8 research outputs found
Healing Mission: Indian Women Shape Mission Emphases of the Christian Medical College in Vellore
- Author
- Athyal Sakhi M.
- Bhabha Homi
- Bharati M. B. E.
- Blaufuss Mary Schaller
- Blaufuss Mary Schaller
- Chakravarti Uma
- Chen Martha Alter
- Chen Martha Alter
- Chen Martha Alter
- Chen Martha Alter
- Chen Martha Alter
- Guha Ranajit
- Harper Susan Billington
- Hedlund Roger E.
- Heim Melissa Lewis
- Howes Clare
- Hunter Jane
- Jeffery Mary Pauline
- Jeffery Mary Pauline
- Jesudasan Usha
- Kumar Nita
- Malone Mary T.
- Pachuau Lalsangkima
- Ray Bharati
- Robert Dana L.
- Said Edward W.
- Sebastian Mrinilini
- Sebastian Mrinilini
- Spivak Gayatri Chakravorty
- Tucker Ruth A.
- Wilson Dorothy Clarke
- Wilson Dorothy Clarke
- Wilson Dorothy Clarke
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Introduction. Daughters of time: The shifting identities of contemporary midwives
- Author
- _____
- _____
- _____
- _____
- _____
- _____
- Acevedo Dolores
- Allen Denise Roth
- Armstrong Sue
- Barclay Leslie
- Barrington Elizabeth
- Bendix Reinhardt
- Benoit Cecilia
- Benoit Cecilia
- Biggs Leslie
- Blanchet Therese
- Boddy Janice
- Bourgeault Ivy
- Bovard Wendy
- Bullock Alan
- Burtch Brian
- Buss Fran Leeper
- Byford Julia
- Cartwright Elizabeth
- Chalmers Beverley
- Chen P. C. Y.
- Cosminsky Sheila
- Daviss Betty Anne
- Daviss Betty Anne
- Davis‐Floyd Robbie
- Davis‐Floyd Robbie E
- Davis‐Floyd Robbie E
- Davis‐Floyd Robbie E
- Davis‐Floyd Robbie E
- Davis‐Floyd Robbie E
- Davis‐Floyd Robbie E.
- DeVries Raymond
- DeVries Raymond
- DeVries Raymond
- DeVries Raymond
- Dieteker Marianne Forthcoming
- Donnison Jean
- Dougherty Molly C
- Durrin Ginny
- Faust Betty B
- Fiedler Deborah C
- Flint Caroline
- Fraser Gertrude
- Fraser Gertrude
- Good Maust Marcia
- Good Maust Marcia
- Graham Sally
- Houston Jennifer
- Huber Brad
- Hunt Nancy Rose
- Hurtado Elena
- Hurtado Elena
- Iskandar M.
- Jambai Amara
- James‐Chetalet Lois
- Jeffery Patricia
- Jeffery Roger
- Jordan Brigitte
- Justice Judith
- Kargbo Thomas K
- Kaufert Patricia
- Kay Margarita
- Kirkham Mavis J.
- Kitzinger Sheila
- Kolenda Pauline
- Kroeger Mary
- Kwast Barbara
- Laderman Carol
- Lay Mary
- Lay Mary
- Lecky‐Thompson Maggie
- Lefeber Yvonne
- Lefeber Yvonne
- Lukere Vicki
- MacCormack Carol
- MacCormack Carol
- Macdonald Margaret
- Marcus George E
- Marland Hilary
- McClain Carol
- Mead Margaret
- Mellado Virginia
- Michaelson Karen
- Milton Gladys
- Morsy Soheir
- Murphy‐Lawless Jo
- Newman Lucile
- Nihell Elizabeth
- Paul Lois
- Pigg Stacy L.
- Robbie Davis‐Floyd
- Romalis Shelley
- Rooks Judith
- Rubel Arthur J.
- Rushing Elizabeth
- Sargent Carolyn
- Sargent Carolyn
- Sargent Carolyn
- Sargent Carolyn
- Sargent Carolyn
- Schreiber Janet M.
- Sesia Paola
- Sheila Cosminsky
- Sieglin Vernonica
- Smith Margaret Charles
- Stacy Leigh Pigg
- Stone Sarah
- Susie Debra Ann
- Szurek Jane
- Trevathan Wenda R.
- Tsing Anna Lowenhaupt
- Villatoro Elba
- Vincent‐Priya Jacqueline
- Weber Max
- Wilson Adrian
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Risk for Recurrent Venous Thromboembolism in Patients With Subsegmental Pulmonary Embolism Managed Without Anticoagulation
- Author
- Accassat Sandrine
- Anderson David
- Aubert Clotilde
- Augereau Cindy
- Bernabet Corinne
- Bertoletti Laurent
- Beuvard Elisabeth
- Blostein Mark
- Boismal Sophie
- Camminada Christelle
- Carrier Marc
- Castellucci Lana
- Chaalal Amina
- Chauvet Carole
- Coadic Julien
- Code Cathy
- Couturaud Francis
- de Moreuil Claire
- Delluc Aurélien
- Dennie Carole
- Des Déserts Marc Danguy
- Duffett Lisa
- Ferré Alexis
- Forgie Melissa
- Forward Nicholas
- Gable Béatrice
- Gandara Esteban
- Girard Philippe
- Gonsalves Carol
- Hamard Aurore
- Hirsch Andrew
- Huisman Menno
- Jezequel Cloé
- Kahn Susan
- Kamphuisen Pieter
- Kare Meissa
- Karovitch Alan
- Keating Mary Margaret
- Kew Andrea
- Klok Frederikus
- Koolian Maral
- Kovacs Judith
- Kovacs Michael
- Kraaijpoel Noémie
- Lazo-Langner Alejandro
- Le Gal Grégoire
- Le Mao Raphael
- Le Moigne Emmanuelle
- Macdonald David
- Malan Antoine Nadège Koffi
- Mallick Ranjeeta
- Maquin Barbara
- Marquette Amélie
- Meyer Guy
- Morin Gisèle
- Mottier Dominique
- Moumneh Thomas
- Parent Florence
- Pastre Jean
- Patterson Jeffery
- Pecarskie Amanda
- Pena Elena
- Phillips Penny
- Pichon Isabelle
- Planquette Benjamin
- Rackel Lori
- Ragueneau Chloé
- Ramsay Tim
- Riberdy Louise
- Righini Marc
- Ritchie Bruce
- Robinson Sue
- Rodger Marc
- Roy Pierre-Marie
