On Putting Knowledge 'First'

There is a New Idea in epistemology. It goes by the name of ‘knowledge first,’ and it is particularly associated with Timothy Williamson’s book Knowledge and Its Limits. In slogan form, to put knowledge first is to treat knowledge as basic or fundamental, and to explain other states—belief, justification, maybe even content itself—in terms of knowledge, instead of vice versa. The idea has proven enormously interesting, and equally controversial. But deep foundational questions about its actual content remain relatively unexplored. We think that a wide variety of views travel under the banner of ‘knowledge first’ (and that the slogan doesn’t help much with differentiating them). Furthermore, we think it is far from straightforward to draw connections between certain of these views; they are more independent than they are often assumed to be. Our project here is exploratory and clarificatory. We mean to tease apart various ‘knowledge first’ claims, and explore what connections they do or do not have with one another. Our taxonomy is offered in §2, and connections are explored in §3. The result, we hope, will be a clearer understanding of just what the knowledge first theses are. We conclude, in §4, with some brief suggestions as to how we think the various theses might be evaluated

Regulation of UVR8 photoreceptor dimer/monomer photo-equilibrium in Arabidopsis plants grown under photoperiodic conditions

The UV RESISTANCE LOCUS 8 (UVR8) photoreceptor specifically mediates photomorphogenic responses to UV-B. Photoreception induces dissociation of dimeric UVR8 into monomers to initiate responses. However, the regulation of dimer/monomer status in plants growing under photoperiodic conditions has not been examined. Here we show that UVR8 establishes a dimer/monomer photo-equilibrium in plants growing in diurnal photoperiods in both controlled environments and natural daylight. The photo-equilibrium is determined by the relative rates of photoreception and dark-reversion to the dimer. Experiments with mutants in REPRESSOR OF UV-B PHOTOMORPHOGENESIS 1 (RUP1) and RUP2 show that these proteins are crucial in regulating the photo-equilibrium because they promote reversion to the dimer. In plants growing in daylight, the UVR8 photo-equilibrium is most strongly correlated with low ambient fluence rates of UV-B (up to 1.5 µmol m−2 s−1), rather than higher fluence rates or the amount of photosynthetically active radiation. In addition, the rate of reversion of monomer to dimer is reduced at lower temperatures, promoting an increase in the relative level of monomer at approximately 8–10 °C. Thus, UVR8 does not behave like a simple UV-B switch under photoperiodic growth conditions but establishes a dimer/monomer photo-equilibrium that is regulated by UV-B and also influenced by temperature

Regulation of transcription by the Arabidopsis UVR8 photoreceptor involves a specific histone modification

The photoreceptor UV RESISTANCE LOCUS 8 (UVR8) specifically mediates photomorphogenic responses to UV-B wavelengths. UVR8 acts by regulating transcription of a set of genes, but the underlying mechanisms are unknown. Previous research indicated that UVR8 can associate with chromatin, but the specificity and functional significance of this interaction are not clear. Here we show, by chromatin immunoprecipitation, that UV-B exposure of Arabidopsis increases acetylation of lysines K9 and/or K14 of histone H3 at UVR8-regulated gene loci in a UVR8-dependent manner. The transcription factors HY5 and/or HYH, which mediate UVR8-regulated transcription, are also required for this chromatin modification, at least for the ELIP1 gene. Furthermore, sequencing of the immunoprecipitated DNA revealed that all UV-B-induced enrichments in H3K9,14diacetylation across the genome are UVR8-dependent, and approximately 40 % of the enriched loci contain known UVR8-regulated genes. In addition, inhibition of histone acetylation by anacardic acid reduces the UV-B induced, UVR8 mediated expression of ELIP1 and CHS. No evidence was obtained in yeast 2-hybrid assays for a direct interaction between either UVR8 or HY5 and several proteins involved in light-regulated histone modification, nor for the involvement of these proteins in UVR8-mediated responses in plants, although functional redundancy between proteins could influence the results. In summary, this study shows that UVR8 regulates a specific chromatin modification associated with transcriptional regulation of a set of UVR8-target genes

Converting energy from fusion into useful forms

If fusion power reactors are to be feasible, it will still be necessary to convert the energy of the nuclear reaction into usable form. The heat produced will be removed from the reactor core by a primary coolant, which might be water, helium, molten lithium-lead, molten lithium-containing salt, or CO2. The heat could then be transferred to a conventional Rankine cycle or Brayton (gas turbine) cycle. Alternatively it could be used for thermochemical processes such as producing hydrogen or other transport fuels. Fusion presents new problems because of the high energy neutrons released. These affect the selection of materials and the operating temperature, ultimately determining the choice of coolant and working cycle. The limited temperature ranges allowed by present day irradiated structural materials, combined with the large internal power demand of the plant, will limit the overall thermal efficiency. The operating conditions of the fusion power source, the materials, coolant, and energy conversion system will all need to be closely integrated.Comment: 22 pages, 4 figures, Proceedings of the Institution of Mechanical Engineers, Part A: Journal of Power and Energy December 11, 201

Photomorphogenic responses to ultraviolet-B light

Exposure to UV-B light regulates numerous aspects of plant metabolism, morphology and physiology through the differential expression of hundreds of genes. Photomorphogenic responses to UV-B are mediated by the photoreceptor UV RESISTANCE LOCUS8 (UVR8). Considerable progress has been made in understanding UVR8 action: the structural basis of photoreceptor function, how interaction with CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1) initiates signaling and how REPRESSOR OF UV-B PHOTOMORPHOGENESIS (RUP) proteins negatively regulate UVR8 action. In addition, recent research shows that UVR8 mediates several responses through interaction with other signaling pathways, in particular auxin signaling. Nevertheless, many aspects of UVR8 action remain poorly understood. Most research to date has been undertaken with Arabidopsis, and it is important to explore the functions and regulation of UVR8 in diverse plant species. Furthermore, it is essential to understand how UVR8, and UV-B signaling in general, regulates processes under natural growth conditions. UV-B regulates the expression of many genes through UVR8-independent pathways, but the activity and importance of these pathways in plants growing in sunlight are poorly understood

