Subjective and Non-subjective Information in Children’s Allegations of Abuse

In this study, we were interested in how interviewers elicit subjective information in investigations of child abuse (e.g., descriptions of thoughts, emotions, opinions). Sixty-one interviews of children aged 4-12 years old were analyzed to determine the amount of subjective information versus non-subjective event details reported, and the type of question that elicited the information. Interviewers elicited more non-subjective than subjective information, although there was more focus on subjective information in the rapport-building phase than in the substantive phase when the allegations were elicited. Interviewer prompts and child responsiveness was congruent such that non-subjective questions elicited more non-subjective information, and subjective interviewer questions elicited more subjective information. The presence of subjective information in children’s testimony can influence children’s credibility, and the results of this study demonstrate that forensic interviewers play a significant part in the level of subjective information children provide

Metformin as a Therapeutic Target in Endometrial Cancers.

Endometrial cancer is the most common gynecologic malignancy in developed countries. Its increasing incidence is thought to be related in part to the rise of metabolic syndrome, which has been shown to be a risk factor for the development of hyperestrogenic and hyperinsulinemic states. This has consequently lead to an increase in other hormone-responsive cancers as well e.g., breast and ovarian cancer. The correlation between obesity, hyperglycemia, and endometrial cancer has highlighted the important role of metabolism in cancer establishment and persistence. Tumor-mediated reprogramming of the microenvironment and macroenvironment can range from induction of cytokines and growth factors to stimulation of surrounding stromal cells to produce energy-rich catabolites, fueling the growth, and survival of cancer cells. Such mechanisms raise the prospect of the metabolic microenvironment itself as a viable target for treatment of malignancies. Metformin is a biguanide drug that is a first-line treatment for type 2 diabetes that has beneficial effects on various markers of the metabolic syndrome. Many studies suggest that metformin shows potential as an adjuvant treatment for uterine and other cancers. Here, we review the evidence for metformin as a treatment for cancers of the endometrium. We discuss the available clinical data and the molecular mechanisms by which it may exert its effects, with a focus on how it may alter the tumor microenvironment. The pleiotropic effects of metformin on cellular energy production and usage as well as intercellular and hormone-based interactions make it a promising candidate for reprogramming of the cancer ecosystem. This, along with other treatments aimed at targeting tumor metabolic pathways, may lead to novel treatment strategies for endometrial cancer

Variable Intrinsic Absorption in Mrk 279

We examine the variability in the intrinsic absorption in the Seyfert 1 galaxy Mrk 279 using three epochs of observations from the Far Ultraviolet Spectroscopic Explorer (FUSE) and two epochs of observations with the Space Telescope Imaging Spectrograph on the Hubble Space Telescope. Rather than finding simple photoionization responses of the absorbing gas to changes in the underlying continuum, the observed changes in the absorption profiles can be understood more clearly if the effective covering fraction of the gas in all emission components, continuum and broad and intermediate velocity width emission lines, is accounted for. While we do not uniquely solve for all of these separate covering fractions and the ionic column densities using the spectral data, we examine the parameter space using previously well-constrained solutions for continuum and single emission component covering fractions. Assuming full coverage of the continuum, we find that of the two velocity components of the Mrk 279 absorption most likely associated with its outflow, one likely has zero coverage of the intermediate line region while the other does not. For each component, however, the broad line region is more fully covered than the intermediate line region. Changes in the O VI column densities are unconstrained due to saturation, but we show that small changes in the nonsaturated C IV and N V column densities are consistent with the outflow gas having zero or partial covering of the intermediate line region and an ionization parameter changing from ~0.01 to ~0.1 from 2002 to 2003 as the UV continuum flux increased by a factor of ~8. The absence of a change in the C III absorbing column density is attributed to this species arising outside the Mrk 279 outflow.Comment: 36 pages, 18 figures, accepted to Ap

Recruiting and Retaining People with Disabilities for Qualitative Health Research: Challenges and Solutions

There are 56.7 million people with disabilities (PWD) living in the United States; yet, PWD are significantly underrepresented in health research. Even when researchers purposively seek to include PWD in studies, challenges emerge related to recruitment and retention, leading to inadequate representation and surface understandings of this population. This in turn contributes to the perpetuation of implicit and explicit health disparities that are already experienced by this population. Grounded within a qualitative, community-based participatory health research framework, we highlight challenges associated with recruiting and retaining PWD in health research, including a critical analysis of the research enterprise structure, how this disables accessible research practices for PWD, and leads to continued skepticism among PWD regarding the value of participating in research. Finally, we propose solutions to create and maintain a culture of access and inclusion as well as long-term collaborative and equity-focused partnerships

Whole-Body MRI and Ethnic Differences in Adipose Tissue and Skeletal Muscle Distribution in Overweight Black and White Adolescent Boys

It is unclear whether ethnic differences exist in adipose tissue (AT) and skeletal muscle (SM) distribution in black and white youth. Investigation into the pattern of AT and SM distribution in black versus white youth may provide insight into the previously reported health disparities between these ethnicities. Therefore, we examined total and regional AT and SM in overweight black and white boys. The study sample included overweight black (n = 19) and white (n = 21) boys (11–18 yr, BMI ≥ 85th) whose body composition was evaluated using whole-body MRI. Despite similar age, Tanner stage, and BMI, black boys had significantly (P < .05) less visceral AT than white boys and more (P < .05) total and lower-body subcutaneous AT (SAT) in both absolute (kg) and relative (%) terms. There was a main effect (P < .05) of ethnicity on the relationship between total and regional AT, such that for a given amount of total body AT (kg), black boys had a greater (P < .05) lower-body SAT and less visceral AT than their white peers. For a given amount of total SM, black boys had more (P < .05) SM in the thigh. Compared with overweight white boys, overweight black boys have less visceral fat, more subcutaneous fat, and more thigh skeletal muscle

Building a successful fertility preservation program at a major cancer center

Over 150,000 reproductive age individuals face fertility-threatening cancer treatments each year. Improved detection and treatment of cancer in reproductive-age patients have greatly increased the long-term survival and made it possible for these individuals to consider their long-term quality-of-life after cancer including having biologic offspring. Various methods of fertility preservation (FP) are now available for both males and females. In order to maximize FP options available to patients facing imminent gonadotoxic therapies, it is crucial that women have quick access to FP care and that providers expedite FP strategies. The overarching goal of a clinical FP program is to help patients and their physicians consider the impact of treatment on future fertility and facilitate FP efforts in what is often a limited time period before cancer treatment begins

Dynamic stretching is effective as static stretching at increasing flexibility

This study examined the effect of dynamic and static (standard) stretching on hamstring flexibility. Twenty-five female volleyball players were randomly assigned to dynamic (n = 12) and standard (n = 13) stretching groups. The experimental group trained with repetitive dynamic stretching exercises, while the standard modality group trained with static stretching exercises. The stretching interventions were equivalent in the time at stretch and were performed three days a week for four weeks. Both stretching groups showed significant improvements (P < .001) in range of motion (ROM) during the intervention. However, no difference in gains in the range of motion between stretching groups was observed. It was concluded that both dynamic stretching and standard stretching are effective at increasing ROM