- Sanchez Olivier
- Scarvelis Dimitri
- Schmidt Jeannot
- Schulman Sam
- Sharif Ismail
- Shivakumar Sudeep
- Smii Siwar
- Solymoss Susan
- Stephan Pauline
- Tagalakis Vicky
- Takach-Lapner Sarah
- Trinh-Duc Albert
- Tromeur Cécile
- van Es Nick
- Verdet Rachel
- Verhamme Peter
- Vinsonneau Ulric
- Wells Philip
- Westendorf Jan-Beyer
- Wu Cynthia
- Yeo Erik
- Zahrai Amin
- Zondag Michelle
- Publication venue
- American College of Physicians
- Publication date
- 01/01/2022
- Field of study
International audienc
The Long-Run Growth in Obesity as a Function of Technological Change
- Author
- S N Haapanen
- A T Mary
- Alan O Sykes
- Alan O Sykes
- Becker Philipson
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Cass R Sunstein
- Christine Jolls
- Claude Bouchard
- D Matthew
- Daniel Kessler
- Daniel Shaviro
- David A Weisbach
- David F Williamson
- David Friedman
- Denise Dipasquale
- Dorice M Czajka-Narina
- Douglas G Baird
- Douglas G Baird
- Douglas G Baird
- Douglas G Baird
- E Keeler
- Gary S Becker
- Geoffrey P Miller
- George Argyropoulos
- Gertrud M Fremling
- H Robert
- Isaac Ehrlich
- J
- J Cawley
- J M Mcginnis
- J Mark Ramseyer
- J Mark Ramseyer
- J Mark Ramseyer
- J Mark Ramseyer
- J Sobal
- Jacob C Seidell
- Jeff E Biddle
- Jo Anne Cassell
- John P Robinson
- John R Lott
- John R Lott
- John R Lott
- John R Lott
- John R Lott
- John R Lott
- John R Lott
- Jonathan M Karpoff
- Jonathan M Karpoff
- Jose A Pag�n
- Judith Rodin
- K Narbro
- Kelly D Brownell
- Kenneth W Dam
- Kenneth W Dam
- Kenneth W Dam
- Kenneth W Dam
- Kenneth W Dam
- Kevin A Kordana
- L Jack
- Lf Chitwood
- Lisa Bernstein
- Lucian Arye Bebchuk
- M Barry
- M William
- M William
- M William
- Michael Grossman
- Mullin
- Neil E Grunberg
- Nikki M Riley
- Pamela S Haines
- Pauline M Ippolito
- Philipson Geoffard
- Posner Philipson
- R Cass
- Randal C Picker
- Randal C Picker
- Randal C Picker
- Richard A Epstein
- Richard A Epstein
- Richard A Epstein
- Richard A Epstein
- Richard A Epstein
- Richard A Posner
- Richard A Posner
- Richard A Posner
- Richard A Posner
- Richard A Posner
- Richard A. Posner
- Richard Craswell
- Robert W Jeffery
- Rodolfo M Nayga
- Sherwin Rosen
- Susan Averett
- Theodore B Vanitallie
- Tomas J Philipson
- Tomas J Philipson &
- Tomas J. Philipson
- W B Arthur
- Weinsier Heini
- William M Landes
- William M Landes
- William M Landes
- William M Landes
- William M Landes
- William M Landes
- Williams Register
- Yannis Bakos
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1999
- Field of study
1983 Selected Bibliography
- Author
- Abramson Paul R
- Allen Helena G
- Alley James C
- Alrnirol Edwin B
- Anderson Robert N
- Anh Nguyen Thi
- Armentrout-Ma Eve
- Armentrout-Ma Eve
- Asian
- Asian American Studies
- Asian Women United of California. Dear Diane
- Baer Florence E
- Baker Houston A. Jr.
- Bang Heeduk
- Baureiss Gunter
- Bearden Russell
- Benjamin Van Tran
- Bliatout Bruce Thowpaou
- Blicksilver Edith
- Boykin Eunice
- Bruchac Joseph
- Buell Paul
- Cabezas Amado Y
- Cabezas Amado Y
- Caley Peter
- Card Josefina J
- Carroll Dennis
- Cerenio Virginia R
- Chan Anthony B
- Chan Jeffery
- Chan Kenyon S
- Chan Loren B
- Chan Sucheng
- Chang Mae-Chu
- Char Tin-Yuke
- Chee Peter
- Chen Donna
- Chiasson Lloyd Ernest
- Chin
- Chin Jean L
- Chung Tai Ki
- Clark Paul Frederick
- Cohon J. Donald.
- Commission on Wartime Relocation and Internment of Civilians. PersonaLJUstice Denied
- Cordova Fred
- Crouchett Lorraine Jacobs
- Dar Rodrigo Antonio
- Dean James F
- DeFries J. C.
- Desbarats Jacqueline
- Deutsch Elizabeth B
- Dinh Tran Van
- Djao A. Wei.
- Dunnigan Timothy
- Egawa Janey
- Egawa Janey
- Egusa Jerry R
- Endo Russell
- Endo Russell
- Estes Donald H
- Finnan Christine R
- Fong Pauline L
- Fong Pauline L
- Fong Pauline L
- Fukuyama Mary A
- Galang Rosita
- Gee Emma
- Gee Patricia Lee
- Geschwender James A
- Glenn Evelyn N
- Gotanda Philip
- Goto Baron
- Hackler Rhoda E. A.
- Haines David W
- Hanawa Yukiko
- Hastings Dorothy M.H.
- Heifetz Julie Ann
- Helweg Arthur W
- Hirano-Nakanishi Marsha
- Hirayama Kasumi K
- Hom Marlon K
- Hongo Garrett Kaoru
- Hsu George
- Hu-DeHart Evelyn
- Hunt Michael H
- Ichioka Yuji
- Ichioka Yuji
- Iino Grace Wada
- Irick Robert L
- Irons Peter
- Ismail Yusoff
- Ito Karen L
- Jackson Peter
- Japantown
- Joe Jeanne
- Jun-Aust Heeson
- Kagiwada George
- Kaneko Lonny
- Katsoyannis Miranda Georgette
- Kearny
- Kent Noel J
- Kim Chong Ok
- Kim Elaine H
- Kim Illsoo
- Kim Kenneth
- Kim Kenneth
- Kim Robert H.C.
