonal violence-related posttraumatic stress disorder (PTSD), child mental health problems, and impaired socioemotional development. However, the existing literature lacks evidence linking constellations of risk factors such as maternal interpersonal-violence-related PTSD, psychopathology, and interactive behavior with toddlers and outcome measures at school-age. This study involved a prospective, longitudinal investigation of 62 mothers and examined the relationship between maternal variables measured when children were in early childhood (mean age 27 months), and child outcomes when children were school-age (age mean = 83.2 months) while retaining a focus on the context of maternal PTSD. To identify and weigh associated dimensions comparatively, we employed sparse canonical correlation analysis (sCCA) aimed at associating dimensions of a dataset of 20 maternal variables in early childhood with that of more than 20 child outcome variables (i.e., child psychopathology, life-events, and socioemotional skills) at school-age. Phase 1 variables with the highest weights were those of maternal psychopathology: PTSD, depressive and dissociative symptoms, and self-report of parental stress. The highest weighted Phase 2 child outcome measures were those of child psychopathology: PTSD, anxiety, and depressive symptoms as well as peer bullying and victimization. sCCA revealed that trauma-related concepts in mothers were significantly and reliably associated with child psychopathology and other indicators of risk for intergenerational transmission of violence and victimization. The results highlight the dimensional and multifaceted nature-both for mothers as well as children-of the intergenerational transmission of violence and associated psychopathology

The Lantern Vol. 52, No. 1, Fall 1985

• Nudes • Orion • Fragments of an Epic • Sunrise • The Planting Season • Nursing Home • Hope Chest • Childhood Swing • Relationships • Elroy, Leopold, and Max • Urban Dragon • The Farmer\u27s Wife • A Ballad of Two Lovers • Betrayal • Choices • Letting Go • Emergence of a Butterfly • Poem for Every Man • Friction • Genesis • All\u27s Well • The Willow Tree • White Wasteland • Moe\u27s Happy Christmas • Rare Bird • Carnivalhttps://digitalcommons.ursinus.edu/lantern/1127/thumbnail.jp

The Lantern Vol. 51, No. 2, Spring 1985

• Electric Pink • Derby Day • Conversation • Seasons of Sonnets • Long After Killing Us • Haunting Memory • Sacrifice • Is This Positive Enough? • My Teddy Bear • A Gentleman of Ten • Hartman Center • Yesterday\u27s Child • Mors Pueris • Momentary Reflections • Children Sleeping • There\u27s No Place Like Home • I Set My Pleasures Adrift • The Beer Can • Fragments of an Epic • Actaeon • She Sleeps • Chicago • Death Light • Tea With Louise • Balance • The Rivers • Chapel • The Hour of Prayer • Une Fille / Une Femme • A One-Way Mirror • Nonconformity • Cada Noche, Lloro • Reflections on an Empty House Down the Street • Evening Melancholy • Abandoned Road • Big Boy • Baby Brothers • Metro Oscuro • Chuchoterhttps://digitalcommons.ursinus.edu/lantern/1126/thumbnail.jp