An in-depth examination of the implementation of the Disability Equality Duty - Executive Summary. A research report for the Office for Disability Issues

In 2007 the Office for Disability Issues commissioned this seven-month study to examine the implementation of the Disability Equality Duty (DED) in England. The research was conducted by teams from the universities of Glasgow and Strathclyde. The full report is available at www.officefordisability.gov.u

An in-depth examination of the implementation of the Disability Equality Duty in England

This seven-month study examined the implementation of the Disability Equality Duty (DED) in England. The DED, introduced through the Disability Discrimination Act 2005, applies to public authorities in England, Wales and Scotland

An In-Depth Examination of the Implementation of the Disability Equality Duty in England: Report for the Office for Disability Issues

This seven-month study examined the implementation of the Disability Equality Duty (DED) in England. The DED, introduced through the Disability Discrimination Act 2005, applies to public authorities in England, Wales and Scotland. The DED comprises a general duty and specific duties. The general duty requires public authorities to carry out their functions with due regard to the need to promote equality between disabled and non-disabled people. The specific duties require public authorities to publish a Disability Equality Scheme (DES) setting out how they intend to fulfil their general duty and specific duties. In addition, certain Secretaries of State must publish an overarching report for their policy sectors every three years. A Code of Practice1 to assist authorities with implementing the Duty was published by the then Disability Rights Commission

Mainstreaming the Disability Equality Duty and the impact on public authorities' working practices

Implemented as part of the 2005 amendments to the Disability Equality Act, the Disability Equality Duty (DED) placed new and important demands on public sector bodies. All such organisations are required to develop policies and working practices which actively promote the equality of disabled people as employees, consumers or visitors. The promotion of equality has to be proactive as opposed to reactive and must be mainstreamed into the normal day to day activities of organisational working practices. Whilst the DED follows on from the framework of previous anti-discrimination legislation set in place over the last fifteen years, it represents a significant change in equality legislation, demands that public sector bodies instigate fundamental changes in their approach towards disability. This article reports on the initial stages of the implementation process of the DED across a range of public sector organisations in England, focussing in particular on how this policy has impacted on mainstreaming. Discussion shows that although organisations show awareness of mainstreaming and its implications for disability equality, there is limited evidence to suggest that the public sector has fully embraced this agenda

Cardiorespiratory risk factors as predictors of 40-year mortality in women and men.: Risk factors and 40-year mortality

International audienceOBJECTIVE: Most historical studies of cardiorespiratory risk factors as predictors of mortality have been based on men. This study examines whether they predict mortality over long periods in women and men. DESIGN: Prospective cohort study. SETTING: Participants were employees of the General Post Office. METHODS: Risk factor data were collected via clinical examination and questionnaire, 1966-7. Associations between cardiorespiratory risk factors and 40-year mortality were determined for 644 women and 1272 men aged 35-70 at examination. MAIN OUTCOME MEASURES: All-cause, cardiovascular (CVD), cancer and respiratory mortality. RESULTS: Associations between systolic blood pressure and all-cause and stroke mortality were equally strong for women and men, hazard ratio (95% confidence interval) 1.25 (1.1 to 1.4) and 1.18 (1.1 to 1.3); and 2.17 (1.7 to 2.8) and 1.69 (1.4 to 2.1), respectively. Cholesterol was higher in women and was associated with all-cause 1.22 (1.1 to 1.4) and CVD 1.39 (1.2 to 1.7) mortality, while associations between 2-hour glucose and all-cause 1.15 (1.1 to 1.2), coronary heart disease (CHD) 1.25 (1.1 to 1.4) and respiratory mortality 1.21 (1.0 to 1.5) were observed in men. Obesity was associated with stroke in women (2.42 (1.12 to 5.24)) and CHD in men (1.59 (1.02 to 2.49)), while ECG ischaemia was associated with CVD in both sexes. The strongest, most consistent predictor of mortality was smoking in women and poor lung function in men. However, evidence of sex differences in associations between the cardiorespiratory risk factors measured and mortality was sparse. CONCLUSIONS: Data from a 40-year follow-up period show remarkably persistent associations between risk factors and cardiorespiratory and all-cause mortality in women and men

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

The fibrillary aggregation of the protein alpha synuclein (Asyn) is a hallmark of Parkinson’s disease, and the identification of small molecule binding sites on fibrils is essential to the development of diagnostic imaging probes. A series of molecular modeling, photoaffinity labeling, mass spectrometry, and radioligand binding studies were conducted on Asyn fibrils. The results of these studies revealed the presence of three different binding sites within fibrillar Asyn capable of binding small molecules with moderate to high affinity. A knowledge of the amino acid residues in these binding sites will be important in the design of high affinity probes capable of imaging fibrillary species of Asyn