- Kirk Maria Carmen D
- Kitano Harry H
- Kitano Harry H
- Knight Rolf
- Koh Howard Kyongju
- Kuo Chia-Ling
- Kuo Spees
- LaBrack Bruce
- LaLande Jeffrey M
- Lee David
- Lee Douglas W
- Lee Evelyn Y
- Lee John Y
- Lee Soon Jung
- Lee Tsi-Yin
- Leonetti Donna L
- Leung Sophia M
- Levine Rhonda E
- Li Peter S
- Li Wen Lang
- Liem Nguyen Dang
- Lim Robert T
- Lin Masuda
- Lin Robert K
- Liu Fu-Li
- Liu John M
- Loo Chalsa
- Lopez David E
- Majka Linda C
- Mandel Jerry
- Mann Ralph
- Mark
- Martin James J
- Matsumoto Y. Scott.
- Matsuo
- Matsushima Noreen Mokuau
- McEvoy E J
- Miller Stuart Creighton
- Moked Margaret
- Mookherjee Harsha N
- Moon Anson
- Morgan William Michael
- Morishima James K
- Myers Ronald Eugene
- Nakanishi Don T
- Nakano Jiro
- Namioka Lensey
- Nguyen Quynh Hoa
- Nguyen San Duy
- Nguyen San Duy
- Nguyen Thuy T
- Nishida Ryoko
- Noguchi Andy
- O'Brien David J
- Ochs Elinor
- Oh M. David.
- Ong Paul
- Orson Muriel Louise
- Oveissi Mohammad Ali
- Palinkas Lawrence A
- Pao Po-Huen
- Patel Narsi
- Pickwell Sheila M
- Poon Wei Chi
- Posadas Barbara M
- Reed Harold Nolan
- Refugee Resettlement
- Reinecke
- Richter Linda K
- Riddle Ronald
- Rohe Randall E
- Rubin
- Ruidl Richard Alan
- Rutledge Paul James
- Saiki Patsy Sumie
- San Juan E. Jr.
- Santos Bienvenido N
- Santos Bob
- Santry Patricia Josephine
- Sataua Kerisiano Sili
- Saunders E. Anne.
- Schultz Sandra L
- Schwartz Laura E
- Schwertfeger Margaret M
- Scott George M. Jr.
- Shavit Elana
- Shikatani Gerry
- Shimizu David L. G.
- Shiomi R.A.
- Smither Robert
- Starr Paul D
- Stein Yi Yi
- Strobridge William
- Sue David
- Sunoo Sonia Shinn
- Sutherland John E
- Suyemoto Toyo
- Suzaki Ruth M
- Tabrah Ruth
- Takaki Ronald
- Taylor Joyce Gillespie
- Taylor Sandra C
- Tien
- Tinker John N
- Tipton-Schutte Mary Kay
- Tobin J.
- Tong Ben
- Tong Benjamin R
- Tsai Shih-Shan
- Tsegga Asaye
- Tsui Kitty
- Tuitele Lui Talusa
- Uba Laura
- Uchida Yoshiko
- Uiagalelei Lealofi
- Vargo Edward N
- Velez Gonzalo Alunan
- Washington State Commission on Asian American Affairs.
- Weissbluth Marc
- Westermeyer Vang
- Wickberg Edgar
- Williams Carolyn L
- Willson Margaret
- Wong Eddie
- Wong Mary Jung
- Wong Morrison G
- Wong Pierina
- Wunder John R
- Yamamoto Joe
- Yamamoto Joe
- Yamamoto Koretsune
- Yamauchi Wakako
- Yang Joe Tsi
- Yeung Wai-Tsang
- Yoneda
- Yoo Jei Hyun
- Young Dana B
- Yu Renqiu
- Yum
- Publication venue
- 'UCLA American Indian Studies Center'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-Gómez Ad
- Adarmes-Gómez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- Alarcón-Martín Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso María Dolores
- Alonso María Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- Antúnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen Päivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez Céline
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse Céline
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
- Brown Kristelle S.
- Brusco Luis Ignacio
- Bråthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido María J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
- Call Katherine
- Call Kathy
- campion Dominique
- Campos-Martin Rafael
- Cano Amanda
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carpén Olli
- Carracedo Ángel
- Carrasquillo Minerva M.
- Carrillo F.
- Carrillo Fátima
- Carrion-Claro M.
- Carrión-Claro Mario
- Casajeros María José
- Castaño Eduardo M.
- Cañabate Pilar
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Challis Ben
- Chang Diana
- Chapuis Julien
- Charbonnier Camille
- Chasman Daniel
- Chasse Scott
- Chatelain Clement
- Chauhan Ganesh
- Chen Chia-Yen
- Chen Hao
- Chen Hubert
- Chen Hung-Hsin
- Chen Xing
- Chene Geneviève
- Chesi Alessandra
- Chesselet Marie-Francoise
- Chhibber Aparna
- Chillotti Caterina
- Chin Nathaniel A.
- Chipi Elena
- Choy David
- Chu Audrey
- Chui Helena C.
- Chung Jaeyoon
- Chung Jaeyoon
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A. H. R.
- Clarimon Jordi
- Clark Christopher
- Clarke Robert
- Close David
- Collinge John
- Comic Hata
- Conti Elisa
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Crohns Marika
- Cruchaga Carlos
- Cuccaro Michael L.
- Cuccaro Michael L.
- Cuesta Carolina
- Cullum Munro
- Cummings Beryl
- Cupples Adrienne L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daly Mark
- Damotte Vincent
- Daniele Antonio
- Darby Eveleen
- Dardiotis Efthimios
- Dartigues Jean-François
- Davies Chloe
- Davies Gail
- Davis Barbara
- Davis Justin Wade
- de Deyn Peter Paul
- De Jager Philip L.
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- DeCarli Charles
- DeCarli Charles S.
- Deckert Jürgen
- del Ser Teodoro
- Deleuze Jean-François
- della Briotta Parola Pietro
- della Briotta Parolo Pietro
- Deloukas Panagiotis
- Deloukas Pangiotis
- Denning Nicola
- Deramecourt Vincent
- Deramerourt Vincent
- DeStefano Anita
- DeToledo John
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Diogo Dorothee
- Djurovic Srdjan
- Dombroski Beth A.
- Dongen Jasper Van
- Donner Kati
- Doody Rachelle S.
- Dowzell Kimberley
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Duperron Marie-Gabrielle
- Dupuis Josée
- Duron Emmanuelle
- Düzel Emrah
- Eaton Susan
- Ehm Meg
- Eicher John
- Eiriksdottir Gudny
- Eklund Kari
- Elenius Klaus
- Elliott Amanda
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilüfer
- Escott-Price Valentina
- Escuela R.
- Escuela Rocío
- Esmaeeli Sahar
- Espinosa Ana
- Espinosa Miguel Angel Labrador
- Etchepareborda Ignacio
- Evans Denis A.
