HIV infection as a risk factor for shigellosis.

We investigated cases of shigellosis in San Francisco and Alameda Counties identified during 1996 by active laboratory surveillance to assess the role of HIV infection as a risk factor for shigellosis. Dramatically elevated rates of shigellosis in HIV-infected persons implicate HIV infection as an important risk factor for shigellosis in San Francisco

Long term changes in body condition and gillnet selectivity in Lake Constance pelagic spawning whitefish Coregonus wartmanni

The body condition of Lake Constance pelagic spawning whitefish Coregonus wartmanii has changed substantially during the past century and significantly altered the length-based selectivity of gillnets. Linked hierarchical models using Bayesian inference and error propagation were used to estimate the monthly body condition of whitefish from 1932-2018 and condition-dependent gillnet selectivity from 1964-2018. As expected, body condition followed past trends in nutrient dynamics and was highest in summer months. Body condition was clearly linked to gillnet selectivity, with a weight increase of a 300 mm whitefish from 205 to 260 g predicted to reduce the mean (from 374 to 330 mm) and standard deviation (from 30.8 to 25.1) of lengths selected by a 38 mm mesh gillnet. Simulations demonstrate that such changes can reduce the mean age in harvest by over 1 year and greatly bias population age distribution estimates if selectivity changes are ignored. Similar variation in gillnet selectivity is expected where trophic conditions or other factors cause body condition differences, and accounting for these changes could reduce biases to inform fishery management.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Nuclear Factor-κB Activation in Endothelium by Chlamydia pneumoniae without Active Infection

Causative molecular mechanisms accounting for the potential link between Chlamydia pneumoniae and atherosclerosis are unknown. Formalin and heat-inactivated C. pneumoniae activated the transcription factor nuclear factor (NF)-κB in cultured porcine endothelium and up-regulated the expression of E-selectin messenger RNA and protein. This up-regulation was abolished by an IκB super-repressor, an NF-κB-specific inhibitor. Live bacteria are not necessary for the activation of endothelial NF-κB, and C. pneumoniae may contribute to atherogenesis without active infection