Studies of the cosmic radiation using a neutron monitor

This thesis is concerned with the production of evaporation neutrons in neutron monitors by the charged particle components of the cosmic radiation at sea level and their detection. The evaporation neutron detection efficiency of a modified I6Y - type monitor is measured using a novel technique which uses stopping negative muons as a source of neutrons, and the result is compared with that expected from previous measurements of other monitors. Use is made of this result in an experimental study of neutron production by unaccompanied cosmic ray protons, pions and muons in the momentum range 1-30 GeV/c. The experiment has, employed an air-gap magnet spectrograph in conjunction with the monitor, and the results of this study are compared with previous work. They confirm previous findings that the yield of evaporation neutrons in monitors from protons and pions is significantly overestimated by the only available theoretical model, and suggestions, are made to account for this discrepancy. Within fairly large statistical errors, the measured neutron production by fast muons agrees with the theoretical predictions. An examination is made of the possibility of using a neutron monitor in conjunction with an air shower detection array to measure the changes in slope of the nuclear active particle (NAP) energy spectrum in extensive air showers (HAS) of energy l0(^17)eV at sea level which may arise due to primary particles of different atomic mass number and fluctuations in the longitudinal development of proton induced showers. Using NAP spectra predicted by a mathematical model of the EAS development it is found that monitors of conventional design are unlikely to be sensitive to these changes although the total neutron yield per shower could be used as a measure of the expected differences in the NAP flux

A comparison of measured and calculated thermal stresses in a hybrid metal matrix composite spar cap element

A hybrid spar of titanium with an integrally brazed composite, consisting of an aluminum matrix reinforced with boron-carbide-coated fibers, was heated in an oven and the resulting thermal stresses were measured. Uniform heating of the spar in an oven resulted in thermal stresses arising from the effects of dissimilar materials and anisotropy of the metal matrix composite. Thermal stresses were calculated from a finite element structural model using anisotropic material properties deduced from constituent properties and rules of mixtures. Comparisons of calculated thermal stresses with measured thermal stresses on the spar are presented. It was shown that failure to account for anisotropy in the metal matrix composite elements would result in large errors in correlating measured and calculated thermal stresses. It was concluded that very strong material characterization efforts are required to predict accurate thermal stresses in anisotropic composite structures

Propagation in the atmosphere of ultrahigh-energy charmed hadrons

Charmed mesons may be produced when a primary cosmic ray or the leading hadron in an air shower collide with an atmospheric nucleon. At energies \ge 10^8 GeV their decay length becomes larger than 10 km, which implies that they tend to interact in the air instead of decaying. We study the collisions of long-lived charmed hadrons in the atmosphere. We show that (\Lambda_c,D)-proton diffractive processes and partonic collisions of any q^2 where the charm quark is an spectator have lower inelasticity than (p,\pi)-proton collisions. In particular, we find that a D meson deposits in each interaction just around 55% of the energy deposited by a pion. On the other hand, collisions involving the valence c quark (its annihilation with a sea cbar quark in the target or c-quark exchange in the t channel) may deposit most of D meson energy, but their frequency is low (below 0.1% of inelastic interactions). As a consequence, very energetic charmed hadrons may keep a significant fraction of their initial energy after several hadronic interactions, reaching much deeper in the atmosphere than pions or protons of similar energy.Comment: 13 pages, version to appear in PR

Giant planets around two intermediate-mass evolved stars and confirmation of the planetary nature of HIP67851 c

Precision radial velocities are required to discover and characterize planets orbiting nearby stars. Optical and near infrared spectra that exhibit many hundreds of absorption lines can allow the m/s precision levels required for such work. However, this means that studies have generally focused on solar-type dwarf stars. After the main-sequence, intermediate-mass stars (former A-F stars) expand and rotate slower than their progenitors, thus thousands of narrow absorption lines appear in the optical region, permitting the search for planetary Doppler signals in the data for these types of stars. We present the discovery of two giant planets around the intermediate-mass evolved star HIP65891 and HIP107773. The best Keplerian fit to the HIP65891 and HIP107773 radial velocities leads to the following orbital parameters: P=1084.5 d; m$_b$sin$i$ = 6.0 M$_{jup}$; $e$=0.13 and P=144.3 d; m$_b$sin$i$ = 2.0 M$_{jup}$; $e$=0.09, respectively. In addition, we confirm the planetary nature of the outer object orbiting the giant star HIP67851. The orbital parameters of HIP67851c are: P=2131.8 d, m$_c$sin$i$ = 6.0 M$_{jup}$ and $e$=0.17. With masses of 2.5 M$_\odot$ and 2.4 M$_\odot$ HIP65891 and HIP107773 are two of the most massive stars known to host planets. Additionally, HIP67851 is one of five giant stars that are known to host a planetary system having a close-in planet ($a <$ 0.7 AU). Based on the evolutionary states of those five stars, we conclude that close-in planets do exist in multiple systems around subgiants and slightly evolved giants stars, but probably they are subsequently destroyed by the stellar envelope during the ascent of the red giant branch phase. As a consequence, planetary systems with close-in objects are not found around horizontal branch stars.Comment: Accepted for publication in A&