- Evans Tavia
- Ewers Michael
- Faber Kelley M.
- Fabrizio Tagliavini
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fan Frank
- Fardo David W.
- Farlow Martin R.
- Farotti Lucia
- Farrell John J.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Hernandez Victoria
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fitzpatrick Annette
- Fladby Tormod
- Fließbach Klaus
- Fohner Alison E.
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Fortea Juan
- Fostinelli Silvia
- Fox Caroline
- Fox Nick
- Fox Nick C.
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frosch Matthew P.
- Frölich Lutz
- Fulton-Howard Brian
- Fulton-Howard Brian
- Färkkilä Martti
- Gailhajenet Anna
- Galasko Douglas R.
- Galeano Pablo
- Galimberti Daniela
- Gamboa Adriana
- Ganguli Mary
- Ganna Andrea
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Garcia-Tabuenca Javier
- García-Alberca Jose Maria
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina Lorena
- Gearing Marla
- Geerlings Mirjam
- Georgantas Bob
- George-Hyslop Peter St
- Germani Sandra
- Gerrish Amy
- Geschwind Daniel H.
- Ghanbari Mohsen
- Ghetti Bernardino
- Ghidoni Roberta
- Ghosh Soumitra
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Giorgio Giaccone
- Glatt Stephen J.
- Goate Alison M.
- Goldhardt Oliver
- Gomez-Fonseca Duber
- Gonzalez Hector M.
- González-Pérez Antonio
- Gordillo Jorge Esparza
- Gormley Padhraig
- Goss Monica
- Gossel Matthias
- Grabe Hans
- Grabowski Thomas J.
- Gracia-Tabuenca Javier
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert
- Grand Quentin Le
- Grande Giulia
- Grant Struan F. A.
- Green Emma
- Green Robert C.
- Greenberg Steven
- Grenier-Boley Benjamin
- Grimmer Timo
- Growdon John H.
- Grunin Michelle
- Grünblatt Edna
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart Marina
- Gurling Hugh
- Gursoy Ulvi
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre Pilar
- Haapasalo Annakaisa
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- Harwood Janet
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- Hedman Åsa
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- Parnetti Lucilla
- Partanen Jukka
- Parveen Kayenat
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- Pastor Ana Belén
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- Paus Tomas
- Pausova Zdenka
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- Pelejà Esther
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- Peltonen Markku
- Peltonen Sirkku
- Pendergrass Sarah
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- Pihlajamäki Jussi
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- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez Rocío
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- Piras Federica
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- Pisanu Claudia
- Pitkäranta Anne
- Piñol-Ripoll Gerard
- Plenge Robert
- Podgornaia Anna
- Polak Thomas
- Politis Daniel G.
- Polk Marsha
- Poon Wayne W.
- Popovic Relja
- Popp Julius
- Posthuma Danielle
- Potter Huntington
- Powell John
- Powell John F.
- Preckler Silvia
- Prestia Federico Ariel
- Priller Josef
- Proitsi Petra
- Prokic Ivana
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- Pulkki Kari
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- Qu Liming
- Quarless Danjuma
- Quenez Olivier
- Quiceno Mary
- Quinn Joseph F.
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- Raikkonen-Talvitie Katri
- Rainero Innocenzo
- Raj Ashok
- Raj Towfique
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- Rajula Reddy
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- Ramirez Alfredo
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- Rathinakannan Venkat Subramaniam
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- Seshadri Sudha
- Sevillano Zulma
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- Shaikho Elmutaz
- Shaw Christopher E.
- Shcherban Anastasia
- Shin Jean
- Shofany Jacob
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- Sipeky Csilla
- Sipilä Kirsi
- Sipilä Timo P.
- Siponen Maria
- Sistonen Tuuli
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Slifer Susan H.
- Sliz Eeva
- Small Scott
- Smaoui Nizar
- Smith A. David
- Smith Amanda G.
- Smith Janet P.
- Smith Jennifer
- Snijders Gijsje J. L.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Yeunjoo
- Song Yeunjoo E.
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spina Salvatore
- Spottke Annika
- Squassina Alessio
- Stern Robert A.
- Stevens Alan B.
- Stordal Eystein
- Strandberg Timo
- Strauss Erich
- Strittmatter Stephen M.
- Ståhlbom Anne Kinhult
- Sultzer David
- Suominen Liisa
- Sussams Rebecca
- Swerdlow Russell H.
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Takalo Mari
- Tanzi Rudolph E.
- Tartan Juan Pablo
- Tasanen Kaisa
- Taskinen Marja-Riitta
- Teipel Stefan
- Teng Edmond
- Tesí Niccolo
- Teumer Alexander
- Thalamuthu Anbupalam
- Thomas Alvin
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Tienari Pentti
- Tilson Jeffrey L.
- Tin Adrienne
- Todd Stephen
- Toso Carlos Reyes
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Trojanowski John Q.
- Troncoso Juan C.
- Tsai Ellen
- Tsolaki Anthoula
- Tsolaki Magda
- Tsuang Debby W.
- Tsuo Kristin
- Tucker-Drob Elliot
- Tukiainen Taru
- Tuomi Tiinamaija
- Tuomilehto Jaakko
- Tuovila Outi
- Turpeinen Miia
- Turton James
- Turunen Joni A.
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Uphill James
- Usiskin Keith
- Uusitalo Hannu
- Uusitalo-Järvinen Hannele
- Vacca Alessandro
- Vainio Seppo
- Valero Sergi
- Valladares Otto
- Valladares Otto
- van Adelsberg Janet
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- van Duijn Cornelia M.
- van Eldik Linda J.
- van Lent Debora Melo
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vargas Liliana
- Vassar Robert
- Verhey Frans
- Vicente Maria Pilar
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega Rosario
- Vilas Raquel Huerto
- Vinters Harry V.
- Virolainen Petri
- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study
- Author
- Abramov Vladislav
- Acar Nazire Pinar
- Agopian Eliz
- Agriesti Julie
- Akhter Salma
- Akiyama Tetsuya
- Alberti Aguilo Maria
- Alboini Paolo Emilio
- Alcon Karan
- Alsharabati Mohammad
- Altiparmak Didem
- Alvermann Sascha
- Alves de Siqueira Carvalho Alzira
- Amaral de Andrade Ana Carolina
- Amato Anthony
- Amato Katherine
- Ambrosio Daniel
- Andersen Henning
- Anderson Amanda
- Andersson Blanka
- Andoin Angela
- Angelini Corrado
- Annes Marcelo
- Antonini Giovanni
- Antozzi Carlo
- Appel Stanley H
- Aranke Shachie
- Arima Hideki
- Arndt Heike
- Arnold Thomas
- Arribas-Ibar Elisabet
- Asada Shizuka
- Atula Sari
- Augusto da Silva Luiz
- Autzen Anne Mette
- Aydinlik Seda
- Azrilin Olga
- Babenko Larisa
- Bali Kuperman Hila
- Balyazin Victor
- Bandukwala Ibrez
- Barohn Richard J
- Beck Kate
- Bednarik Josef
- Bekircan-Kurt Can Ebru
- Benatar Michael
- Berger Alan Ross
- Bernitsas Evanthia
- Bertorini Tulio
- Bettini Mariela
- Bevilacqua Francesca
- Beydoun Said
- Bhavaraju-Sanka Ratna
- Bilsker Martin
- Bird Shawn
- Bjarbo Lena
- Blackmore Derrick
- Blount Ira
- Bodkin Cynthia
- Bonanno Silvia
- Bonifati Domenico Marco
- Bostantzopoulou Sevasti
- Boterhoven Heidi
- Bouhour Franç
- Boz Cavit
- Bratton Joan
- Bravver Elena
- Bril Vera
- Brooks Benjamin
- Brown Gavin
- Brown Morris
- Bulle Oliveira Acary Souza
- Burdette Maryanne
- Burns Ted M
- Butters Janelle
- Caliskan Yagmur
- Callison Karen
- Campanella Angela
- Campbell Natasha
- Carnes Donna
- Carrara Fernanda
- Carter Cynthia
- Casasnovas Pons Carlos
- Caserta Cinzia
- Cash Tiyonnoh
- Cavalcante Lino Valeria
- Cavdar Tugce Kirbas
- Cavus Hakan
- Charalambous Despoina
- Chaudhry Vinay
- Chilingaryan Amaiak
- Chmelikova Magda
- Cho Eun Bin
- Chopra Manisha
- Cierny Marek
- Cochrane Thomas
- Coelho Erica
- Cooley Anne
- Corse Andrea
- Cortes Vicente Elena
- Costabile Teresa
- Crabtree Brigid
- Cudia Paola
- D&apos
- D&apos
- da Cruz Pacheco Daiane
- da Penha Morita Ananias Maria
- Dada Martineli Torres Debora
- Daniels Kevin
- Darnell Taylor
- David William
- Davies Debbie
- de Baets Marc
- De Bleecker Jan
- de Cassia Santos Aline
- de Koning Kathy
- De Mey Katrien
- De Rosa Anna
- de Visser Marianne
- Decressac Sonia
- Deneve Michel
- Deruelle Fabienne
- Desnuelle Claude
- Dezsi Livia
- Dheel Christina
- Di Pasquale Antonella
- Dias Brockhausen Igor
- Diaz-Manera Jordi
- Dicapua Daniel
- Diez Tejedor Exuperio
- Dimitriou Aikaterini
- Dimitrova Diana
- DiSanzo Beth
- Distad Jane
- Dogan Baki
- Donahue Craig
- Doreen Ho
- Downing Sharon
- Droker Brian
- Duran Gustavo
- Echevarria Laura
- Eduardo Ng
- Efendi Husnu
- Engel Marguerite
- Erä
- Erdem-Ozdamar Sevim
- Eriksson Jaana
- Evoli Amelia (ORCID:0000-0003-0282-8787)
- Fä
- Faber Catherine
- Faigle Casey
- Feder David
- Fernanda Butinhao Cristiani
- Fernandez-Fournier Mireya
- Filla Alessandro
- Fionda Laura
- Frasca Vittorio
- Freimer Miriam
- Fricke Karin
- Fujii Yuko
- Fukuda Yusuke
- Fukudome Takayasu
- Fukui Sachie
- Funaka Soichiro
- Futono Kazumi
- Fyfe Beverly
- Gaboreau Morgane
- Gabriele Maria
- Gallatti Nichole
- Gamez Josep
- Garcia Alejandra Dalila
- Garcia Rebekah
- Garcia Sonia
- Garibaldi Matteo
- Gazioglu Sibel
- Genge Angela
- Gervais-Bernard Helene
- Gheller Friedrich Maurí
- Giacomelli Elena
- Gibson Tamar
- Gilchrist James
- Gingele Stefan
- Goldstein Jonathan
- Gollogly Jakit
- Gomes da Silva Tamires Cristina
- Gonç
- Gondo Yuichiro
- Gori Maria
- Goyal Namita
- Goyal Neelam
- Greenbereg Nelly
- Gross Bella
- Guerreiro Alexandre
- Guidon Amanda
- Guinrich Sandra
- Guptill Jeffrey
- Gutmann Laurie
- Gutmann Ludwig
- Hø
- Haar Laura
- Hafer-Macko Charlene
- Halton Sharon
- Harbo Thomas
- Harrison Tuula
- Hart Adam
- Hartmann J. Edward
- Harvey Brittany
- Hasan Rosa
- Hasuike Tomoya
- Hayashi Takashi
- Hehir Michael
- Henderson Kendrick
- Herbert Carol
- Hewlett Jasmine
- Hietala Albert
- Higuchi Eriko
- Hisahara Shin
- Hobson-Webb Lisa
- Holzberg Shara
- Homedes-Pedret Christian
- Hong Vu
- Hong Yoon-Ho
- Hopkins Steve
- Horvath Melinda
- Hourquin Caroline
- Howard James F
- Hoyle J. Chad
- Huynh Kristin
- Hwang Eun Bi
- HyeJin Ra
- Ikeda Yasuko
- Illa Isabel
- Imai Tomihiro
- Imamura Tomomi
- Inghilleri Maurizio
- Inoue Masashi
- Iorio Raffaele
- Jacob Saiju
- Jacobs Daniel
- Jasinarachchi Mahi
- Jeffery Dennis
- Jia Kelly
- Jingu Maki
- Jones Floyd
- Jones H. James
- Jons Daniel
- Juel Vern
- Junkerova Jana
- Jurajdova Ivana
- Kamakura Sachiko
- Kamegamori Ikuko
- Kaminska Anna
- Kanai Tetsuya
- Kanda Takashi
- Kane Jennifer
- Kaneko Yoko
- Kang Hoo Nam
- Kanzaki Akiko
- Kaplan Lindsay
- Karam Chafic Karam
- Kasioti Eleni
- Kassebaum Nicole
- Katz Jonathan
- Katzberg Hans
- Katzin Lara
- Kaufman Jacob
- Kaur Harpreet
- Kawai Motoharu
- Kawamata Jun
- Kawamura Tomohiro
- Kazamel Mohamed
- Keijzers Maria Johanna
- Keo Roseann
- Keung Benison
- Khan Omar
- Khoury Julie
- Kikutake Keiko
- Kim Byoung Joon
- Kim Byung-Jo
- Kim MiRi
- Kim Seung Min
- Kim Yool-hee
- Kincaid John
- Kissel John T
- Kobashikawa Tomomi
- Kobayashi Eri
- Kobayashi Hisako
- Koga Megumi
- Koga Michiaki
- Koh Da Yoon
- Konno Shingo
- Konyane Monika
- Koo Yong Seo
- Korobko Denis
- Kostera-Pruszczyk Anna
- Kosykh Evgeniya
- Kramer Megan
- Kumar Sriwastava Shitiz
- Kumar Aditya
- Kurkova Barbora
- Kwan Justin
- Kwon JuYoung
- Lö
- Laaksonen Mikko
- Lacour Arnaud
- Lahaut Pauline
- Lai Eugene
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- Lange Dale
- Lay Luis
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- Le Masson Gwendal
- Lee Chang Nyoung
- Lee HyeLim
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- Lee JiEun
- Leong Wai-Kuen
- Levine-Weinberg Mark
- Liang Lu
- Lim Jae-Sung
- Lin Frank
- Lindberg Christopher
- Lindsay Molly
- Lisak Robert
- Liu Ye
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- Lopez Ruiz Pedro
- Lovas Gabor
- Lucy Shannon
- Macagnan Ana Paula
- Maeda Yasuhiro
- Maeda Yasuko
- Maessen Jos
- Maestri Tassoni Michelangelo
- Maggi Lorenzo
- Mahdi-Rogers Mohamed
- Mahieu Delphine
- Maier Gal
- Makamori Masayuki
- Malekniazi Ali
- Malkova Nadezhda
- Manning Erin
- Mantegazza Renato
- Maqsood Fatima
- Marano Enrico
- Marburger Tessa
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- Masaki Katsuhisa
- Massie Rami
- Mathew Veena
- Matolcsi Judit
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- Matsuse Dai
- Matsushita Takuya
- Mazia Claudio Gabriel
- McClain Terry
- McKenna Kaitlyn
- McKinnon Jonathan
- McKinnon Naya
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- Mercelis Rudy
- Merle Hé
- Messina Silvia
- Micheels Angela
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- Miesen Monique
- Miller Robert
- Millois Edouard
- Min Ju-Hong
- Minton Brian
- Miranda Carolina
- Mitazaki Teiichiro
- Mitropoulou Efstathia
- Mitsikostas Dimos-Dimitrios
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- Mori Masahiro
- Morikawa Miyuki
- Morino Stefania
- Mosmiller Betsy
- Motomura Masakatsu
- Moutarde Julie
- Mozaffar Tahseen
- Mukaino Akihiro
- Mumfrey-Thomas Sandi
- Muppidi Srikanth
- Murahara Takashi
- Murai Hiroyuki
- Murata Mayumi
- Nagaishi Akiko
- Nagane Yuriko
- Nakamura Yumiko
- Nakane Shunya
- Nakayama Ritsu
- Nakazora Hiroshi
- Narikawa Koichi
- Nations Sharon
- Naunton Kerry
- Nemeth Joanne
- Nesterova Yulia
- Nigro Catherine
- Nogueira Coelho Erica
- Norwood Fiona
- Novakova Iveta
- Nowak Richard J
- Nye Joan
- Nyrhinen Anne
- O&apos
- Ogasawara Junichi
- Ogawa Miki
- Oksaranta Olli
- Okubo Yoshinori
- Okumura Meinoshin
- Olalde Heena
- Omoto Masatoshi
- Onar Musa Kazim
- Onesti Emanuela
- Orrico Daniele
- Ortea Carolina
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- Outteryck Olivier
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- Ozen Aydin Cigdem
- Paiva Gabriel
- Palacios Natalia Julia
- Papadopoulou Nikoletta
- Papagiannopoulos Sotirios
- Park SangAe
- Pascuzzi Robert
- Patrick Kara
- Patti Francesco
- Patwa Huned
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- Richman David
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- Rosenfeld Jeffrey
- Roy Gulmohor
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- Rugiero Marcelo
- Saba Juliet
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- Salajegheh Mohammed
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- Sanjak Mohammad
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- Sathasivam Sivakumar
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- Schommer Clara
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- Seddigh Arshira
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- Sen Sedat
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- Seok Hung Youl
- Seok Jinmyoung
- Shabbir Yasmeen
- Shah Akshay
- Shah Jaimin
- Sharma Khema
- Shimohama Shun
- Shimose Shigemi
- Shimpo Misa
- Shin Ha Young
- Shin MiJu
- Shin Susan
- Shinozaki Hirokazu
- Shiraishi Hirokazu
- Shirane Maoko
- Siddiqi Zaeem
- Silvestri Nicholas
- Simpson Ericka
- Sivak Mark
- Skripuletz Thomas
- Smalley Nicole
- Smetcoren Charlotte
- Smith Lisa
- Snook Riley
- Sohail Faisal
- Solé
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- Souza Iandra
- Srinivasan Jayashri
- Stangel Martin
- Steele Julie
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- Suriane Fialho Tomá
- Suzuki Hidekazu
- Suzuki Shuichiro
- Suzuki Yasushi
- Swenson Andrea
- Szabadosne Brigitta
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- Taber Sandra
- Taichi Namie
- Takada Kazumi
- Takada Mihoko Takada
- Takahashi Masanori
- Tandan Rup
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- Thompson Lisa
- Tilkin Petra
- Tobon Gonzalez Alejandro
- Toncrova Stanislava
- Toska Shirli
- Tran Anh
- Trebst Corinna
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- Tselis Alexandros
- Tsuda Emiko
- Tsuda Tomoko
- Tsukita Kenichi
- Tuan Vu
- Tuga Celal
- Tun Ozlem
- Tyblova Michaela
- Uehara Taira
- Ugur Muzeyyen
- Utsugisawa Kimiaki
- Uzawa Akiyuki
- Van Damme Philip
- Van den Abeele Guy
- van der Kooi Anneke
- Vanderhook Mollie
- Varga Edina
- Varghese Mary
- Vecsei Laszlo
- Veiga Thabata
- Ventura Nicholas
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- Vermersch Patrick
- Vial Christophe
- Vidal Gonzalo
- Vidal Nuria
- Vinge Lotte
- Vissing John
- Vlaikidis Nicholas
- Vohanka Stanislav
- Vytopil Michael
- Wagemaekers Linda
- Waheed Waqar
- Wang Jing-Jing
- Wanschitz Julia
- Watanabe Masanori
- Watling Dave
- Weiner Elaine
- Weiss Michael
- Welsh Lesly Welsh
- Wenninger Stephan
- Wheeler Lauren
- Wielanek-Bachelet Anne-Cé
- Wilken Miguel
- Willlems Natasha
- Wilson Amy
- Witting Nanna
- Wolfe Gil
- Wolfova Marcela
- Woodall Amy
- Yamamoto Daisuke
- Yamashita Yumi
- Yarmoschuk Asya
- Yilmaz Ezgi
- Yoshida Seiko
- Yoshikawa Chieko
- Yoshimura Shunsuke
- Yuen T So
- Zakalik Karen
- Zampaki Martha
- Zapletalova Olga
- Zephir Hé
- Zilliox Lindsay
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis. We further assessed the efficacy and safety of eculizumab in this patient population in a phase 3 trial. Methods We did a phase 3, randomised, double-blind, placebo-controlled, multicentre study (REGAIN) in 76 hospitals and specialised clinics in 17 countries across North America, Latin America, Europe, and Asia. Eligible patients were aged at least 18 years, with a Myasthenia Gravis-Activities of Daily Living (MG-ADL) score of 6 or more, Myasthenia Gravis Foundation of America (MGFA) class II\ue2\u80\u93IV disease, vaccination against Neisseria meningitides, and previous treatment with at least two immunosuppressive therapies or one immunosuppressive therapy and chronic intravenous immunoglobulin or plasma exchange for 12 months without symptom control. Patients with a history of thymoma or thymic neoplasms, thymectomy within 12 months before screening, or use of intravenous immunoglobulin or plasma exchange within 4 weeks before randomisation, or rituximab within 6 months before screening, were excluded. We randomly assigned participants (1:1) to either intravenous eculizumab or intravenous matched placebo for 26 weeks. Dosing for eculizumab was 900 mg on day 1 and at weeks 1, 2, and 3; 1200 mg at week 4; and 1200 mg given every second week thereafter as maintenance dosing. Randomisation was done centrally with an interactive voice or web-response system with patients stratified to one of four groups based on MGFA disease classification. Where possible, patients were maintained on existing myasthenia gravis therapies and rescue medication was allowed at the study physician's discretion. Patients, investigators, staff, and outcome assessors were masked to treatment assignment. The primary efficacy endpoint was the change from baseline to week 26 in MG-ADL total score measured by worst-rank ANCOVA. The efficacy population set was defined as all patients randomly assigned to treatment groups who received at least one dose of study drug, had a valid baseline MG-ADL assessment, and at least one post-baseline MG-ADL assessment. The safety analyses included all randomly assigned patients who received eculizumab or placebo. This trial is registered with ClinicalTrials.gov, number NCT01997229. Findings Between April 30, 2014, and Feb 19, 2016, we randomly assigned and treated 125 patients, 62 with eculizumab and 63 with placebo. The primary analysis showed no significant difference between eculizumab and placebo (least-squares mean rank 56\uc2\ub76 [SEM 4\uc2\ub75] vs 68\uc2\ub73 [4\uc2\ub75]; rank-based treatment difference \ue2\u88\u9211\uc2\ub77, 95% CI \ue2\u88\u9224\uc2\ub73 to 0\uc2\ub796; p=0\uc2\ub70698). No deaths or cases of meningococcal infection occurred during the study. The most common adverse events in both groups were headache and upper respiratory tract infection (ten [16%] for both events in the eculizumab group and 12 [19%] for both in the placebo group). Myasthenia gravis exacerbations were reported by six (10%) patients in the eculizumab group and 15 (24%) in the placebo group. Six (10%) patients in the eculizumab group and 12 (19%) in the placebo group required rescue therapy. Interpretation The change in the MG-ADL score was not statistically significant between eculizumab and placebo, as measured by the worst-rank analysis. Eculizumab was well tolerated. The use of a worst-rank analytical approach proved to be an important limitation of this study since the secondary and sensitivity analyses results were inconsistent with the primary endpoint result; further research into the role of complement is needed. Funding Alexion Pharmaceuticals
Part 1. Bibliographies and Other Research and Reference Guides, Including Dictionaries, Encyclopedias, Grammars and Phrase Books
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- Abdi Wazir H.
- Abdullaev K. A.
- Abramson David MacKenzie
- Adams Laura L.
- Adams Laura Lee
- Adib Khalid
- Agadjanian Victor
- Akcali Pinar
- Akiner Shirin
- Akiner Shirin
- Akramov Kamiljon
- al-Khathllan Saleh Mohammed Farhan
- Al-Sati Saud M.
- Alaolmolki Nozar
- Allison Roy
- Alves Marinne
- Amanzholova Dina A.
- Andriessen M.
- Ansari Aimee A.
- Arik Kagan
- Aronson Howard I.
- Asanaliev Tilek Asanalievich
- Asanova Jazira K.
- Babur
- Baijumanov Djanbulat
- Baker Thomas A.
- Baldauf Ingeborg
- Balzer Marjorie M.
- Barton Nan
- Bedford Daniel Peter
- Beiglarbeigi Salaheddin Afshar
- Bell James Ethan
- Benfield Richard W.
- Bertsch Gary K.
- Bockhorst Sarah
- Boljurova Ishengul
- Brooks Karen McConnell
- Brown Andrew James
- Brown Bess
- Burnes Alexander
- Buronov Jamaldin
- Burton Audrey
- Bury Jeffrey T.
- Cajee Mas'ood
- Carlisle Donald S.
- Carlisle Heather Lynn
- Cavanaugh Cassandra
- Cavis Marni D.
- Chabot Philippe Andre
- Charney Craig
- Chenard Stéphane
- Chiappetta Carrie Lynn
- Childress David Hatcher
- Claassen Ernest G.
- Clark William Carl
- Clement Victoria
- Clifford
- Clinton Bill
- Cooper Mary Ewan
- Coudouel Aline
- Craumer Peter
- Cunha Stephem Farrell
- Damrel David W.
- Dave Bhavna
- Deibler Ruth
- Demko George J.
- Dickens Mark
- Dillon Michael
- Din Hayaud
- Din Hayaud
- Dobson Richard B.
- Dobson Richard B.
- Doi Mary M.
- Dosmukhamedov E. K.
- Dror David
- Dunmore Charles Adolphus Murray
- Dzhiembaeva Alia
- Eastep Wayne
- Eastern Middle
- Ebel Robert E.
- Edgeworth Linda
- Eitzen Hilda Carper
- Ellisseeff Vadime
- Ely Delfina Isabel
- Engelmann Kurt E.
- Erdal Marcel
- Erdem Cagri
- Esposito John L.
- Fahnestock Alan L.
- Ferguson Gary A.
- Fihl Esther
- Fletcher Joseph
- Foltz Richard
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- Frank Andre Gunder
- Frye Richard N.
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- Gall Timothy L.
- Giebel Herbert Norman
- Gies Jacques
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- Halpern Rachel
- Hanks Reuel R.
- Harrison Nathaniel P.
- Harrison Tony
- Hedin Sven Anders
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- Herrmann Georgina
- Hickey Beth Ellen
- Hiebert Frederick Talmage
- Hocker Aimee C.
- Hopkirk Kathleen
- Husmann Lisa Eileen
- Ibrahim Ablahat
- Igolinskaya Rimma
- Imamkhodjaeva Oidinposha
- Irwin Mark
- Islam Muhammad
- Jackson George R.
- Ji Ping
- Johnson Ericka
- Jones Scott A.
- Jordan David
- Jourdan Uwe
- Kadir Djelal
- Kafesoglu Ibrahim
- Kamberi Dolkun
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- Kanaev Alexander N.
- Kandiyoti Deniz
- Kangas Roger David
- Kanlidere Ahmet
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- Karasik Theodore William
- Karimi-Hakkak Ahmad
- Karimov I.
- Kasymov Ilkhom
- Kasymova Nazokat A.
- Kato Shizuko
- Keesbury Jill
- Keller Shoshana
- Keller Shoshana
- Kemal S.
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- Keshavjee Salmaan
- Khachaturian Armen G.
- Khakimov Akbar
- Khudonazarov Davlat
- Kiasatpour Soleiman M.
- Kiessling Kerstin L.
- King Steven Douglas
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- Koichuyev T. K.
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- Kotenyova Tatyana E.
- Krekel Bryan A.
- Lameer J.
- Landis Edwin R.
- Lape Maureen
- Law David A.
- Levashov Georgiy Georgievich
- Levin Theodore
- Levin Theodore Craig
- Levitin Leonid
- Lewis J. Stuart
- Library of Congress
- Library of Congress
- Library of Congress
- Logachev V. A.
- Luloff Gregory M.
- Luong Pauline Jones
- Luster Aaron
- Lynch Dov
- Lyons Shawn T.
- MacLeod Calum
- Maddock Kenneth
- Manz Beatrice Forbes
- Marefat Roya
- Martin Virginia
- Matas David
- McCabe William A.
- McCray Thomas R.
- McCreery Scott L.
- McDaneld A. Scott
- Meffert Peter R.
- Menon Rajan
- Merefat Roya
- Micallef Roberta Maria
- Michaels Paula A.
- Michaels Paula Anne
- Micklin Philip
- Micklin Philip P.
- Millward James A.
- Mitrokhin N.
- Moriak Christopher Frank
- Musaev Qudrat M.
- Nazarbayev Nursultan N.
- Nazpary Joma
- Nepesova Roza Gaibovna
- Nicolle David
- Northrop Douglas Taylor
- Nowicki Marvin E.
- O'Donnell Jennifer Jane
- Olcott Martha Brill
- Omarova Saule Tarikhovna
- Otorbaev K.
- Paksoy Hasan B.
- Paksoy Hasan B.
- Paterson Michael T.
- Payne Matthew J.
- Peimani Hooman
- Peters Nigel
- Plagier Sally
- Pohl Michaela
- Poliakov Sergei
- Popovych Erika I.
- Powell John D.
- Practical Information
- Privratsky Bruce G.
- Prokhoroff Georges
- Pulley Anne Laura Helena
- Qualin Anthony J.
- Rajaee Bahrain M.
- Rajaee Bahram
- Razvi Syed Abbas Hasan
- Reichl Karl
- Rerikh Nikolai K.
- Rezun Miron
- Richrnan Alvin
- Righetti Scott R.
- Roberts Courtney S.
- Roberts Scan R.
- Rofi'i Imam
- Rottier Peter
- Rouse Mary Patricia Joan
- Rumer Boris Z.
- Rutland Peter
- Rywkin Michael
- Sabol Steven
- Sabol Steven
- Sahadeo Jeffery Frank
- Sato Kyoko
- Savin Kenneth S.
- Schoeberlein-Engel John Samuel
- Schwalbe Nina
- Scott Andrea
- Seaman Gary
- Segas Gregory Paul
- Sewall Bella Katy
- Shackelford Sharen M.
- Shackelford Sharen M.
- Shadmanaw Qurban
- Sharp Deanne
- Sharp John R.
- Shashenkov Maxim
- Shub Anatole
- Shukurov Emil
- Shukurov Emil
- Siegal Jennifer
- Simpson David W.
- Sinnott Peter James
- Sinor Denis
- Skagen Ottar
- Skallerup Thomas Mark
- Skinner R. Kenneth
- Skoczylas Elehie N.
- Small Eric E.
- Smith David Roger
- Song Jun
- Spengler William F.
- Spengler William F.
- Spitkovsky Julia
- Stahl Thomas Brian
- Stanford Mark Steven
- Stein Aurel Sir.
- Stone Christopher Bradford Ian
- Sullivan Barry Lynn
- Swafford Michael
- Söylemez Orhan
- Tadjbakhsh Shahrbanou
- Tadjbakhsh Shahrbanou
- Tadjbakhsh Shahrbanou
- Tang Sniping
- Taube Herman
- Taylor Rupert J.
- Terry Hilja R.
- Thurman J. Michael
- Thurman Michael
- Toops Stanley Winfield
- Tousley Scott W.
- Tritz Julie Ann
- Tsai Tsung-te
- Tylynski Jacqueline K.
- Unseth Benjamin
- Uribes Rebecca
- Utschig A.
- Verrier Anthony
- Vertkin Dmitri
- Vincent Donna M.
- Walter Mariko Namba
- Wang David
- Wang Meng
- Warikoo Kulbhushan
- Wasilewska Ewa
- Wasyliw Lynne Anne
- Watts Ian Kenneth
- Wenmin Liu
- Woff Richard
- Wolfe Keith David
- Wood Leonard James
- Wood William A.
- Wood William A.
- Yasuda Osamu
- Yazar Hatice
- Yu Yaohua
- Zanca Russell G.
- Zeybek A. Yavuz
- Zhang Feng
- Zhao Yueyao
- Zhou Xijuan
- Zimmerman Shelley Ann
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study